JOURNAL OF HAZARDOUS MATERIALS
·
2025
·
IF 11.3
Xinyu Guo,Zhibao Liu,Hui Chen,Yuqi Zhu,Yaopeng Zhang,Fang Li,Chunyan Ma,Chensi Shen
The coexistence of antimony (Sb) contamination from textile industries and phosphorus (P) enrichment poses a significant yet understudied threat to aquatic ecosystems. This study elucidates how P availability determines Sb toxicity in cyanobacteria. Under P-deficient conditions (0 and 3.0 mg/L), Sb (50 μg/L) consistently inhibited Synechococcus sp. growth (by 29.5 % and 14.1 %, respectively) over 144 h. While, at optimal and high P levels (5.4 and 9.0 mg/L), Synechococcus sp. cells exhibited initial inhibition followed by growth promotion (by 18.8 % and 38.7 %, respectively). Mechanistically, P-deficient cells accumulated 3.7-fold more Sb, developed severe SOD/CAT imbalance (5.2-fold increase and 44.9 % decrease), and showed substantially higher ROS levels despite rapid initial Sb(III) oxidation. These divergent physiological responses were underpinned by distinct molecular adaptations. Transcriptomic analysis revealed that P-sufficient cells strategically upregulated sulfate transporters while downregulating phosphate transporters (pstS/pstC/pstA) to minimize Sb uptake, exhibited balanced redox regulation, and maintained efficient electron transport chains. In contrast, P-deficient cells upregulated emergency stress responses (flavodoxin FldA) but failed to maintain effective metal transport regulation. This study establishes nutrient status as a key determinant of Sb toxicity, demonstrating that eutrophication transforms Sb from an inhibitor to a promoter, with implications for cyanobacterial bloom management.
研究领域:
环境科学
·
分子生物学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Current Nanoscience
·
2024
·Vol. 21
·期 2
·345-353
·
IF 1.4
Liqing Zeng,Yazhen Chen,Baiqi Pan,Hui Yang,Yuyan Chen,Mei Xu,Songmei Chen,Fan Yang,Chongyu Gu
BackgroundMicroplastics is a new type of global pollutant that can absorb pollutants in the environment and enter the food chain. Arsenic (As) is a kind of heavy metal element, and its pollution to the environment has been triggered concern. Currently, the escalating threat to marine ecology posed by both microplastics and heavy metal pollution is garnering increasing attention, particularly concerning their detrimental impact on human health.MethodsThe aim of this paper is to study the adsorption of As by microplastics and their combined toxic effects on clams, which were determined by joint toxicity test.ResultsDuring the initial 48 hours, the fatality rates for larval clams exposed to As (III)-adsorbed microplastics, including polypropylene (PP), polyethylene (PE), polystyrene (PS), polyvinyl chloride (PVC), and polymethyl methacrylate (PMMA) at concentrations ranging from 10 mg/L to 500 mg/L, varied in the range of 0-30.0%, 0-10.0%, 0-30.0%, 0-15.0%, and 0-50.0%, respectively. Similarly, adult clams exhibited fatality rates within the ranges of 0-35.0%, 0-25.0%, 0-30.0%, 0-50.0%, and 0-15.0%. However, these rates increased significantly after 48 hours, reaching 80.0% (PP), 62.0% (PE), 40.0% (PS), 60.0% (PVC), and 70.0% (PMMA) for larval clams, and 85.0% (PP), 72.0% (PE), 40.0% (PS), 72.0% (PVC), and 65.0% (PMMA) for adult clams, respectively. In contrast, when exposed to microplastics concentrations exceeding 1000 mg/L with adsorbed As (III), both larval and adult clams experienced fatality rates that initially peaked between 55.0% and 100.0% within the first 48 hours. Throughout the entire incubation period with As (III) alone, the fatality rates for larval and adult clams remained relatively low, ranging from 0-20.0% and 0-15.0%, respectively.ConclusionThe mortality rate of clams directly correlated with the input of microplastic particles containing As (III); specifically, an increase in the concentration of microplastics resulted in higher fatality rates and accelerated death rates among the clams. Clams demonstrated varying toxicological responses to the different types of microplastics.
研究领域:
环境科学
·
毒理学
·
海洋生物学
✓ 已验证
DOI
高影响因子
CHEMOSPHERE
·
2019
·
IF 5.108
Min Chen,Yongfei Gao,Xiaoxue Bian,Jianfeng Feng,Weiqi Ma,Lin Zhu
Aquatic organisms are often exposed to time-varied concentrations of contaminants due to pulsed inputs in natural water. Traditional toxicology experiments are usually carried out in a constant exposure pattern, which is inconsistent with the actual environment. In this study, a refined toxicokinetic-toxicodynamic (TK-TD) model was used to study the toxic effects of Pb and Cd on zebrafish larvae under three pulse exposures with 2, 4, and 6 h, respectively. The parameter sensitivity analysis showed that J M, max had the greatest impact on the output of the model. Cd or Pb pulse exposure resulted in less death than constant exposure at the same time-weighted average (TWA) concentrations. Survival fraction in larvae under 6 h interval between two pulses of Pb or Cd was larger than that under 2 h and 4 h interval. Toxicity under constant exposure of Cd or Pb was greater than that under 2, 4, and 6 h interval pulse exposure because the cumulative Cd or Pb concentration in the body under constant exposure was greater than that under pulse exposure. The results also showed that the stochastic death (SD) model was more suitable than the individual tolerance (IT) model for predicting the survival fraction of larvae under pulse exposure to Pb and Cd, which was indicated by higher R 2 (0.670–0.940) in SD model than that (0.588–0.861) in IT model. Our model provides approaches for laboratory toxicity testing and modeling approaches for addressing the toxicity of heavy metal pulsed exposure.
研究领域:
生态毒理学
·
环境科学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
CHEMOSPHERE
·
2022
·
IF 8.943
Jing Ma,Fu Chen,Yanfeng Zhu,Xiaoxiao Li,Haochen Yu,Yan Sun
The toxicological impacts of microplastics (MPs) and antibiotics in the soil environment have gradually drawn widespread attention, while little research has focused on the combined pollution of MPs and antibiotics on plants. In this work, a 21-day hydroponic study was conducted to test the hypothesis that polystyrene MPs (0.1, 1 and 10 μm particle sizes, 50 mg/L) and ciprofloxacin (CIP) (1.0 and 5.0 mg/L) had a joint toxicity to wheat seedlings and they could be absorbed by wheat. Plant samples were taken for analyses after 21 days of exposure. The results showed that 0.1 and 1 μm MP could enter wheat roots but only the former could translocate to aerial parts. Moreover, 0.1 μm MP showed a greater toxicity effect than 1 μm MP, whereas 10 μm MP exhibited little toxicity on wheat. The dosing of 0.1 μm MP significantly increased the toxic effects of CIP to wheat. Compared to the control treatment (without MPs and CIP), 0.1 μm MPs-5.0 mg/L CIP treatment resulted in inhibition of root length and weight by 60.1% and 44.3%, respectively, while the contents of chlorophyll a and chlorophyll b decreased by 36.3% and 44.6%, respectively. The presence of CIP (5.0 mg/L) potentially aggravated the combined toxicity. The exposure of 0.1 μm MP significantly reduced root superoxide distumase activity but increased root malondialdehyde content. The amount of CIP in wheat tissues carried by MPs was negligible compared with the uptake quantity of CIP by wheat.
研究领域:
环境科学
·
植物学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
ENVIRONMENTAL POLLUTION
·
2017
·
IF 5.099
Biying Wu,Lizhong Zhu,X. Chris Le
The wide occurrence and high environmental concentration of titanium dioxide nanoparticles (nano-TiO 2 ) have raised concerns about their potential toxic effects on crops. In this study, we employed a GC-MS-based metabolomic approach to investigate the potential toxicity of nano-TiO 2 on hydroponically-cultured rice ( Oryza sativa L.) after exposed to 0, 100, 250 or 500 mg/L of nano-TiO 2 for fourteen days. Results showed that the biomass of rice was significantly decreased and the antioxidant defense system was significantly disturbed after exposure to nano-TiO 2 . One hundred and five identified metabolites showed significant difference compared to the control, among which the concentrations of glucose-6-phosphate, glucose-1-phosphate, succinic and isocitric acid were increased most, while the concentrations of sucrose, isomaltulose, and glyoxylic acid were decreased most. Basic energy-generating ways including tricarboxylic acid cycle and the pentose phosphate pathway, were elevated significantly while the carbohydrate synthesis metabolism including starch and sucrose metabolism, and glyoxylate and dicarboxylate metabolism were inhibited. However, the biosynthetic formation of most of the identified fatty acids, amino acids and secondary metabolites which correlated to crop quality, were increased. The results suggest that the metabolism of rice plants is distinctly disturbed after exposure to nano-TiO 2 , and nano-TiO 2 would have a mixed effect on the yield and quality of rice.
研究领域:
植物学
·
环境科学
·
毒理学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
AQUATIC TOXICOLOGY
·
2014
·
IF 3.513
Tao Wang,Xiaohua Long,Yongzhou Cheng,Zhaopu Liu,Shaohua Yan
Copper nanoparticles (Cu-NPs) were widely used in various industrial and commercial applications. In this study the effects of Cu-NPs and soluble Cu were investigated on juvenile Epinephelus coioides . The fish were exposed in triplicate to control, 20 or 100 μg Cu L −1 as either copper sulphate (CuSO 4 ) or Cu-NPs in a semi-static aqueous culture for 25 days. The growth parameters were significantly lower at 100 μg Cu L −1 as CuSO 4 or Cu-NPs treatment compared to control. Time-dependent Cu accumulation in all tissues increased with increasing the Cu dose. The percentage of total Cu found in remaining tissues (head, bones, fins, etc.) decreased more in the CuSO 4 than Cu-NPs treatment after 25 days, but increased in all other tissues (especially in liver). Compared with the control, either Cu-NPs or CuSO 4 induced higher malonaldehyde concentration in tissues by overwhelming total superoxide dismutase activity, total glutathione concentration and Na + /K + -ATPase activity, but the opposite results were recorded for the brain. With increasing the CuSO 4 or Cu-NPs dose, apoptosis was exacerbated in the liver and gills, more so by CuSO 4 than Cu-NPs. Overall, these findings showed that Cu-NPs had the toxic effects similar to dissolved Cu; hence, Cu-NPs need to be included in the assessment of toxicological impacts in the aquatic environment.
研究领域:
环境科学
·
毒理学
·
水产养殖学
✓ 已验证
DOI
PubMed
高影响因子
JOURNAL OF HAZARDOUS MATERIALS
·
2018
·
IF 6.434
Wei Lin,Ruifen Jiang,Yaxin Xiong,Jiayi Wu,Jianqiao Xu,Juan Zheng,Fang Zhu,Gangfeng Ouyang
It has been reported that nanoplastics (NP) could cause serious toxicity and accumulative effects on aquatic organisms as well as interact with organic pollutants and influence potential hazards when exposed to biota. The current study aimed to quantitatively investigate the combined acute toxic effect of polychlorinated biphenyls (PCBs) and nano-sized polystyrene (PS) plastic on aquatic organisms based on analyte speciation. First, the combined acute toxicity of PCB-18 and 100 nm PS to Daphnia magna ( D. magna ) in water was evaluated. Then, speciation analysis of the exposure system was conducted by measuring the sorption coefficients ( logK NP ) of PCBs to nano-sized PS (ranging from 5.28 to 6.56), which demonstrated the PS could substantially decrease the free concentrations of PCBs. The results showed that a low concentration of the PS could decrease the toxicity to D. magna ., which might be originated from the decreased free concentration of PCB-18. However, when the PS concentration was high enough, an opposite effect was observed because the PS dominated the lethality instead of PCB-18. The current study is helpful to clarify the PCB occurrence in ecosystems and provide an in-depth understanding of the eco-toxicological effects of nanoscale plastics.
研究领域:
环境科学
·
生态毒理学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
MOLECULES
·
2023
·Vol. 28
·期 12
·4774
·
IF 4.6
Qingqing Xiang,Ying Zhou,Chengxia Tan
Prothioconazole (PTC) is a broad-spectrum triazole fungicide with one asymmetric center and consists of two enantiomers,R-(−)-PTC andS-(+)-PTC. To address the concern of its environmental safety, the enantioselective toxic effects of PTC onScendesmus obliquus(S. obliquus) were investigated. PTC racemates (Rac-PTC) and enantiomers exhibited dose-dependent acute toxicity effects againstS. obliquusat a concentration from 1 to 10 mg·L−1. The 72 h-EC50 value ofRac-,R-(−)-, andS-(+)-PTC is 8.15, 16.53, and 7.85 mg·L−1, respectively. The growth ratios and photosynthetic pigment contents of theR-(−)-PTC treatment groups were higher than theRac- andS-(+)-PTC treatment groups. Both catalase (CAT) activities and esterase activities were inhibited in theRac- andS-(+)-PTC treatment groups at high concentrations of 5 and 10 mg·L−1, and the levels of malondialdehyde (MDA) were elevated, which exceeded the levels in algal cells for theR-(−)-PTC treatment groups. PTC could disrupt the cell morphology ofS. obliquusand induce cell membrane damage, following the order ofS-(+)-PTC ≈Rac-PTC >R-(−)-PTC. The enantioselective toxic effects of PTC onS. obliquusprovide essential information for its ecological risk assessment.Keywords:prothioconazole;toxicity effects;Scenedesmus obliquus;enantioselectivity
研究领域:
环境科学
·
毒理学
·
生态学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
ENVIRONMENTAL POLLUTION
·
2025
·
IF 7.3
Shengtao Jiang,Qinqin Zhu,Panpan Hong,Jiancheng Chen,Huayue Zhu,Jianqiang Zhu,Hangbiao Jin
Cyclotriphosphazenes (CTPs) have been widely used as flame retardant electrolyte additives in the manufacturing of lithium-ion batteries (LIBs). However, their environmental occurrence, behaviors, and toxic effects have not been well explored. This study analyzed six CTPs in surface water and sediment samples collected surrounding a LIB manufacturing park. All target CTPs were detected in surface water samples, displaying the detection frequencies of 10–90 %. Phosphonitrilicchloridetrimer (HCCTP; 55 ng/L) exhibited the highest mean water concentration, followed by ethoxy(pentafluoro)cyclotriphosphazene (EPFCTP; 29 ng/L) and hexafluorocyclotriphosphazene (HFCTP; 24 ng/L). Detection frequencies of CTPs in sediment were in the range of 19–95 %. EPFCTP (mean 24 ng/g dw) and hexaphenoxycyclotriphosphazene (HPCTP; 20 ng/g dw) were the predominant CTPs in sediment. HPCTP (3.5 ± 0.61) displayed the highest mean log K oc value, which was followed by phosphonitrilicchloridetrimer (HCCTP; 3.2 ± 0.69), EPFCTP (2.8 ± 0.60), and HFCTP (2.6 ± 0.43). In addition, a high-throughput phenotypic screening assay was used to evaluate the toxic effects of CTPs on Caenorhabditis elegans . Target CTPs showed different effects on the four phenotypic parameters (i.e., length, movement, survival, and fecundity) of Caenorhabditis elegans , and HCCTP was the most toxic CTP at the exposure levels of 50–500 μM. To our awareness, this study provides the first evidence on the environmental behaviors and toxic effects of CTPs. These findings are critical for the development of strategies to mitigate the release and toxic impact of CTPs derived from the LIB manufacturing.
研究领域:
环境科学
·
毒理学
✓ 已验证
DOI
PubMed
高影响因子
Scientific Reports
·
2025
·Vol. 15
·期 1
·1-16
·
IF 3.9
Zeng Liqing,Yang Hui,Tong Tong,Chen Jielun,Huang Yujie,Yang Jiaming,Xiao Yuhui,Yang Fan,Chen Yazhen
This study delved into the impact of aging on the properties of five common microplastic types, including polymethylmethacrylate (PMMA), polystyrene (PS), polyvinyl chloride (PVC), polyethylene (PE), and polypropylene (PP). The aging process significantly altered the particle size distribution: PS, PP, and PMMA underwent a contraction, with average sizes decreasing by 6.8%, 3.2%, and 1.7%, respectively, whereas PE and PVC experienced an expansion, with increases of 3.1% and 1.7%. Notably, aging generally increased the specific surface area of all microplastics by more than 20%, a change that could influence their environmental interactions. Scanning electron microscopy revealed marked surface cracks and depressions in aged PE and PVC, in contrast to minor surface alterations in PS and PMMA. Fourier transform infrared spectroscopy further indicated modifications in the characteristic peaks of aged PMMA, PP, and PE microplastics. Exposure experiments demonstrates that increasing microplastic concentrations from 100 mg/L to 5000 mg/L accelerated mortality rates in clams, with juveniles exhibiting slower mortality onset compared to adults. Prolonged exposure led to rising mortality rates across all groups, suggesting a cumulative toxic effect from long-term microplastic exposure. These findings underscore the environmental ecological risks associated with the altered physicochemical properties of aged microplastics, particularly for the Philippine clam. This study provides an essential insight for advancing our understanding of microplastic behavior and their ecological impacts, highlighting the need for further research to mitigate these environmental threats.
研究领域:
生态学
·
环境科学
·
海洋生物学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
·
2021
·Vol. 29
·期 14
·20711-20720
·
IF 4.223
Jiang Ying,Du Linna,Cheng Qilu,Jin Zhuo,Hui Cai,Zhao Yuhua,Jiang Hui,Xu Ligen
Nanoparticles and organic pollutants are two major contaminants found in aquatic environments. Algae are regarded as the model organism for the risk assessment of pollutants in water. In our previous study, we investigated the toxic effects of nonylphenol (NP), a typical organic water pollutant, on algae; however, it remains unclear how algae respond to the coexistence of NP and nanoparticles. In this study, a concentration gradient of nanoscale zero-valent iron (nZVI; 10, 50, 100, and 200 mg/L) was added to NP-exposed Dictyosphaerium sp. to investigate both the toxic effects of this combination and the potential for NP removal. nZVI had a dose-dependent effect on NP-exposed algae, with high nZVI concentrations significantly decreasing algal biomass and pigment content, as well as severely damaging algal cellular ultrastructure. In addition, genes involved in antioxidant response, photosynthesis, and ribosome synthesis were significantly altered when NP-exposed algae were incubated with nZVI. In contrast to high nZVI concentrations, adding a small concentration of nZVI led to reduced toxicity in NP-exposed algae, while significantly enhancing the NP removal rate. This study improves our understanding of algal responses to various pollutants and suggests that nZVI may assist in the remediation of NP in aquatic ecosystems.
研究领域:
环境科学
·
分子生物学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
JOURNAL OF RARE EARTHS
·
2020
·
IF 3.104
Vivian Andoh,Huaiyang Guan,Lin Ma,Weiguo Zhao,Long Li,Guohua Wu
Neodymium (Nd) is one of the most famous members of rare earth elements family. With the increasing global demand for Nd, it can inevitably enter the environment and affect the ecological environment through the food chain and other ways. Therefore, it is very important to study the biological effects of Nd. In this study, the biological effects of 3 kinds of Nd compounds, i.e. neodymium oxide (Nd 2 O 3 ), neodymium chloride (NdCl 3 ) and neodymium nitrate (Nd(NO 3 ) 3 ), were evaluated by using silkworm models through the method of intravascular injection. Each of the three Nd compounds was prepared into 6 groups at different concentrations (40, 50, 60, 70, 80, 90 μg/μL). The results show that within the certain concentration range, Nd compounds show great damage to the growth of silkworms since high death rate is observed: the death rate from Nd 2 O 3 group is floating between 30% and 80%, the one from NdCl 3 group is between 17% and 33% and that from Nd(NO 3 ) 3 group is between 23% and 37%. It also reveals that Nd compounds have some negative effects on the body length and weight of silkworms. However, the histophysiological study shows that the three Nd compounds cause no obvious negative effects on the cell morphologies in midgut, fat body and silk gland. The XRD and FTIR spectra show that the secondary and the crystalline structures of silks are not destroyed, the TGA and DTG data exhibit that the thermal stability of silks is not damaged, and the tensile test shows that the mechanical properties of silks are not affected significantly by the intake of Nd compounds. In general, the intake of Nd compounds has significant inhibitory effects on silkworm growth but little negative impact on silk structures or cell morphology, the study can provide useful toxicological data for the safe application of Nd compounds in various fields.
研究领域:
环境科学
·
生物学
✓ 已验证
DOI
高影响因子
危险品化学品经营许可证（带存储）