JOURNAL OF MEMBRANE SCIENCE
·
2025
·
IF 9
Tingming Ye,QingJi Wang,Jing Qi,Baiwen Ma,Tao Lyu,Chengzhi Hu,Mathias Ulbricht,Huijuan Liu
The development of cost-effective and sustainable water treatment technologies is crucial for supporting the water sector and the public in achieving global sustainable development goals (SDG 6) and carbon neutrality targets. Ultrafiltration (UF), known for its compactness, relatively high performance, and ease of operation, has been widely deployed in water treatment. However, its limitations in removing some emerging contaminants (ECs) and membrane fouling issues have hindered its broader application. This study investigated the incorporation of bioaugmented filtration into conventional UF processes to enhance ECs removal and mitigate membrane fouling during the treatment of real drinking water sources. In addition to effectively removing microorganisms (eukaryotes and bacteria), polysaccharides (13.9%), and inorganic pollutants (CaCO 3 , MgO, SiO 2 , and Al 2 O 3 ), the proposed approach also demonstrated superior removal (4.6%–100.0%) of four target ECs (atenolol, carbamazepine, trimethoprim, and sulfamethoxazole) compared to direct UF process (1.5%–47.5%). After 56 days of operation, the bioaugmented pre-treatment significantly reduced transmembrane pressure (TMP) by 80.2% compared to the direct UF process. Mechanisms studies further reassured that ECs removal followed oxidation during bioaugmentation pre-treatment. The time-of-flight secondary ion mass spectrometry with in-depth analysis capability (around 5 nm) revealed that the UF membrane primarily removed atenolol through adsorption. The toxicity prediction results of typical ECs and their degradation intermediates indicated a significant reduction in ecological risk for most intermediates. The findings from this work demonstrate the feasibility of using low-carbon and few-chemical water treatment technologies to secure drinking water quality.
研究领域:
环境科学
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水处理技术
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可持续发展
✓ 已验证
产品关联
DOI
高影响因子
CHEMICAL ENGINEERING JOURNAL
·
2018
·
IF 6.735
Jiaoqin Liu,Chenguang Li,Ruijuan Qu,Lianhong Wang,Jianfang Feng,Zunyao Wang
Hydroperfluorocarboxylic acids (H-PFCAs) have attracted worldwide attention for their potential use as alternatives to perfluorocarboxylic acids (PFCAs). Decomposition of these chemicals is of great significance due to their possible environmental risks. In this work, the photodegradation of typical H-PFCAs (HC n F 2n COOH, n = 4, 6, 10) in water by a 500 W mercury lamp was systematically examined. We found that the photodegradation of H-PFCAs all followed pseudo-first-order kinetics, and the photoreactivity increased with carbon chain length. The degradation pseudo-first-order rate coefficients of H-PFCAs were slightly slower than the corresponding PFCAs. The decomposition efficiency of HC 10 F 2 COOH was enhanced by lowering pH, but inhibited by the presence of humic acid. Three common inorganic ions showed inhibitory effect on HC 10 F 2 COOH photodegradation, with the order of NO 3 − > CO 3 2− > HCO 3 − . This is because these anions have different light absorption, making less light available for compound degradation. As a photosensitizer, Fe 3+ had an obvious promoting effect on the reaction. According to the products identified by mass spectrometry analysis, decarboxylation, defluorination and elimination reaction were mainly involved in the photodegradation of HC 10 F 2 COOH. Toxicity predictions by ECOSAR program showed that photolysis can reduce the aquatic toxicity of HC 10 F 2 COOH. This work could provide useful information for developing a simple and effective technology to treat H-PFCAs in water.
研究领域:
环境科学
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化学
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产品关联
DOI
高影响因子
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
·
2024
·Vol. 25
·期 24
·13231
·
IF 4.9
Yaqing Guo,Kai Wu,Haoran Yang,Xiaoyu Lin,Huiying Yang,Xianfu Wu
Ginsenoside Re was the major bioactive component found rich inPanax ginsengC. A. Meyer, which exerted excellent cardiovascular protection, anti-inflammatory, and anti-oxidation effects. The generation of unexpected degradation products (DPs) may influence the therapeutic effect of Re, or even bring toxic effects to patients. However, to date, only a few reports were available about the stability of Re. The present study aims to systematically investigate the degradation behaviors of Re under different stress conditions, including hydrolysis (acidic, basic, and neutral), oxidation, humidity, thermal, and photolytic (ultraviolet and visible light) conditions. A total of thirteen DPs were putatively identified, and among them, nine were discovered for the first time in our study. The results showed that Re was sensitive to exposure to acidic, basic, and oxidation conditions. It underwent a series of chemical degradation reactions, including deglycosylation, dehydration, addition, oxidation at the double bond, and isomerization under various stress conditions. Structural characterization of these DPs was carried out by UHPLC-DAD-CAD and LC-LTQ/Orbitrap. A plausible mechanism of their formation was proposed to support the structures of all DPs of Re. In silico toxicity prediction and metabolism behavior assessment were done by Derek Nexus and Meteor Nexus software. Re and DP-1 to DP-6 were predicted to possess potential skin irritation/corrosion toxicity. DP-11 and DP-12 bear the potential for carcinogenicity, mutagenicity, irritation, hepatotoxicity, and skin sensitization. The observation of these DPs updates our knowledge regarding the stability of Re, which provides valuable information for quality control and to choose suitable storage conditions.
研究领域:
中药化学
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药物分析
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毒理学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Journal of Water Process Engineering
·
2024
·
IF 6.3
Feng Liu,Huanhuan Zhang,Nian Liu,Junxia Wang,Maolin Chen,Feiyue Qian
Wafer surface treatment is a crucial step in the integrated circuit packaging process, which would generate high-strength organic wastewater using propylene glycol monomethyl ether (PGME) as a photoresistor thinner. This study investigated the performance of Fenton oxidation and catalytic ozonation (O 3 /H 2 O 2 /FeOOH) for removing refractory organics in wafer surface treatment wastewater by optimizing operation and combining utilizations. Gas chromatography–mass spectrometry was employed to analyze intermediates composition in the effluents treated by various advanced oxidation processes , and the toxicity of organics was predicted using the Quantitative Structure-Activity Relationship tool. Fenton oxidation outperformed O 3 /H 2 O 2 /FeOOH in the removal efficiencies of chemical oxygen demand (COD) and PGME, but produced 9.60 kg·m −3 of chemical sludge . Additionally, 3-hydroxy- N -phenylaniline, an acutely toxic compound, was dominant in the intermediates of Fenton oxidation, indicating the ecological risks of chemical sludge. O 3 /H 2 O 2 /FeOOH followed by Fenton oxidation (O 3 /H 2 O 2 /FeOOH + Fenton) exhibited higher total organic carbon removal (77.7 %) with less chemical sludge production (8.47 kg·m −3 ) than the reverse combination (Fenton + O 3 /H 2 O 2 /FeOOH). Although the intermediates of aniline, ketone, and ester exhibited considerable acute and developmental toxicity , the significant improvement in biodegradability of the effluents (BOD 5 /COD ratio of 0.36 > 0.02 for raw wastewater) favored subsequent biological treatment. These findings provide guidance for the cost-effective treatment of wafer surface treatment through rational designing combined processes.
研究领域:
环境科学
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化学工程
✓ 已验证
产品关联
DOI
高影响因子
CHEMOSPHERE
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2017
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IF 4.208
Liyun Ma,Xiaojing Mao,Xiao Sun,Li Xu
Non-steroidal anti-inflammatory drugs (NSAIDs) are one of the most frequently used pharmaceuticals in animals. In the current study, the biotransformation of five NSAIDs by pig liver microsomes (PLMs) was studied. The pseudo-first-order kinetics mode was obtained for the metabolization of the studied NSAIDs by PLMs in vitro . The metabolites were identified by high performance liquid chromatography with a high-resolution LTQ-Orbitrap mass spectrometry. The hydroxylation of benzene was confirmed to be the dominating metabolic pathway. Finally, the toxicity of the metabolites was predicted by the Estimation Programs Interface Suite software based on quantitative structure-activity relationships. Decreased toxicity was expected for the most metabolites of the studied NSAIDs except flurbiprofen, whose main metabolite exhibited slightly more toxicity. The present study provided a preliminary foundation to understand the metabolites of some NSAIDs and their toxicity, which was of great significance in animal food safety.
研究领域:
药理学
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毒理学
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动物医学
✓ 已验证
DOI
高影响因子
JOURNAL OF HAZARDOUS MATERIALS
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2021
·
IF 10.588
Yao Lu,Jun-Kun Liang,Hai-Yan Wang,Chao Wang,Zhi-Min Song,Qing Hu,Qian-Yuan Wu
Tannic acid is ubiquitously present in various simulated and real water sources and in wastewater. Various chlorinated disinfection byproducts (Cl-DBPs) are generated via reactions with tannic acid during disinfection with chlorine. We used high-resolution mass spectrometry in combination with our self-developed halogen extraction code to selectively identify Cl-DBPs. Our strategy enabled successful detection of 35 Cl-DBP formulas formed by chlorination of tannic acid, and we identified 26 of these structures. The structures of 17 novel Cl-DBPs are firstly reported here. The reaction pathways of these Cl-DBPs were tentatively proposed. These Cl-DBPs are likely to be generated during chlorination at various chlorine doses, from 0.0 to 10.0 mg-Cl 2 /L, and 14 of the 26 Cl-DBPs were detected in simulated drinking water , which implies a relatively high probability of incidence. Quantitative structure-activity relationship toxicity analyses predicted that most of these Cl-DBPs would exhibit much higher acute toxicity than the common DBPs trichloromethane and monochloroacetic acid and that some of these compounds would induce developmental toxicity and be mutagenic, which further emphasizes that these Cl-DBPs should raise concerns. This study broadens our understanding of the Cl-DBPs formed from tannic acid and should prompt wider application of our analytical strategy in environmental matrices.
研究领域:
环境科学
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毒理学
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分析化学
✓ 已验证
DOI
PubMed
高影响因子
JOURNAL OF HAZARDOUS MATERIALS
·
2015
·
IF 4.529
Jian Li,Li Xu,Zhi-guo Shi,Min Hu
In this study, a novel two-dimensional liquid chromatographic (2D-LC) system was developed for simultaneous separation and toxicity prediction of pharmaceutical and its related substances. A conventional ODS column was used on the 1st-D to separate the sample; while, bio-partitioning micellar chromatography served as the 2nd-D to predict toxicity of the components. The established system was tested for the toxicity of ibuprofen and its impurities with known toxicity. With only one injection, ibuprofen and its impurities were separated on the 1st-D; and LC50 values of individual impurity were obtained based on the quantitative retention–activity relationships, which agreed well with the reported data. Furthermore, LC50 values of photolysis transformation products (TPs) of carprofen, ketoprofen and diclofenac acid (as unknown compounds) were screened in this 2D-LC system, which could be an indicator of the toxicity of these TPs and was meaningful for the environmental monitoring and drinking water treatment. The established 2D-LC system was cost-effective, time-saving and reliable, and was promising for fast online screening of toxicity of known and unknown analytes in the complex sample in a single step. It may find applications in environment, pharmaceutical and food, etc.
研究领域:
分析化学
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毒理学
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环境科学
✓ 已验证
DOI
高影响因子
ENVIRONMENTAL POLLUTION
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2020
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IF 6.793
Dali Wang,Qing Ning,Jiayu Dong,Bryan W. Brooks,Jing You
Antibiotics in the environment usually co-exist with their transformation products with retained toxicity, raising concerns about environmental risks of their combined exposure. Herein, we reported a novel predictive approach for evaluating the individual and combined toxicity for photodegradation products of fluoroquinolone antibiotics (FQs). Quantitative structure-activity relationship (QSAR) models with promising predictive performance were constructed and validated using experimental data obtained with 13 FQs and 78 mixtures towards E. coli . A structural descriptor reflecting the interaction among FQ molecules and the target protein was employed in the QSAR models, which was obtained through molecular docking and thus provided a rational mechanistic explanation for these models. The predicted results indicated that the degradation products displayed varying degrees of changes compared to the parent FQs, while the combined toxicity of FQs and their degradation products was mostly additive. Furthermore, following UV irradiation the degradation products displayed elevated capacity of inducing resistance mutations in E. coli , though their overall toxicity was reduced. This result highlights the implications of antibiotic degradation products on resistance development in bacteria and stresses the importance of considering such impacts during environmental risk assessments of antibiotics.
研究领域:
环境科学
·
微生物学
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毒理学
✓ 已验证
DOI
PubMed
高影响因子
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
·
2023
·Vol. 30
·期 45
·100596-100612
·
IF 5.8
Liu Shuai,Kang Yong,Hua Weijie
It is essential to develop an efficient technology for the elimination of refractory contaminants due to their high toxicity. In this study, a novel underwater bubbling pulsed discharge plasma (UBPDP) system was proposed for the degradation of Orange II (OII). The degradation performance experiments showed that by enhancing the peak voltage and pulse frequency, the degradation efficiency of OII increased gradually. The removal efficiencies under different air flow rates were close. Reducing OII concentration and solution conductivity could promote the elimination of OII. Compared with neutral and alkaline conditions, acidic condition was more beneficial to OII degradation. The active species including ·OH, ·O 2 − , 1 O 2 , and hydrated electrons were all involved in OII degradation. The concentrations of O 3 and H 2 O 2 in OII solution were lower than those in deionized water. During discharge, the solution pH increased while conductivity decreased. The variation of UV–vis spectra with treatment time indicated the effective decomposition of OII. Possible degradation pathways were speculated based on LC-MS. The toxicity of intermediate products was predicted by the Toxicity Estimation Software Tool. Coexisting constituents including Cl − , SO 4 2− , HCO 3 − , and humic acid had a negative effect on OII removal. Finally, the comparison with other technology depicted the advantage of the UBPDP system.
研究领域:
环境科学
·
化学工程
✓ 已验证
产品关联
DOI
PubMed
高影响因子
JOURNAL OF HAZARDOUS MATERIALS
·
2023
·
IF 13.6
Yuxuan Liu,Bei Su,Hongxin Mu,Yu Zhang,Ling Chen,Bing Wu
Wastewater discharge is considered to be one of the anthropogenic factors affecting the water quality of urban rivers. The source and composition of wastewater are complex and diverse, and it is difficult to evaluate its effect on water quality and ecological health of receiving waters. Environmental DNA method can determine all species living in waters by examining DNA sequences, reflecting the impact of water quality changes on aquatic systems. In this study, water samples from two urban rivers were collected in dry and wet seasons, and the composition of pollutants was investigated by nontarget screening. Based on the pollutant composition, compound toxicity prediction and concentration addition model were used to predict the toxicity changes of pollutants in the urban rivers. More than 1500 suspect organic pollutants were nontarget screened, and silafluofen was found to be a major toxicity contributor. Environmental DNA analysis was combined with water quality measure and pollutant toxicity prediction to reveal the effects of pollutants from different sources on aquatic ecosystems . Fish diversity was negatively correlated with the mixed toxicity of organic pollutants, suggesting potential ecological risk in these two urban rivers. Our study developed a water quality assessment method based on pollutant composition and toxicity, and the potential risk of nonpoint source pollutants on aquatic ecosystems should not be neglected.
研究领域:
生态学
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环境科学
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毒理学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
SCIENCE OF THE TOTAL ENVIRONMENT
·
2024
·
IF 8.2
Fan Li,Lei Lei,Yuxi Zhou,Xiaochen Wang,Yindan Zhang,Jianghuan Hua,Jian Han,Lihua Yang,Bingsheng Zhou
The novel brominated flame retardants (NBFRs) have received wide concerns due to their ubiquitous occurrence in the environment and their potential risks to ecosystems and human health. However, the toxicity data of NBFRs are still lacking, especially their toxicity comparison data, and toxicity predictions for untested NBFRs are extremely limited. In this study, eight commonly used NBFRs and decabromodiphenyl ether (BDE209) were selected to compare their toxicity at concentrations between 0.03 and 3.69 μM, by exposing zebrafish embryos until 120 h post-fertilization (hpf) and evaluating 18 toxicity indicators including basic development indicators and a series of behavioral indicators. The toxicity potency of the tested compounds ranked by the total number of significantly affected endpoints were pentabromobenzene (PBB) ≈ 2,4,6-tribromophenol (TBP) > BDE209 ≈ bis(2-ethylhexyl) tetrabromophthalate (TBPH) > pentabromotoluene (PBT) ≈ 2-ethylhexyl-2,3,4,5-tetrabromobenzoate (EHTBB) > 1,2-bis(2,4,6-tribromophenoxy)ethane (BTBPE) > hexabromobenzene (HBB) > decabromodiphenyl ethane (DBDPE). Almost all the tested compounds affected the locomotor behavior of zebrafish larvae, suggesting that the refined behavioral indicators were sensitive endpoints. Furthermore, the quantitative structure-activity relationship (QSAR) model we developed suggested that molecular surface area (MSA) might be the critical factor for determining the developmental neurotoxicity of NBFRs to zebrafish larvae, except for congeners with larger molecules (e.g. DBDPE, BTBPE). These findings would contribute to elucidating the toxicity differences among various NBFRs and provide important references for their toxicity prediction.
研究领域:
环境科学
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毒理学
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计算生物学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Journal of Environmental Chemical Engineering
·
2022
·
IF 7.968
Jie Tian,Junyan Wei,Yeping Liang,Ruixue Guo,Beibei Li,Ruijuan Qu,Dongmei Zhou,Zunyao Wang,Ping Sun
This study aimed to investigate the catalytic performance of Fe 3 O 4 /ZnO in the ozonation of 1-hexyl-3-methyl imidazolium bromide ([HMIM]Br). The Fe 3 O 4 /ZnO composite was prepared by a quick and convenient two-step coprecipitation method, and the optimum mass ratio of Fe 3 O 4 :ZnO was determined as 1:8. The structure, surface morphology, and chemical composition of the Fe 3 O 4 /ZnO composites were studied by characterization methods. The degradation efficiency of [HMIM]Br reached 96% in 5 min in catalytic ozonation with the Fe 3 O 4 /ZnO composite, an increase of 20% compared with ozonation alone. Moreover, the pseudo-first-order rate constant was 1.5 times higher than ozonation alone. With the increase in the catalyst dosage, the degradation efficiency of [HMIM]Br first improved and then decreased, and the optimum dosage was 0.25 g/L. The increase in pH value and the introduction of Cu 2+ effectively promoted the catalytic ozonation of [HMIM]Br with Fe 3 O 4 /ZnO, while the reducing inorganic ions inhibited the ozonation reaction. Different water matrices had little influence on the catalytic performance of Fe 3 O 4 /ZnO. Radical scavenging and EPR experiments showed that hydroxyl radicals (•OH), superoxide radicals (O 2 •- ) and singlet oxygen ( 1 O 2 ) were the main active species in this system. Meanwhile, product identification showed that the degradation of [HMIM]Br mainly included hydroxylation, imidazole ring cleavage and bond cleavage. Toxicity prediction illustrated that the catalytic ozonation of [HMIM]Br could effectively reduce its toxicity. The efficiency, toxicity, reusability, and stability experiments suggested that the developed catalyst, Fe 3 O 4 /ZnO composite, had promising prospects in catalytic ozonation.
研究领域:
环境科学
·
化学工程
✓ 已验证
产品关联
DOI
高影响因子
危险品化学品经营许可证（带存储）