SCIENCE OF THE TOTAL ENVIRONMENT
·
2024
·
IF 8.2
Ping Zhang,Furong Yang,Lulu Ran,Cancan Yang,Can Tang,Xiaojiang Ke,Juanni Chen,Wei Xiao,Lin He,Zhifeng Xu
Traditional risk assessments of chiral pesticides mainly depend on racemic form, which is often incomprehensive. This study conducted systemic investigations on the bioactivity , toxicity, and ecotoxicological effects of hexythiazox (HTZ) at the enantiomer level. The elution order and absolute configuration of HTZ enantiomers were determined. ( 4R, 5R )-(+)-HTZ exhibited 708 and 1719 times higher bioactivity against Tetranychus cinnabarinus and Tetranychus urticae eggs than ( 4S, 5S )-(−)-HTZ, respectively. Molecular docking indicated greater interactions between ( 4R, 5R )-(+)-HTZ and chitin synthase leading to higher bioactivity of ( 4R, 5R )-(+)-HTZ. However, ( 4S, 5S )-(−)-HTZ induced greater changes in protein and malondialdehyde content, and antioxidant and detoxification enzyme activities than ( 4R, 5R )-(+)-HTZ in earthworms. Furthermore, integrated biomarker response results indicated ( 4S, 5S )-(−)-HTZ exhibited higher toxic effects on earthworms than ( 4R, 5R )-(+)-HTZ. Finally, significant differentially expressed genes (DEGs) were observed in earthworms after exposure to ( 4R, 5R )-(+)-HTZ and ( 4S, 5S )-(−)-HTZ, respectively. These DEGs were mainly enriched in glycolysis/gluconeogenesis and purine metabolism pathways in earthworms. Additionally, six metabolism pathways were also enriched, including pyruvate metabolism, fatty acid biosynthesis , oxidative phosphorylation , citric acid cycle , fatty acid degradation , and ATP-binding cassette transporters. These findings suggest that earthworms exhibited enantiomer-specific responses to ( 4R, 5R )-(+)-HTZ and ( 4S, 5S )-(−)-HTZ. This study provides systemic insight into the toxicity mechanism of HTZ at the enantiomer level and the potential to develop ( 4R, 5R )-(+)-HTZ as a high-efficiency and low-risk pesticide.
研究领域:
农药科学
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环境毒理学
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分子生物学
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DOI
PubMed
高影响因子
Frontiers in Microbiology
·
2022
·
IF 6.064
Cao Xiaoxu,Zhao Wei,Zhang He,Lin Jitong,Hu Jingying,Lou Yanhong,Wang Hui,Yang Quangang,Pan Hong,Zhuge Yuping
Introduction: The large-scale development of animal husbandry and industrialization lead to more and more serious co-contamination from heavy metals and antibiotics in soils. Ecotoxic effects of residues from antibiotics and heavy metals are of increasing concern.Materials and Methods: In this study, oxytetracycline (OTC) and cadmium (Cd) were selected as target pollutants to evaluate the individual and combined effects on nitrification process using four different soil types sampled from North to South China through a 56-day incubation experiment.Results and Discussion: The results demonstrated that the contaminations of OTC and Cd, especially combined pollution had significant inhibitory effects on net nitrification rates (NNRs) as well as on AOA and AOB abundance. The toxic effects of contaminants were greatly enhanced with increasing OTC concentration. AOB was more sensitive than AOA to exogenous contaminants. And the interaction effects of OTC and Cd on ammonia oxidizers were mainly antagonistic. Furthermore, Cd contaminant (with or without OTC) had indirect effects on nitrification activity via inhibiting mineral N and AOA/AOB, while OTC alone indirectly inhibited nitrification activity by inhibiting ammonia oxidizers. The results could provide theoretical foundation for exploring the eco-environmental risks of antibiotics and heavy metals, as well as their toxic effects on nitrification processes.
研究领域:
环境科学
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土壤学
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生态毒理学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
JOURNAL OF NANOPARTICLE RESEARCH
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2014
·Vol. 16
·期 11
·1-13
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IF 2.278
Liu Wenjuan,Yao Jun,Cai Minmin,Chai Hankuai,Zhang Chi,Sun Jingjing,Chandankere Radhika,Masakorala Kanaji
A new nanopesticide, carboxymethyl-β-cyclodextrin-Fe 3 O 4 magnetic nanoparticles-Diuron (CM-β-CD-MNPs-Diuron), was synthesized from an inclusion complex of CM-β-CD-MNPs as host and diuron as guest molecules. The transmission electron microscopy revealed it had an average diameter of 25 nm which is more or less the same as that of MNPs (average diameter ~23 nm). The CM-β-CD grafting was confirmed by infrared spectroscopy, and the amount of CM-β-CD grafted on the surface of MNPs was determined to be 144.1 mg/g by thermogravimetry. The feasibility of using CM-β-CD-MNPs as a nanocarrier for loading diuron was verified by investigating the formation of inclusion complex. The complexation of CM-β-CD-MNPs with diuron followed the Langmuir adsorption isotherm. In this work, the potential toxic effect of CM-β-CD-MNPs-Diuron on soil microbial was evaluated by microcalorimetry, urease enzyme and real-time quantitative PCR (qPCR). The thermokinetic parameters were observed to decrease with increase in the loading of CM-β-CD-MNPs-Diuron in soil. The urease activity data showed that there was a significant effect ( p < 0.05) of CM-β-CD-MNPs-Diuron on the enzyme activity. The microcalorimetric analysis was in agreement with qPCR, confirming the toxic effect of this nanopesticide on microorganism in soil.
研究领域:
环境科学
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微生物学
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纳米技术
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产品关联
DOI
高影响因子
AQUACULTURE
·
2024
·
IF 3.9
Ningbo Wang,Yinan Wang,Rongrong Zhang,Aili Sun,Yin Lu,Zeming Zhang,Xizhi Shi
Triphenylphosphine oxide (TPPO) as a new organophosphorus flame retardant is extensively used in the industrial and pharmaceutical fields due to its chemical stability and abundance. In marine environments, TPPO accumulates as a result of natural ecological processes. This study aimed to evaluate the accumulation process and toxicological effects of TPPO utilizing mussels ( Mytilus coruscus ), a species traditionally employed in marine monitoring and commonly cultivated in offshore aquaculture. GC–MS/MS was employed to quantify the accumulation of TPPO in the gill, gonad, muscle, and digestive gland tissues of mussels exposed to three sublethal concentrations (20.0, 100.0, and 500.0 μg/L) over durations of 3, 7, 14, and 28 days, as well as the examining of the chemical and molecular parameters. Results showed that the accumulation of TPPO (100.0 and 500.0 μg/L) increased throughout the 28 d of exposure, and the peak accumulation of 20.0 μg/L TPPO was detected on 14 d. Short-term TPPO exposure did not cause oxidative stress in mussels. Chronic exposure for 28 days resulted in significant oxidative damage and oxidative stress in mussels, as evidenced by elevated expression and activity of SOD, increased levels of glutathione and malondialdehyde, and upregulation of HSP70 and HSP90, metallothionein, and CYP4Y1, alongside the initiation of apoptotic cell death. TPPO exposure activated natural immune genes and disrupted lipid metabolism in mussels. This study demonstrated the persistent accumulation of TPPO in mussels, highlighting its ecotoxicological hazards and underscoring the necessity to predict the risks associated with widespread environmental exposure to TPPO.
研究领域:
环境科学
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海洋生物学
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毒理学
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生态学
✓ 已验证
产品关联
DOI
高影响因子
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
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2019
·
IF 4.527
Shuyan Zhao,Tianqi Liu,Bohui Wang,Jia Fu,Tiankun Liang,Zhe Zhong,Jingjing Zhan,Lifen Liu
While N-ethyl perfluorooctane sulfonamidoethanol (EtFOSE) is a precursor of perfluorooctane sulfonate (PFOS), its bioaccumulation, transformation and toxicological effects in earthworms ( Eisenia fetida ) exposed to quartz sands are poorly understood. The present study showed that except for parent EtFOSE, N-ethylperfluorooctane sulfonamide acetate (EtFOSAA), N-ethyl perfluorooctane sulfonamide (EtFOSA), perfluorooctane sulfonamide acetate (FOSAA), perfluorooctane sulfonamide (FOSA) and PFOS were detected in earthworms, with EtFOSAA as the primary biotransformation product. The biota-to-sand accumulation factor (BSAF) and uptake rate coefficient ( k u ) of EtFOSE were 5.7 and 0.542/d, respectively. The elimination rate constants ( k e ) decreased in the order EtFOSA (0.167/d) ∼ FOSAA (0.147/d) > FOSA (0.119/d) ∼ EtFOSAA (0.117/d) > EtFOSE (0.095/d) > PFOS (0.069/d). No significant effects were observed in malondialdehyde (MDA) contents and acetylcholinesterase (AChE) activities between EtFOSE treatments and controls. EtFOSE could cause significant accumulation of reactive oxygen species (ROS) in earthworms. Peroxidase (POD), superoxide dismutase (SOD) and catalase (CAT) were significantly activated by 41.4–74.3%, 37.2–44.4% and 32.4–52.3% from day 4–10, respectively, while 8-Hydroxy-2-deoxyguanosine (8-OHdG) levels were elevated by 47.7–70.3% from day 8–10, demonstrating that EtFOSE induced oxidative stress and oxidative DNA damage in earthworms. Significant increase of glutathione-S-transferase (GST) with 41.6–62.8% activation (8–10 d) gave indirect evidence on the conjugation of EtFOSE or its corresponding metabolites during phase II of detoxication. This study provides important information on the fate and potential risks of EtFOSE to terrestrial invertebrates.
研究领域:
环境科学
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毒理学
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生态毒理学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
ENVIRONMENTAL POLLUTION
·
2016
·
IF 4.839
Fan Zhang,Zhuang Wang,Se Wang,Hao Fang,Mindong Chen,Defu Xu,Lili Tang,Degao Wang
Understanding how engineered nanoparticles (ENPs) interact with natural organic acids is important to ecological risk assessment of ENPs, but this interaction remains poorly studied. Here, we investigate the dispersion stability, ion release, and toxicity of yttrium oxide nanoparticles (nY 2 O 3 ) suspensions after exposure to two low molecular weight natural organic acids (LOAs), namely benzoic acid and gallic acid. We find that in the presence of LOAs the nY 2 O 3 suspensions become more stable with surface zeta potential more positive or negative, accompanied by small agglomerated size. LOA interaction with nY 2 O 3 is shown to promote the release of dissolved yttrium from the nanoparticles, depending on the concentrations of LOAs. Toxic effects of the nY 2 O 3 suspensions incubated with LOAs on Scenedesmus obliquus as a function of their mixture levels show three types of signs: stimulation, inhibition, and alleviation. The mechanism of the effects of LOAs on the nY 2 O 3 toxicity may be mainly associated with the degree of agglomeration, particle-induced oxidative stress , and dissolved yttrium. Our results stressed the importance of LOA impacts on the fate and toxicity of ENPs in the aquatic environment.
研究领域:
环境科学
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纳米技术
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生态毒理学
·
水化学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
·
2024
·
IF 4.9
Lanlan Gao,Hong Wang,Yunlei Zhou,Zhipeng Tian,Huanshun Yin,Jun Wang
MXene-based Ti 3 C 2 T X composite aerogels (βCD-MXene-SA) were prepared using thin layers of MXene and sodium alginate (SA) as matrix materials, β-cyclodextrin (β-CD) as surface modifier, and epichlorohydrin as cross-linker. The βCD-MXene-SA was characterized by scanning electron microscopy, X-ray diffraction and Fourier transform infrared (FTIR) spectroscopy, and the results demonstrated that the βCD-MXene-SA had a larger specific surface area and a more developed pore structure. In addition, the maximum adsorption capacity of this βCD-MXene-SA for dibutyl phthalate (DBP) under the optimal adsorption conditions was 25 mg/g. The adsorption kinetics showed that the adsorption process was in good agreement with both kinetic models. The adsorption isotherms were consistent with the Langmuir and Freundlich adsorption isotherm models, suggesting that the adsorption of DBP by βCD-MXene-SA was the result of the combined effect of physisorption and chemisorption. The adsorption process may include monolayer adsorption on homogeneous surfaces and multilayer adsorption on multilayer surfaces. Outside, the ecotoxicological effects of DBP on crops were explored. The results showed that the treated wastewater could promote the growth of green beans, indicating that the toxicity of wastewater was significantly reduced after adsorption treatment.
研究领域:
材料科学
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环境科学
·
化学工程
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生态毒理学
✓ 已验证
产品关联
DOI
高影响因子
危险品化学品经营许可证（带存储）