ANALYTICAL SCIENCES
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2024
·Vol. 40
·期 6
·1023-1030
·
IF 1.8
Zhang Yuecheng,Sun Lingbo,Li Chengjia,Ma Jing,Zhang Shiyu,Wang QingQing,Ma Hongyan
Dopamine (DA) is a neuromodulatory molecule that plays critical roles in many biological processes. The dysfunctions of the DA system are closely associated with several nervous system diseases. Therefore, it is urgent to establish a simple and accurate method for DA analysis. In this study, an economic and accurate DA ratiometric sensor was established using dual-emission carbon dots (DE-CDs). DE-CDs were first synthesized by the one-step solvothermal method and two separate fluorescence emission peaks at 340 and 500 nm were observed under the excitation of 310 nm. In the presence of Hg 2+ , the fluorescence signal at 340 nm was significantly quenched, while the signal at 500 nm keeps stable. Upon adding DA, the quenched signal at 340 nm was significantly recovered, whereas the signal at 500 nm remains stable. Therefore, a novel ratiometric sensor for DA analysis was established. This method shows a good linear range from 500 nM to 100 μM, and the detection limit was calculated to be 80 nM. Moreover, this established method shows excellent specificity and could be applied in real sample analysis, showing great potential for application in clinical research. Graphical abstract
研究领域:
分析化学
·
生物医学
✓ 已验证
DOI
PubMed
高影响因子
MICROCHEMICAL JOURNAL
·
2024
·
IF 4.9
Huijun Guo,Jie Chen,Siqi Li,Yifei Qi,Guoxin Wang,Yue Zhang
In this work, a ratiometric double signals electrochemical sensing platform was constructed for creatinine (Cre) analysis employing silver nanoparticles (AgNPs)@ MXenes/thionine acetate (THAT) composites. The synthesis of MXenes/THAT composites was utilized to modify on the surface of a screen-printed electrode (SPE) via dripping coating, followed by the electro-deposition of AgNPs. While the anodic current of the AgNPs decreased in the presence of Cre due to the competive reaction for forming metal complexes, the current of THAT remained invariant, which attained a ratiometric response. Under optimized conditions, the response current ratio ( I Ag /I THAT ) decreases while the concentration of Cre increased linearly between 0 ∼ 1.2 mM, with 0.01 μM as a adaptive detection limit. It provided a new sensing platforming for employing double-signals nanostructures with remarkable stability and sensitivity to design ratiometic sensors for analysis of Cre in human urine samples with real-time.
研究领域:
分析化学
·
生物医学工程
✓ 已验证
产品关联
DOI
高影响因子
MICROCHEMICAL JOURNAL
·
2021
·
IF 4.821
Yuecheng Zhang,Chengjia Li,Lingbo Sun,Jie Zhang,Xiaojun Yang,Hongyan Ma
Hexavalent chromium ion (Cr(VI)) is one of the most severe environmental nonbiodegradable pollutants. Considering its high biological toxicity, it is of great significance to establish a method for Cr(VI) analysis with high sensitivity and reliability. Therefore, a simple and sensitive ratiometric sensor is developed according to the coordination between Cr(VI) and carbon dots (CDs). In the presence of Cr(VI), the original CDs photoluminescence (PL) emission at 445 nm was significantly shifted to 565 nm and gradually intensified. The coordination mechanism was investigated, the results indicated that the dual-amino groups at ortho-position of benzene ring is critical for this coordination. Under the optimal condition, a good linear relationship between the concentration of Cr(VI) and the PL intensity ratio I 565 /I 445 was obtained from 120 nM to 200 µM, with a low detection limit of 37 nM. Moreover, this method is applied into real water samples analysis with a high quality.
研究领域:
环境科学
·
分析化学
✓ 已验证
产品关联
DOI
高影响因子
ANALYST
·
2021
·Vol. 146
·期 13
·4348-4356
·
IF 4.616
Qi Wu,LiHeng Feng,Jian Bin Chao,Yu Wang,Shaomin Shuang
A new fluorescent probe, 3-(benzo[d]thiazol-2-yl)-5-bromosalicylaldehyde-4N-phenyl thiosemicarbazone (BTT), for ratiometric sensing of Zn2+ ions in methanol/HEPES buffer solution (3 : 2, pH = 7.4) is reported in this paper. The presence of Zn2+ ions yields a significant blue shift in the maximum emission of BTT from 570 nm to 488 nm, accompanied by a clear color change from orange to green. This emission change of BTT upon binding to Zn2+ in a 1 : 1 ratio may be due to the block of excited state intramolecular proton transfer (ESIPT) as well as chelation enhanced fluorescence (CHEF) on complex formation. The limit of detection (LOD) determined for Zn2+ quantitation was down to 37.7 nM. In addition, the probe BTT displays the ability to image both exogenous Zn2+ ions loaded into HeLa cells and endogenous Zn2+ distribution in living SH-SY5Y neuroblastoma cells.
研究领域:
分析化学
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生物医学
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材料科学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
JOURNAL OF LUMINESCENCE
·
2021
·
IF 3.599
He Li,Hong-Gang Ye,Rui Cheng,Jiazhuang Guo,Zhi-Bin Liang,Ge Li,Qing Li,Cai-Feng Wang,Su Chen
Carbon dots have been rapidly developed as a kind of luminescent nanomaterials . However, methods for the synthesis of long-wavelength-emissive carbon dots are still not mature enough. Meanwhile, developing a fast and highly sensitive method to detect residual veterinary drugs in food is particularly significant for food safety. Herein, we report the facile fabrication of red-emissive carbon dots (R-CDs) for ratiometric sensing of veterinary drugs. With use of sorbitol and o -phenylenediamine as precursors, R-CDs was prepared via a one-pot solvothermal approach. The resulting R-CDs show mainly excitation-independent and dual-emissive photoluminescence (PL) located at 597 and 645 nm. Meanwhile, the PL quantum yield (QY) of R-CDs without further surface treatment is 33% under 540 nm excitation. Interestingly, the R-CDs exhibit fast fluorescence response to malachite green oxalate (MG oxalate), 1-aminohydantoin hydrochloride (AHD) and pefloxacin , which are abused widely and retained easily in animals. Ratiometric sensing of these veterinary drugs were successfully performed taking the advantage of dual-emissive PL property; the detection limits of MG oxalate, AHD and pefloxacin were 0.79, 0.25 and 0.85 μM, respectively.
研究领域:
食品安全
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纳米材料科学
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分析化学
✓ 已验证
产品关联
DOI
高影响因子
OPTICAL MATERIALS
·
2021
·
IF 3.08
Li Chen,Limin Zheng,Fangqi Wang,Simin Yi,Donghao Liu,Xinzhi Huang,Rong Chen,Hua He
In the present work, a dual-emission sensor constructed with CdTe quantum dots and Zr-MOF, was developed for sensing ascorbic acid (AA). Based on the distinct fluorescent responses of CdTe and UiO-66-NH 2 to AA, UiO-66-NH 2 @CdTe can be developed as a ratiometric sensor for AA detection. In this ratiometric sensor, the emission of UiO-66-NH 2 is quenched while the emission of CdTe is increased with the addition of AA. Benefiting from the confinement effect of the UiO-66-NH 2 host, the presented sensor showed good sensitivity toward AA and great selectivity over other structural analogs.
研究领域:
分析化学
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材料科学
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纳米技术
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产品关联
DOI
高影响因子
Nanoscale Advances
·
2018
·Vol. 1
·期 3
·1086-1095
·
IF 0
Dan Li,Guannan Wang,Yongjin Peng,Zhenhua Chen,Xianhui Gao,Liming Cheng,Xifan Mei
Herein, we developed a special strategy for the fast sensitization of red emitting copper nanoclusters with the assistance of green emitting copper nanoclusters. Compared to most previous methods based on AIE, which do not maintain the water solubility or tiny size of nanoclusters, the charming features of the copper nanoclusters were retained after the fabrication. Furthermore, the product was employed for the detection of sulphide, which revealed its ratiometric sensing ability in water since the ratio of the intensity change for green and red emission was related to the sulphide concentration. In addition, after the addition of Zn2+, the green and red emission was either enhanced or quenched via the corresponding mechanism. This enables the facile fabrication of promising white light-harvesting materials since the species of the emitting color can be simply tuned.
研究领域:
材料科学
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分析化学
✓ 已验证
DOI
PubMed
ORGANIC & BIOMOLECULAR CHEMISTRY
·
2017
·Vol. 15
·期 12
·2569-2574
·
IF 3.564
Yadong Qiao,Zhiyi Yao,Wenqi Ge,Li Zhang,Hai-Chen Wu
We have developed a ratiometric sensor based on polyelectrolyte-induced pyrene excimers for the rapid and visual detection of heparin in aqueous media. This sensor has a simple preparation method, fast response, low cost, and high sensitivity and selectivity. As a complementary strategy for the detection of heparin based on the formation of pyrene excimers, this approach could identify heparin specifically over chondroitin sulphate, which is the major interferent in most sensing systems for the detection of heparin. The detection limit of this approach can be as low as 0.14 μM using fluorescence measurements. To the best of our knowledge, this is among the lowest LOD for the detection of heparin reported in the literature. It enables the rapid and visual detection of heparin both in buffered solution and serum samples.
研究领域:
生物化学
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分析化学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
INORGANIC CHEMISTRY
·
2021
·
IF 5.165
Chen Lin,Man Wang,Jiawei Tang,Zhenyan Zhu,Pengyan Wu,Aonan Hu,Lijiao Zhang,Jian Wang
A novel two-fold interpenetrated metal–organic framework, namely Co–EDDA, was synthesized by hydrothermal reaction of 5,5′-[ethane-1,2-diylbis(oxy)]diisophthalic acid (H4EDDA), Co(NO3)2·6H2O, and 1,4-di(1H-imidazol-1-yl)benzene in water in an alkaline environment and structurally characterized. Co–EDDA could display clear dual-emission signals at 350 and 430 nm, representing the charge transfer emission between metal ions and the ligand and the ligand-based emission, respectively, which represents the ratiometric luminescence response to chromium(III) with high selectivity and sensitivity (limit of detection of 0.54 μM). Comprehensive studies indicate that the detection can be attributed to the interaction between the Cr3+ ions and the O atoms on the ether bond in Co–EDDA.
研究领域:
材料科学
·
分析化学
✓ 已验证
DOI
高影响因子
CHEMICAL ENGINEERING JOURNAL
·
2024
·
IF 13.3
Xiaofan An,Yuhong Liu,Yunxue Sun,Xuetao Zhang,Yuhua Liu,Yuanyuan Tao,Longsuo Guo,Xiaoping Jiang,Meng Gao
The development of portable flexible sensors for sensitive gas detection with antibacterial activity is of great significance for protecting human health and environment safety. In this paper, we designed a ratiometric sensing platform (PLA@RPEG@TBSN) for reliable and visual monitoring of gaseous H 2 O 2 by electrospinning technology, which reveals self-antibacterial function and highly photostability simultaneously. By employing the aggregation-induced emission (AIE) active nanoparticles (TBSN) as fluorescent responder and Rose Bengal modified photosensitive polymer (RPEG) as reference unit, accurate ratiometric sensing process of PLA@RPEG@TBSN film was realized based on the specific peroxide-mediated reaction between TBSN and H 2 O 2 . The flexible film system demonstrated superior sensing performance toward H 2 O 2 vapor, including excellent selectivity, visualized color change and low detection limit (7 ppb). Additionally, benefitting from the photodynamic activity of RPEG , the PLA@RPEG@TBSN film exhibited highly effective antibacterial performance (killing 84 % of bacteria). Moreover, the multifunctional wearable potential is supported by employing film sensor onto the protective mask, which reveals dual capabilities of ratio sensing and resistance bacteria aerosols, encouraging the application of the sensor in complex practical scenario.
研究领域:
生物医学工程
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材料科学
·
分析化学
✓ 已验证
产品关联
DOI
高影响因子
ELECTROCHIMICA ACTA
·
2022
·
IF 7.336
Qi Kang,Yuan Huang,Xuemei Ma,Mengmeng Li,Cheng Ma,Dazhong Shen
The electrochemiluminescence (ECL) spectral information is useful in ECL mechanism investigations, ratiometric ECL sensors and multi-analyte determinations. To overcome the shortcomings of low sensitivity in charge coupled devices (CCD) ECL spectrometer and low time efficiency for spectrum discrimination by using single band-pass filter (BPF) in one potential scan, a simple and sensitive ECL spectrum measurement platform is developed by placing a portable BPF array turntable device (with eleven measurement channels and one indicator channel) between the working electrode and photomultiplier in a conventional ECL analyzer. The systematic error due to the time dependent ECL intensity, which is the main obstacle for ECL spectrum measurement in wavelength scan mode, is neutralized by using the accumulated intensity for each channel in a group of spectrum measurement cycles. In a spectrum-resolved ratiometric ECL sensor for miroRNA-141 determination, near-infrared ECL emitter of methionine-stabilized Au nanoclusters (Met-Au NCs) is used as the tag and blue ECL emitter of g-C 3 N 4 as the reference. The ratio of the total ECL intensity in near-infrared wavelength region (from Met-Au NCs) to that in blue wavelength region (from g-C 3 N 4 ) is in linear correlation with the logarithmic concentration of microRNA-141 from 1 fM to 10 pM, with the limit of detection of 0.22 fM.
研究领域:
分析化学
·
生物医学工程
·
分子生物学
✓ 已验证
DOI
高影响因子
SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
·
2024
·
IF 4.3
Yuyang Wang,Shuoran Chen,Zongyi Xu,Xiwei Bao,Yuxiang Dong,Lin Li,Yizhong Shi,Shigang Wan,Changqing Ye
A ratiometric nanosensor was developed for detecting methyl orange (MO) based on down/up-conversion luminescence achieved by a triplet–triplet annihilation upconversion luminescence (TTA-UCL) system. The probe, utilizing sensitizer and annihilator fluorophores encapsulated in nanomicelles, demonstrated high sensitivity and selectivity for MO detection. The energy transfer from UCL to MO endowed the sensor with responsive capabilities. The unaffected triplet–triplet energy transfer process maintained the phosphorescence signal constant, serving as a reference to construct the ratiometric sensor along with the UCL signal. Additionally, a smartphone-assisted colorimetric detection method was also developed based on the ratiometric sensor, enabling rapid and convenient detection of MO without the need for a spectrometer. The performance of the nanosensor in real water samples confirmed its potential for practical environmental applications.
研究领域:
环境科学
·
分析化学
·
光学传感
✓ 已验证
产品关联
DOI
PubMed
高影响因子
危险品化学品经营许可证（带存储）