CHEMICAL ENGINEERING JOURNAL
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2022
·
IF 16.744
Jie Zhang,Yingying Li,Jingyu Hu,Yuanqiang Sun,Ran Yang,Zhaohui Li,Lingbo Qu
Phosgene is a very dangerous but important industrial intermediate and is a significant threat to public health. There is, therefore, an urgent need to develop a rapid, visual, and on-site detection method for phosgene. Sensitive and selective phosgene responsive carbon dots (CDs) were synthesized by employing 2-nitro-4-aminodiphenylamine as precursors. The amine group of the CDs can interact selectively with phosgene to effect acylation reactions, which cause color changes from yellow to amaranth and remarkable changes in fluorescence from bright yellow to orange-red due to modification of the CDs’ intramolecular charge transfer (ICT) process. The CDs exhibited fast response (<2 s) for detection of phosgene with an ultralow detection limit (0.63 nM). Furthermore, a portable CD/polystyrene droplet system was developed for rapid and on-site visualization of phosgene. Specifically, the droplet system not only can realize rapid on-spot visual inspection of gaseous phosgene in the liquid phase with the naked eye, but also could make long-term visualization in the solid phase via a polystyrene membrane after solvent volatilization. This study has expanded the scope for application of CDs in sensing field, and provides a new and effective strategy for fabrication excellent platform for real-time detection of phosgene leakage in industrial and public safety applications.
研究领域:
化学传感
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环境监测
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材料科学
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产品关联
DOI
高影响因子
SENSORS AND ACTUATORS B-CHEMICAL
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2011
·
IF 3.37
Wei Lu,Mengyu Zhang,Keyuan Liu,Bin Fan,Zheng Xia,Liming Jiang
A simple and efficient chemosensor 1 was synthesized by reacting thiosemicarbazide with 1-naphthaldehyde. It was found that the sensor is highly selective toward fluoride anions in both UV–vis and fluorescence channels in DMSO solution. Especially, the spectral responses of the sensor along with a visible color change can be switched back and forth by successively adding F − and HSO 4 − anions into the DMSO solution, which may be represented by a complementary “IMPLICATION/INHIBIT” logic gate at molecular level employing both the ions as the chemical inputs. Based on such a reversible and reproducible sensing system, we designed a molecular-scale sequential memory unit displaying “Writing-Reading-Erasing-Reading” and “Multi-write” functions in the form of binary logic.
研究领域:
分析化学
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超分子化学
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化学生物学
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分子工程
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生物传感器
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DOI
高影响因子
TALANTA
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2020
·
IF 5.339
Rui Gao,Dan Li,Siqing Zheng,Haixin Gu,Wei Deng
Accurate and selective in-field detection of metal ions in complex media has gained wide interests due to the complexed matrices and weak affinity towards sensing surface. Herein, we develop a first trimodal method for sensing of Zn 2+ in complex matrices by stimuli-responsive N-[6-piperazinyl-2-pyridinyl]-N-(2-pyridinylmethyl)-2-Pyridinemethanamine dithiocarbamates (DPY) modified gold nanorods (GNRs-DPY). The presence of Zn 2+ triggers the aggregation of GNRs-DPY, leading to increment of color and fluorescence intensity of the sensing system, which could be visually discerned with bare eye. Moreover, the intensive electromagnetic enhancement among “hot spots” of GNRs, generated during self-aggregation of the GNRs-DPY caused by Zn 2+ , lowers the detection limit of SERS assay to 6 × 10 −3 pM. It is noteworthy that GNRs-DPY based sensing platform not only enables distinguishing Zn 2+ from Cd 2+ , with simplicity and rapidity, but also demonstrates as trimodal nanoprobe for sensitive and selective quantitative determination of Zn 2+ in different matrices. Therefore, the GNRs-DPY provides a new strategy for accurate and credible on-spot determination of Zn 2+ in complicated specimens, as well as offering multiple applications in point-of-care monitoring.
研究领域:
分析化学
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纳米生物技术
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环境监测
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分子诊断
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金属离子传感
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DOI
高影响因子
Journal of Materials Chemistry B
·
2025
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IF 5.7
Tingting Lei,Yating Xu,Yuanyu Tang,Siyi Tan,Jiafu Xiao,Shaojing Zhao,Minhuan Lan
Achieving highly selective visual detection of thiram is essential for ensuring food safety and environmental protection. Here, we developed a smartphone-integrated colorimetric and fluorometric dual-mode sensor based on copper-doped carbon dots (Cu-CDs). The Cu-CDs were synthesized via hydrothermal treatment of L-tryptophan and CuCl2·2H2O. These Cu-CDs exhibited two fluorescence emission peaks at 350 nm and 450 nm, with a fluorescence quantum yield of 20.8%. Cu2+ on the surface of the Cu-CDs could selectively bind to thiram to form a Cu2+-thiram complex, which quenched the fluorescence at 450 nm of Cu-CDs via the inner filter effect and dynamic quenching effect. In contrast, the fluorescence at 350 nm was changed slightly. The color of the solution was changed from colorless to yellow. These changes allowed for a fluorometric and colorimetric dual-mode optical response. The proposed sensor possessed high sensitivity and selectivity and demonstrated reliable performance in real water samples. Its integration with a smartphone further enabled convenient, on-site detection. This work presented a robust and cost-effective strategy for monitoring thiram in applications related to food safety and environmental protection.
研究领域:
分析化学
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食品安全
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环境监测
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纳米生物技术
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传感器开发
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产品关联
DOI
PubMed
高影响因子
MICROCHIMICA ACTA
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2021
·Vol. 189
·期 1
·1-11
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IF 5.833
Shen Yanting,Zhao Yuhui,Zhu Yanyan,Wang Jing
A novel colorimetric/fluorescent dual-mode nanosensor for Hg 2+ detection was constructed using expanded mesoporous silica (EMSN)-encapsulated ultrasmall platinum nanoclusters (EMSN@Pt NCs) with improved peroxidase-like and stable fluorescent activities. The sensing technique was based on the mechanism that the peroxidase mimetic activity and fluorescence intensity of EMSN@Pt NCs can be inhibited in the presence of Hg 2+ . In this sensing platform, a linear range of 5–50 nM with a detection limit of 1.78±0.38 nM and quantification limit of 5.93 nM was obtained via fluorescent analysis. A linear calibration curve from 0.25 to 200 nM with a detection limit of 8.25±0.51 nM and quantification limit of 27.47 nM was achieved via colorimetric analysis. The proposed dual-mode probe possesses excellent selectivity and reliability for Hg 2+ detection, which can function as an efficient nanosensor for the quantitative determination of Hg 2+ in Pueraria lobata . Graphical abstract
研究领域:
分析化学
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纳米技术
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环境科学
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产品关联
DOI
PubMed
高影响因子
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
·
2025
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IF 8.5
Pan Liu,Hui Li,Kai Wang,Chuang Jiang,Xiyao Liang,Yuqing Zhang,Zhenyu Yu,Yaqing Xiao,Jinhui Zhou,Yingnan Liu
In this study, aloe emodin and β- d -glucose pentaacetate were added into potato starch/polyvinyl alcohol for the construction of colorimetric/fluorescent dual-pass intelligent response labels. Inspired by the lotus leaf structure, retained the advantages of the label itself and solved the hydrophilic problem of the label, and further developed a multi-functional dual-channel smart label with hydrophobicity and self-adhesion. The water contact angle of the prepared T-AEB label was 120.1 ± 0.8°, and the adhesion was 8 to 12 kPa. After burying T-AEB label in the soil for 35 days, the degradation rate reached 85 %, reflecting excellent ecological security. At pH (7–13) and volatile ammonia (25 to 25,000 ppm) conditions, the label's own color would change dramatically to indicate the effect. In sunlight, as the ammonia concentration increases, the color of the label changed from yellow to purplish red. Correspondingly, the fluorescent color of the label changed from yellow to blue. Under a 365 nm UV lamp. In addition, the label was successfully used for freshness monitoring of shrimp and razor clams during storage at 4 °C, 25 °C and − 20 °C. The smart label was a novel, economical, convenient and food freshness dual monitoring system, which was of great significance to improve food safety and quality monitoring.
研究领域:
食品科学
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材料科学
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分析化学
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智能包装
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环境监测
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产品关联
DOI
PubMed
高影响因子
SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
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2024
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IF 4.3
Yidan Liang,Bo Han,Xiaokang Lu,Yuqi Zhang,Ji-Jiang Wang
Lysine (Lys) and arginine (Arg) play a crucial role in the human diets, medical diagnostics, and functional biomaterial synthesis. The imbalance of intake for these two amino acids causes various diseases. Although many analytical techniques have been reported for the detection of amino acids, there are still some issues such as the need for bulky instruments, professional operators, sensitivity to be improved, and real-time detection. Here, a novel colorimetric-fluorimetric probe based on a terphenyl derivative (TPT) has been synthesized for the precise detection of Lys and Arg. In the EtOH-H 2 O solution of TPT, the NH 2 group at the chain end of Lys/Arg undergoes a nucleophilic addition reaction with C N groups of benzothiazole groups of the probe TPT, which breaks the initial long-conjugated system of the probe molecule. As a result, blue shifts can be observed for both UV–vis absorption spectra and fluorescence spectra, accompanying with color changes of the TPT solution. The UV–vis absorption peak of TPT solution shifts from ∼410 nm to ∼325 nm, and the solution color changes from light-yellow to colorless. The fluorescence emission shifts from ∼580 nm to ∼470 nm and the bright-yellow TPT solution changes to blue under the irradiation of 365 nm UV light. For colorimetric method, the limits of detection (LoD) are 0.82 μM and 0.90 μM for Lys and Arg, respectively. For fluorimetric method, they are 2.02 nM and 1.62 nM for Lys and Arg, respectively. In addition, TPT has good selectivity and anti-interference for Lys and Arg. The synthesized probe TPT has been successfully used for the precise detection of Lys and Arg in drugs and for fluorescence imaging of living cells. This work demonstrates that terphenyl-based derivatives are promising organic probes for the detection of Lys and Arg, providing a new way for designing other amino acids probes.
研究领域:
分析化学
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生物化学
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生物医学工程
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材料科学
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产品关联
DOI
PubMed
高影响因子
ACS Nano
·
2023
·
IF 17.1
Zhiqiang Li,Wen Zhang,Qi Zhang,Peiwu Li,Xiaoqian Tang
The multimodal lateral flow immunoassay (LFIA) has provided accurate and reliable results for fast and immediate detection. Nonetheless, multimodal LFIA remains challenging to develop biosensors with high sensitivity and tolerance to matrix interference in agro-food. In this study, we developed a self-assembled multivalent fluorescence-nanobody (Nb26-EGFP-H6) with 16.5-fold and 30-fold higher affinity and sensitivity than a monovalent nanobody (Nb26). Based on the Nb26-EGFP-H6, we synthesized enhanced immune-probes Zn-CN@Nb26-EGFP-H6 by pyrolyzing and oxidizing an imidazolating zeolite framework-8 (ZIF-8) to obtain photothermal metal–carbon nanomaterials (Zn-CN) for immobilizing Nb26-EGFP-H6. The rough and porous structure of Zn-CN with a large surface area facilitates the enrichment and immobilization of antibodies. A trimodal lateral flow immunoassay (tLFIA) with colorimetric, fluorescent, and photothermal triple signal outputs was constructed for the detection of aflatoxin B1 (AFB1) in maize. Attractively, the Zn-CN-based tLFIA’s multiplex guarantees accurate and sensitive detection of AFB1, with triple signal detection limits of 0.0012 ng/mL (colorimetric signals), 0.0094 ng/mL (fluorescent signals), and 0.252 ng/mL (photothermal signals). The sensitivity of the trimode immunosensor was 628-fold and 42-fold higher than that of the original Nb26-based ELISA (IC50) and the unimodal LFIA (LOD). This work provides an idea for constructing a sensitive, tolerant matrix and efficient and accurate analytical platform for rapidly detecting AFB1 in food.
研究领域:
纳米技术
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分析化学
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食品安全
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生物技术
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产品关联
DOI
PubMed
高影响因子
JOURNAL OF HAZARDOUS MATERIALS
·
2024
·
IF 12.2
Wei Chen,Xiayu Peng,Lichao Kang,Shengnan Dong,Jian Zhang,Yunfeng Zhao,Fengxia Sun
The development of a versatile platform for bacterial assay and elimination is urgently needed due to the danger that bacteria pose to human life. Here, we synthesized a trimetallic deposition and horseradish peroxidase (HRP)-embedded porous coordination network-224 hybrid nanozymes (PCN-224 @AuPdPt@HRP) with outstanding peroxidase activity and fluorescence quenching ability. On this basis, we designed a dual recognition strategy-driven colorimetric-fluorescence dual-mode detection platform using Listeria monocytogenes as a pattern analyte. The platform consisted of an aptamer-modified PCN-224 @AuPdPt@HRP (PCN-224 @AuPdPt@HRP@Aptamer) specifically recognizing Listeria monocytogenes and vancomycin-coated 96-well plates. In the presence of vancomycin, which has the ability to recognize and inactivate gram-positive bacteria, the significant peroxidase activity of PCN-224 @AuPdPt@HRP@Aptamer in the precipitate was able to catalyze the color change of the substrate by H 2 O 2 . Meanwhile, the residual PCN-224 @AuPdPt@HRP@Aptamer in the supernatant was able to change the fluorescence of fluorescein-labeled deoxyribonucleic acid (FAM-DNA). In summary, this paper presents a multifunctional platform capable of detecting and eliminating residual bacteria in real environments. This strategy is expected to facilitate the development of multifunctional biosensors based on metal–organic framework probes and also provide environmental health.
研究领域:
生物技术
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分析化学
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微生物学
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材料科学
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环境健康
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产品关联
DOI
PubMed
高影响因子
NEW JOURNAL OF CHEMISTRY
·
2023
·Vol. 47
·期 22
·10849-10856
·
IF 3.3
Hufeng Fang,Shan Xu,Jinhong Gong,Lidan Tang,Xiaomei He,Ying Lin,Hao Yang,Kun Yan,Dan Su,Yujing Leng
Metabolic alkalosis, the most common acid–base disorder, is related to significantly increased mortality in hospitalized patients. Hunting for pH sensors lying in the neutral to alkaline pH range still remains challenging and in demand. Herein, we engineered a colorimetric/fluorescent method for monitoring alkalic pH based on a phenylboronic acid-containing probe (DDPB). In this approach, the dicyanoisophorone group of DDPB acted as an optical signal moiety, while the boronic acid acted as the latent pH response site. It was exactly deciphered that the reversible pH monitoring principle is based on the deprotonation/protonation mechanism and intramolecular charge transfer (ICT) strategy via1H NMR and DFT calculations. This approach presented a pH-sensitive response over pH values ranging from 7.00 to 10.23 (pKa = 9.33) with excellent reversibility. We further explored its application in sensing pH on a paper substrate for visual and rapid detection. In addition, it was successfully applied to measure pH variations in HK-2 cells when the cells underwent alkalosis. This work extends the application of optical probes based on boronic acid under alkaline pH conditions, and provides a new strategy for the design of alkaline pH probes.
研究领域:
化学
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材料科学
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生物医学工程
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细胞生物学
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DOI
高影响因子
Analytical Methods
·
2020
·Vol. 12
·期 7
·943-950
·
IF 2.596
Dandan Li,Lihua Gong,Zhenyang Qiao,Congcong Zhu,Qiaojuan Jia,Huajie Kong,Shuyan Jiao
A novel highly selective colorimetric fluorescence probe, POPH, has been successfully synthesized and it shows remarkable selective and sensitive response to Cu2+ in aqueous media (HEPES buffer, pH = 7.4). The fluorescence of probe POPH immediately decreased when 1.1 equiv. of Cu2+ was added to a solution of probe POPH, accompanied by color change from wathet blue to colorless under 365 nm UV lamp illumination. The possible bonding model of probe POPH with Cu2+ was examined through HRMS, FESEM, TEM, FTIR spectroscopy and DFT calculations. Moreover, the probe POPH could be used for monitoring Cu2+ in living cells using laser scanning confocal microscopy.
研究领域:
分析化学
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材料科学
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生物化学
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理论化学
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产品关联
DOI
高影响因子
SENSORS AND ACTUATORS B-CHEMICAL
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2022
·
IF 9.221
Yuxuan Bai,Yu He,Manman Wang,Gongwu Song
Ti 3 C 2 MXene quantum dots (Ti 3 C 2 MQDs) are recognized as promising new nanomaterial recently, while the majority of the Ti 3 C 2 MQDs manifest limited maximum emission in the blue-light range. Herein, the green fluorescence nitrogen, phosphorus-doped Ti 3 C 2 MQDs (N, P-Ti 3 C 2 MQDs) were synthesized via facile microwave-assisted method, which greatly reduces the reaction time. The as-prepared N, P-Ti 3 C 2 MQDs showed excitation-dependent photoluminescence , anti-photobleaching, and favorable dispersibility . Interestingly, the fluorescence of N, P-Ti 3 C 2 MQDs can be quenched by 1,10-phenanthroline-Fe (II) complex (Phen-Fe 2+ ) via inner filter effect (IFE), accompanied by the increased orange color. After introduction of nitrite (NO 2 - ), owing to the redox reaction between NO 2 - and Fe 2+ , the fluorescence will be recovered and the color varies from orange to colorless gradually. Therefore, a colorimetric/fluorometric dual-modal recognition of NO 2 - was fabricated based on N, P-Ti 3 C 2 MQDs and Phen-Fe 2+ complex. Moreover, paper-based test trips were facilely made by the N, P-Ti 3 C 2 MQDs/Phen-Fe 2+ sensing system in response to ultrafast-response, real-time detection of NO 2 - with the assistant of smartphone. This study tendered a novel dual-channel method for real-time visual assay of NO 2 - as well as provided insightful research into functionalized Ti 3 C 2 MQDs regarding in food analysis.
研究领域:
材料科学
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分析化学
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纳米技术
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环境科学
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食品科学
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产品关联
DOI
高影响因子
危险品化学品经营许可证（带存储）