JOURNAL OF MEMBRANE SCIENCE
·
2023
·
IF 9.5
Yuhang Guo,Fusheng Pan,Guangzhaoyao Yang,Runnan Zhang,Shiyao Yu,Yuhan Wang,Ziting Zhu,Wenqing Gao,Zhiming Zhang,Tong Li,Zhongyi Jiang
Oxygenation membranes operate as indirectly contacting barriers between blood and gas in extracorporeal membrane oxygenation (ECMO), improving oxygenation and removing carbon dioxide from blood. However, the low gas exchange efficiency of the current poly (4-methyl-1-pentene) (PMP) artificial lung membrane results in a high prime volume. Facilitated transport membrane is a fascinating strategy to construct high-performance membranes for blood-gas exchange. This study put forward hybrid strategy by using metal-covalent organic frameworks (MCOFs) to construct facilitated transport membrane of PMP flat membranes and hollow fiber membranes (HFMs) via thermally induced phase separation (TIPS) to achieve facilitated blood-gas exchange. Cu-TAPB-COF nanosheets (CuCON) with framework structure and abundant active metal sites were synthetized and introduced into PMP to construct hybrid oxygenation membranes, reducing the resistance of gas exchange channels and ensuring the high affinity toward CO 2 and O 2 . Cu + and benzene rings existed in aromatic skeleton as well as the tunable structure, that could ensure the stability of MCOF and the uniform distribution of facilitated transport sites. The prepared PMP-CuCON-1 HFMs exhibited O 2 and CO 2 exchange rate of ∼467.5 ml min −1 m −2 and ∼309.1 ml min −1 m −2 in blood gas exchange process, which was 143.1% and 261.3% higher than the commercial PMP HFM, respectively. Asymmetric structure ensured resistance to plasma leakage for more than two weeks, and Cu + kept stable in CuCON and hybrid membranes. The hybrid membrane exhibited superior blood-gas exchange performance and good hemocompatibility, possessing great potential for application.
研究领域:
生物医学工程
·
材料科学
·
人工器官研究
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产品关联
DOI
高影响因子
ACS Nano
·
2025
·
IF 16
Lunhao Zhi,Yu Bai,Xueqin He,Junhan Tang,Siyu Li,Chong Cheng,Shudong Sun,Changsheng Zhao
Extracorporeal membrane oxygenation (ECMO) is the most important support for patients with severe cardiopulmonary failure. As the key component, the oxygenation membrane has suffered the risk of blood coagulation and plasma leakage in the long term. Herein, we prepare a sulfonate polyamide film on poly(ether sulfone) (PES) support via interfacial polymerization modulated by a sulfonate amine monomer. The pore diameter of the prepared polyamide film is ∼3.67 Å (exactly a little smaller than the water molecule, the base of plasma). By such size repulsion effect, the polyamide film demonstrates remarkable plasma leakage resistance (confirmed by human plasma circulation). Moreover, the introduction of the sulfonate amine monomer effectively enhances the anticoagulation performance (activated partial thromboplastin time (aPTT) prolongation >10 s). In addition, the PES support used for interfacial polymerization is modified and realizes improved porosity, hydrophilicity, and positive charge potential, resulting in lower mass transfer resistance and improved interfacial strength between the support and polyamide film. ECMO-simulated circulation tests prove the facilitation effect on gas exchange derived from the support modification and interfacial polymerization modulation. This work provides a composite membrane simultaneously with significant plasma leakage resistance and anticoagulation properties for efficient blood oxygenation.
研究领域:
生物医学工程
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材料科学
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产品关联
DOI
PubMed
高影响因子
ACS Applied Materials & Interfaces
·
2019
·
IF 8.456
Min Wen,Cheng Peng,Ming Yao,Chao Wang,Tingzhen Ming,Biaoling Peng,Fuzhi Huang,Jie Zhong,Yi-Bing Cheng,Qi Zhang
The gas–liquid membrane contactor forms a gas–solid–liquid interface and has a high potential for the applications in gas adsorption, catalysis, energy exchange, and so on. Porous superhydrophobic membranes show a great gas separation/adsorption ability. However, the complicated device architecture and the durability issue are normally concerned especially for the continuous circulation of gas and liquid. In this work, we present a free-standing gas-conductive circuit simply formed by connecting the superamphiphobic porous monoliths (SAPMs) to achieve an efficient under-liquid gas adsorption. The porous worm-like SAPM is prepared with low-temperature expandable graphite and polyvinylidenefluoride, exhibiting superamphiphobicity and superaerophilicity after fluoridation. The as-made SAPM circuits can be used as a reliable gas conductor under numerous liquids, such as water, alkaline, acidic, and oily solutions. In this work, the CO2 adsorption capacities of the SAPM circuits are evaluated under NaOH and methyldiethanolamine solutions and the mass transfer rate can reach up to 9.61 mmol m–2 s–1. Moreover, the effective human blood oxygenation process is also demonstrated using SAPM circuits. Thus, the reported SAPM provides an alternative gas–liquid exchanging method and the simplified process could be of great benefit to the cost-effectively large-scale CO2 capture or gas exchanging applications.
研究领域:
材料科学
·
环境科学
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生物医学工程
✓ 已验证
产品关联
DOI
PubMed
高影响因子
JOURNAL OF MATERIALS SCIENCE & TECHNOLOGY
·
2023
·
IF 10.9
Yunbo Feng,Qian Wang,Shudong Sun,Weifeng Zhao,Changsheng Zhao
Artificial lung membranes as the core module of the extracorporeal membrane oxygenation technology (ECMO) execute the function of extracorporeal blood-gas barrier accomplishing CO 2 /O 2 exchange with blood. However, the unsatisfactory hemocompatibility and difficulty in functionalization are the prominent challenges faced by current artificial lung membrane materials. In this study, polyethersulfone (PES) composite membranes with self-anticoagulant property and high gas exchange efficient are fabricated by blending PES matrix with poly(vinylamine) (PVAm) modified carboxylic carbon nanotubes (mCNTs) and citrate-based poly(octamethylene-citrate) (POC) pre-polymers. The mCNTs construct specific gas transfer channels within the composite membranes to enhance the gas permeability, while the POC pre-polymers provide anticoagulant property based on the chelation to blood Ca 2+ and the inactivation effect to intrinsic coagulation factors. Importantly, directed by the actual ECMO gas exchange mode, we design a gas-liquid convectional circulation device that could evaluate gas exchange efficiency for the composite membranes under mimetic ECMO state. Therefore, this strategy not only proposes a new design method of advanced artificial lung membranes to solve the practical challenges in the current ECMO technology, but also establishes a scientific testing method to evaluate the gas exchange performance for new-type artificial lung membrane materials in the future.
研究领域:
生物医学工程
·
材料科学
✓ 已验证
产品关联
DOI
高影响因子
JOURNAL OF MEMBRANE SCIENCE
·
2025
·
IF 9
Bingyang Lu,Junchang Guo,Hao Yang,Xiao Han,Peng Yu,Shengjun Cheng,Zhenxu Shi,Dehui Wang,Weifeng Zhao,Jing Luo,Xu Deng
Gas exchange membranes, as the crucial components of extracorporeal membrane oxygenation (ECMO) systems, enable efficient O 2 /CO 2 exchange in blood while maintaining adequate oxygen saturation in patients. However, clinical gas exchange membranes remain prone to thrombosis complications, which severely compromise their gas exchange effectiveness. To address this, we propose a blood-repellent gas exchange membrane (BRGEM) that helps in preventing thrombosis due to its minimal solid-liquid contact areas, while significantly enhancing gas exchange through a gas-liquid direct contact diffusion strategy. Notably, the BRGEM exhibits a 22.09-fold reduction in thrombus formation without anticoagulants compared to commercial ECMO membranes, demonstrating its exceptional anti-fouling properties. Furthermore, the membrane enables rapid oxygen recovery in the acute respiratory distress syndrome rabbit model, achieving approximately 12.97-fold improvement. We anticipate this strategy will significantly advance the development of next-generation blood oxygenation membranes and artificial lung technologies, offering transformative potential for future clinical applications.
研究领域:
生物医学工程
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膜技术
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呼吸医学
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生物材料
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人工器官
✓ 已验证
产品关联
DOI
高影响因子
JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART B-APPLIED BIOMATERIALS
·
2016
·Vol. 105
·期 7
·1737-1746
·
IF 2.881
Weiping Wang,Zhi Zheng,Xin Huang,Wenling Fan,Wenkui Yu,Zhibing Zhang,Lei Li,Chun Mao
Polyethylene glycol (PEG) and heparin (Hep) were grafted onto polysulfone (PSF) membrane by plasma-induced surface modification to prepare PSF–PEG–Hep membranes used for artificial lung. The effects of plasma treatment parameters, including power, gas type, gas flow rate, and treatment time, were investigated, and different PEG chains were bonded covalently onto the surface in the postplasma grafting process. Membrane surfaces were characterized by water contact angle, PEG grafting degree, attenuated total reflectance-Fourier transform infrared spectroscopy, ultraviolet–visible spectrophotometry, X-ray photoelectron spectroscopy, critical water permeability pressure, and scanning electron microscopy. Protein adsorption, platelet adhesion, and coagulation tests showed significant improvement in the hemocompatibility of PSF–PEG–Hep membranes compared to pristine PSF membrane. Gas exchange tests through PSF–PEG6000–Hep membrane showed that when the flow rate of porcine blood reached 5.0 L/min, the permeation fluxes of O 2 and CO 2 reached 192.6 and 166.9 mL/min, respectively, which were close to the gas exchange capacity of a commercial membrane oxygenator. © 2016 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 105B: 1737–1746, 2017.
研究领域:
生物材料
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生物医学工程
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表面化学
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产品关联
DOI
PubMed
高影响因子
JOURNAL OF MEMBRANE SCIENCE
·
2022
·
IF 10.53
Yunbo Feng,Qian Wang,Lunhao Zhi,Shudong Sun,Changsheng Zhao
Artificial lung membrane as extracorporeal blood-gas barriers could execute similar functions as human alveoli, whereby accomplish blood gas exchange process, providing imperative life support for patients with cardiopulmonary failure. However, the gas exchange performance for current membranous modules is restrained to the dense polymer matrix with low CO 2 permeability. Meanwhile, it has long been difficult to balance the contradiction between haemorrhagic risk generated by heparin systemic anticoagulation and thrombogenesis during extracorporeal blood circulation. Here, inspired by the natural mammalian alveoli, a biomimetic consecutive gas exchange network (CGEN) is constructed on porous PES substrate by using aperture-modulated UIO-66-NH 2 nanoparticles and hydrophilic CO 2 -affinitive polymer matrix to simulate the physiological structures and gas exchange features of human alveoli in vitro. The porous MOF particles within CGEN establish the main gas exchange channels, which not only enhance the total gas permeation, but also improve the CO 2 /O 2 permselectivity to 13.17, approaching to the level of natural alveoli. Additionally, the prepared composite membrane with good hemocompatibility could effectively inhibit the formation of thrombus and provide a reliable local self-anticoagulation state during extracorporeal blood circulation. Overall, this biomimetic thin film composite membrane could provide new ideals for the preparation of advanced artificial lung membrane.
研究领域:
生物医学工程
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材料科学
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组织工程
✓ 已验证
产品关联
DOI
高影响因子
Cell Reports Physical Science
·
2023
·
IF 8.9
Yue Yang,Wenqing Gao,Yun Chang,Zhenyi Zhao,Hechen Shen,Zhi Wang,Tong Li,Song Zhao
Summary Extracorporeal membrane oxygenation (ECMO) is a life support system that provides extracorporeal respiration and circulation. Current oxygenation membranes still face the challenges of plasma leakage, low gas exchange efficiency of O 2 and CO 2 , and poor biocompatibility. Here, we describe the design and realization of a biomimetic Janus membrane to simulate the structural characteristics of the alveolar blood-gas barrier. The asymmetric structure is constructed by sequential assembly of a hydrophobic polydimethylsiloxane layer, hydrophilic amino acid layer, and sulfonate grafting layer, which provide the functions of preventing plasma leakage, improving gas exchange performance, and maintaining biocompatibility. Importantly, the membrane can offer efficient blood oxygenation, achieving O 2 and CO 2 transfer rates of ∼54 and ∼131 mL m −2 min −1 , respectively. This work demonstrates that the smartly designed Janus structure provides the desired comprehensive properties of an oxygenation membrane and offers valuable guidance for the development of more advanced oxygenation membranes.
研究领域:
生物医学工程
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材料科学
·
生物材料
·
组织工程
✓ 已验证
DOI
高影响因子
Advanced Membranes
·
2025
·
IF 9.5
Xing Lv,Xiaoyun Wang,Xing Zhang,Yangming Cheng,Huiqin Zhang,Yong Mei,Xufeng Chen,Ting He,Zhaoliang Cui
The Artificial Womb Technology (AWT) system is a piece of biomedical equipment that supports the in vitro development of extremely premature infants. The system draws fetal blood, oxygenates it, removes carbon dioxide (CO 2 ), and then delivers it back to the fetus. This prevents the fetus from switching to a pulmonary breathing pattern prematurely, which provides critical time for lung tissue development. Researchers have utilized extracorporeal membrane oxygenation (ECMO) technology to provide the fetus with oxygen. In this study, we developed a new method using artificial blood instead of maternal blood in a liquid-liquid dual-circulation. Additionally, since preterm infants require greater blood compatibility and the oxygenated membrane must have anticoagulant properties, the membrane was modified to enhance hemocompatibility and anticoagulant properties. PMP membranes were functionalized with polydopamine (PDA), after which (3-(methacrylamido) propyl) dimethyl (3-thiopropyl) ammonium hydroxide inner salt (SPP) and fondaparinux sodium were successively grafted. Protein adsorption reached 18.3 μg/cm 2 (64.3% reduction), while hemolysis rate dropped to 0.19% (85.4% reduction). The results confirm that the functionalized modified membrane not only meets the blood compatibility requirements of the dual-circulation system but also accurately replicates the recurrent process of fetal-maternal gas exchange through its biomimetic design, providing key technical support for the clinical translation of the AWT system.
研究领域:
生物医学工程
·
人工器官
·
膜技术
·
纳米生物技术
·
再生医学
·
新生儿护理
✓ 已验证
产品关联
DOI
高影响因子
SEPARATION AND PURIFICATION TECHNOLOGY
·
2023
·
IF 8.6
Jing Gao,Yong Li,Huimin Li,Tianxiang Chen,Huasheng Xiao,Xinzhi Chen
An effective symmetric structured dual phase mixed conducting oxygen separation membrane made of 60 wt% Ce 0.9 Gd 0.1 O 2-δ − 40 wt% Ba 0.5 Sr 0.5 Co 0.8 Fe 0.2 O 3-δ (60CGO-40BSCF) were prepared by the aqueous tape casting. The symmetric ceramic membranes consisted of a dense thin layer with a thickness of around 50 µm in the middle, and two porous substrates (around 290 µm thick) located on the two sides of the middle thin dense layer. In this case, both the bulk diffusion of oxygen ion and surface gas exchange are simultaneously optimized to enlarge the oxygen permeation flux. In addition, a symmetric structure favors to stabilize the ceramic membrane. Compared with monotonous dense membrane, the porous supported symmetric membrane delivered higher permeation fluxes, e.g., 3.78 ml cm −2 min −1 at 975 °C under an air/He gradient, while an oxygen permeation flux of 1.42 ml cm −2 min −1 was obtained for the monotonous dense membrane. As increasing the O 2 partial pressure in the feed side to 0.8 atm, an oxygen permeation flux of 8.67 ml cm −2 min −1 was obtained. The current study implies that the porous supported symmetric membrane structure is an efficient strategy to enhance the oxygen permeation flux.
研究领域:
材料科学
·
陶瓷工程
·
化学工程
·
膜技术
✓ 已验证
产品关联
DOI
高影响因子
JOURNAL OF MEMBRANE SCIENCE
·
2025
·
IF 9
Yuhang Guo,Guangzhaoyao Yang,Shiyao Yu,Jing Huang,Fusheng Pan,Runnan Zhang,Haojun Fan,Zhongyi Jiang
Poly (4-methyl-1-pentene) (PMP) is widely used between blood and gas in extracorporeal membrane oxygenation (ECMO). However, it is more suitable to miniaturize the oxygenator from an economic and biosafety standpoint, that necessitates the PMP oxygenation membrane with enhanced gas permeance and hemocompatibility. This study introduced fluorinated covalent organic framework (FCOF) nanofiber into PMP matrix to construct PMP-FCOF hybrid flat sheet membranes and hollow fiber membranes (HFMs) via thermally induced phase separation (TIPS). FCOF exhibits structural and chemical similarity with PMP, ensuring the good compatibility with PMP matrix. The abundant C–F bonds rendered membrane low-surface-energy of ∼30.2 mN m −1 for PMP–FCOF–3 flat sheet membrane, exhibiting better hemocompatibility compared with that of ∼34.4 mN m −1 for the PMP membrane. The fabricated PMP–FCOF–3 HFMs for blood gas exchange with O 2 exchange rate of ∼309.8 mL min −1 m −2 , which was 77.3 % higher than the commercial PMP HFM, and comparable CO 2 exchange rate of ∼251.7 mL min −1 m −2 with commercial PMP HFM. The blood-gas exchange and hemocompatibility were synergistically enhanced by a simple hybrid strategy, exhibiting great application potentials.
研究领域:
生物医学工程
·
材料科学
·
化学工程
✓ 已验证
产品关联
DOI
高影响因子
Biomedical Materials
·
2015
·Vol. 10
·期 6
·065022
·
IF 3.697
Weiping Wang,Xin Huang,Haiyan Yin,Wenling Fan,Tao Zhang,Lei Li,Chun Mao
In this study, polyethylene glycol acrylate (PEGA) was introduced onto the surface of polysulphone (PSF) membrane to prepare PSF–PEGA membranes through low-temperature plasma technology for haemocompatibility improvement of artificial lungs. The effects of plasma power, PEGA solution concentration and dipcoating temperature on surface modification were systematically investigated. Results of Fourier transform infrared spectroscopy, x-ray photoelectron spectroscopy and PEGA grafting degree confirmed that PEGA was successfully grafted onto the PSF membranes. Contact angle values showed that the hydrophilicity of the PSF–PEGA membrane surface increased by 21.5%. The results of the protein adsorption, platelet adhesion and coagulation tests further showed the excellent haemocompatibility of the modified membrane. Gas exchange tests also revealed that at a porcine blood flow rate of 5 l min−1, O2 and CO2 exchange rates through the PSF–PEGA membrane were 198.6 and 170.9 ml min−1, respectively; approximately this is the gas exchange capacity of commercial respiratory assistance devices.
研究领域:
材料科学
·
生物医学工程
·
医疗器械
✓ 已验证
DOI
PubMed
高影响因子
危险品化学品经营许可证（带存储）