SCIENCE OF THE TOTAL ENVIRONMENT
·
2021
·
IF 7.963
Yin-Zhi Lv,Xiao-Jun Luo,Jian-Liang Zhao,Shan-Quan Wang,Bi-Xian Mai
Antibiotic levels in black-odor water could reflect the usage amount of antibiotics in population. On the other hand, these antibiotics are the source of antibiotics in the environmental water. Currently, researches on antibiotics in black-odor sediments are still lacking. In this study, 174 black and odor sediment samples from 74 cities in 28 provinces in China were collected for analysis. Among 44 targeted antibiotics, 13 antibiotics were detected in more than 30% of sediment samples. Fluoroquinolones and tetracyclines were the predominant antibiotics in these field samples, with average concentrations of up to 2074 and 1902 ng/g dry weight (dw), respectively, followed by macrolides (87.9 ng/g dw), lincosamides (8.06 ng/g dw) and sulfonamides (8.38 ng/g dw). High antibiotic contamination levels were almost always detected in black-odor sludges from economically less developed small cities; however, the difference in antibiotic concentrations between well-developed and small cities in China was not statistically significant. In addition, among the seven regions within China, no significant difference in concentrations was observed for the most antibiotics. Variances in antibiotic composition patterns in the 28 provinces of China may be due to differences in bacterial resistance, prescription habits, efficacy, and sediment carbon concentrations among various regions. There were significant positive correlations among some antibiotics in the same or different classes.
研究领域:
环境科学
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公共卫生
·
药理学
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DOI
高影响因子
Journal of Environmental Sciences
·
2025
·
IF 6.3
Bo Gong,Chang Xu,Shan Zhao,Xiao-Min Sun,Shu-Guang Wang,Xian-Zheng Yuan,Chao Song
The photochemical transformation of fluoroquinolones (FQs) represents a crucial environmental phenomenon eliciting growing concern. Nevertheless, the impact and mechanisms of ubiquitously coexisting copper ions, i.e., Cu(II), remain elusive. Here, the role of Cu(II) in the photochemical transformation of FQs was systematically investigated via experimental characterizations and theoretical simulations. Cu(II) markedly inhibited the photolysis of levofloxacin (LEV), a representative FQs model, from 0.0078 to 0.0040 min −1 after a 100-min irradiation under simulated sunlight with the molar ratio of Cu(II): LEV at 1:1. The micro-level mechanisms were explored, including the ligand-to-metal charge transfer in complexation, modifications to reactive sites and activities with various reactive species, and higher hole-electron separation extents. In addition, the triplet excited state, singlet oxygen, and hydroxyl radical in LEV and LEV-Cu(II) with 1: 1 molar ratio played pivotal roles in the transformation, contributing 20.77/20.02 %, 13.87/14.59 %, and 7.96/4.68 %, respectively. Furthermore, considering more FQs models, the inhibition of Cu(II) on the transformation was found to universally exist in ciprofloxacin, enoxacin, enrofloxacin, norfloxacin, ofloxacin and pefloxacin, and their multiple molecular descriptors were changed with a same tendency. This work provides a comprehensive understanding of the transformation of antibiotics within complex aqueous matrices, contributing to further estimation of antibiotics removal and ecological risks.
研究领域:
环境科学
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药物化学
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生物无机化学
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产品关联
DOI
高影响因子
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
·
2019
·Vol. 26
·期 33
·34345-34356
·
IF 2.914
Liu Lili,Chen Xin,Wang Zhiping,Lin Sen
Fluoroquinolones (FQs) occur broadly in natural media due to its extensive use, and it has systematic effects on our ecosystem and human immunity. In this study, long-root Eichhornia crassipes was reclaimed as a multi-functional activated carbon (MFAC) to remove fluoroquinolones (FQs) from contaminated water. To get insight into the adsorption mechanism, multiple measurements, including FTIR and XPS analyses, were employed to investigate the adsorption processes of ciprofloxacin and norfloxacin as well as the experiments of effect of exogenous factors on adsorption performances. The results confirmed that the adsorption of FQs by MFAC was mainly attributed to the electrostatic interaction, hydrogen bond interaction, and electronic-donor-acceptor (EDA) interaction. In addition, the kinetics and thermodynamics experiments demonstrated that the MFAC possessed great adsorption performance for FQs. According to the Langmuir model, the saturated adsorption capacities exceeded 145.0 mg/g and 135.1 mg/g for CIP and NOR at 303.15 K, respectively. The column experiments were conducted to explore the application performance of MFAC on the advanced treatment of synthetic water at different flow rates and bed depths. The adsorption capacity of CIP on MFAC was estimated by the Thomas models and the bed-depth service time (BDST) models, reaching 127.56 mg/g and 11,999.52 mg/L, respectively. These results also provide a valid approach for the resource recycling of the redundant long-root Eichhornia crassipes plants.
Graphical abstract
研究领域:
环境科学
·
材料科学
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产品关联
DOI
PubMed
高影响因子
MICROCHEMICAL JOURNAL
·
2025
·
IF 5.1
Su Han Wang,Min Lin,Jing Liu,Jian Ping Wang,Ning Peng Wu
The quinolone efflux pump (QepA) protein of a fluoroquinolones-resistant Escherichia coli was grafted on Fe 3 O 4 to synthesize a type of magnetic composite Fe 3 O 4 @QepA. This material was combined with 4 fluorescent tracers to develop a semi-homogeneous fluorescent array on 96-well microplate for determination of fluoroquinolones (FQs) in chicken, and the results were analyzed by using linear discriminant analysis method. Results showed this method could discriminatively determine 15 FQs at the concentration ≥10 ng/g, and could identify each drug species at the concentration ≥2 ng/g. The method exhibited satisfactory recoveries in chicken sample (61.7 %–119.8 %). The analysis results for some unknown samples were consistent with a liquid chromatography mass spectrometry method. This is the first paper reporting a semi-homogeneous fluorescent array for discriminative determination of small molecule substances, and this array can be used as an accurate tool to determine the 15 FQs in meat sample.
研究领域:
分析化学
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微生物学
·
食品安全
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产品关联
DOI
高影响因子
JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES
·
2015
·
IF 2.729
Huili Wang,Ming Gao,Mei Wang,Rongbo Zhang,Wenwei Wang,Randy A. Dahlgren,Xuedong Wang
Herein, we developed a novel integrated device to perform phase separation based on ultrasound-assisted salt-induced liquid–liquid microextraction for determination of five fluoroquinones (FQs) in human body fluids. The integrated device consisted of three simple HDPE components used to separate the extraction solvent from the aqueous phase prior to retrieving the extractant. A series of extraction parameters were optimized using the response surface method based on central composite design. Optimal conditions consisted of 945 μL acetone extraction solvent, pH 2.1, 4.1 min stir time, 5.9 g Na 2 SO 4 , and 4.0 min centrifugation . Under optimized conditions, the limits of detection (at S/N = 3) were 0.12–0.66 μg L −1 , the linear range was 0.5–500 μg L −1 and recoveries were 92.6–110.9% for the five FQs extracted from plasma and urine. The proposed method has several advantages, such as easy construction from inexpensive materials, high extraction efficiency, short extraction time, and compatibility with HPLC analysis. Thus, this method shows excellent prospects for sample pretreatment and analysis of FQs in human body fluids.
研究领域:
分析化学
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药物分析
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医学检测
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产品关联
DOI
PubMed
高影响因子
AQUATIC TOXICOLOGY
·
2023
·
IF 4.5
Dantong Jia,Xiuqi You,Moran Tang,Yitao Lyu,Jingrun Hu,Weiling Sun
Fluoroquinolones (FQs) are known to have genotoxicity to aquatic organisms. However, their genotoxicity mechanisms, individually and in combination with heavy metals, are poorly understood. Here, we investigated the single and joint genotoxicity of FQs, ciprofloxacin (CIP) and enrofloxacin (ENR), and metals (Cd and Cu) at environmentally relevant concentrations (0.2 µM) to zebrafish embryos. We found that FQs or/and metals induced genotoxicity (i.e., DNA damage and cell apoptosis) to zebrafish embryos. Compared with their single exposure, the combined exposure of FQs and metals elicited less ROS overproduction but higher genotoxicity, suggesting other toxicity mechanisms may also act in addition to oxidation stress. The upregulation of nucleic acid metabolites and the dysregulation of proteins confirmed the occurrence of DNA damage and apoptosis, and further revealed the inhibition of DNA repair by Cd and binding of DNA or DNA topoisomerase by FQs. This study deepens the knowledge on the responses of zebrafish embryos to exposure of multiple pollutants, and highlights the genotoxicity of FQs and heavy metals to aquatic organisms.
研究领域:
环境科学
·
毒理学
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产品关联
DOI
PubMed
高影响因子
APPLIED CLAY SCIENCE
·
2022
·
IF 5.907
Qianqian Chang,Boqiang Gao,Hu Yang
In this work, a series of novel composite adsorbents (k-TAFe) was designed and fabricated through a one-step method, that is, the chelation crosslinking of tannic acid, kaolin particles and different contents of Fe(III). k-TAFe had a high efficiency in adsorption of various fluoroquinolones antibiotics (FQs) from water. The detailed performance of k-TAFe in FQs adsorption, including the influences of Fe(III) content, solution pH, inorganic and organic additives, adsorption time and FQs' concentration, has been investigated systematically using ofloxacin (OFL), one of popular FQs, as an example. The maximal OFL uptake of k-TAFe was 0.405 mmol/g at an initial pH of 6.0. On the basis of the analysis of the x-ray photoelectron and fourier transform-infrared spectra before and after adsorption, the comparison in the apparent performance of k-TAFe in adsorption of seven FQs with similar structures and their two sub-structural analogs, and theoretical calculation, multiple adsorption mechanisms, including chelating effect, hydrogen bonding, electrostatic attraction , and π-π electron–donor–acceptor interactions, were involved and discussed in detail. Among them, chelating effect due to Fe(III) played a key role in OFL adsorption, and the addition of kaolin particles synergistically enhanced Fe(III) fixed on the composite adsorbents, increased the Fe(III) contents, and caused an improved OFL uptake of k-TAFe. Because of the evident advantages of environmental-friendliness, high adsorption performance and low cost, k-TAFe as an efficient adsorbent has notable application potentials in removal of FQs from water.
研究领域:
环境科学
·
材料科学
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DOI
高影响因子
FOOD CHEMISTRY
·
2024
·
IF 8.5
Hongmei Liu,Yue Li,Sikai Wang,Sisi Zhang,Guoqi Zhang,Yan Zhao
Herein, a new, environmentally friendly, and economical magnetic solid-phase extraction method for fluoroquinolones (FQs) from milk samples was developed using novel recyclable zeolitic imidazolate framework functionalized magnetic multiwalled carbon nanotubes (Fe 3 O 4 @MWCNTs@SiO 2 @ZIF-8) as adsorbents. Various characterization techniques, including scanning electron microscopy, N 2 adsorption-desorption analysis, and vibrating sample magnetometry, demonstrated that the adsorbent possessed a remarkable specific surface area, pore volume, and superparamagnetic properties, rendering it an excellent adsorbent. Combined with high-performance liquid chromatography, this method exhibited excellent linearity (R 2 ≥ 0.9991) over the concentration range of 0.5–500 μg L −1 , low limits of detection (0.10–0.34 μg kg −1 ), and low limits of quantification (0.30–1.00 μg kg −1 ). Finally, the developed method was successfully applied to analyze FQs in milk samples with recoveries ranging from 83.3% to 107.7% and relative standard deviations below 4.2%. The high efficiency and sensitivity of this method highlight the potential application of Fe 3 O 4 @MWCNTs@SiO 2 @ZIF-8 for analyzing FQs in complex matrices.
研究领域:
分析化学
·
环境科学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
·
2020
·
IF 3.99
Chun Yang,Rui Li,Qi Wang,Wenhao Wang,Pei Gao,Bibo Hu
The functionalized mesoporous silica (FMS) and core-shell magnetic functionalized mesoporous silica (MMS) were synthesized on the basis of unfunctionalized mesoporous silica (UMS) via alkyl modification and one-pot reaction. Its adsorption properties to enrofloxacin (ENR), pefloxacin (PEF) and ciprofloxacin (CIP) were systematically investigated in single and binary systems. The results indicated the adsorption performance of MMS is five times higher than UMS. Batch adsorption experiments demonstrated the MMS had a higher adsorption capacity and adsorption efficiency for FQs, with the maximum adsorption capacities of 201.52 mg g -1 for CIP, 275.46 mg g -1 for PEF and 286.35 mg g -1 for ENR. Meanwhile, over 80% and 90% removals were achieved within 5 min and 10 min. Experiment results also presented that: MMS was able to reach the maximum adsorption capacity around pH 7.0 and maintain high adsorption capacity at a high concentration of humic acid. Besides, MMS showed the selective adsorption to three FQs in the binary adsorption experiments. The reusability experiment suggested the MMS possess excellent stability. H-bonding, electrostatic interaction and hydrophobic interaction were the main driving force between three FQs and MMS. Moreover, the adsorbent can be readily separated from water solution by an external magnet. These obtained results could be used for adsorbent design in considering of the properties of the adsorbates and the reuse of adsorbents.
研究领域:
环境科学
·
材料科学
✓ 已验证
产品关联
DOI
高影响因子
CHEMICAL ENGINEERING JOURNAL
·
2021
·
IF 13.273
Hengduo Xu,Yanqing Sheng
SO 4 ●− and ● OH are recognized as valid reactive species in the FeS-activated persulfate system. However, whether other reactive species are generated in this process remains unclear. In this study, a FeS-based peroxymonosulfate (PMS) (FeS/PMS) system was developed for the degradation of chloramphenicol (i.e., chloramphenicol (CAP) and thiamphenicol (TAP)) and fluoroquinolone (i.e., ciprofloxacin (CIP) and norfloxacin (NOR)) antibiotics. In addition to SO 4 ●− and ● OH, Fe(IV) was identified as another reactive species by using methyl phenyl sulfoxide (PMSO) and methyl phenyl sulfone (PMSO 2 ) as probe compounds. Although Fe(IV) participated in antibiotic degradation, the contribution of Fe(IV) was smaller than that of SO 4 ●− due to its low redox potential and weak competition ability. Efficient degradation of antibiotics was achieved in the FeS/PMS system within 120 min using 6 mM PMS and 0.6 g/L FeS at initial pH of 7.0, with removal percentages of 93.5%, 98.5%, 100% and 100% for CAP, TAP, CIP and NOR, respectively. The S 2− acted as an electron donor to facilitate continuous Fe(III) reduction and Fe(II) regeneration. Based on the degradation intermediates of antibiotic, the reaction pathways were proposed to involve side chain cleavage, hydroxylation, denitration, deoxygenation, decarboxylation and dehalogenation. In addition to its performance in simulated waters, the FeS/PMS system also presented effective antibiotic degradation in real surface water. This study provides new insights into the mechanism of multiple reactive species generation in the FeS-activated PMS process and extends the potential engineering applications in antibiotic degradation and in situ water quality remediation.
研究领域:
环境科学
·
化学工程
✓ 已验证
产品关联
DOI
高影响因子
ANALYTICAL AND BIOANALYTICAL CHEMISTRY
·
2016
·Vol. 408
·期 22
·6105-6114
·
IF 3.125
Wang Huili,Gao Ming,Gao Jiajia,Yu Nana,Huang Hong,Yu Qing,Wang Xuedong
In conventional microextraction procedures, the disperser (organic solvent or ionic liquid) is left in the aqueous phase and discarded after finishing the microextraction process. Because the disperser is water-soluble, it results in low extraction recovery for polar compounds. In this investigation, an ionic-liquid-based microextraction (ILBME) was integrated with salting-out assisted liquid-liquid microextraction (SALLME) to build an ionic-liquid-based, salt-induced, dual microextraction (ILSDME) for isolation of five fluoroquinolone antibiotics (FQs) with high polarity (log P , −1.0 to 1.0). The proposed ILSDME method incorporates a dual microextraction by converting the disperser in the ILBME to the extractor in the SALLME. Optimization of key factors was conducted by integrating single-factor experiments and central composite design. The optimized experimental parameters were 80 μL [C 8 MIM][PF 6 ] as extractor, 505 μL acetone as disperser, pH = 2.0, 4.1 min extraction time, and 4.2 g of Na 2 SO 4 . Under optimized conditions, high ERs (90.6–103.2 %) and low LODs (0.07–0.61 μg kg −1 ) were determined for five FQs in swine feed. Experimental precision based on RSDs was 1.4–5.2 % for intra-day and 2.4–6.9 % for inter-day analyses. The combination of ILBME with SALLME increased FQ recoveries by 15–20 % as compared with SALLME, demonstrating that the ILSDME method can enhance extraction efficiency for polar compounds compared to single-step microextraction. Therefore, the ILSDME method developed in this study has wide application for pretreatment of moderately to highly polar pollutants in complex matrices.
A dual microextraction was developed by integrating ionic-liquid-based microextraction with salting-out assisted liquid-liquid microextraction for isolation of five fluoroquinolone antibiotics (FQs) with high polarity (log P = −1.0 to 1.0). The principle of dual microextraction is based on converting the remaining disperser from the first microextraction into an extractor in the second microextraction. Single-factor experiment and central composite design were applied for optimizing operational parameters using 3D response surfaces and contour lines. Under optimized conditions, the method provided high extraction recoveries and low LODs for five FQs in swine feed. The prominent advantage of the dual microextraction is rapid and highly efficient extraction of moderately to highly polar fluoroquinolones from complex matrices
研究领域:
分析化学
·
环境科学
·
兽医学
✓ 已验证
DOI
PubMed
高影响因子
CHEMICAL ENGINEERING JOURNAL
·
2019
·
IF 8.355
Cong Geng,Zhijie Liang,Fuyi Cui,Zhiwei Zhao,Chen Yuan,Jinying Du,Chuang Wang
Due to the inefficient treatment by the biotic and UV-disinfection processes in wastewater treatment plants, the broad-spectrum Fluoroquinolone antibiotics (FQs) are frequently detected in water environment around the world. In this work, the photo-degradation of three FQs (norfloxacin-NOR, ciprofloxacin-CIP, levofloxacin-LEV) by VUV/UV irradiation was investigated. The results showed that the degradation of FQs in VUV/UV irradiation system were more effective than that in UV irradiation system by enhanced the defluorination and decarboxylation . FQs could be degraded more efficiently with high temperature and low initial concentration, and the effect of flow rate was small. Initial pH played a key role in degradation of NOR and CIP. Most anions could slightly affect the FQs removal in water, except the carbonate and phosphate species. 1 O 2 and ·OH played the primary role in FQs degradation in VUV/UV system. Defluorination, decarboxylation, and piperazine ring oxidation were the main degradation pathways for three FQs degradation, but demethylation was a particular degradation pathway of LEV. Antibacterial activities of FQs aqueous sample were reduced in both VUV/UV and UV system, while the removal of antibacterial activities in the VUV/UV process were more efficient than UV process for NOR and LEV. VUV/UV system was more energy-saving for removing FQs. These results suggested that VUV/UV system is potential alternative in replacing or enhancing UV system in wastewater treatment plants for FQs removal in the future.
研究领域:
环境科学
·
水处理工程
✓ 已验证
产品关联
DOI
高影响因子
危险品化学品经营许可证（带存储）