International Journal of Nanomedicine
·
2023
·
IF 8
Haiying Hua,Nan Zhang,Dan Liu,Lili Song,Tuanbing Liu,Shasha Li,Yongxing Zhao
Personalized and precise nanomedicines are highly demanded for today’s medical needs. Liposomes are ideal candidates for the construction of multifunctional drug delivery systems. In this study, a liposome was used to improve the clinical issues of docetaxel (Doc), a potent antimitotic chemotherapy for prostate cancer (PC). RLT, a low-density lipoprotein receptor (LDLR)-binding peptide, and PEG were conjugated to the liposomes, and gold nanorods (GNRs) were also incorporated into the liposomes. The GNRs/Doc-liposome-RLT (GNRs/DocL-R) was tested in PC-3 cells and in PC-3 tumor-bearing nude mice. Results showed that GNRs/DocL-R possessed a diameter approximately 163.15±1.83 nm and a zeta potential approximately −32.8±2.16 mV. GNRs/DocL-R showed enhanced intracellular entrance, increased accumulation in the implanted tumor region, and the highest tumor inhibition in vitro and in vivo. Therefore, the multifunctional GNRs/DocL-R was a potential cancer treatment via combined chemo- and thermotherapy.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
COLLOIDS AND SURFACES B-BIOINTERFACES
·
2023
·
IF 5.8
Weiwei Tang,Jiapeng Kang,Lu Yang,Jialin Lin,Jing Song,Dan Zhou,Feng Ye
Phototherapies, in the form of photodynamic therapy (PDT) and photothermal therapy (PTT), have great application prospects in the field of biomedical science due to high precision and non-invasiveness. Because of the limited therapeutic efficacy of single phototherapy, researchers start to focus on combined PTT-PDT. Here, we designed a composite nanomaterial for PTT-PDT. H-TiO 2 mesoporous spheres were prepared by sol-gel method and hydrogenation treatment. After modification with polydopamine (PDA), they were combined with indocyanine green (ICG) and NPe6 photosensitizers and coated by thermosensitive liposomes to prepare H-TiO 2 @ [email protected] @NPe6 @Lipo nanocomposite component. The results indicated a substantial improvement of the component in the aspects of spectral response range, photothermal conversion efficiency and light absorption performance by modification and photosensitizers, in the absence of any toxicities on cells. Thermal induction and sequential irradiation with 808 nm and 664 nm lasers induced the aggregation of H-TiO 2 @ [email protected] @NPe6 @Lipo at the tumor site to generate hyperthermia and massive reactive oxygen species (ROS), resulting in decreased cell activity or even cell apoptosis and restrained growth of allograft tumors. These findings underscore the favorable effects of H-TiO 2 @ [email protected] @NPe6 @Lipo on the combined phototherapies and provide approaches for the development of nano-drugs in the context of liver cancer.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Journal of the American Chemical Society
·
2022
·
IF 16.383
Yuan Tian,Zhiliang Gao,Ning Wang,Ming Hu,Yi Ju,Qiang Li,Frank Caruso,Jingcheng Hao,Jiwei Cui
Surface modification with poly(ethylene glycol) (PEGylation) is an effective strategy to improve the colloidal stability of nanoparticles (NPs) and is often used to minimize cellular uptake and clearance of NPs by the immune system. However, PEGylation can also trigger the accelerated blood clearance (ABC) phenomenon, which is known to reduce the circulation time of PEGylated NPs. Herein, we report the engineering of stealth PEG NPs that can avoid the ABC phenomenon and, when modified with hyaluronic acid (HA), show specific cancer cell targeting and drug delivery. PEG NPs cross-linked with disulfide bonds are prepared by using zeolitic imidazolate framework-8 NPs as templates. The reported templating strategy enables the simultaneous removal of the template and formation of PEG NPs under mild conditions (pH 5.5 buffer). Compared to PEGylated liposomes, PEG NPs avoid the secretion of anti-PEG antibodies and the presence of anti-PEG IgM and IgG did not significantly accelerate the blood clearance of PEG NPs, indicating the inhibition of the ABC effect for the PEG NPs. Functionalization of the PEG NPs with HA affords PEG NPs that retain their stealth properties against macrophages, target CD44-expressed cancer cells and, when loaded with the anticancer drug doxorubicin, effectively inhibit tumor growth. The innovation of this study lies in the engineering of PEG NPs that can circumvent the ABC phenomenon and that can be functionalized for the improved and targeted delivery of drugs.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
COLLOIDS AND SURFACES B-BIOINTERFACES
·
2024
·
IF 5.4
Wanling Chen,Nanxi Xiang,Jiahong Huang,Huixian Xu,Zhenyuan Wang,Bo Ruan,Jichuan Zhang,Chengyu Wu,Jiaheng Zhang,YanZhen Liang
Collagen-based skincare products can replenish collagen in the skin; however, collagen cannot easily penetrate the dermis, limiting its effectiveness. Therefore, nanomaterials that can enable collagen to effectively penetrate the dermis are urgently needed. This study aimed to determine the potential role of the supramolecular collagen nanoparticles, namely, lactoferrin, recombinant human collagen, and palmitoyl tripeptide-5, in improving the effectiveness of skincare products. Lactoferrin and recombinant collagen served as carriers encapsulating palmitoyl tripeptide-5, with an encapsulation rate of 94.18%. The supramolecular collagen nanoparticles demonstrated good stability after 1 month. Transdermal efficiency was improved by 69.90%, allowing the nanoparticles to penetrate deeply into the dermis. Within 28 days of use, the moisture content of the stratum corneum increased by 10.51%, facial elasticity improved by 8.15%, skin firmness increased by 12.53%, facial melanin index decreased by 1.84%, and individual type angle increased by 19.10%. Within 14 days, there was a 24.69% reduction in eye bag wrinkles and a 37.61% reduction in nasolabial wrinkles. Wrinkle lengths decreased by 10.22% and 21.57%, and areas decreased by 34.41% and 27.92%, respectively. The supramolecular collagen nanoparticles displayed multiple skincare benefits, including moisturizing, whitening, wrinkle reduction, and firming. In conclusion, the supramolecular collagen nanoparticles are promising candidates for cosmetic products.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Applied Materials Today
·
2025
·
IF 6.9
Huixian Xu,Rui Ye,Ye Zhong,Wanling Chen,Jichuan Zhang,Zhenyuan Wang,Le Du,Fan Hu,Chengyu Wu,Jiaheng Zhang
Although retinol and its derivatives are effective anti-aging substances, they can induce “retinoid dermatitis.” To solve this problem, a novel 4-t-butylcyclohexanol α-lipoic acid ionic liquid (BLA-IL) was prepared and confirmed. Retinol can be directly dissolved into BLA-IL, encapsulated into nanoparticles (NPs) and form retinoid-loaded ionic liquid NPs. In-vivo and ex-vivo studies investigated the developed formulation's safety, transdermal enhancement, and efficacy. Safety assessments revealed that BLA-IL-mediated TRPV1 antagonism was achieved. In particular, IL-NPs increase the amount of retinoid in the skin by 4.3 times compared to the free retinoid and 27 % more than NPs. Based on in vivo and in vitro experiments, BLA-IL synergistically doubled the effect of fibroblast COL-I synthesis, with upregulation to 756.9 %, simultaneously enhancing COL-I, COL3A1, and Elna gene expression and inhibiting MMP-1, reactive oxygen species, and neutrophil aggregation. Clinically, retinoid-loaded IL-NPs significantly improved wrinkles, R2, collagen intensity, ITA°, and l -value compared to free retinoid in volunteers. In conclusion, this study displayed that BLA-IL NPs could promote transdermal delivery and achieve synergistic anti-aging efficacy. It could be a promising technology combining IL and nano-technology in the pharmaceutic and cosmetic transdermal areas.
✓ 已验证
产品关联
DOI
高影响因子
危险品化学品经营许可证（带存储）