NEUROENDOCRINOLOGY LETTERS
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2024
·
IF 0.6
Xiumei Cheng,Xinyi Cao,Yichun Yang,Lingxiao Wang,Yuxuan Yang,Yunjian Pan,Yongliang Zheng,Churong Wei,Yougen Luo
Objective: Methylmercuric chloride (MMC) has neurotoxicity, while hydrogen sulfide (H2S) has shown inhibitory properties against nerve damage induced by various factors. The study aimed to investigate the impact of H2S on MMC-induced learning and memory impairment in mice and to explore the underlying mechanisms. Methods: A mouse model of learning and memory impairment was established by MMC gavage, and sodium hydrosulfide (NaHS) was used as an H2S donor for intervention. Cell viability and live/dead cell ratio in HT22 neuronal cells were assessed by CCK-8 assay and Calcein/PI staining, respectively. The Morris water maze test was performed to evaluate the learning and memory abilities of mice. Western blotting was utilized to determine protein expressions of BDNF and TrkB. The effects of H2S on MMC-induced learning and memory impairment were investigated based on the BDNF/TrkB pathways. Results: (1) MMC treatment decreased cell viability and reduced the ratio of live cells in HT22 cells, while H2S reversed these changes. (2) MMC prolonged escape latency, decreased platform crossing frequency, and reduced quadrant distance percentage of the platform in the Morris water maze test, while H2S reversed the above changes. (3)MMC downregulated BDNF and TrkB expression levels, while H2S suppressed these changes induced by MMC. (4)Treatment with 7, 8-DHF (a TrkB agonist) significantly attenuated MMC-induced prolonged escape latency and reduced platform crossing frequency. Conclusions: Our findings demonstrated that H2S ameliorated learning memory deficits in mice by reversing the inhibitory effects of MMC on BDNF/TrkB signaling pathway.
研究领域:
神经科学
·
毒理学
✓ 已验证
DOI
PubMed
高影响因子
MATERIALS & DESIGN
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2024
·
IF 7.6
Wei Chen,Xu Liu,Dong Hu,Xu Liu,Xi Zhu,Xuejun Fan,Guoqi Zhang,Jiajie Fan
During operation in environments containing hydrogen sulfide (H 2 S), such as in offshore and coastal environments, sintered nanoCu in power electronics is susceptible to degradation caused by corrosion. In this study, experimental and molecular dynamics (MD) simulation analyses were conducted to investigate the evolution and mechanism of H 2 S-induced corrosion of sintered nanoCu, and bulk Cu was used as the reference. The following results are obtained: (1) Both sintered nanoCu and bulk Cu reacted with O 2 prior to reacting with H 2 S, forming Cu 2 O, Cu 2 S, CuO, and CuS. In addition, sintered nanoCu exhibited more severe corrosion. (2) For both sintered nanoCu and bulk Cu, H 2 S-induced corrosion resulted in the deterioration of electrical, thermal, and mechanical properties, and sintered nanoCu experienced a greater extent of deterioration. (3) As was ascertained through Reactive Force Field (ReaxFF) MD simulations, the penetration of H 2 S and O 2 combined with the upward migration of Cu resulted in the formation of a corrosion film. In addition, compared to bulk Cu, the H 2 S and O 2 penetration in the sintered nanoCu structure was observed to occur to a greater depth, accounting for the more pronounced performance degradation.
研究领域:
材料科学
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电子工程
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产品关联
DOI
高影响因子
SENSORS AND ACTUATORS B-CHEMICAL
·
2021
·
IF 7.46
Xia Gao,Guangming Sun,Xinke Wang,Xiaodong Lin,Shuo Wang,Yaqing Liu
As a vital signaling molecules, hydrogen sulfide (H 2 S) with abnormal concentrations is correlated with many diseases. Therefore, development of novel assays for quantitative and selective detection of H 2 S is important. Herein, we synthesized a host-guest metal-organic framework (MOF), i.e., RhB/UiO-66-N 3 (here, RhB means rhodamine B) by a mildly and simply way, as reaction-based ratiometric fluorescent nanosensor for selective detection and intracellular imaging of H 2 S. In the presence of H 2 S, the RhB/UiO-66-N 3 exhibits dual emissions at 425 nm and 575 nm under irradiation of single excitation wavelength. The blue fluorescence at 425 nm (F 425 ) is attributed to the H 2 S-mediated biorthogonal reduction of azide to amine, and the red fluorescence at 575 nm (F 575 ) originating from RhB is served as an internal reference. With increasing concentrations of H 2 S, the intensity of blue fluorescence increases while the intensity of red fluorescence has no obvious change. With F 425 /F 575 as readout, turn-on and ratiometric fluorescence detection of H 2 S was achieved with good selectivity and sensitivity. Interestingly, RhB/UiO-66-N 3 can be tuned from microscale to nanoscale sizes, and endows high stability under physiological conditions. The exogenous and endogenous H 2 S in live cells has been further targeted and imaged, demonstrating its considerable potential for extensive applications.
研究领域:
生物化学
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医学
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材料科学
✓ 已验证
DOI
高影响因子
SENSORS AND ACTUATORS B-CHEMICAL
·
2024
·
IF 8
Hong Zhang,Haowei Zhu,Shibin Nie,Siyu Wu,Xiaoyong Liu,Songfeng Yin
In this study, four sodium superionic conductors Na 3 Zr 2-x Zn x Si 2 PO 12 (x=0, 0.1, 0.2, 0.3) were used as solid electrolytes for planar mixed-potential gas sensors (Zn0, Zn1, Zn2, and Zn3 sensors) to detect hydrogen sulfide (H 2 S) and sulfur dioxide (SO 2 ). The total conductivity of the Na 3 Zr 2-x Zn x Si 2 PO 12 electrolyte first increased and then decreased with increasing Zn 2+ doping. When doped with 0.2 mol of Zn 2+ , the electrolyte exhibited the highest total conductivity of 6.37 × 10 -5 S·cm -1 at 25°C, which was 14.2 times higher than that of the undoped electrolyte. At 25°C, the response of the Zn2 sensor to 10 ppm H 2 S was -237.8 mV, which was 6.9, 2.1, and 5.8 times that of the Zn0, Zn1, and Zn3 sensors, respectively. A high response of -58.6 mV was obtained by the Zn2 sensor at 25°C for 0.5 ppm H 2 S. In addition, the sensitivity to H 2 S at 25°C was -150.9 mV/decade. In comparison with reported mixed-potential H 2 S sensors, the Zn2 sensor demonstrated significantly higher response and sensitivity at room temperature. Moreover, the Zn2 sensor responded to 10 ppm SO 2 and H 2 S almost equally at 25°C. The gas sensing behavior was discussed in terms of the variation of sodium ionic conductivity, Na 3 PO 4 phase proportion, and ZnS formation under H 2 S or SO 2 atmosphere. Additionally, taking the detection of H 2 S-contaminated environments as an example, a gas leakage detection and alarm platform based on the Zn2 sensor was designed. This study provides insights into designing and developing high-performance mixed-potential gas sensors for H 2 S and SO 2 at room temperature.
研究领域:
材料科学
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环境科学
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化学
✓ 已验证
DOI
高影响因子
LUMINESCENCE
·
2017
·Vol. 33
·期 1
·161-167
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IF 1.509
Lili Chen,Hongliang Tan,Fugang Xu,Li Wang
With recognition of the biological importance of hydrogen sulfide (H 2 S), we present a simple and effective fluorescent probe for H 2 S using a Tb 3+ coordination polymer–Cu 2+ compound (DPA/Tb/G–Cu 2+ ). Dipicolinic acid (DPA) and guanosine (G) can coordinate with Tb 3+ to form a macromolecular coordination polymer (DPA/Tb/G). DPA/Tb/G specifically binds to Cu 2+ in the presence of coexisting cations, and obvious fluorescence quenching is observed. The quenched fluorescence can be exclusively recovered upon the addition of sulfide, which is measured in the mode of time-resolved fluorescence. The fluorescence intensities of the DPA/Tb/G–Cu 2+ compound enhance linearly with increasing sulfide concentrations from 1 to 30 μM. The detection limit for sulfide in aqueous solution is estimated to be 0.3 μM (at 3σ). The DPA/Tb/G–Cu 2+ compound was successfully applied to sense H 2 S in human serum samples and exhibited a satisfactory result. It displays some desirable properties, such as fast detection procedure, high selectivity and excellent sensitivity. This method is very promising to be utilized for practical detection of H 2 S in biological and environmental samples.
研究领域:
分析化学
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生物化学
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环境科学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
JOURNAL OF PHYSICS D-APPLIED PHYSICS
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2020
·Vol. 53
·期 32
·325102
·
IF 3.169
Guojia Huang,Yujie Li,Cui Chen,Zizheng Yue,Wei Zhai,Maodong Li,Bo Yang
A novel photonic crystal fiber (PCF) Mach–Zehnder interferometer (MZI) was proposed for detecting hydrogen sulfide (H2S) gas. Two single-mode fibers (SMFs), two multi-mode fibers (MMFs), and a PCF are sequentially fused to form a MZI with SMF-MMF-PCF-MMF-SMF structure. Titanium dioxide/amino-functionalized graphene quantum dots (TiO2/af-GQDs) composite is coated on the surface of the PCF as a sensing membrane. The fabricated sensing membrane is characterized by x-ray photoelectron spectroscopy, x-ray diffraction and scanning electron microscopy. Furthermore, the properties of the sensor are examined. The results show that a uniform TiO2/af-GQDs film with a thickness of 1 μm is successfully coated on the surface of the PCF. The sensor has a sensitivity of 26.62 pm ppm−1, showing good linearity and selectivity for H2S in the range of 0 ∼ 55 ppm. The response time and recovery time are about 68 s and 77 s, respectively. The sensor has the advantages of low cost, small volume and simple structure, which is suitable for on-line monitoring of H2S.
研究领域:
光学传感
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材料科学
·
环境监测
✓ 已验证
DOI
高影响因子
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