Tengfei Ma,Xinyun Zhai,Mengdie Jin,Yongkang Huang,Mengzhen Zhang,Haobo Pan,Xiaoli Zhao,Yaping Du
As the number of diabetics increases yearly and diabetic ulcer is the most concerned diabetic complication, it is of great urgency to develop a novel multifunctional material with high efficiency to promote diabetic wound healing. In this paper, ceria (CeO 2 )-modified upconversion nanoparticles which loaded in polycaprolactone membranes were successfully prepared as a ceria-based wound dressing for chronic wound healing. In this system, near-infrared (NIR) light is used as a switch to control the photodynamic antibacterial therapy by converting the NIR photons into ultraviolet light, which can further trigger CeO 2 to produce reactive oxygen species. In addition, the well-known antioxidant ability of CeO 2 endows the wound dressing with prominent capability to resist the oxidative stress around chronic wounds. In summary, both photodynamic antibacterial therapy and good antioxidant property are realized simultaneously in this CeO 2 -based system to promote the healing of diabetic chronic wounds.
Yuping Jiang,Jiaman Xu,Quan Lin,Junyao Song,Maokun Sheng,Jintae Lee,Jinsheng Shi,Xiaoying Kong,Yulong Tan
Ferric phosphate (FePOs) nanoenzymes can express peroxidase (POD) activity under the dual stimulation of an acidic environment and high H2O2 concentrations. In living organisms, this generates reactive oxygen species (ROS) in sites of lesion infection, and thus FePOs nanoenzymes can act as antimicrobial agents. Here, CeO2 and ZnO2 were immobilized in a scallop-type FePOs nanoenzyme material loaded with a photosensitizer, indocyanine green, to synthesize a multifunctional cascade nanoparticle system (FePOs–CeO2–ZnO2–ICG, FCZI NPs). H2O2 concentrations could be adjusted through the ZnO2 self-activation response to the slightly acidic environment in biofilms, further promoting the release of ROS from the POD-like reaction of FePOs, achieving amplification of oxidative stress, DNA and cell membrane damage, and exploiting the photodynamic/photothermal effects of indocyanine green to enhance the antibiofilm effects. CeO2 can remove redundant ROS by switching from Ce4+ to Ce3+ valence, enhancing its ability to fight chronic inflammation and oxidative stress and thus promoting the regeneration of tissues around infection. By maintaining the redox balance of normal cells, increasing ROS at the infection site, eliminating redundant ROS, and protecting normal tissues from damage, the synthesized system maximizes the elimination of biofilms and treatment at the infection site. Therefore, this work may pave the way for the application of biocompatible nanoenzymes.
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