INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
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2025
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IF 8.5
Wenda Wang,Shaofei Nie,Chunyi Luo,Li Xu,Xue Zhang,Siyu Liu,Zhiping Wu,Fuquan Xiong,Lishu Shao,Weihua Luo
Reactive oxygen species-based chemodynamic therapy overcomes the tissue penetration limitations inherent in traditional photodynamic therapy and sonodynamic therapy for tumor treatment, thereby garnering significant attention. However, the transient nature of reactive oxygen species and the nonspecific release of chemotherapeutic agents remain great challenges in chemodynamic therapy. In this study, a dual-network nanosystem based on ellagic acid-modified lignin grafted with vinyl pyrrolidone copolymer and loaded with paclitaxel (EAMLVP@PTX) is constructed. While exposed to the acidic tumor microenvironment, the nanoparticles undergo a charge reversal, inducing cationic endocytosis of tumor parenchymal cells. Furthermore, ellagic acid units endow the nanosystem with mitochondrial targeting capability in colon cancer cells. Consequently, reactive oxygen species is produced, resulting in the partial activation of the dynamic network within the nanosystem and further release of anti-cancer drugs, which in turn generates additional reactive oxygen species. This creates a self-sustaining reactive oxygen species cycle, initiating programmed cell death to enhance anti-tumor treatment under sustained oxidative stress. Both in vitro and in vivo experiments demonstrate that the nanosystem exhibits significant antitumor efficacy against colon cancer, with minimal side effects observed. The EAMLVP@PTX effectively addresses the challenges associated with the short life of reactive oxygen species and the specificity of drug delivery, and demonstrates prominent chemo/chemodynamic synergistic therapeutic effects, thereby offering a highly promising strategy for cancer treatment.
研究领域:
生物医学工程
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肿瘤学
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药剂学
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产品关联
DOI
PubMed
高影响因子
Advanced Energy Materials
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2025
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IF 26
Jie Chen,Wanfang Li,Ruoxuan Sun,Lei Yan,Shikun Li,Zhuying Xu,Xuezhi Zeng,Yong Hu
Neutral Zn–air batteries offer advantages in dendrite suppression and carbonation resistance, however, their performance is limited by high overpotentials resulting from insulating discharge products and sluggish oxygen kinetics. Herein, a closed-loop iodide-oxygen cycle mechanism for a neutral aqueous Zn–air/iodide hybrid battery (ZAIB), integrating oxygen and iodide redox chemistry, is proposed. A multifunctional electrocatalyst, featuring FeN nanoparticles anchored on a hierarchically porous carbon matrix, is designed to drives oxygen reduction reactions (ORR) and iodide oxidation/reduction reactions (IOR/IRR). This catalyst spatially confines zinc hydroxyacetate dihydrate (ZHA) precipitates within its honeycomb meso-macroporous framework, thereby preserving triple-phase boundaries. During discharge, I – generated from I 3 – reduction enhances the kinetics, thereby increasing discharge voltage. Concurrently, OH – formed during ORR reacts with the electrolyte to produce ZHA. Upon charging, thermodynamically favored low-potential IOR dominates, regenerating I 3 – from I – and decomposing ZHA to release OH – . The released OH – then spontaneously reacts with I 3 – to regenerate I – and evolve O 2 , resulting in a reduced charge voltage. Consequently, the neutral ZAIB achieves a low charge/discharge voltage gap (640.1 mV), high energy efficiency (54.0%), and exceptional stability (>1800 h at 2 mA cm −2 ). This synergistic mediator-catalyst codesign strategy offers a viable pathway to high-performance neutral metal–air systems.
研究领域:
电化学
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储能技术
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材料科学
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电池技术
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催化
✓ 已验证
产品关联
DOI
高影响因子
SEPARATION AND PURIFICATION TECHNOLOGY
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2024
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IF 8.1
Xueyu Hu,Jian Zhang,Yihan Liu,Tiancheng Wen,Xiaohong Yao,Chao Long
The non-thermal plasma catalysis holds great promise for VOCs removal, and the development of catalysts with electronic metal-support interaction (EMSI) effect is beneficial for VOCs removal. In this study, we prepared three Mn@M catalysts with EMSI coordination structures by encapsulating MnO x particles within the mesoporous molecular sieve (MCM-41) with different pore size (2.9 nm, 4.4 nm, and 7.9 nm), and investigated the effect of pore size on EMSI and non-thermal plasma catalytic performance of Mn@M for toluene. Among three catalysts, Mn@M2 with an average pore size of 4.38 nm exhibited the strongest EMSI and superior redox capabilities, thus demonstrating the highest mineralization rate, carbon balance, and CO 2 selectivity for plasma catalytic oxidation of toluene. The EMSI effect leads to the formation of electron-rich and electron-poor centers on the Si-O-Mn-O bond, facilitating the generation of reactive oxygen species and enhancing the oxygen cycle. In addition, the reaction degradation pathway was investigated using in situ DRIFTS and GC–MS. This study provides valuable insights for designing highly effective supported catalysts by pore confinement to degrade VOCs in adsorption-plasma catalysis system.
研究领域:
环境科学
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催化
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化学工程
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材料科学
✓ 已验证
产品关联
DOI
高影响因子
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