ChemCatChem
·
2015
·Vol. 8
·期 3
·615-623
·
IF 4.556
Fangfang Wu,Meilin Lv,Xiaoqin Sun,Yinghao Xie,Hongmei Chen,Shuang Ni,Gang Liu,Xiaoxiang Xu
Graphical Catching the rays : Nitrogen doping is an efficient approach to endow the wide-band-gap semiconductor Sr 4 Nb 2 O 9 with visible-light responses. Efficient photocatalytic oxygen production from water is achieved with this N-doped Sr 4 Nb 2 O 9 under visible-light illumination, which is influenced strongly by synthetic conditions. DFT calculations reveal the critical role of nitrogen, which forms additional energy levels within the band gap of Sr 4 Nb 2 O 9 . Photocatalytic water splitting is an appealing process for solar energy conversions yet it is often limited by the slow oxidation of water to oxygen half-reaction. Here we performed an investigation on N-doped Sr 4 Nb 2 O 9 as a water oxidation photocatalyst. Our results show that N doping is an effective approach to improve the visible-light response of Sr 4 Nb 2 O 9 . Efficient photocatalytic oxygen production was observed after N doping, and the highest production rate of ∼27 μmol h −1 under visible-light irradiation corresponds to an apparent quantum efficiency of ∼0.31 %. Clear anodic photocurrent can be generated under visible-light illumination, and the flat-band potential was determined to be ∼−1.25 V vs. Ag/AgCl at pH 7. Theoretical calculations reveal that N doping introduces additional valence bands and is responsible for the visible-light response. Variations in light absorption and photo-oxidation performance can be controlled by modifying these valence band positions using different nitridation temperatures.
研究领域:
材料科学
·
能源化学
✓ 已验证
产品关联
DOI
高影响因子
RSC Advances
·
2016
·Vol. 6
·期 74
·70547-70552
·
IF 3.289
Qiu-Yun Chen,Dong-liang Huang,Yin-Bing Wang,Jian Shao,Ling-Ling Qu
The development of dye-loaded nanosorbcats can make best use of their advantages in removing dyes from wastewater, also bypassing their disadvantages. Herein, functionalized Fe2O3 nano-rods (pfa@Fe2O3) were synthesized by using tween-80 induced assembly of pyrrol-2-methanoic acid (pfa) and iron(III) salts, and characterized by FT-IR, XRD, EPR, and SEM. The pfa@Fe2O3 nanorods’ adsorption capacity for methylene blue (MB) was 450 mg g−1 compared to only 39 mg g−1 for α-Fe2O3. Moreover, the kinetics to reach equilibrium were approximately 0.5 h and the pfa@Fe2O3 nanorods can be used as efficient recyclable adsorbents for MB. In particular, the MB loaded MB@pfa@Fe2O3–water system could also be used as dioxygen generator when irradiated with red LED light (10 W). The light induced intramolecular charge transfer between catalysts and photosensitizers was more efficient in the MB@pfa@Fe2O3/H2O system, and it exerted higher activity for water oxidation than the traditional catalyst/Ru(bpy)32+ system. Control experiment results suggested that the α-Fe2O3 can’t be used as LED light driven catalysts for water oxidation. In conclusion, the MB@pfa@Fe2O3 nanorods were efficient recyclable nanosorbcats for LED-light-driven dioxygen generation using water as oxygen source.
研究领域:
材料科学
·
环境科学
·
光化学
✓ 已验证
DOI
高影响因子
Materials Today
·
2025
·
IF 22
Yahui Han,Lin Du,Jinfu Wu,Hongjian Zhang,Guangzhen Yang,Yi Zheng,Chengtie Wu
Diatoms, the typical marine algae with autotrophic oxygen generation and siliceous frustules, are anticipated to address the current obstacle of oxygen deprivation, cellular dysfunction, and repair imperfection in most intricate damaged tissues. Here, we are motivated to apply the Chaetoceros species , an ancient diatom, to an engineered cross-species domesticator for challenging tendon-to-bone injuries. This construct augmented the osteotendinous differentiation of tendon stem/progenitor cells, stamped by the silicon ions released from frustules and the up-regulated oxygen through photosynthetic behavior. The biocompatibility was at the forefront without adverse effects on rat subcutaneous models. The construct promoted hypoxia alleviation and locomotion recovery of rotator-cuff-torn (RCT) rat models. Pre-differentiated constructs induced by sacrificial diatoms displayed superb interface maturation in RCT rabbit models. The photosynthesis and inorganic ion interactive regeneration within a cross-species construct permits the creation of such a diatom-derived artificial domesticator, promising a paradigm shift towards the accomplishment of state-of-the-art regeneration comparable to natural tissues.
研究领域:
再生医学
·
生物材料学
·
组织工程
✓ 已验证
产品关联
DOI
高影响因子
JOURNAL OF ALLOYS AND COMPOUNDS
·
2023
·
IF 6.2
Jiajia Cai,Zhichao Xu,Xiangxuan Tang,Hao Liu,Xinyu Zhang,Haijin Li,Jianmin Wang,Song Li
The metal-organic frameworks (MOFs)/derivates emerged as promising catalysts for hydrogen generation from electrolyzing water, however, further improvements in the activities are still awaited. Herein, bimetallic MOFs and the derivates were developed for catalyzing the oxygen evolution reaction (OER) and hydrogen evolution reaction (HER) by regulating the morphology, and activity of the intermediates. We demonstrated the activity and morphology of the catalysts strongly correlated with the atomic ratio of Ni and Co in bimetallic MOFs. The hierarchical Ni 0.1 Co 0.9 -MOF delivered a relatively low overpotential of 384 mV to afford 100 mA/cm 2 for OER, but a high overpotential of 512 mV for HER. While the phosphide Ni 0.1 Co 0.9 P only needed an overpotential of 276 mV to deliver 100 mA/cm 2 for HER. And we discussed the roles of bimetallic sites and phosphorous in OER and HER in depth. More importantly the Ni 0.1 Co 0.9 -MOF and Ni 0.1 Co 0.9 P were integrated to drive the overall water splitting, at a current density of 10 mA/cm 2 , the overpotential value is 500 mV. This work provided insights into the exploration of efficient MOFs/derivates catalysts and shed new light on the novel combination for water electrolysis.
研究领域:
材料科学
·
电化学
✓ 已验证
DOI
高影响因子
CHEMICAL ENGINEERING JOURNAL
·
2025
·
IF 13.2
Jiali Tang,Yanlu Chen,Hao Lai,Qi Zeng,Yu Li,Junqi Feng,Ningjing Lin,Ronghua Jin,Junjie Liu,Tao Luo,Zixuan Liang
Tumor hypoxia remains a formidable barrier to the efficacy of conventional cancer therapies, promoting therapeutic resistance and fostering immunosuppressive microenvironments. To overcome these challenges, a novel ImmunoSonogen Nanoplatform was engineered, seamlessly integrating ultrasound-triggered oxygen generation, immunomodulation, and targeted drug delivery for enhanced treatment of colon cancer. This platform incorporated barium titanate (BTO), a piezoelectric oxygen generator, encapsulated within mesoporous silica nanoparticles (MSNs), loaded with the bioactive flavonoid icaritin (ICT), and functionalized with hyaluronic acid (HA) for precise tumor targeting. Under ultrasound (US) irradiation, BTO generated oxygen and reactive oxygen species (ROS), mitigated tumor hypoxia and amplifying ICT-induced cytotoxicity and immunogenic cell death (ICD). The HA modification ensured selective nanoparticle accumulation within tumor tissues, thereby minimizing off-target effects and systemic toxicity. In vitro and in vivo studies revealed that the ImmunoSonogen Nanoplatform not only robustly suppressed tumor growth but also triggered potent antitumor immune responses through the upregulation of pro-inflammatory cytokines and the recruitment of immune cells. Additionally, ICT-mediated activation of key oncogenic pathways synergized with ROS-induced oxidative stress to dismantle tumor survival mechanisms. This integrated approach, combining oxygenation, immunomodulation, and sonodynamic activation, offered an innovative solution to counteract hypoxia-driven cancer progression. The promising therapeutic outcomes and favorable safety profile underscored the potential of the ImmunoSonogen Nanoplatform for clinical translation, advancing the future of cancer therapy.
研究领域:
肿瘤学
·
纳米医学
·
免疫学
✓ 已验证
产品关联
DOI
高影响因子
Advanced Healthcare Materials
·
2021
·Vol. 11
·期 3
·2102135
·
IF 9.933
Shuting Lu,Wei Feng,Caihong Dong,Xinran Song,Xiang Gao,Jinhe Guo,Yu Chen,Zhongqian Hu
Reactive oxygen species (ROS) has been employed as a powerful therapeutic agent for eradicating tumor via oxidative stress. As an emerging ROS-involving noninvasive anticancer therapeutic modality, sonodynamic therapy (SDT) with high tissue penetration depth and benign remote spatiotemporal selectivity has been progressively utilized as the distinct alternative for ROS-based tumor treatment. However, the hypoxic tumor microenvironment substantially restricts the sonodynamic effect. In this work, an oxygen self-sufficient hybrid sonosensitizer on the basis of photosynthetic microorganisms cyanobacteria (Cyan) integrated with ultrasmall oxygen-deficient bimetallic oxide Mn 1.4 WO x nanosonosensitizers, termed as M@C, is designed and engineered to overcome the critical issue of hypoxia-induced tumor resistance and strengthen the SDT effect. The sustained photosynthetic oxygen production by Cyan under light illumination can promote Mn 1.4 WO x nanosonosensitizers to produce more ROS against cancer cells both in vitro and in vivo under ultrasound (US) irradiation. Especially, the sustained oxygen evolution for suppressing the gene expression of hypoxia-inducible factor 1alpha (HIF-1 α ) further boosts and augments the SDT efficiency. Thus, this work provides the paradigm that the rationally engineered biohybrid microorganism-based multifunctional sonosensitizers can serve as an effective bioplatform for augmenting the therapeutic efficiency of SDT, particularly for the treatment of hypoxic tumors.
研究领域:
肿瘤学
·
生物医学工程
·
纳米医学
✓ 已验证
DOI
PubMed
高影响因子
ACS Nano
·
2018
·
IF 13.709
Piao Zhu,Yu Chen,Jianlin Shi
Ultrasound (US)-triggered sonodynamic therapy (SDT) can solve the critical issue of low tissue-penetrating depth of traditional phototriggered therapies, but the SDT efficacy is still not satisfactorily high in combating cancer at the current stage. Here we report on augmenting the SDT efficacy based on catalytic nanomedicine, which takes the efficient catalytic features of nanoenzymes to modulate the tumor microenvironment (TME). The multifunctional nanosonosensitizers have been successfully constructed by the integration of a MnOx component with biocompatible/biodegradable hollow mesoporous organosilica nanoparticles, followed by conjugation with protoporphyrin (as the sonosensitizer) and cyclic arginine-glycine-aspartic pentapeptide (as the targeting peptide). The MnOx component in the composite nanosonosensitizer acts as an inorganic nanoenzyme for converting the tumor-overexpressed hydrogen peroxide (H2O2) molecules into oxygen and enhancing the tumor oxygen level subsequently, which has been demonstrated to facilitate SDT-induced reactive oxygen species production and enhance SDT efficacy subsequently. The targeted accumulation of these composite nanosonosensitizers efficiently suppressed the growth of U87 tumor xenograft on nude mice after US-triggered SDT treatment. The high in vivo biocompatibility and easy excretion of these multifunctional nanosonosensitizers from the body have also been evaluated and demonstrated to guarantee their future clinical translation, and their TME-responsive T1-weighted magnetic resonance imaging capability provides the potential for therapeutic guidance and monitoring during SDT.
研究领域:
生物医学工程
·
肿瘤学
·
纳米医学
✓ 已验证
DOI
PubMed
高影响因子
RSC Advances
·
2017
·Vol. 7
·期 46
·28797-28801
·
IF 3.108
W. X. Liao,X. L. Zhao,T. S. Wang
The relatively wide band gap (>2.0 eV) and limited light absorption ranges (only up to 600 nm) of photocatalysts severely restrict the exploitation of solar energy. Herein, we developed a Bi7.38Cr0.62O12+x crystal photocatalyst with a narrow band gap of 1.98 eV and a broad light absorption range of ∼650 nm. Unlike other broad light absorption range photocatalysts (up to ∼650 nm) such as red phosphorus, Fe2O3, and CdSe, which are either unstable or show low photocatalytic performances, the as-synthesized Bi7.38Cr0.62O12+x crystal photocatalyst exhibits a steady photocatalytic activity for the decomposition of methylene blue, methyl blue, and phenol, and production of O2.
研究领域:
材料科学
·
环境科学
✓ 已验证
产品关联
DOI
高影响因子
BIOMATERIALS
·
2022
·
IF 15.304
Haiyan Pan,Quan Zou,Tingting Wang,Dong Li,Shao-Kai Sun
Diverse oxygen generation strategies have been developed to overcome hypoxia in tumors for enhancing the therapeutic efficacy, but inevitably suffering from tedious synthesis process of oxygen generators in vitro before in vivo administration. Herein, we show direct injection of commercially and clinically used KMnO 4 into solid tumors enables in situ formation of MnO 2 as an oxygen depot for cascade oxidation damage and enhanced photodynamic therapy. KMnO 4 can damage tumor tissues by oxidation and generate MnO 2 , and subsequent intravenous injection of Ce6 allows MnO 2 -triggered hypoxia-modulated photodynamic therapy of tumors. Excellent cascade tumor suppression effect is realized both in vitro and in vivo based on the KMnO 4 –Ce6 system without the need of synthesis. The proposed strategy lays down a novel way with unprecedented superiors of no need of synthesis process and ultra-facile administration procedure for tumor hypoxia-modulated cascade therapy.
研究领域:
肿瘤学
·
生物医学工程
·
药理学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Frontiers in Oncology
·
2023
·
IF 4.7
Zhang Lidong,Liu Xiaoguang,Mao Yinghua,Rong Shu,Chen Yonghong,Qi Yong,Cai Zhipeng,Li Hong
Tumor hypoxic environment is an inevitable obstacle for photodynamic therapy (PDT) of melanoma. Herein, a multifunctional oxygen-generating hydrogel loaded with hyaluronic acid-chlorin e6 modified nanoceria and calcium peroxide (Gel-HCeC-CaO2) was developed for the phototherapy of melanoma. The thermo-sensitive hydrogel could act as a sustained drug delivery system to accumulate photosensitizers (chlorin e6, Ce6) around the tumor, followed by cellular uptake mediated by nanocarrier and hyaluronic acid (HA) targeting. The moderate sustained oxygen generation in the hydrogel was produced by the reaction of calcium peroxide (CaO2) with infiltrated H2O in the presence of catalase mimetic nanoceria. The developed Gel-HCeC-CaO2 could efficiently alleviate the hypoxia microenvironment of tumors as indicated by the expression of hypoxia-inducible factor -1α (HIF-1α), meeting the “once injection, repeat irradiation” strategy and enhanced PDT efficacy. The prolonged oxygen-generating phototherapy hydrogel system provided a new strategy for tumor hypoxia alleviation and PDT.
研究领域:
生物医学工程
·
肿瘤学
·
材料科学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
CHEMICAL ENGINEERING JOURNAL
·
2018
·
IF 6.735
Bin He,Huanhuan Liu,Zheng Lin,Lei Yan,Jiqiang Ning,Yijun Zhong,Changcheng Zheng,Ziyang Zhang,Yong Hu
The practical application of photocatalytic water splitting is essentially limited by the slow kinetic nature of the water oxidation process. Therefore, it is highly desirable but challenging to explore a low-cost and high-efficiency water oxidation catalyst for the aim of commercialization and industrialization. We herein report the first-time synthesis of a novel and high-efficiency visible-light-driven photocatalyst composed of flower-like Co(CO 3 ) 0.5 (OH)·0.11H 2 O (CCO) nanowires and Bi 2 WO 6 (BWO) nanosheets, i.e. CCO/BWO nanocomposite, via a facile hydrothermal method. Without utilizing any additional cocatalyst, the composite of CCO/BWO in 30% weight ratio exhibits extraordinarily high photoactivity and photostability towards O 2 evolution, achieving an average O 2 generation rate of 953 µmol h −1 g −1 under visible-light irradiation (λ > 420 nm).
研究领域:
材料科学
·
环境科学
✓ 已验证
产品关联
DOI
高影响因子
Nanomaterials
·
2023
·Vol. 13
·期 16
·2302
·
IF 5.3
Zhen Pei,Tengteng Qin,Rui Tian,Yangxin Ou,Xingzhong Guo
Transition metal sulphide electrocatalytic materials possess the bright overall water-splitting performance of practical electrocatalytic technologies. In this study, an amethyst-like MoS2@Ni9S8/Co3S4rod electrocatalyst was constructed via a one-step hydrothermal method with in-situ-grown ZIF-67 nanoparticles on nickel foam (NF) as a precursor. The rational design and synthesis of MoS2@Ni9S8/Co3S4endow the catalyst with neat nanorods morphology and high conductivity. The MoS2@Ni9S8/Co3S4/NF with the amethyst-like rod structure exposes abundant active sites and displays fast electron-transfer capability. The resultant MoS2@Ni9S8/Co3S4/NF exhibits outstanding hydrogen evolution reaction (HER) and oxygen evolution reaction (OER) electrocatalytic activities, with low overpotentials of 81.24 mV (HER) at 10 mA cm−2and 159.67 mV (OER) at 50 mA cm−2in 1.0 M KOH solution. The full-cell voltage of overall water splitting only achieves 1.45 V at 10 mA cm−2. The successful preparation of the amethyst-like MoS2@Ni9S8/Co3S4rod electrocatalyst provides a reliable reference for obtaining efficient electrocatalysts for overall water splitting.
研究领域:
材料科学
·
电化学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
危险品化学品经营许可证（带存储）