CHEMICAL PAPERS
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2018
·Vol. 72
·期 6
·1339-1345
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IF 0.963
Li Bin,Chen Dan,Zhang Xiaoli,Dong Wenbo,Zhao Binxia
A catalyst comprised of 4-dimethylaminopyridine (DMAP) functionalized silica gel (SG-DMAP) was prepared via a convenient N-alkylation of 4-methylaminopyridine (MAP) with γ-chloropropylated silica gel promoted by potassium iodide. FT-IR, TG, SEM results illustrated that the DMAP was successfully immobilized on silica gel and the BET result suggested the pore structure was not altered after immobilization process. The highest immobilization amount of 0.75 mmol/g was obtained at 130 °C for 12 h. Activity test demonstrated that silica gel immobilized DMAP could be serve as a heterogeneous catalyst for the acylation with significant activity and stability.
研究领域:
有机化学
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催化材料
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DOI
高影响因子
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
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2021
·
IF 5.279
Jia-Xu Nan,Jing-Fang Yang,Hong-Yan Lin,Yao-Chao Yan,Shao-Meng Zhou,Xue-Fang Wei,Qiong Chen,Wen-Chao Yang,Ren-Yu Qu,Guang-Fu Yang
Exploring novel p-hydroxyphenylpyruvate dioxygenase (EC 1.13.11.27, HPPD) inhibitors has become one of the most promising research directions in herbicide innovation. On the basis of our tremendous interest in exploiting more powerful HPPD inhibitors, we designed a family of benzyl-containing triketone-aminopyridines via a structure-based drug design (SBDD) strategy and then synthesized them. Among these prepared derivatives, the best active 3-hydroxy-2-(3,5,6-trichloro-4-((4-isopropylbenzyl)amino)picolinoyl)cyclohex-2-en-1-one (23, IC50 = 0.047 μM) exhibited a 5.8-fold enhancement in inhibiting Arabidopsis thaliana (At) HPPD activity over that of commercial mesotrione (IC50 = 0.273 μM). The predicted docking models and calculated energy contributions of the key residues for small molecules suggested that an additional π–π stacking interaction with Phe-392 and hydrophobic contacts with Met-335 and Pro-384 were detected in AtHPPD upon the binding of the best active compound 23 compared with that of the reference mesotrione. Such a molecular mechanism and the resulting binding affinities coincide with the proposed design scheme and experimental values. It is noteworthy that inhibitors 16 (3-hydroxy-2-(3,5,6-trichloro-4-((4-chlorobenzyl)amino)picolinoyl)cyclohex-2-en-1-one), 22 (3-hydroxy-2-(3,5,6-trichloro-4-((4-methylbenzyl)amino)picolinoyl)cyclohex-2-en-1-one), and 23 displayed excellent greenhouse herbicidal effects at 150 g of active ingredient (ai)/ha after postemergence treatment. Furthermore, compound 16 showed superior weed-controlling efficacy against Setaria viridis (S. viridis) versus that of the positive control mesotrione at multiple test dosages (120, 60, and 30 g ai/ha). These findings imply that compound 16, as a novel lead of HPPD inhibitors, possesses great potential for application in specifically combating the malignant weed S. viridis.
研究领域:
植物学
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药理学
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DOI
PubMed
高影响因子
DESALINATION
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2025
·
IF 9.8
Shunyan Ning,Sizhi Xu,Jiaxu Zheng,Shichang Zhang,Xiangbiao Yin,WenLong Li,Yuezhou Wei,Lifeng Chen
Spent fuel reprocessing typically produces high-level liquid waste (HLLW), where lots of palladium and other radioactive nuclides exist. Palladium recovery from HLLW contributes to not only increasing the palladium supply but also addressing the issue of furnace clogging during the vitrification of HLLW. To achieve this, several aminopyridine-functionalized silica-based resins (SiPAc-NH-Pys) were prepared in this study through in-situ polymerization and post-synthetic modification, and the adsorption behaviors and mechanisms toward palladium were systematically studied by batch experiment and spectroscopy. The results showed that aminopyridine-functionalized SiPAc-NH-Pys with porous structure and uniform shapes were successfully prepared. These SiPAc-NH-Pys exhibited high selectivity for palladium in simulative HLLW, with almost no affinity for lanthanides or alkaline metal ions. In addition, SiPAc-NH-Pys exhibited fast adsorption and desorption kinetics, with equilibrium reached within 10 min. The adsorption kinetics were fitted well by the pseudo-second-order kinetic model, and the adsorption isotherm was well described by the Langmuir model. Spectroscopy experiments suggested that the nitrogen atom in the pyridine ring was the main active site for palladium adsorption and that nitrate anions were involved in palladium coordination; thus, they were co-adsorbed. The direct and selective recovery of palladium from simulative HLLW was finally realized in column mode, with the recovery rate close to 100 %. Overall, this work provides excellent functional material candidates for the separation of rare metal palladium from HLLW, showing significant potential.
研究领域:
核化学与化工
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材料科学
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环境科学
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产品关联
DOI
高影响因子
JOURNAL OF CHEMICAL AND ENGINEERING DATA
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2025
·
IF 2.1
Bin Ou,Lemei Huang,Shi Su,Yanyan Huang,Zhijia Wang,Xiaobing Liu,Kui Wu
In this work, the solid–liquid equilibrium solubility and the impact of different solvents on 2-aminopyrimidine were explored across 17 distinct single-solvent systems, including methanol, ethanol, n-propanol, isopropanol, n-butanol, isobutanol, n-pentanol, isopentanol, ethyl acetate, butanone, 2-pentanone, acetone, acetonitrile, ethyl formate, methyl acetate, cyclopentanone, and cyclohexanone, at atmospheric pressure and temperatures ranging from 272.65 to 323.35 K. It was observed that in all these solvents, solubility increases as the temperature rises. At 298.15 K, the molar solubility sequence in the solvents is as follows: cyclopentanone > cyclohexanone > ethyl formate > methanol > ethyl acetate > butanone > methyl acetate > acetone > n-propanol > ethanol > 2-pentanone > n-butanol > isobutanol > isopropanol > isopentanol > n-pentanol > acetonitrile. The solubility data obtained from experiments were fitted using four models: the modified Apelblat model, the Buchowski–Ksiazaczak λh model, the NRTL model, and the Wilson model, all of which demonstrated a good fit. The modified Apelblat model yielded the most accurate correlations, as indicated by the lowest average ARD and RMSD values. Furthermore, using the Wilson model, the thermodynamic properties of the mixing process of 2-aminopyrimidine in the chosen solvents were calculated, revealing that the mixing was spontaneous and primarily driven by entropy. The results of this study provide valuable insights for the purification, crystallization, and industrial application of 2-aminopyrimidine and similar compounds.
研究领域:
化学工程
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物理化学
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DOI
高影响因子
JOURNAL OF ORGANOMETALLIC CHEMISTRY
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2020
·
IF 2.304
Muhammad Usman,Haojie Yu,Li Wang,Pavel A. Zhizhko,Dmitry A. Lemenovskiy,Dmitry N. Zarubin,Amin Khan,Kaleem-ur-Rehman Naveed,Ahsan Nazir,Shah Fahad
For overcoming the migration problems of ferrocene (Fc)-based burning rate catalysts (BRCs) as well as for enhancing burning rate (BR) of ammonium perchlorate (AP)-based propellants, ferrocenylated-amino pyridines (AP-Fcs) and ferrocenylated-amino thiazoles (AT-Fcs) have been synthesized. The synthesis of AP-Fcs and AT-Fcs was confirmed by nuclear magnetic resonance ( 1 H NMR). Electrochemical properties of these ferrocenylated derivatives were explored by cyclic voltammetry (CV). The BR catalytic activities of AP-Fcs and AT-Fcs on thermal decomposition of AP were examined by thermogravimetric (TG) and differential thermogravimetric (DTG) techniques. Thermal analysis results showed that AP-Fcs and AT-Fcs showed good BR catalytic effects on thermal decomposition of AP. AP-Fcs and AT-Fcs were also applied for anti-migration studies in comparison with catocene (Cat) and ferrocene. It was found that AP-Fcs and AT-Fcs displayed anti-migratory behavior.
研究领域:
化学
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材料科学
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DOI
高影响因子
JOURNAL OF CHEMICAL AND ENGINEERING DATA
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2023
·
IF 2.6
Shuai Yan,Haojian Zhang,Renjie Xu,Zonghua Wang
Experimental mole fraction solubility of methyl 2-aminopyridine-4-carboxylate in methanol/ethanol/isopropanol/n-propanol/acetonitrile/toluene/water/N,N-dimethylformamide (DMF) and ethanol/n-propanol/acetonitrile/DMF + water was determined by the isothermal saturation method between 278.15 and 323.15 K at 101.2 kPa. For methyl 2-aminopyridine-4-carboxylate + monosolvents, the increase of temperature was synchronized with the increase of solubility, and the maximum solubility (0.0377 and 323.15 K) was obtained in methyl 2-aminopyridine-4-carboxylate + toluene. For methyl 2-aminopyridine-4-carboxylate + mixed solvents, in addition to temperature, the proportion of cosolvents was also the main influencing factor, and the maximum solubility of methyl 2-aminopyridine-4-carboxylate (0.02845 and 323.15 K) was obtained in DMF + water at wDMF = 0.9. The Jouyban–Acree model (J-A), van’t Hoff–Jouyban–Acree model (V-J-A), and modified Apelblat–Jouyban–Acree model (A-J-A) were utilized to correlate the solubility of methyl 2-aminopyridine-4-carboxylate in four binary solvent mixtures, and Apelblat model, van’t Hoff model, and λh model were used to correlate the methyl 2-aminopyridine-4-carboxylate solubility in eight monosolvents. This study presented insights into modulating a methyl 2-aminopyridine-4-carboxylate crystallization process and understanding equilibrium behaviors in different solvents.
研究领域:
化学工程
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药物科学
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DOI
高影响因子
JOURNAL OF MOLECULAR STRUCTURE
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2021
·
IF 3.196
Ronghui Wu,Zhuoran Chen,Xingjun Gao,Xinlei Chen,Shouwen Jin,Li He,Bin Chen,Daqi Wang
Cocrystallization of the ordinarily accessible 4-dimethylaminopyridine (DMAP), with a series of aromatic acids gave a gross of eight anhydrous and hydrous multicomponent molecular salts. The eight salts have been characterised by XRD, IR and EA, their melting points were also reported. Their structural and supramolecular manners are fully evaluated. The result unveils that among all the crystals only the ring N at the DMAP moieties are protonated with the organic acids deprotonated, giving the ion pair. Apart from salt 8 , all the crystal packing is interpreted by the strong charge-assisted N-H⋯O H-bonds from the NH + and the deprotonated acidic groups. The O-H•••O H-bonds were also found at 3 – 8 . All compounds are organic salt, the cation and anion were at 1:1 for 1 – 5 and 7 - 8 , salt 6 has the ratio of 2:1. Further analysis on the crystal packing showed that a different sets of additional CH-N, CH-O/CH 3 -O, CH-S, CH 3 -CH, CH 3 -CH 3 , CH 3 -C π , CH-π/CH 3 -π, I-π, O-S, I-I and π-π contacts contribute to the stabilization and expansion of the total 2D/3D structures. For the synergism of the various weak forces these salts took homo/hetero supramolecular synthons or both.
研究领域:
化学
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材料科学
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DOI
高影响因子
CHEMICAL ENGINEERING JOURNAL
·
2024
·
IF 13.3
Shuliang Chen,Li Zhao,Xinrong Li,Zhen Chen,Xianzhi Hu,Futing Zi
Recovering gold from rich waste printed circuit boards (WPCBs) resource are of great significance to gold development and utilization. In this paper, cationic pyridine polymers with different configurations were designed and synthesised for highly selective and efficient recovery of gold from a WPCB leaching solution. The structures and performances of the cationic pyridine polymers were analysed using a 4–aminopyridine polychloromethylstyrene (4–AP/PCMS). The results indicate that the 4–AP/PCMS performed well in an acidic environment, including in the 5 % aqua regia solution. Gold adsorption on the 4–AP/PCMS followed pseudo–second–order kinetics and Langmuir isotherm models, suggesting that chemisorption occurred via a single–layer mechanism with a maximum loading capacity of 437.68 mg/g. Further, Au(III) adsorption on the 4–AP/PCMS involved electrostatic interactions and reduction between pyridine and AuCl 4 − . After five adsorption–desorption cycles, the adsorption rate remained above 99 %, whereas in actual leaching solutions it reached 92.24 %. All five pyridine polymers demonstrated outstanding Au(III) selectivity over binary and multicomponent solutions containing Cu(II), Ni(II), Co(II), Zn(II), Fe(III), Cd(II), and Mg(II), benefitting from the cationic pyridine skeleton. Contact patterns between the cationic pyridine polymers and AuCl 4 − considerably affected the gold loading capacity, and a single–point contact was found to be favourable for gold adsorption. These results indicated that cationic pyridine polymers are promising for recovering gold from WPCB leaching solutions.
研究领域:
材料科学
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环境科学
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化学工程
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产品关联
DOI
高影响因子
Gels
·
2025
·Vol. 11
·期 4
·224
·
IF 5.3
Tingxiang Wu,Amatjan Sawut,Rena Simayi
This study utilized the Schiff base reaction as a chemical bonding method to successfully graft 2-aminopyridine onto oxidized sodium alginate, resulting in the formation of modified sodium alginate (OSM). Subsequently, the OSM/polyacrylic acid (OSM/PAA) hydrogel was synthesized via a thermally initiated free radical polymerization process and evaluated as an adsorbent for the removal of heavy metal ions from wastewater. Comprehensive characterization of the prepared samples was performed using FT-IR, SEM, and TGA. The influence of temperature, pH, adsorbent dosage, contact time, and heavy metal ion concentration on the adsorption capacity of the OSM/PAA adsorbent in simulated wastewater was thoroughly investigated. Additionally, a detailed analysis of the adsorption thermodynamics, kinetics, and mechanisms was conducted. Experimental results indicated that at 25 °C, pH 5.0, and an adsorbent dosage of 0.4 g/L, the maximum adsorption capacities of the OSM/PAA hydrogel for Cu(II), Zn(II), and Ni(II) were 367.64 mg/g, 398.4 mg/g, and 409.83 mg/g, respectively. These findings suggest that the adsorption of heavy metal ions by OSM/PAA is a spontaneous, heterogeneous chemical process with significant potential for practical applications in wastewater treatment.
研究领域:
环境科学
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材料科学
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产品关联
DOI
PubMed
高影响因子
JOURNAL OF POROUS MATERIALS
·
2020
·Vol. 27
·期 6
·1639-1648
·
IF 2.183
Zhang Tiantian,Li Bin,Zhang Xiaoli,Wang Jiao,Wei Longhui,Zhao Binxia,Li Binglin
N,N′-dimethyl-N-(4-pyridyl)-1,2-ethanediamine (DMPE) as a special N-alkylation precursor of 4-dimethylaminopyridine (DMAP) was grafted on the surface of γ-chloropropylated functionalized mesoporous silica MCM-41 to prepare immobilized DMAP. Characterization results of small angle X-ray diffraction, thermogravimetry and derivative thermogravimetry, Fourier transform infrared, scanning electron microscopy, energy-dispersive X-ray and transmission electron microscopy indicated that DMAP was successfully covalently bound to the surface of MCM-41. The highest loading of DMAP reached 0.9 mmol/g, which was 2.5 times higher than that of DMAP immobilized on the normal silica gel. The prepared immobilized DMAP as nucleophilic heterogeneous catalysts was successfully used for the acetylation reaction to produce α-tocopherol acetate. The highest yield reached 90.1% under the optimal condition which was summarized as follows: immobilized DMAP 100 mg, substrates mole ratio (acetic anhydride/α-tocopherol) 3:1, reaction temperature 50 ℃, stirring intensity 500 rpm, reaction in toluene for 12 h. The recyclability and stability of the DMAP grafted MCM-41 were excellent, as demonstrated by its use 20 times during batch operation without any loss of productivity.
研究领域:
化学工程
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材料科学
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DOI
高影响因子
DALTON TRANSACTIONS
·
2019
·Vol. 48
·期 22
·7862-7874
·
IF 4.052
Chuyang Jing,Liang Wang,Qaiser Mahmood,Mengmeng Zhao,Guangqian Zhu,Xianhui Zhang,Xiaowu Wang,Qinggang Wang
In this study, a series of 2-R-6-(1-(alkylamino)methyl)pyridine-iron complexes [alkyl: (CPh3) Fe1H; (CHPh2) Fe2H; (CHPh2) Fe3Me; (CHMePh) Fe4H; (CH2Ph) Fe5H; (CHMe2) Fe6H; (C6H11) Fe7H; (CH2(4-OMe)Ph) Fe8H; (CH2(4-CF3)Ph) Fe9H; (CH2(2,4,6-Me3)Ph) Fe10H; (CH2Ph) Fe11Me] were synthesized and well characterized by ATR-IR spectroscopy, HRMS spectroscopy and elemental analysis. In addition, Fe3Me, Fe4H, Fe7H and Fe11Me were characterized by X-ray diffraction analysis: Fe3Me and Fe11Me adopted distorted tetrahedral geometries in the solid state while Fe4H and Fe7H were found in dimeric or polymeric forms respectively in which chlorides acted as bridging ligands. The catalytic capacities of these iron complexes were investigated for isoprene polymerization. Upon activation with a MAO cocatalyst, the catalytic activities of complexes varied as a function of the steric and electronic influences of substituents. In general, the catalysts bearing the least steric groups and electron-withdrawing groups exhibited relatively high activities. An outstanding activity of 190.6 × 104 g·mol−1·h−1 was obtained by Fe5H [CH2Ph]. Moreover, changes in the steric hindrance around the metal center showed a notable effect on the selectivity of monomer enchainment. In particular, most of the polymers obtained by these complexes bearing flexible frameworks were in favor of 3,4-enchainment.
研究领域:
材料化学
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催化化学
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产品关联
DOI
PubMed
高影响因子
RSC Advances
·
2013
·Vol. 3
·期 45
·23596-23603
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IF 2.562
Guang-Zhen Zou,Hong Gao,Jian-Lan Liu,Shun-Ping Zhao,Zheng-Fang Tian,Xiao-Ming Ren
Kaolinite (K), a polar and layered aluminosilicate mineral, was used as the host for three aminopyridine isomers: 2-aminopyridine (2-APy), 3-aminopyridine (3-APy), and 4-aminopyridine (4-APy). We inserted these isomers into the kaolinite interlayer to produce the intercalated compounds 2-APy-K, 3-APy-K, and 4-APy-K, respectively. These intercalated compounds show distinct ν(O–H) bands arising from the inner and inner-surface hydroxyl groups of kaolinite. They also have diverse deintercalation temperatures of about 112 °C for 2-APy-K, 136 °C for 3-APy-K, and 181 °C for 4-APy-K, indicating that the host–guest interaction is different for each of these intercalated compounds. One-step dielectric relaxation appears in 2-APy-K and 3-APy-K, while two-step dielectric relaxation appears in 4-APy-K in the low-frequency regime (f < 104 Hz). The dielectric relaxation in these compounds arises from the dipole motion of intercalatant molecules under an applied ac electrical field. Our results shed light on the design and preparation of new hybrid materials with technologically important physical properties using a host–guest chemical approach.
研究领域:
材料科学
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物理化学
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产品关联
DOI
高影响因子
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