JOURNAL OF ALLOYS AND COMPOUNDS
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2021
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IF 5.316
Fangyou Meng,Yuan Yu,Dongfeng Sun,Songmin Lin,Yangyang Chu,Wenhui Chu,Qingmei Su,Bingshe Xu
A novel PANI/Ni 2 P hybrid electrocatalyst with enhanced performance in hydrogen evolution reaction was explored. The current densities of the PANI/Ni 2 P hybrid electrocatalyst could achieve 10 mA cm −2 under much lower overpotential of 83 mV with a small Tafel slope of 69 mV dec −1 . This was due to the fact that nitrogen atoms in polyaniline had more isolated electrons, which could capture protons from hydrated ions to form protonated amino groups, thus accelerating the kinetics process of hydrogen evolution. Moreover, the current densities of the PANI/Ni 2 P hybrid electrocatalysts was only slightly attenuated after 5000 cycles, showing good stability and application potential of the PANI/Ni 2 P hybrid electrocatalysts. The effect of the thickness of the polyaniline layer on the performance of the PANI/Ni 2 P hybrid catalyst was fully discussed. This work also provided a new strategy to increase the catalytic activity of non-noble metal catalysts.
研究领域:
材料科学
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电化学
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产品关联
DOI
高影响因子
PLoS One
·
2013
·Vol. 8
·期 12
·e82595
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IF 3.73
Ruofeng Shang,Shengyu Wang,Ximing Xu,Yunpeng Yi,Wenzhu Guo,YuLiu,Jianping Liang
Novel pleuromutilin derivatives designed based on the structure of valnemulin were synthesized and evaluated for their in vitro antibacterial activities. These pleuromutilin derivatives with substituted amino moiety exhibited excellent activities against methicillin-resistant Staphylococcus aureus, methicillin-resistant Staphylococcus epidermidis, Escherichia coli, and Streptococcus agalactiae. Compound 5b showed the highest antibacterial activities and even exceeded tiamulin. Moreover, the docking experiments provided information about the binding model between the synthesized compounds and peptidyl transferase center (PTC) of 23S rRNA.
研究领域:
药物化学
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微生物学
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DOI
PubMed
高影响因子
JOURNAL OF MEMBRANE SCIENCE
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2014
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IF 4.908
Wenjuan He,Zhi Wang,Wen Li,Shichun Li,Zhiheng Bai,Jixiao Wang,Shichang Wang
Fixed carrier membranes containing amino groups show attractive performance in CO 2 separation for clean energy supply and greenhouse gas reduction. However, the separation performance of fixed carrier membranes at high feed pressure is limited by the facilitated transport ability of membranes as well as the CO 2 -induced plasticization. In this work, the tertiary amino group containing fixed carrier membranes were prepared by interfacial polymerization (IP) with hexane-soluble trimesoyl chloride (TMC) and aqueous-soluble 1,4-bis (3-aminopropyl) piperazine (DAPP), N -aminoethylpiperazine (EAP) and 3,3′-diamino- N -methyldipropylamine (DNMDAm). The results show that the membrane prepared with TMC and DAPP exhibits the highest CO 2 separation performance due to efficient CO 2 facilitated transport and high plasticization resistance. Efficient facilitated transport of CO 2 in the membrane is due to the high content of cyclic tertiary amino groups which possess high stoichiometric CO 2 loading and high rate constant of amine-CO 2 reaction. Moreover, high plasticization resistance of the membrane is attributed to the appropriate stiffness of polymer chains provided by IP. The membrane prepared with TMC and DAPP shows promising applications in high-pressure fuel gas purification.
研究领域:
材料科学
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环境科学
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能源工程
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产品关联
DOI
高影响因子
mAbs
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2018
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IF 5.165
De-zhi Li,Bing-nan Han,Rui Wei,Gui-yang Yao,Zhizhen Chen,Jie Liu,Terence C.W. Poon,Wu Su,Zhongyu Zhu,Dimiter S. Dimitrov,Qi Zhao
Site-specific conjugation of small molecules to antibody molecules is a promising strategy for generation of antibody-drug conjugates. In this report, we describe the successful synthesis of a novel bifunctional molecule, 6-(azidomethyl)-2-pyridinecarboxyaldehyde (6-AM-2-PCA), which was used for conjugation of small molecules to peptides and antibodies. We demonstrated that 6-AM-2-PCA selectively reacted with N-terminal amino groups of peptides and antibodies. In addition, the azide group of 6-AM-2-PCA enabled copper-free click chemistry coupling with dibenzocyclooctyne-containing reagents. Bifunctional 6-AM-2-PCA mediated site-specific conjugation without requiring genetic engineering of peptides or antibodies. A key advantage of 6-AM-2-PCA as a conjugation reagent is its ability to modify proteins in a single step under physiological conditions that are sufficiently moderate to retain protein function. Therefore, this new click chemistry-based method could be a useful complement to other conjugation methods.
研究领域:
化学
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生物化学
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药学
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产品关联
DOI
PubMed
高影响因子
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
·
2024
·
IF 7.7
Haitao Ren,Yuqing Chen,Abdelkader Labidi,Ke Zhao,Xiaoqian Xu,Sarah I. Othman,Ahmed A. Allam,Hassan Ahmad Rudayni,Chuanyi Wang
Developing carbon quantum dots (CQDs) from bio-waste lignin for effectively detecting Cu 2+ is of great significance for promoting the value-added utilization of lignin resources. However, the limited amount of surface-active groups and low quantum yield of lignin-based CQDs hinder their application in this regard. Herein, bio-waste lignin was converted into value-added amine functionalized CQDs using a facile two-step hydrothermal approach. The as-synthesized CQDs modified with amino groups exhibit bright green fluorescence, abundant surface functional groups, high water solubility and uniform particle size (3.9 nm). Systematic analysis demonstrates that the rich NH 2 groups (~12.3 %) on the CQDs backbone improve their fluorescence properties (quantum yield increased from 3.4 % to 21.1 %) and specific detection ability for Cu 2+ . The developed NH 2 -CQDs serve as an efficient fluorescent probe , displaying high sensitivity and selectivity towards Cu 2+ in aqueous system, with a detection limit of 2.42 μmol/L, which is lower than the maximum permitted amount of Cu 2+ in drinking water (20 μmol/L). The detection mechanism of NH 2 -CQDs for Cu 2+ is attributed to the synergy of static quenching and photo-induced electron transfer . This study provides a valuable reference for the synthesis of high-quality fluorescent CQDs from lignin resources and the effective detection of trace Cu 2+ in aquatic environments.
研究领域:
材料科学
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环境科学
·
分析化学
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产品关联
DOI
PubMed
高影响因子
Bioactive Materials
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2022
·
IF 16.874
Ying Chen,Yonglin Wang,Xianfang Jiang,Jinhong Cai,Yuting Chen,Hanji Huang,Yuan Yang,Li Zheng,Jinmin Zhao,Ming Gao
Excessive cell-free DNA (cfDNA) released by damaged or apoptotic cells can cause inflammation, impacting the progression of rheumatoid arthritis (RA). cfDNA scavengers, such as cationic nanoparticles (NPs), have been demonstrated as an efficient strategy for treating RA. However, most scavengers are limited by unfavorable biocompatibility and poor scavenging efficacy. Herein, by exploiting the favorable biocompatibility, biodegradability and bioadhesion of polydopamine (P), we modified P with dimethylamino groups to form altered charged DPs to bind negatively charged cfDNA for RA therapy. Results showed that DPs endowed with superior binding affinity of cfDNA and little cytotoxicity, which effectively inhibited lipopolysaccharide (LPS) stimulated inflammation in vitro , resulting in the relief of joint swelling, synovial hyperplasia and cartilage destruction in RA rats. Significantly, DPs with higher DS of bis dimethylamino group exhibited higher positive charge density and stronger cfDNA binding affinity, leading to excellent RA therapeutic effect among all of the treated groups, which was even close to normal rats. These finding provides a novel strategy for the treatment of cfDNA-associated diseases.
研究领域:
纳米技术
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药学
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风湿病学
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炎症研究
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产品关联
DOI
PubMed
高影响因子
ACS Applied Materials & Interfaces
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2022
·
IF 10.383
Dingyang Chen,Tingting Ma,Xinyue Zhao,Xiaofei Jing,Rui Zhao,Guangshan Zhu
Efficient capture of radioiodine from aqueous solutions is of importance for sustainable development of nuclear energy and protection of the environment. However, current adsorbents under exploration suffer from limited adsorption capacity and powder form that are unfavorable for practical applications. Herein, we applied a “multi-functionalization integration” idea to construct novel electrospun fiber adsorbents (N-MOF-PAN fibers) containing cationic quaternary ammonium groups, uncharged amine groups, and porous MOF material (UiO-66-NH2), which in synergy adsorb iodine effectively from both saturated I2 aqueous solution and I3– aqueous solution. Iodine species (94.6%) could be removed from saturated I2 solution within 180 min, and 98.7% of iodine species were captured from I3– solution within 240 min. Additionally, the N-MOF-PAN fibers exhibited high iodine uptake capacities of 3.56 g g–1 from a concentrated KI/I2 aqueous solution and 3.61 g g–1 from the Langmuir isotherm model, surpassing many reported iodine adsorbents in the aqueous medium. Characterization and mechanism analysis indicated that multiple active sites simultaneously attribute to the high binding affinity toward iodine species through physical adsorption and chemical adsorption. Furthermore, benefiting from their macroscopic architecture, N-MOF-PAN fibers were used as the adsorption column for dynamic iodine capture with a bed volume of 1490 mL, which is much higher than commercially activated carbons. Overall, this work provides guidance for the development of novel fiber adsorbents for related applications.
研究领域:
环境科学
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材料科学
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核工程
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化学工程
✓ 已验证
产品关联
DOI
PubMed
高影响因子
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