INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
·
2024
·Vol. 25
·期 2
·943
·
IF 4.9
Tao Mao,Jinhua Gan,Keping Yuan,Li He,Yali Yu,Ziduo Liu,Yuntao Zhou,Gaobing Wu
Red swamp crayfish,Procambarus clarkii(P. clarkii), is an important model crustacean organism used in many types of research. However, the effects of different doses of aminomethylphosphonic acid (AMAP) on the transcriptome and metabolites ofP. clarkiihave not been explored. Thus, this study investigated the molecular and metabolic mechanisms activated at the different exposure dosages of AMAP inP. clarkiito provide new insights into the strategies ofP. clarkiiin response to the high concentrations of AMAP in the environment. In the present study, theP. clarkiiwere divided into three groups (control group; low-dosage AMAP exposure; high-dosage AMAP exposure), and hepatopancreatic tissue samples were dependently taken from the three groups. The response mechanisms at the different dosages of AMAP were investigated based on the transcriptome and metabolome data ofP. clarkii. Differentially expressed genes and differentially abundant metabolites were identified in the distinct AMAP dosage exposure groups. The genes related to ribosome cell components were significantly up-regulated, suggesting that ribosomes play an essential role in responding to AMAP stress. The metabolite taurine, involved in the taurine and hypotaurine metabolism pathway, was significantly down-regulated.P. clarkiimay provide feedback to counteract different dosages of AMAP via the upregulation of ribosome-related genes and multiple metabolic pathways. These key genes and metabolites play an important role in the response to AMAP stress to better prepare for survival in high AMAP concentrations.Keywords:AMAP;P. clarkii;transcriptomics;metabolome
研究领域:
环境科学
·
分子生物学
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DOI
PubMed
高影响因子
SEPARATION AND PURIFICATION TECHNOLOGY
·
2024
·
IF 8.1
Emilia J. Virtanen,Esa Kukkonen,Janne Yliharju,Minnea Tuomisto,Janne Frimodig,Kimmo Kinnunen,Elmeri Lahtinen,Mikko M. Hänninen,Ari Väisänen,Matti Haukka,Jani O. Moilanen
Herein we report the use of nylon-12-based 3D-printed filters incorporating α-aminomethylphosphonic acid as an active additive for the recovery of Y, Nd, and Dy from the mining waste solution containing Al, K, Ca, Sc, Fe, Co, Cu, Zn, Y, Nd, Dy, and U. Nylon-12 was chosen for the polymer matrix of the filter due to its inactivity towards the studied metals. The micrometer-level structure of the filters was studied with a scanning helium ion microscope and X-ray tomography to reveal the porosity, pore size, and active additive distribution in the filters. Furthermore, FTIR spectroscopy was used to analyze the compositional changes in the 3D-printed filters after the printing and adsorption processes. Adsorption of the metals was studied at a pH range of 1–4, and the following adsorption trend Sc > Fe > U > Y, Nd, Dy > Al, Cu, Zn > K, Ca, Co was observed in each of the studied pH values. The sequential recovery process for metals was studied at pH 2, and desorption of the metals from the filters was performed with 6 M HNO 3 . 100 % adsorption of REEs, Fe, and U was achieved during the recovery process, and on average, over 88 % of the adsorbed Y, Nd, and Dy were desorbed from the filters. In contrast to Y, Nd, and Dy, the desorption of Sc, Fe, and U was minimal (Fe and U) or negligible (Sc) with 6 M HNO 3 due to their strong coordination to the active additive. Maximum adsorption capacities for Y, Nd, Dy, and U were determined by using linear Langmuir adsorption isotherm. The best maximum adsorption capacity was determined for Sc, Q max = 0.51 mmol/g followed by U, Nd, Dy, and Y with capacities of 0.47, 0.24, 0.23, and 0.17 mmol/g, respectively. Overall, this study achieved a complete removal of Sc, Fe, and U from the simulated mining waste solution leaving a final eluate that mainly contained Y (320 μg), Nd (350 μg), Dy (330 μg), and Al (710 μg) demonstrating the applicability of the 3D-printed filters in the recovery of Y, Nd, and Dy from the multimetal solution.
研究领域:
材料科学
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环境工程
·
化学工程
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DOI
高影响因子
JOURNAL OF STRUCTURAL CHEMISTRY
·
2023
·Vol. 64
·期 3
·474-485
·
IF 0.8
Li L.,Yuan F.
Abstract Reaction of H 3 salmp (H 3 salmp = 2-bis(salicylidieneamino)methylphenol) and lanthanide ions has afforded three lanthanide-schiff base complexes. One is homodinuclear [Nd(Hsalmp)(NO 3 )(EtOH)] 2 ·2EtOH ( 1 ), other two are heteroleptic tetranuclear [LnNa(salmp)(sal)(EtOH) 3 ] 2 (Ln = Nd ( 2 ), Ce ( 3 ); sal = salicylaldehydato) architectures. In complex 1 , the counter Hsalmp 2– anions adopt NO 3 donor sets, wheras in complexes 2 and 3 , the counter salmp 3– anions select N 2 O 3 donor sets and sal – anions chose O 2 donor sets, in which cleavage of C=N groups in ligand has taken place. The amount of alkali has displayed a vital influence on preparation of these complexes. Both of the complexes were elucidated by elemental analysis, IR, fluorescence spectra and X-ray crystallography.
研究领域:
化学
·
配位化学
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DOI
高影响因子
Cell Reports Physical Science
·
2025
·
IF 7.3
Yan-Wei Jiang,Zhong-Wei Zhang,Chi Wai Cheung,Jun-An Ma
Trifluoromethyl ketones (TFMKs) represent a crucial class of functional groups in organic synthesis and drug design. Carbo- and heteroatom-substituted methyl TFMKs have been developed extensively, leading to a broad array of structurally diverse trifluoromethylated compounds. However, aminomethyl TFMKs remain largely underexplored, likely due to the intrinsic incompatibility between amino and carbonyl groups. Here, we present a modular strategy for accessing aminomethyl TFMKs in a cyclic acetal-protected form. Using 2-(trifluoromethyl)-1,3-dioxolane-2-carboxylic acid as a masked trifluoroacetyl radical precursor, along with nitroarenes and tertiary alkylamines as readily available reaction components, we demonstrate the feasibility of assembling these compounds under metallaphotocatalytic conditions. This approach selectively yields a diverse array of N -(2-trifluoromethyl)dioxolanylmethyl aniline compounds, which act as inactivated forms of arylaminomethyl TFMKs and can be readily converted into arylaminomethyl TFMKs, various amine derivatives, and azaheterocycles. The structurally distinctive trifluoromethylated dioxolanylmethyl anilines and their downstream products hold significant potential for pharmaceutical and agrochemical development.
研究领域:
有机化学
·
药物化学
·
合成化学
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DOI
高影响因子
DESIGNED MONOMERS AND POLYMERS
·
2015
·
IF 2.78
Guang-Zhen Mo,Yan-Cheng Wu,Zhi-Feng Hao,Qiao-Fang Luo,Xin-Yu Liang,Li-Tao Guan,Zhao-Yang Wang
Using aminomethyl benzimidazole (AMB) as a model of benzimidazole-type drugs, a potential biodegradable drug-loaded polymer poly(lactic acid-co-aminomethyl benzimidazole) (PLAAMB) is synthesized as designed via direct melt polycondensation starting from d,l-lactic acid (LA). When the molar feed ratio LA/AMB is 40/1, the optimal synthetic conditions, including catalyst type and dosage, polycondensation temperature, and copolymerization time are discussed. After the prepolymerization at 140 °C for 8 h, using 0.4 wt% stannous oxide (SnO) as the catalyst, the melt copolymerization at 160 °C for 6 h gives the copolymer with the biggest weight-average molecular weight (Mw) 5300 Da. The structure and properties of the copolymer are systematically characterized with Fourier transform infrared, 1H NMR, gel permeation chromatography, differential scanning calorimetry, and X-ray diffraction. And the investigations on the influences of different molar feed ratios on the properties of PLAAMB show that, the copolymer PLAAMB with the biggest Mw of 9400 Da can be obtained. After the drug model AMB as a monomer is introduced into polylactic acid during the condensation, the Tg of the obtained PLAAMB is lower than the Tg of homopolymer poly(d,l-lactic acid) (PDLLA). The Mw and crystallinity of PLAAMBs can meet the requirement of drug-loaded polymers in the drug delivery.
研究领域:
高分子化学
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药物化学
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生物材料学
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产品关联
DOI
高影响因子
JOURNAL OF INDUSTRIAL AND ENGINEERING CHEMISTRY
·
2015
·
IF 3.512
Na Cao,Xin Xie,Yu Zhang,Yanbao Zhao,Liuqin Cao,Lei Sun
Dendritic porous tin oxide/silica (DTS) nanospheres (NSs) were prepared by emulsion-condensation route. DTS NSs have an average diameter of 80 nm and possess accessible center-radial large pore channels, which endow them high surface area, less drug diffusion resistance and more mass transport. SnO 2 quantum dots (QDs) embedded in silica skeleton can be used to track the drug release behavior. DTS NSs were coated by chitosan/polymethacrylic acid and polymer shell would make them achieve great loading capacity and pH-sensitive release for aminomethylbenzoic acid (AMBA).
研究领域:
材料科学
·
药学
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产品关联
DOI
高影响因子
JOURNAL OF APPLIED POLYMER SCIENCE
·
2013
·Vol. 130
·期 5
·3718-3725
·
IF 1.395
Yan Xia,Guang Lu Han,Qiu Gen Zhang,Yi Gong,Ian Broadwell,Qing Lin Liu
CuO-filled aminomethylated polysulfone hybrid membranes were prepared for sulfur removal from gasoline. The as-prepared membranes were characterized using Fourier transform infrared spectroscopy (FTIR), scanning electron microscopy (SEM), and X-ray diffraction (XRD). The separation performance of the hybrid membranes was evaluated by pervaporation (PV) separation of n -heptane/thiophene binary mixture. CuO-filling leads to a decrease in permeation flux. The sulfur-enrichment factor increased first and then decreased with increasing CuO loading, and it is worth noting that there is a rebound in enrichment factor above 8 wt % CuO loading. Influencing factors such as nitrogen content, feed temperature, sulfur content, and various hydrocarbons on membrane PV performance were also evaluated. Permeation flux of 23.9 kg·μm·m − 2 ·h − 1 and sulfur-enrichment factor of 3.9 can be achieved at 4 wt % CuO loading in PV of n -heptane/thiophene binary mixture with 1500 μg·g − 1 sulfur content. © 2013 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 130: 3718–3725, 2013
研究领域:
材料科学
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环境工程
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产品关联
DOI
高影响因子
ChemCatChem
·
2019
·Vol. 11
·期 11
·2649-2656
·
IF 4.495
Kuo Zhou,Haiyan Liu,Huimin Shu,Shuwen Xiao,Dechao Guo,Yingxin Liu,Zuojun Wei,Xiaonian Li
Graphical Raney to the rescue ! High value-added 2,5-bisaminomethylfuran was one-pot synthesized from 5-HMF over Raney Ni with a yield of 60.7 %. DFT calculations were conducted to support our speculation that Ni can harmonize NH 3 and H 2 on its surface most suitably for the reductive amination reactions. Reductive amination of furfuryl alcohol, furfural and 5-hydroxymethylfurfural (5-HMF) were carried out on various metal catalysts. Over Raney Ni catalyst, we obtained the highest furfurylamine yields of 81.8 % and 94.0 % from furfuryl alcohol in absence and presence of H 2 , respectively. While furfural was used as the substrate, 100 % yield of furfurylamine could be achieved over Raney Ni under rather moderate conditions. Although 5-HMF was completely converted over all catalysts used, the highest yield of 2,5-bisaminomethylfuran (60.7 %) was obtained over Raney Ni at 160 °C in 12 h. The DFT calculations on the adsorption behavior of NH 3 and H 2 on different metal surfaces showed that the difference of the adsorption energy between NH 3 and H 2 on Ni is lower than those of other metals, indicating that less metal active sites on Ni surface is occupied by NH 3 , which leaves more active sites for dehydrogenation/hydrogenation reactions and in the end promotes the reductive amination reactions.
研究领域:
化学工程
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催化科学
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产品关联
DOI
高影响因子
BIOCHEMICAL ENGINEERING JOURNAL
·
2022
·
IF 4.446
Shan Yuan,Miaomiao Jin,Chao Xu,Wencheng Yin,Mingsha Zhao,Mo Xian,Wei Liu
3-(Aminomethyl) pyridine (3-AMP) is a versatile compound for the synthesis of pharmaceuticals, agricultural chemicals and numerous polymers. Efficient and mild biocatalytic synthesis is often an excellent supplement to traditional chemical synthesis methods. However, there has been no report of biocatalytic 3-AMP synthesis. In this paper, 3-AMP was synthesized for the first time by using biocatalysts co-expressing carboxylic acid reductase from Neurospora crassa (ncCAR) and ω-transaminase from Ochrobactrum anthropi (OATA) in one pot. In addition, the metabolic pathway was optimized by knocking out the transcriptional dual regulator arcA , which resulted in a 90% increase in the yield of 3-AMP. Furthermore, efficient self-sufficient whole-cell bioconversion was established by optimization, achieving 93% yield and a 40.6 mM (4.4 g/L) titer of 3-AMP without additional carbon sources. This whole-cell bioconversion system was also suitable for the high-efficiency biocatalytic synthesis of other aromatic or heterocyclic primary amines, such as benzylamine, 2-furfurylamine, 4-fluorobenzylamine, 2,4-difluorobenzylamine and 2-(aminomethyl) pyridine. Being entirely biocatalytic, our one-pot procedure provides considerable advantages in terms of economic, environmental and safety impacts over reported chemical methods.
研究领域:
生物化学
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合成生物学
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生物技术
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产品关联
DOI
高影响因子
Journal of Biobased Materials and Bioenergy
·
2016
·Vol. 10
·期 5
·378-384
·
IF 0.635
Chen Wei,Jiang Yetao,Sun Yong,Wang Yanjun,Li Zheng,Wang Xiaoyu,Zeng Xianhai,Liu Shijie,Lin Lu
5-Dimethylaminomethyl-2-Furanmethanol (DMMF) is an essential precursor for the production of ranitidine, a drug for gastropathy. Herein a facile pathway to the value-added pharmaceutical intermediate DMMF from carbohydrates, such as glucose and fructose, was developed for the first
time. The reaction was carried out under catalyst-free conditions using N, N-dimethyl formamide (DMF) as the amine donor in formic acid (FA). A plausible reaction mechanism from carbohydrates to DMMF was also proposed.
研究领域:
有机化学
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药物化学
·
生物转化
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DOI
高影响因子
JOURNAL OF SOL-GEL SCIENCE AND TECHNOLOGY
·
2017
·Vol. 83
·期 2
·467-477
·
IF 1.575
Fu Likang,Zhang Libo,Wang Shixing,Zhang Gengwei,Peng Jinhui
A new adsorbent was synthesized via functionalizing nano-silica with 4-(aminomethyl) pyridine for selective recovery of gold. The adsorbent was characterized by Fourier transform infrared spectroscopy, thermogravimetric analysis, X-ray photoelectron spectroscopy and transmission electron microscopy, and BET (surface area and porosimetry analyzer). The results indicated that the maximum adsorption capacity of Au(III) was 55.5 mg/g at pH 4.0 and room temperature. The adsorption reaction was fairly rapid and reached equilibrium within 30 min. The adsorption processes of Au(III) were fitted well to the Langmuir isotherm model and adsorption kinetics of Au(III) followed the pseudo-second-order rate equation. The adsorption mechanism lies on the chelation and ion exchange between gold ions and amines/hydroxyl groups. The adsorbent had good reusability after five cycles. Moreover, 4-(aminomethyl) pyridine-Silica nanoparticles has a good selectivity in the adsorption of Au(III) from the coexisting ions. Therefore, 4-(aminomethyl) pyridine functionalized nano-silica could be of great potential as new adsorbent for the selective recovery of Au(III) from industrial effluents and waste e-products. Graphical
研究领域:
环境化学
·
材料科学
·
冶金工程
·
污染控制
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资源回收
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DOI
高影响因子
ACS Applied Materials & Interfaces
·
2022
·
IF 10.383
Xia Chen,Jihuai Wu,Guodong Li,Yitian Du,Qi Chen,Chunyan Deng,Yuan Xu,Sijia Zhu,Fangfang Cai,Juanmei Liu,Yuelin Wei,Yunfang Huang
The rapid development of perovskite solar cells (PSCs) makes it one of the most competitive photovoltaic devices in the field of new energy. However, the suboptimal performance and poor stability caused by numerous defects are still the main factors limiting the development of PSCs. Herein, a polarized molecule additive of 4-(aminomethyl) benzonitrile hydrochloride (AMBNCl) is introduced into perovskite. Owing to its special polar electron density distribution, −C≡N group, −NH3+ terminal, and Cl– ions, the modification of AMBNCl can improve the quality of perovskite crystal growth, passivate the defects of Pb2+, adjust the energy level array between the perovskite layer and hole-transport layer, and alleviate the carrier nonradiative recombination. As a result, the AMBNCl-modified device achieves a champion efficiency of 23.52%. The unpacked device still maintained 91.2% of its original efficiency after storing in an air environment (RH ∼40%, 25 °C) for 50 days.
研究领域:
材料科学
·
能源科学
·
光伏技术
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产品关联
DOI
PubMed
高影响因子
危险品化学品经营许可证（带存储）