Antioxidants
·
2022
·Vol. 11
·期 11
·2145
·
IF 7.675
Yuanfang Chen,Yuwei Yang,Haikang Tang,Ziqi Zhang,Xiaoliang Zhou,Wenqing Xu
Radiation exposure can immediately trigger a burst of reactive oxygen species (ROS), which can induce severe cell death and long-term tissue damage. Therefore, instantaneous release of sufficient radioprotective drugs is vital to neutralize those accumulated ROS in IR-exposed areas. To achieve this goal, we designed, synthesized, and evaluated a novel oral ROS-responsive radioprotective compound (M1) with high biocompatibility and efficient ROS-scavenging ability to act as a promising oral drug for radiation protection. The compound is stably present in acidic environments and is hydrolyzed in the intestine to form active molecules rich in thiols. M1 can significantly remove cellular ROS and reduce DNA damage induced by γ-ray radiation. An in vivo experiment showed that oral administration of M1 effectively alleviates acute radiation-induced intestinal injury. Immunohistochemical staining showed that M1 improved cell proliferation, reduced cell apoptosis, and enhanced the epithelial integrity of intestinal crypts. This study provides a promising oral ROS-sensitive agent for acute intestinal radiation syndrome.Keywords:ROS response;aminothiols;oral administration;radioprotection;intestinal damage
研究领域:
药理学
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放射生物学
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治疗学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
COLLOIDS AND SURFACES B-BIOINTERFACES
·
2019
·
IF 3.973
Feng Huo,Yuhang Liu,Yuran Tang,Yongqin Cao,Chao Tan,Feng Yang,Xiupei Yang
Au 11 (SG) 7 gold nanoparticles (GNPs) were synthesized from HAuCl 4 using thiol compounds containing an amino group to serve as both the reducing agent and the ligand. A three-dimensional network structure (…Au-SNH 2 →M n+ ⟵H 2 NS-Au…) was formed after the M n+ (Pb 2+ , Cd 2+ , Zn 2+ and Ag + ) coordinated the gold nanoparticles through the amino group in the thiol ligand, which promoted aurophilicity (…Au…Au…) and induced GNP aggregation and emission. The differences in coordination between the amino group and metal ions resulted in different emission wavelengths (Pb 2+ , Cd 2+ , Zn 2+ and Ag + : λ ex = 365 nm˜370 nm, λ em = 580, 645, 630 and 565 nm). Aggregation induced emission of amino thiol capped GNPs via coordination of Pb 2+ or Cd 2+ can be used as a fluorescent sensor of the both metal ions (λ ex = 365 nm, λ em = 580/645 nm) and were used for living bioimaging in vivo and in vitro.
研究领域:
纳米技术
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材料科学
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分析化学
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生物医学工程
✓ 已验证
产品关联
DOI
PubMed
高影响因子
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
·
2025
·
IF 0
Maqinana Siphosethu,Kowenje Chrispin B. O.,Ojwach Stephen O.
Reactions of N 1 ,N 3 -bis(2-mercaptoethyl)isophthalamide with (3-aminopropyl)triethoxysilane (3-APTES) afforded the the corresponding Schiff base chelating ligand, (1Z,3Z)-N 1 ,N 3 -bis(2-mercaptoethyl)-N' 1 ,N' 3 bis(3(triethoxysilyl)propyl) isophthalimidamide ( L1 ) in high yields. Subsequent immobilization of L1 on mesoporous silica supports (SBA-15 and MCM-41) following a divergent method produced the respective fabricated L1@SBA-15 and L1@MCM-41 materials. Characterization of the fabricated chelating agents was accomplished using SEM, TEM, EDX, BET, PXRD, FT-IR, and TGA-DTA/DSC techniques. The fabricated materials were used as adsorbents for the removal of Cd(II), Pb(II) and Cr(VI) metal ions from water. Both the L1@SBA-15 and L1@MCM-41 materials demonstrated high extraction efficiencies for Cd(II) and Pb(II) cations, achieving over 98% and 97% removal, respectively, across a broad pH range (3–9). For Cr(VI) anions, relatively lower optimal extraction efficiencies of 67% and 77% were recorded between pH 3–12, for L1@SBA-15 and L1@MCM-41 , adsorbents, respectively. Faster extraction kinetics were observed for Cd(II) and Pb(II) cations, with over 94% removal achieved within 30 min, even at low initial metal concentrations (5 ppm) and adsorbent dosages (10 mg). Kinetic modelling showed that the adsorption process followed a pseudo -second-order kinetics, with high correlation coefficients (R 2 ) for Cd(II), Pb(II), and Cr(VI) of 0.97573, 0.97348, and 0.91017 using L1@MCM-41 , and 0.9754, 0.97089, and 0.89411 using L1@SBA-15 , respectively. Equilibrium data best fitted the Freundlich isotherm model, with R 2 values of 0.97952, 0.99892, and 0.97374 for L1@SBA-15 and 0.99879, 0.99999, and 0.90923 for L1@MCM-41 , corresponding to Cd(II), Pb(II), and Cr(VI), respectively. In competitive metal ion systems, the extraction selectivity followed the order Cd(II) > Pb(II) > Cr(VI), with L1@SBA-15 exhibiting superior overall performance compared to L1@MCM-41 . The extraction mechanism was postulated to occur through the coordination of the metal ions to the nitrogen/sulfur donor atoms in the chelating agents, consistent with the hard and soft acid and base (HSAB) principle. Furthermore, L1@MCM-41 demonstrated notable regeneration potential, retaining Cr(VI) extraction efficiencies over four successive cycles. Graphical
研究领域:
环境化学
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材料科学
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无机化学
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水处理技术
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吸附科学
✓ 已验证
产品关联
DOI
PubMed
Nature Communications
·
2022
·Vol. 13
·期 1
·1-14
·
IF 17.694
Arabi Maryam,Ostovan Abbas,Wang Yunqing,Mei Rongchao,Fu Longwen,Li Jinhua,Wang Xiaoyan,Chen Lingxin
Chiral discrimination is critical in environmental and life sciences. However, an ideal chiral discrimination strategy has not yet been developed because of the inevitable nonspecific binding entity of wrong enantiomers or insufficient intrinsic optical activities of chiral molecules. Here, we propose an “inspector” recognition mechanism (IRM), which is implemented on a chiral imprinted polydopamine (PDA) layer coated on surface-enhanced Raman scattering (SERS) tag layer. The IRM works based on the permeability change of the imprinted PDA after the chiral recognition and scrutiny of the permeability by an inspector molecule. Good enantiomer can specifically recognize and fully fill the chiral imprinted cavities, whereas the wrong cannot. Then a linear shape aminothiol molecule, as an inspector of the recognition status is introduced, which can only percolate through the vacant and nonspecifically occupied cavities, inducing the SERS signal to decrease. Accordingly, chirality information exclusively stems from good enantiomer specific binding, while nonspecific recognition of wrong enantiomer is curbed. The IRM benefits from sensitivity and versatility, enabling absolute discrimination of a wide variety of chiral molecules regardless of size, functional groups, polarities, optical activities, Raman scattering, and the number of chiral centers.
研究领域:
环境科学
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生命科学
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分析化学
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材料科学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
危险品化学品经营许可证（带存储）