Journal of Materials Chemistry B
·
2016
·Vol. 4
·期 24
·4295-4301
·
IF 4.872
Suhang Wang,Han Cao,Yiming Zhong,Yuhong Yang,Zhengzhong Shao
Curcumin (Cur) has been demonstrated as an efficacious anti-tumor agent. However, its therapeutic applications are largely limited by its extremely low aqueous solubility, low stability and poor bioavailability. In this work, a simple one-pot synthesis was developed to fabricate a novel aminoclay–curcumin (AC–Cur) hybrid via the in situ loading of Cur over AC. The resultant hybrid was amenable to exfoliation and readily dispersible in aqueous media. Compared with free Cur, the AC–Cur hybrid displayed significantly enhanced solubility of Cur in both acidic and neutral environments, as well as enhanced stability of Cur in both neutral and alkaline environments. More importantly, this hybrid achieved a much better therapeutic effect than free Cur against various tumor cell lines, which was mainly attributed to its significantly improved solubility, stability and cellular uptake. Our results suggest that such an AC–Cur hybrid with high bioavailability can potentially be applied in nanomedicine for the treatment of malignant tumours.
研究领域:
药剂学
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肿瘤学
·
纳米医学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Molecular Catalysis
·
2024
·
IF 3.9
Jie Han,Xin Wen,Hongchao Wang,Tianren Wang,Yuzhen Sun,Luis Ricardez-Sandoval,Guoyi Bai
Selective semi-hydrogenation of alkynes plays a pivotal role in the field of chemical production but still suffers from low selectivity and catalyst stability. Herein, an aminoclay-derived nickel catalyst was constructed by replacing part of Mg 2+ by Ni 2+ in the skeleton and coordinating Ni 2+ with aminopropyl groups via a self-assembly synthetic strategy. The introduction of Ni 2+ facilitated the exfoliation of lamellar structure, resulting in highly exposed and uniformly dispersed Ni nanoparticles. The optimal catalyst showed an excellent catalytic performance with 99.9 % conversion and 98.9 % regio- selectivity to alkene ( cis / trans = 94:6) in diphenylacetylene semi-hydrogenation. Experimental data and theoretical calculations validated that the aminopropyl groups on NiMg-AC improved the activity and selectivity to alkene by tuning the adsorption/desorption energies of substrate/product. Furthermore, this non-precious metal catalyst showed stable activity and selectivity during cyclic testing, thanks to the strong interaction between Ni and the aminopropyl groups. This "self-assembly" synthetic strategy provides valuable guidance for the preparation of aminoclay-derived Ni catalysts for selective semi-hydrogenation.
研究领域:
化学工程
·
材料科学
✓ 已验证
DOI
高影响因子
CLAYS AND CLAY MINERALS
·
2021
·Vol. 69
·期 4
·434-442
·
IF 1.609
Zhang Mingzhu,Sun Shiyong,Lv Rui,Golubev Yevgeny Aleksandrovich,Wang Ke,Dong Faqin,Kotova Olga Borisovna,Kotova Elena Leonidovna
Lipase is an industrial enzyme, the catalytic efficiency of which is restricted by various environmental factors. To improve this efficiency, immobilization technology has been utilized in the past to improve the stability of lipase in harsh conditions. Immobilization technology can be divided into physical methods and chemical methods. Some unsolved problems remain in current immobilization technology. The interaction between enzyme and immobilization support is weak and reversible during physical adsorption, resulting in poor stability of the immobilized enzyme and the contamination of substrate solution by leached enzymes. In chemical methods, enzyme-active sites might be inactivated due to the chemical reactions between enzyme molecules and support, resulting in a decrease in the enzymes’ catalytic activity (Liu et al., 2018a ). The objective of the current study was to construct a nanostructured lipase via Mg-amino-clay as a carrier and improve the catalytic activity and stability of lipase by immobilization. Lipase produced by Aspergillus oryzae was immobilized on aminopropyl functionalized magnesium phyllosilicate (a 2:1 trioctahedral talc-like silicate Mg-amino-clay) via a 1-(3-Dimethylaminopropyl)-3-ethyl-carbodiimide hydrochloride (EDC) coupling agent. The physical and chemical properties of the Mg-amino-clay and Mg-amino-clay-based nanostructured biocatalyst (Mg-clay-lipase) were characterized by X-ray diffraction, Fourier-transform infrared spectroscopy, and scanning electron microscopy. Optimal immobilization conditions were determined by taking into account the following variables: amount of initial lipase, EDC concentration, and reaction time. The results revealed that the optimum temperature, pH, and thermal stability of Mg-clay-lipase were greater than equivalent values for free lipase under optimal conditions (described below – Process for Immobilization of Lipase on Mg-amino-clay ). The Michaelis-Menten constant (K m ) values were 5.25 mM and 7.42 mM while the maximum reaction rates ( v max ) were 30.58 mM/(L·min) and 55.87 mM/(L·min) for free lipase and Mg-clay-lipase, respectively. The present study provided a new nanostructured biocatalyst and demonstrated that the enzyme activity and stability of Mg-clay-lipase were superior to those of free lipase due to the mechanism of 'interface activation'.
研究领域:
生物化学
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材料科学
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产品关联
DOI
高影响因子
Journal of Water Process Engineering
·
2017
·
IF 0
Rong Wang,Guohua Jing,Xiaobin Zhou,Bihong Lv
Nanoscale zero-valent iron (nZVI) coated by Mg-aminoclay (MgAC) was prepared by the liquid-phase reduction method for high-efficiency removal of Cr(VI). The particles (MgAC-nZVI) were characterized by X-ray diffraction (XRD), fourier transform infrared (FTIR), transmission electron microscope (TEM), zeta potential analysis and X-ray photoelectron spectroscopy (XPS). It was found that the positively charged MgAC was capable of inhibiting the aggregation of nZVI particles and improving their dispersion stability in aqueous solution. Batch experiments showed that an iron dose of 0.125 g·L −1 in the form of MgAC-nZVI, at an initial Cr(VI) concentration of 20 mg·L −1 could maintain a good performance on Cr(VI) removal at a wide pH range. It was proved that the presence of co-existing ions (Cu 2+ , Ni 2+ and SO 4 2− ) except PO 4 3− in the solution had positive influence on the removal of Cr(VI). Due to the large accessible surface area and the protonated amino groups (-NH 3 + ) on the particle surface, MgAC-nZVI could remove Cr(VI) through fast adsorption and efficient reduction. The removal of Cr(VI) by using MgAC-nZVI was proved to be in accordance with the pseudo-second-order adsorption kinetics . Based on the identification of the reduction products, Cr(VI) was reduced by Fe 0 to form Cr(III). Eventually, the Cr(VI) was removed in a way of Cr(III)-Fe(III) co-precipitates adsorbed on the surface of MgAC-nZVI particles. Moreover, the MgAC-nZVI particles have a better performance of reusability than the uncoated nZVI .
研究领域:
环境科学
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材料科学
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产品关联
DOI
APPLIED SURFACE SCIENCE
·
2019
·
IF 5.155
Jun Xu,Rujie Chen,Lei Jia,Xiaoke Shen,Tongqian Zhao,Lei Su,Shengli Guo,Tieliang Ma,Beibei Zhang,Qi Guo,Zhijun Ge,Taofeng Zhu
Although there have been many studies on the detection or degradation of tetracyclines (TCs), there are few reports about the ability to combine the detection and degradation functions of TCs integrated on one nano-platform. Herein we developed a facile strategy to synthesize citric acid and Eu 3+ grafted amionclay@Au nanocomposite (AC@Au-Cit-Eu) that exhibited remarkable effect on visual detection, while the original AC@Au nano-platform displayed unprecedented visible-light-driven photodegradation efficiency of TCs. The results show that the AC@Au-Cit-Eu nanosensor can achieve rapid visual inspection of antibiotic TC in aqueous solution and real milk samples. The detection limit of the nanosensor for TCs was 11.2 nM. More importantly, the test strip made with AC@Au-Cit-Eu can also realize the real-time detection of TC through the color scanning APP in the smartphone. Meanwhile, the results also proved that the AC@Au nano-platform had good photocatalytic performance with a 93.33% degradation rate in 40 min for TCs and the reaction rate constant was significantly higher than many other photocatalysts . This strategy greatly reduced the lengthy process from discovery to disposal of antibiotic residues and greatly utilizes nanocomposites.
研究领域:
环境科学
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材料科学
·
分析化学
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产品关联
DOI
高影响因子
Journal of Environmental Chemical Engineering
·
2023
·
IF 7.7
Yifan Zeng,Shiyong Sun,Rui Lv,Ke Wang,Yevgeny Aleksandrovich Golubev,Sen Lin,Faqin Dong,Elena Leonidovna Kotova,Olga Borisovna Kotova
In recent years, nanozymes have become promising alternatives to natural enzymes owing to their high catalytic efficiency, substrate specificity, and mild reaction conditions. The catalytic performance of nanozymes can be further improved by doping heterogeneous metals to provide high redox potentials . However, nanozymes for the degradation of endocrine-disrupting chemicals (EDCs) have been scarcely studied, and the degradation mechanisms remain unclear. Herein, a series of aminoclays (ACs) containing various metal dopants were prepared and employed for the degradation of phenolic compounds . The as-synthesized ACs with a Cu-Mn molar ratio of 1:7 (CuMnAC-1–7) showed excellent stability and superior activity for oxidizing bisphenol A (BPA) than natural laccases owing to the electron transport between Cu 2+ /Cu + and Mn 4+ /Mn 3+ in the nanozyme. The catalytic oxidation process of BPA consists of a non-free radical pathway mediated by Mn 3+ , as well as a free radical pathway facilitated by superoxide radicals (O 2 ·- ) and singlet oxygen ( 1 O 2 ). Specifically, Mn 3+ deprived the electrons of the BPA benzene ring to form phenolic hydroxyl radicals , which were then polymerized to BPA dimers. Cu + in the structure reduced Mn 4+ to Mn 3+ , accelerating the electron deprivation of BPA and promoting the polymerization reaction. Finally, the high-charge-density region on the dimeric benzene ring tended to lose electrons and form free radicals, facilitating the polymerization into trimers and tetramers. The CuMnAC-1–7 could remove 95% of BPA at a concentration of 200 mg/L within 1 h under acidic conditions. This study provides a new strategy to design high-performance laccase nanozymes for EDCs degradation .
研究领域:
环境科学
·
生物化学
·
材料科学
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产品关联
DOI
高影响因子
AAPS PHARMSCITECH
·
2019
·Vol. 20
·期 8
·1-11
·
IF 2.608
Li Jinyu,Qiao Sen,Tan Guoxin,Yu Yibin,Liu Dandan,Pan Weisan
A synthetic, dispersible magnesium aminoclay (MgAC) was synthesized in the present study. Besides, structural and spectroscopic detections were conducted to investigate the MgAC nanoclay. With a poor aqueous solubility, methotrexate (MTX) has been applied as a valid antitumor agent in recent years. In our research, an unobtrusive sol-gel process was carried out to manufacture the MgAC-MTX nanohybrids through entrapment of MTX over MgAC in situ . The final product was capable of desquamating and thus dispersed in water, equably. In comparison with rough MTX, the MgAC-MTX nanocomposite with a preferable treatment efficacy against MCF-7 cells was mainly attributed to the preeminent enhanced aqueous solubility, controlled release and the increased cellular uptake capacity. Moreover, with excellent anticancer function and hypotoxicity as vindicated in vivo , the MgAC-MTX nanohybrid was supposed to own the potency in the application of malignant tumors cure as a valid nanomedicine. It turned out that, by virtue of its high bioavailability, the MgAC-MTX nanohybrids with high bioavailability is deserving of further study for the treatment of cancers.
研究领域:
纳米医学
·
癌症研究
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药剂学
·
材料科学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
JOURNAL OF LUMINESCENCE
·
2021
·
IF 3.599
Lei Jia,Xiangzhen Chen,Jun Xu,Lina Zhang,Xiyan Dong,Dan Zhao,Ning Bi,Taofeng Zhu,Tongqian Zhao
It is of vital significance to achieve accurate real-time detection of tetracycline (TC). In this research, the ratio fluorescence detection of tetracycline is realized by introducing europium-based aminoclay containing carbon dots with good sensitivity to tetracycline through subsequent surface modification. With the increase of tetracycline concentration, the fluorescence intensity of rare earth europium fluorophore increases continuously, while the fluorescence intensity of CDs is basically unchanged. The CIE chromaticity coordinate confirms that the luminous color of the probe can be adjusted continuously from blue to red. The results exhibit this approach owns the favourable linearity to TC within 0–12.5 μM and 10–25 μM, and the high sensitivity with a low detection limit of 3.133 nM. Moreover, it can entirely satisfy the requirements of field detection because the rapid monitoring time as short as 30 s. The multicolor fluorescence detection strategy is reliable and feasible in the field test of TC in various actual samples. In addition, a TC floating detector based on vertical float structure is designed to achieve the rapid visual detection of TC in simulated flow environment. The superiority of the sensing platform opens up a neo-pathway for point-of-care monitoring of TC residues.
研究领域:
分析化学
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环境监测
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生物传感器
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纳米技术
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食品安全
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药物分析
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材料科学
✓ 已验证
DOI
高影响因子
危险品化学品经营许可证（带存储）