Materials Today Bio
·
2025
·
IF 10.2
Yue Chen,Di Wu,Quan Li,Zhenghua Wei,Qian Liu,Jin Li,Daohui Gong,Chaowang Huang,Qianyi You,Hang Qian,Guansong Wang
Acute lung injury (ALI) and acute respiratory distress syndrome (ARDS) cause severe lung inflammation and damage, compromising respiratory function. Nanomedicine offers hope in controlling this inflammation. DNA nanostructures, as drug carriers, stand out due to their non-toxic, programmable, and precisely controllable traits. However, they face challenges in physiological stability and functionalization as carriers. Here, we introduce TET AG , DNA tetrahedra assembled and functionalized with aminoguanidine without magnesium. Aminoguanidine not only aids tetrahedron assembly but also inhibits the cyclic GMP-AMP synthase and stimulator of interferon (cGAS-STING) pathway, a key inflammatory signal. By integrating STING siRNA into TET AG (TET AG -STING), we achieve synergistic anti-inflammatory effects in ALI/ARDS. Our results show that TET AG offers improved stability and cellular uptake. Importantly, TET AG -STING exhibits potent anti-inflammatory activity in vitro and in a Lipopolysaccharides-induced mouse model following intratracheal administration. This significantly improves lung injury scores and pulmonary functions. These findings underscore aminoguanidine’s therapeutic potential in ALI/ARDS and highlight the promise of DNA nanostructures in medical applications.
研究领域:
医学
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纳米医学
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分子生物学
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DOI
PubMed
高影响因子
JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY
·
2020
·
IF 4.673
Xianqing Deng,Mingxia Song
Two series of aminoguanidines containing an alkynyl moiety were designed, synthesised, and screened for antibacterial and anticancer activities. Generally, the series 3a–3j with a 1,2-diphenylethyne exhibited better antibacterial activity than the other series (6a–6k) holding 1,4-diphenylbuta-1,3-diyne moiety antibacterial activity. Most compounds in series 3a–3j showed potent growth inhibition against the tested bacterial strains, with minimum inhibitory concentration (MIC) values in the range 0.25–8 µg/mL. Compound 3g demonstrated rapid and persistent bactericidal activity at 2 × MIC. The resistance study revealed that resistance of the tested bacteria towards 3g is not easily developed. Molecular docking studies revealed that compounds 3g and 6e bind strongly to the LpxC and FabH enzymes. Moreover, excellent activity of selected compounds against the growth of cancer cell lines A549 and SGC7901 was also observed, with IC50 values in the range 0.30–4.57 µg/mL. These findings indicate that compounds containing the aminoguanidine moiety are promising candidates for the development of new antibacterial and anticancer agents.
研究领域:
药理学
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药物化学
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微生物学
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肿瘤学
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DOI
PubMed
高影响因子
TRIBOLOGY LETTERS
·
2025
·Vol. 73
·期 2
·1-16
·
IF 3.3
Fan Junjing,Shen Yan,Liu Ye,Qu Jinghao,Liu Jie,Yu Baihong,Xu Jiujun
Aminoguanidine-based ionic liquid which can reduce the friction coefficient and wear depth has been developed as lubricant additives for the piston ring and cylinder liner within 80–240 °C. The friction coefficient and wear depth reduction become more significant as the temperature increases. At 240 °C, the coefficient of friction decreases by 23.1% compared to fully formulated mineral based engine oil (FFO). The wear depth of the piston ring and cylinder liner decreases by 9.1% and 16.0%, respectively. Addition of aminoguanidine-based ionic liquid (AO-IL) promotes the tribo-chemical reaction of zinc dialkylphosphorodithiloate (ZDDP), distributing S, P and Zn on the cylinder liner honing platform rather than in the honing groove. The plastic deformation causes a significant reduction of flakes on the edges of the cylinder liner honing platforms and less furrow damage along the sliding direction. The worn surface of the diamond-like carbon (DLC) piston ring shows a denser distribution of white bright spots and a higher sp 2 C=C/sp 3 C–C ratio.
研究领域:
材料科学
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机械工程
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DOI
高影响因子
CHEMICAL ENGINEERING JOURNAL
·
2013
·
IF 3.473
Dong-Peng Li,Yan-Ru Zhang,Xuan-Xuan Zhao,Bao-Xiang Zhao
Magnetic nanoparticles (MNPs) modified with aminoguanidine (AG) were synthesized and characterized with transmission electron microscopy (TEM), X-ray diffraction (XRD), vibrating sample magnetometer (VSM) and infra-red spectra (IR). Adsorption of acid dyes onto this new adsorbent was further studied in terms of pH, contact time and initial dye concentration. Maximum adsorption capacity reached from pH 1.3 to 2.5 for different dyes. The adsorption can be better described by pseudo-second-order kinetic model compared to pseudo-first-order kinetic model. The adsorption behavior fits quite well with the Langmuir rather than the Freundlich model. The mean energy of adsorption ( E ) calculated from the Dubinin–Radushkevich (D–R) isotherm model confirmed the involvement of chemical adsorption . This adsorbent could remove acid dyes with different structures rapidly with high adsorption capacity. Moreover, the adsorbent possesses good reusability.
研究领域:
环境科学
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材料科学
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DOI
高影响因子
JOURNAL OF MEMBRANE SCIENCE
·
2025
·
IF 9
Bin Liu,Xinyue Cui,Xiaozhen Lu,Xuewu Zhu,Lin Wang,Junyong Zhu
Positively charged polyamide (PA) nanofiltration (NF) membranes with sub-nanopores show promise for lithium extraction from salt-lake brines with high Mg 2+ /Li + ratios. This study introduces the use of triamino guanidine (TG), a highly positively charged molecule, to regulate grafting on monolayer PA membranes, resulting in dual-layer (PEI-TMC-TG) NF membranes. The monolayer PA membranes were created via spin-coating assisted interfacial polymerization between polyethyleneimine (PEI) and tricarbonyl chloride (TMC). The PEI/TMC-TG NF membranes exhibited several advantages over unmodified PEI-TMC NF membranes, including higher positive charge density, narrower pore size distribution, excellent hydrophilicity, and a more porous separation layer microstructure. Experimental results indicated that enhanced Donnan effect, size sieving, and dielectric repulsion within the sub-nanopores contributed to exceptional Li + /Mg 2+ selectivity during filtration of East Taijiner brine (S Li + /Mg 2+ = 64.5). Furthermore, the TG hydrophilic layer significantly improved water permeability (15.4 LMH/bar) and long-term stability. To reduce membrane fouling in the charge-positive NF process by removing organic matter from complex salt lake brine, we explored electrocoagulation as a pre-treatment method and identified optimal conditions for the EC-NF process. This strategy maximizes sustainable lithium recovery from brine in an economically viable green manner while enhancing the efficiency of NF membranes for lithium extraction from salt lakes.
研究领域:
环境科学
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材料科学
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DOI
高影响因子
JOURNAL OF MEMBRANE SCIENCE
·
2023
·
IF 9.5
Zhan Hao,Xinxia Tian,Vladimir Mankol,Qinghua Li,Jixiao Wang,Zhi Wang,Song Zhao
Tuning the reactivity and diffusion of amine monomers in interfacial polymerization (IP) process could efficiently regulate the formation and structure of the polyamide (PA) selective layer. Herein, novel thin-film composite NF membranes with dense and ultrathin PA selective layer were fabricated using 1,3,5-benzenetricarbonyl trichloride (TMC) and ultra-low concentration triaminoguanidine (Tg) as reactive monomers. Fabrication parameters, including Tg concentration, NaOH concentration and reaction time, were systematically explored to optimize the desalination performance of PA-Tg NF membrane. During the stability test over 48 h, PA-Tg-0.06 membrane displayed a water permeance of ∼12 L m −2 h −1 ·bar −1 and Na 2 SO 4 rejection of ∼99%. Meanwhile, detailed comparisons were made between PA-Tg NF membrane and a typical NF membrane fabricated with PIP as an aqueous monomer, including characteristics of the monomers as well as the structure, water permeance, salt rejection and antifouling property of the membranes. Molecular dynamics simulation and interfacial diffusion experiments indicated that the Tg monomer exhibited a higher reactivity but a lower diffusivity than the PIP monomer, making it feasible for the fabrication of PA-Tg NF membrane with ultra-low concentration of Tg monomer. In addition, compared with the PA-PIP membrane, the PA-Tg membrane exhibited a smoother, more hydrophilic and negatively charged surface, as well as a thinner and denser selective layer, thereby showing a higher water permeance, salt rejection and stronger fouling resistance.
研究领域:
材料科学
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环境工程
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DOI
高影响因子
Food Analytical Methods
·
2022
·Vol. 16
·期 2
·377-385
·
IF 3.498
Liu Mei,Sun Zhaomeng,Guo Rong
Developing effective detection systems of pathogenic microbes is urgent to prevent human from bacterial infection. In this study, Pseudomonas aeruginosa ( P. aeruginosa ) as a model foodborne pathogen, we report a versatile strategy for construction of functionalized carbon dots-based sensors for detection of P. aeruginosa . The aminoguanidine-functionalized carbon dots (AG-CDs) with high biocompatibility and low toxicity were synthesized by a greener hydrothermal reaction between ascorbic acid and aminoguanidine. The AG-CDs exhibit good trapping ability toward P. aeruginosa due to the binding of the aminoguanidine residues to lipopolysaccharide (LPS) on P. aeruginosa . The fluorescence provided by AG-CDs/ P. aeruginosa conjugates is closely correlated with P. aeruginosa content. The linear detection range is 3–3 × 10 7 CFU/mL and the limit of detection is 1 CFU/mL. The fluorescence sensor exhibited successful practical applications of detecting P. aeruginosa in water and food. The finding provides the great potential of simple, inexpensive and efficient advantages in bacteria determination.
研究领域:
微生物学
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生物传感
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食品科学
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DOI
高影响因子
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
·
2024
·Vol. 31
·期 26
·38298-38309
·
IF 0
Yang Yihuai,Hu Xianzhi,Zi Futing,Chen Shuliang,Zhao Li,Li Xinrong,Lin Yue
Thiosulfate gold leaching is one of the most promising green cyanide-free gold extraction processes; however, the difficulty of recovering Au(I) from the leaching system hinders its further development. This study prepared aminoguanidine-functionalized microspheres (AGMs) via a one-step reaction involving nucleophilic substitution between aminoguanidine hydrochloride and chloromethylated polystyrene microspheres and used AGMs to adsorb Au(I) from thiosulfate solutions. Scanning electron microscopy, Brunauer–Emmett–Teller analysis, Fourier transform infrared spectroscopy, and X-ray photoelectron spectroscopy were used to analyze the structure and properties of AGMs. Experiments were designed to investigate the effects of pH, temperature, initial Au(I), and thiosulfate concentrations on the gold adsorption performance of AGMs. Results demonstrated that AGMs can efficiently adsorb Au(I) from thiosulfate solutions in a wide pH range. The adsorption process conforms to the pseudo-second-order kinetic model and Langmuir isotherm model, with a maximum capacity of 22.03 kg/t. Acidic thiourea is an effective desorbent, and after four adsorption–desorption cycles, the adsorption rate of Au(I) by AGMs is 78.63%, which shows AGMs have good cyclic application potential. Based on the results of characterization, experiments, and density functional theory calculations, the mechanism for the adsorption of [Au(S 2 O 3 ) 2 ] 3− on AGMs involves anion exchange. Importantly, AGMs exhibited satisfactory adsorption property for Au(I) in practical Cu 2+ –NH 3 (en)–S 2 O 3 2− systems. This study provided experimental reference for the recovery of Au(I) from thiosulfate solution. Graphical Abstract
研究领域:
化学工程
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材料科学
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DOI
PubMed
ARCHIV DER PHARMAZIE
·
2020
·Vol. 354
·期 2
·2000165
·
IF 2.59
Yushan Huang,Hongmei Hu,Rui Yan,Liwen Lin,Mingxia Song,Xiaodong Yao
A series of 3-phenyl-1-phenylsulfonyl pyrazoles containing an aminoguanidine moiety was designed, synthesized, and evaluated for their antimicrobial and anticancer activities. The majority of the target compounds showed broad-spectrum antimicrobial activity against the tested strains, with minimum inhibitory concentration (MIC) values ranging from 2 to 64 μg/ml. Compound 5k , showing the most potent antimicrobial activity against Bacillus subtilis CMCC 63501 and multidrug-resistant Staphylococcus aureus ATCC 43300 with an MIC value of 2 μg/ml, was the most promising one in this series. It was also effective for S. aureus ATCC 33591 and multidrug-resistant Escherichia coli ATCC BAA-196 at higher concentrations. The bactericidal time–kill kinetics test illustrated that compound 5k had rapid bactericidal potential. Docking results exhibited that compound 5k showed various kinds of binding to the FabH receptor, reflecting that 5k could bind with the active site well. All compounds showed excellent activity against the investigated cancer cells, with IC 50 values ranging from 1.90 to 54.53 µM. Among them, compound 5f showed prominent cytotoxicity with IC 50 = 1.90 µM against A549 cells, while exhibiting lower inhibitory activity against 293T cells (IC 50 = 41.72 µM), indicating that it has the potential for a good therapeutic index as an anticancer drug.
研究领域:
药物化学
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微生物学
·
肿瘤学
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DOI
PubMed
高影响因子
SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
·
2021
·
IF 4.098
Kanagaraj Rajalakshmi,Tongtong Deng,Selvaraj Muthusamy,Meng Xie,Jimin Xie,Kang-Bong Lee,Yuanguo Xu
Citrate is a tricarboxylate, plays vital role in prostate cancer (PC) and the level of citrate is an indicator for PC identification. Herein, triaminoguanidine carbon dots (TAG-CDs) prepared by one step hydrothermal method and used as a citrate receptor. Notably the TAG-CDs without alkaline treatment were highly fluorescent at pH 7 with high quantum yield (11.3%). TAG-CDs were characterized through TEM, XRD, FT-IR, UV–vis and spectrofluorimetry. It is noted that the average size was of 2.8 nm, the presence of highly disordered carbon, retain the functionality of TAG. The absorbance maxima obtained at 294 nm and good emitting response observed at 396 nm. The Y-aromaticity of receptor guanidinium moiety acts as Lewis acid and have peculiar interaction with Lewis base citrate via electrostatic interaction and also protons in the TAG participate hydrogen bonds with citrate, which causes quenching of TAG-CDs. From the obtained linear quenching equation the LOD was found to be 4 nM. The probe expressed high selectivity, high interference tolerance (500 – fold), fast response in 15 mins and good biocompatible. Finally, TAG-CDs utilized for the intracellular imaging of citrate in live MCF-7 cells, it showed good cytotoxicity and delivered contrast images in presence, absence of citrate. TAG-CDs detected the citrate level in human urine samples, the obtained results are validated with HPLC method.
研究领域:
癌症研究
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分析化学
·
生物材料
·
生物成像
·
生物医学工程
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产品关联
DOI
PubMed
高影响因子
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
·
2024
·
IF 7.7
Changyan Dong,Yi Cheng,Meihui Zhang,Mianhua Chen,Zhongli Yan,Sumei Zhou,BenxuYang,Qingbin Guo,Changlu Wang,Shufen Wu
In this study, four Monascus pigments (ankaflavin, AK; monascin MS; rubropunctatin, O 1 ; monascorubrin, O 2 ) were proved to exhibit considerable anti-glycation properties in bovine serum albumin (BSA)-fructose model. AK (40.62 %) and MS (48.38 %) were found to exert lower inhibitory effects on the formation of fluorescent advanced glycation end products (AGEs) than aminoguanidine (59.4 %), while O 1 (90.64 %) and O 2 (93.82 %) displayed much stronger abilities. AK and MS could trap methylglyoxal (MGO) with maximum capture rates of 85.67 % and 84.90 %, respectively, and only mono-MGO adducts of them were detected. LC-Orbitrap MS/MS analysis revealed that four pigments significantly altered the type and reduced the number of the glycated sites and they all covalently bound to BSA, with O 1 and O 2 possessing high reactivity. Altogether, AK and MS suppressed fluorescent AGEs formation mainly via trapping MGO and covalently interacting with BSA, and blocking free amino groups was the dominant mechanism for O 1 and O 2 . These findings presented new insights into Monascus pigments as dietary supplement for inhibiting protein glycation.
研究领域:
生物化学
·
食品科学
·
药理学
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DOI
PubMed
高影响因子
METABOLISM-CLINICAL AND EXPERIMENTAL
·
2015
·
IF 3.894
Qian Huang,Yuan Chen,Nian Gong,Yong-Xiang Wang
Objective Methylglyoxal is known to be associated with the development of nephropathy , retinopathy , and other complications in diabetes. The present study tested the hypothesis that endogenously increased levels of methylglyoxal in diabetes are causally associated with the induction of neuropathic pain . Materials and methods Streptozotocin- and methylglyoxal-induced pain models were established in rats, and the anti-nociceptive effects of the methylglyoxal scavenging agents, selective transient receptor potential channel ankyrin 1 (TRPA1) antagonist, and Nav1.8 antagonist were tested. Results Systemic injection of streptozotocin in rats induced a prolonged increase in plasma methylglyoxal by approximately 60%, which was correlated with the progressive development of mechanical allodynia and thermal hyperalgesia . Local subcutaneous injection of methylglyoxal into the hindpaw produced dose-dependent and biphasic flinching nociceptive responses, which resembled formaldehyde (formalin)-induced nociception . The local methylglyoxal nociception was significantly blocked by co-injection into the hindpaw of the selective transient receptor potential channel ankyrin 1 (TRPA1) antagonist, A967079, and the Nav1.8 antagonist, A803467. Co-incubation with the methylglyoxal scavengers, aminoguanidine , d -arginine, and metformin , reduced the level of free methylglyoxal by more than 90%, and injection of their incubation solutions into the hindpaw produced negligible (3–17%) nociception. Like the clinically effective anti-diabetic neuropathic pain drug gabapentin , systemic injection of aminoguanidine, d -arginine, and metformin at doses that effectively inhibit paw-injected methylglyoxal-induced nociception significantly blocked streptozotocin-induced mechanical allodynia. Conclusion Endogenously increased methylglyoxal may mediate diabetic neuropathic pain via activation of both TRPA1 and Nav1.8 expressed on primary afferent sensory neurons , and injection of methylglyoxal into the hindpaw may serve as a simple and robust model for testing the anti-diabetic pain drugs.
研究领域:
药理学
·
神经科学
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糖尿病研究
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疼痛管理
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产品关联
DOI
PubMed
高影响因子
危险品化学品经营许可证（带存储）