OPTICS AND SPECTROSCOPY
·
2013
·Vol. 115
·期 4
·596-600
·
IF 0.559
Wang Rui-yong,Wu Jing,Wang Lv-jing,Wang Rui,Dou Huan-jing
A novel CdTe quantum dots (QDs) based technology platform was established in aqueous solution. It can perform accurate and simple determination of aminophylline concentration in pharmaceutical samples with satisfactory results. Under optimum conditions, the relative fluorescence intensity of CdTe quantum dots is linearly proportional aminophylline concentration from 2.00 to 80.0 μg mL −1 with a correlation coefficient of 0.9979 for aminophylline determination and a detection limit of 0.531 μg mL −1 .
研究领域:
分析化学
·
药剂学
·
纳米医学
·
药物分析
·
生物传感
✓ 已验证
DOI
高影响因子
APPLIED SURFACE SCIENCE
·
2013
·
IF 2.112
Yan Zhang,Zhaojun Wang,Weimin Zhou,Guoquan Min,Meidong Lang
Cationic poly(ɛ-caprolactone) modified hollow mesoporous silica (HMSNs) was achieved by a post graft method via covalent linkage between the silanols on the surface of silica and the trimethoxysilane groups at the end of the poly(γ-(carbamic acid benzyl ester)-ɛ-caprolactone). The trimethoxysilane groups were introduced to poly(γ-(carbamic acid benzyl ester)-ɛ-caprolactone) by ring opening polymerization of γ-(carbamic acid benzyl ester)-ɛ-caprolactone (γCABɛCL) with 3-aminopropyl trimethoxysilane as initiator. Subsequently, the polymer was grafted to the HMSNs and the protected groups of Cbz were removed, thus the amino groups were obtained accordingly. The structure of the polymer was confirmed by 1 H NMR. In addition, the TEM and SEM demonstrated that the HMSNs were spherical and the polymer was well coated on the spheres. FTIR, TGA and N 2 adsorption results proved that the modified processes were effective and the structure of the HMSNs was well reserved. The cationic surface was further confirmed by zeta potential. Moreover, the potential application of the HMSNs in drug delivery was studied with ammonium glycyrrhizinate (AMG) as model drug. Results showed that the cationic HMSNs could be an efficient AMG carrier.
研究领域:
材料科学
·
药学
·
生物医学工程
✓ 已验证
产品关联
DOI
高影响因子
FOOD AND AGRICULTURAL IMMUNOLOGY
·
2019
·
IF 2.398
Xiaoling Wu,Steven Suryoprabowo,Hua Kuang,Liqiang Liu
Aminophylline (AMP), a bronchodilator drug, is a modified form of theophylline (the pharmacological active ingredient). AMP is often given to treat respiratory diseases, including bronchial asthma, blocked emphysema, panting bronchitis, and cardiogenic asthma. In this study, we developed a rapid and sensitive method to determine AMP concentration in mouse serum. A sensitive monoclonal antibody against AMP was produced by immunizing BALB/c mice with a well-characterized AMP2-keyhole limpet hemocyanin and coating antigen (hapten-AMP1-OVA). The coating antigen and goat anti-mouse IgG antibody were sprayed onto a nitrocellulose membrane representing the test and control lines, respectively. Under optimized conditions, the cut-off limits of the test strip were 50 ng/mL in 0.01 M phosphate buffered saline (pH 7.4) and 250 ng/mL in serum. The results were obtained within 10 min and revealed that this immunochromatographic strip test is a sensitive, rapid, and simple tool for the detection of AMP in serum.
研究领域:
药理学
·
分析化学
·
免疫学
✓ 已验证
DOI
高影响因子
Journal of Materials Chemistry C
·
2024
·
IF 5.7
Xingxing Duan,Bufan Yu,Guangrong Jin,Dengliang Zhang,Jiangshan Chen,Dongge Ma
During the past few years, significant progress has been achieved with blue perovskite light-emitting diodes (PeLEDs) based on quasi-two-dimensional (quasi-2D) perovskites with chloride (Cl) and bromine (Br) ions toward improving their external quantum efficiencies (EQEs). However, mixed-halide quasi-2D PeLEDs still suffer from serious efficiency roll-off and spectral instability. Here, modification of mixed-Cl/Br quasi-2D perovskites with a multi-functional additive is proposed to achieve efficient blue PeLEDs with reduced efficiency roll-off and stable electroluminescence (EL) spectra. Aminophylline (AMP) with Lewis base characteristics was employed as the additive to incorporate with the CsPb(Cl/Br)3 based quasi-2D perovskites. It was observed that the introduction of the AMP additive suppressed the low dimensional phases in the quasi-2D blue perovskite film, leading to the carriers being harvested for radiative recombination rather than being located at the low dimensional phases. In addition, the AMP additive, containing carbonyl and imine groups, can coordinate with the uncoordinated Pb2+, which enables the passivation of defects and the reduction of trap-assisted non-radiative recombination in the blue quasi-2D perovskite films. As a result, based on the AMP-modified quasi-2D perovskites, the champion PeLED achieved a maximum EQE of 13.2% with a stable EL peak at 484 nm, which is 1.6 times that of the pristine device without the AMP additive. Importantly, the AMP-modified blue PeLEDs maintained an EQE as high as 11.5% at a high luminance of 1000 cd m−2, demonstrating a significantly reduced EQE roll-off. Meanwhile, the AMP-modified devices presented more stable spectra than the pristine devices under various voltages or continuous operation at an identical initial luminance. This study demonstrated a facile modification strategy by using a multi-functional additive to facilitate the improvement of efficiency roll-off and spectral stability in mixed-Cl/Br quasi-2D blue PeLEDs.
研究领域:
材料科学
·
光电技术
✓ 已验证
产品关联
DOI
高影响因子
JOURNAL OF CELLULAR BIOCHEMISTRY
·
2018
·Vol. 120
·期 6
·9648-9655
·
IF 2.959
Chaozhi Ma,Liyuan Zou,Yu Xia,Yijun Tu,Daquan Xue,Yanfang Yang,Dan Liu,Yanwen Liu,Hezhen Wu,Hanxiong Dan,Pengtao You
Asthma is characterized by airway inflammatory infiltration, which leads to airway remodeling and airway hyperreactivity. Coleus forskohlii (CFK) has been used to treat asthma, however, the mechanism involved is not clear. To explore the antiasthma mechanism of extracts of Coleus forskohlii (ECFK), guinea pigs were administered with a spray of phosphoric acid histamine, and rats were sensitized with ovalbumin (OVA). Hematoxylin and eosin staining (H&E) were used to evaluate pathological changes in lung tissue. Enzyme-linked immunosorbent assay (ELISA) was used to determine cytokine levels in serum and bronchoalveolar lavage fluid (BALF). Immunohistochemistry and Western blot analysis were used to assess the expression of intercellular cell adhesion molecule-1 (ICAM-1), phosphorylation of p65 (p-p65), matrix metallopeptidase 9 (MMP-9), and tissue inhibitor of metalloproteinase 1 (TIMP-1). After ECFK treatment, the asthma incubation period of guinea pigs was significantly prolonged. The H&E results showed that the number of eosinophils in the 12.8 g/kg ECFK group was significantly lower when compared with the control group. Moreover, ELISA results demonstrated that interleukin (IL)-4, IL-5, and IL-17 in serum and BALF were significantly decreased, and interferon-γ (IFN-γ) and IL-10 were increased after ECFK treatment. In addition, ECFK treatment resulted in downregulation of ICAM-1, p-p65, MMP-9, and TIMP-1 in lung tissue after being sensitized by OVA. In conclusion, our findings indicated that ECFK significantly alleviated OVA-induced inflammatory infiltration and airway remodeling in asthma. This study laid a theoretical foundation for the clinical use of ECFK.
研究领域:
药理学
·
免疫学
·
呼吸医学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
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