Membranes
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2021
·Vol. 11
·期 9
·705
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IF 4.106
Kaifeng Gu,Sichen Pang,Yong Zhou,Congjie Gao
Nanofiltration (NF) is a separation technology with broad application prospects. Membrane fouling is an important bottleneck-restricting technology development. In the past, we prepared a positively charged polyethyleneimine/trimesic acid (PEI/TMA) NF membrane with excellent performance. Inevitably, it also faces poor resistance to protein contamination. Improving the antifouling ability of the PEI/TMA membrane can be achieved by considering the hydrophilicity and chargeability of the membrane surface. In this work, sodium chloroacetate (ClCH2COONa) is used as a modifier and is grafted onto the membrane surface. Additionally, 0.5% ClCH2COONa and 10 h modification time are the best conditions. Compared with the original membrane (M0, 17.2 L m−2h−1), the initial flux of the modified membrane (M0-e, 30 L m−2h−1) was effectively increased. After filtering the bovine albumin (BSA) solution, the original membrane flux dropped by 47% and the modified membrane dropped by 6.2%. The modification greatly improved the antipollution performance of the PEI/TMA membrane.Keywords:nanofiltration;sodium chloroacetate;modification;antipollution performance
研究领域:
材料科学
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环境工程
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高影响因子
COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
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2023
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IF 5.2
Jia Yang,Xitong Sun,Qian Li,Lin Cheng,Ruihao Wang,Xiyan Sun,Liaoyuan An,Weihong Chen,Li Wei,Qingda An
A multifunction-integrated adsorbent based on zwitterion functionalized cellulose (MCC@PGMA-IAA) was synthesized by surface grafting polymerization and then modification with polyethyleneimine and sodium chloroacetate in turn. The adsorbent exhibited high functional group contents, switchable surface charge and chelating structure of iminoacetic acid. With the methylene blue , azophloxine, Ni(II) and Cr(VI) as the models of cationic/anionic dyes and heavy metal ions , batch experiments were conducted. The material showed strong adsorption abilities for dyes and heavy metal ions, with maximum adsorption capacities up to 440.5 mg/g, 320.5 mg/g, 59.3 mg/g, and 127.9 mg/g for methylene blue, azophloxine, Ni(II) and Cr(VI), respectively. Especially, the adsorption capacities of methylene blue and Ni(II) after zwitterionic functionalization increased by 50 times and 95.5% than those after polyethyleneimine modification. The adsorption equilibria were achieved within 10–120 min, and the adsorbent exhibited excellent removal efficiency. Furthermore, the adsorbed pollutants were conveniently desorbed by low concentration of HCl or NaOH solution, and the adsorbent had good reusability. Mechanism studies proved that electrostatic attraction and chelation were main driving forces. These results showed that MCC@PGMA-IAA had the characteristics of extensive sources, simple preparation and multifunctional integration, which was poised to develop as universal adsorbent for removing heavy metal ions and dyes.
研究领域:
环境科学
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材料科学
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化学工程
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JOURNAL OF FLUORESCENCE
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2025
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IF 3.1
Xu Zhaobin,Wang Xinling,Li Wenyao,Yang Wenjie,Xu Na,Chen Yushi,Luo Shengnan,Ma Fang,Chen Huiping,Wang Can,Zhang Liguo
Detection of tumor biomarkers is critical for early cancer diagnosis and cancer therapeutic monitoring, but traditional methods often lack sufficient sensitivity and specificity, especially at low biomarker concentrations. To address this challenge, in this study a multiplex detection platform based on core–shell quantum dot-encoded silica microspheres was developed for highly sensitive, simultaneous detection of multiple tumor biomarkers in a single assay. The core–shell silica architecture provides a high surface area for bioconjugation, while embedded quantum dots (QDs) offer strong fluorescence, making them ideal labels. Carbon quantum dots (CQDs), which have low toxicity, superior biocompatibility, and high photostability, were used as reporter molecules instead of organic dyes. This choice improved detection sensitivity and reduced the detection system’s environmental toxicity relative to traditional dye-based assays. After optimizing QD–silica conjugation and immunoassay conditions, the platform achieved highly sensitive multiplex detection of four tumor biomarkers (AFP, CEA, CA125, CA19-9) commonly used in early cancer screening. Results demonstrated specific detection of all four targets within a short time frame, with excellent stability and reproducibility. By enhancing sensitivity for these biomarkers and reducing assay toxicity while improving stability, this platform shows significant potential to greatly improve early cancer screening and cancer therapeutic monitoring in clinical practice.
研究领域:
肿瘤学
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生物医学工程
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生物传感与诊断
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纳米技术
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分析化学
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Advanced Science
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2025
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IF 14.1
Zonghua Tian,Yun Chen,Jingyi Zhou,Shilin Zhang,Hongrui Fan,Xuwen Li,Tao Sun,Chen Jiang
Dysregulated cholesterol metabolism, driven by a complex array of mechanisms, is a defining characteristic of glioblastoma (GBM) and plays a crucial role in the development of resistance to therapeutic interventions. In this study, supramolecular nanoscavengers are engineered by harnessing the intrinsic binding affinity between endogenous small-molecule cholesterol and β-cyclodextrin (β-CD). This host-guest interaction enabled both targeted drug release and cholesterol clearance through competitive displacement within the cholesterol-rich microenvironment of GBM. Consequently, tumor-associated cholesterol dysregulation is effectively disrupted, resulting in significant inhibition of cellular proliferation and invasion. Furthermore, the supramolecular nanoscavengers interfered with the metabolic crosstalk between tumor cells and immune cells involving cholesterol, thereby remodeling the immunosuppressive tumor microenvironment and demonstrating substantial therapeutic efficacy in vivo. Additionally, the dynamic and reversible binding between β-CD and various guest molecules facilitated efficient delivery of the supramolecular host to the central nervous system (CNS). Collectively, these findings presented a promising strategy for targeting cholesterol as an intervention in the treatment of GBM as well as other CNS disorders associated with altered cholesterol metabolism.
研究领域:
肿瘤学
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纳米医学
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代谢学
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免疫治疗
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神经肿瘤学
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超分子化学
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药物递送系统
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Catalysts
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2025
·Vol. 15
·期 3
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IF 4
Yafeng Huang,Rui Pang,Shanshan Sun,Xiufang Chen,Fengtao Chen,Wangyang Lu
The peroxymonosulfate (PMS)-assisted photocatalytic process has shown considerable potential for the treatment of wastewater. g-C3N4-based catalysts are widely applied to eliminate organic pollutants in wastewater. However, the bulk catalyst prepared by dicyandiamide has the drawback of a low surface area (10 m2/g), while the porous catalyst prepared by urea suffers from a low catalyst yield based on urea (3.5%). To address these challenges, a porous V-doped carbon nitride (V/CN) was designed through one-step thermal polymerization using urea and dicyandiamide as the carbon nitride precursor and NH4VO3as the V precursor. When the ratio of urea to dicyandiamide was 10:1, the yield of V/CN was improved, while it maintained a rich porous structure with a specific surface area (64.6 m2/g). The synergetic effect of V doping and nanosheet and hollow tubular structures facilitated the separation of photogenerated carriers, leading to boosting the photocatalytic activity of g-C3N4in the PMS system. V/CN(10:1) could completely degrade CBZ within 20 min, exhibiting an equivalent catalytic efficiency comparable to that of V/CN prepared by urea (V/UCN), while markedly surpassing both V/DCN and CN prepared by urea alone (UCN) in performance. This study presents an economical and effective approach for the photocatalytic degradation of pharmaceutical pollutants in aquatic environments.
研究领域:
环境科学
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材料化学
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光催化
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水处理技术
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Journal of Water Process Engineering
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2026
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IF 6.6
Xinyu Jia,Ruihao Wang,Qian Li,Xiyan Sun,Shuxian Li,Li Wei,Yu Tian,Jiangdong Xiang,Xitong Sun
In this work, a multifunctional adsorbent based on zwitterion modified Ti 3 C 2 T x MXene (MPI) was synthesized by surface grafting polymerization, followed by modification with polyethylenimine and sodium chloroacetate. This adsorbent exhibited a high density of functional groups, switchable surface charge characteristics and plenty of active sites of iminoacetic acid chelating groups. Subsequently, methylene blue, congo red, Pb(II), and Cr(VI) were selected as model compounds for cationic/anionic dyes and heavy metal ions to estimate the adsorption performance. The material exhibited exceptional adsorption capacities, and the maximum adsorption capacities were determined as 479.8 mg/g for methylene blue, 481.9 mg/g for congo red, 300.6 mg/g for Pb(II) and 265.9 mg/g for Cr(VI), respectively. Adsorption equilibrium was reached within 10–120 min and the adsorbent showcased excellent removal efficiency. Moreover, the adsorbent demonstrated excellent reusability，with no significant changes after ten consecutive adsorption-desorption cycles. Mechanism studies revealed that electrostatic attraction and chelation played dominant roles in the adsorption process. These results suggest that MPI possesses advantages of simple preparation, multifunctional integration, high adsorption performance, and good stability, making it a promising universal adsorbent for the removal of both dyes and heavy metal ions from wastewater.
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NEW JOURNAL OF CHEMISTRY
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2026
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IF 2.6
Yijing Li,Xiaogang Luo,Piaowen Yang,Jian Xiao,Zhaoyan Chi
The effective removal of trace trimethoprim (TMP) from aquatic environments remains a significant challenge due to the limited efficiency of conventional adsorbents at low concentrations. In this study, a novel composite adsorbent, MMT/CMCBS, was successfully fabricated by incorporating montmorillonite (MMT) into a carboxymethylated cellulose (CMC) matrix through an optimized extrusion-dropping method. The structural and chemical properties of the beads were systematically characterized using FESEM-EDS, FT-IR, XRD and XPS revealing a stable macroporous structure (≈1.5 mm diameter) with well-dispersed MMT. Fixed-bed column experiments demonstrated that MMT/CMCBS exhibits exceptional performance for TMP removal, achieving a removal efficiency of 99.874% and maintaining over 90% performance after four regeneration cycles. The breakthrough curves were well-described by the Adams-Bohart models (R2 > 0.94), indicating favorable dynamic adsorption behavior. Mechanism analysis further revealed that the synergistic removal of TMP was driven by hydrogen bonding and chemisorption between the TMP molecules and the functional groups of the composite. This study provides a highly efficient, stable, and environmentally friendly strategy for the elimination of TMP from water, offering significant potential for continuous-flow water treatment.
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CHEMISTRY-A EUROPEAN JOURNAL
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2026
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IF 3.6
Weiya Niu,Yongjian Wang,Sucheng Liu,Yizhe Wang,Zhengchao Liang,Yu Zhang,Renliang Lyu,Xiaogang Luo
The development of high-capacity and selective adsorbents for fluoride (F − ) removal is hindered by its inherent characteristics, including its small ionic radius, high charge density, strong hydration ability, high mobility and solubility, as well as the weak diffusion driving force at low concentrations. In this study, a novel composite adsorbent was prepared by loading UiO-66-NH 2 onto carboxymethylated cellulose beads (UiO-66-NH 2 @CMCBs) via an in-situ generation strategy for efficient adsorption and recovery of F − . The highly porous structure and abundant surface carboxyl groups of CMCBs provide favorable coordination sites, promoting the growth of UiO-66-NH 2 . Under environmental conditions (25°C, pH 7.4), UiO-66-NH 2 @CMCBs completely remove F − from aqueous solutions with an initial concentration of 10.0 mg L −1 . Furthermore, UiO-66-NH 2 @CMCBs demonstrated excellent column adsorption performance and outstanding reusability, maintaining a removal efficiency exceeding 80% after 5 cycles. These results highlight the potential of UiO-66-NH 2 @CMCBs as an efficient and recyclable adsorbent for the practical treatment of fluoride-contaminated water. Graphical
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PROGRESS IN ORGANIC COATINGS
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2026
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IF 7.9
Zhenjie Xu,Xuanhao Zhang,Simiao Yu,Guangming Zhou,Tao Liu,Zhengyang Ji,Jie Liu,Gang Lu
Polypropylene (PP) is widely used in transparent packaging, optical components, and functional membranes; however, its intrinsic hydrophobicity and poor interfacial adhesion severely restrict the construction of durable superhydrophilic surfaces. To overcome these limitations while preserving the excellent bulk properties of PP, a durable and scalable superhydrophilic coating was fabricated by introducing a mussel-inspired polydopamine (PDA) adhesive interlayer, followed by the deposition of an organic–inorganic hybrid coating composed of zwitterionic poly(carboxybetaine acrylamide) (PCBAA) and silica sol. The PDA interlayer provides robust interfacial adhesion between the coating and PP substrate, while zwitterionic PCBAA introduces abundant hydration sites to enhance surface hydrophilicity and silica nanoparticles reinforce the hybrid network structure. FTIR and XPS analysis confirmed the successful synthesis of CBAA and the successful immobilization of the hybrid coating on the PP surface. The coating with a CBAA/silica sol mass ratio of 1:2 exhibited the best overall performance, achieving a water contact angle of approximately 5°, excellent antifogging capability, and high optical transparency. At −15 °C, the coating exhibited a freezing time of 603 s, corresponding to a freezing delay of 425 s relative to pristine PP. Moreover, the optimized coating maintained stable superhydrophilicity after hot-water treatment and immersion under acidic and neutral conditions, while retaining good hydrophilicity after repeated sandpaper abrasion. These results demonstrate that the PDA-PCBAA/SiO₂ hybrid coating provides a simple and effective strategy for fabricating multifunctional superhydrophilic PP surfaces with excellent antifogging, anti-icing, and durability.
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BIOMACROMOLECULES
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2025
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IF 5.4
Yilin Wang,Yufeng Yuan,Wei Liao,Zaikai Zhuang,Xueying An,Bo Jiang,Chaofeng Zhang,Sehrish Manan,Peng Wang,Yongcan Jin
Lignin, a complex biopolymer, has promising biomedical applications due to its unique structure and chemical modifiability. This study shows that lignin modified with hydroxyl and carboxyl groups enhances GSH adsorption, thereby improving cytotoxicity and selectivity against osteosarcoma. The modified lignin induces mitochondrial dysfunction via mPTP activation, resulting in membrane depolarization, cytochrome c release, and ATP depletion, ultimately triggering the pro-apoptotic protein BAX and downregulation of the antiapoptotic protein BCL2. Moreover, lignin treatment significantly increased reactive oxygen species (ROS) levels while depleting intracellular GSH, further promoting oxidative stress-induced apoptosis. In vivo studies confirmed that lignin samples were effective in inhibiting tumor growth with a favorable biosafety profile. Among them, CML showed the strongest anticancer effect. These findings highlight the potential of modified lignin as a safe and effective therapeutic agent for OS treatment, offering a novel strategy to enhance oxidative-stress-mediated tumor cell apoptosis while sparing normal cells.
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INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
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2025
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IF 8.5
Huiwen Hou,Didi Gao,Na Lu,Wen Tang,Wenjie Liu,Feiyan Zhao,Xinqing Gao,Hanlin Wang,Yuhan Di,Hui Zhang,Hailong Wang,Feng Sun,Haining Tan
Hepatocellular carcinoma (HCC) is among the most prevalent and deadly cancers worldwide, with high recurrence and metastasis rates that significantly impact patient survival. Targeted therapy has emerged as a promising alternative to conventional treatments. This offers tumor-specific drug delivery while minimizing adverse systemic effects. In this study, we present folate acid (FA)-carboxymethylated mannan (CM)- monomethyl auristatin E (MMAE) conjugate (FA-CM-MMAE, FCMMM), an innovative glycosylated dual-target nanoparticle designed for the precise delivery of MMAE to HCC cells. These nanoparticles utilize FA and CM as their targeting ligands and exhibit pH-responsive drug release in acidic tumor microenvironments. This allows enhanced specificity and reduces off-target toxicity. In vitro studies have demonstrated that FCMMM nanoparticles selectively deliver MMAE to HepG2 cells via receptor-mediated pathways, alleviating MMAE-associated toxicity in normal cells. Furthermore, in vivo experiments in HCC-bearing mouse models have shown efficient tumor-specific accumulation of the drug, significant inhibition of tumor growth, and markedly lower levels of systemic toxicity than MMAE. This dual-targeting strategy integrates precise tissue targeting with controlled drug release. It addresses critical limitations of traditional HCC therapies such as nonspecific drug distribution, systemic toxicity, and drug resistance mechanisms. FCMMM shows potential as a next-generation nanoparticle platform for safer, more effective chemotherapeutic intervention in hepatic cancer.
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CARBOHYDRATE POLYMERS
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2025
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IF 12.5
Hailing Shi,Ruihao Ge,Kai Li,Kui Liu,Yixuan Wang,Fengyu Quan,Kewei Zhang,Xing Tian
Solar energy-driven water evaporation technology presents a sustainable method for seawater desalination and wastewater treatment. However, creating a biomass-based interfacial evaporator that achieves high salt resistance and rapid evaporation rates remains a significant challenge. In this study, we prepared a novel foam from carboxymethylated regenerated cellulose fibers, leveraging their natural orientation properties and excellent hydrophilicity. This foam featured hierarchically ordered water transport channels and numerous hydrophilic groups, which enhanced water transport efficiency and decreased the enthalpy of evaporation. The incorporation of polypyrrole gave it effective photothermal conversion properties. The foam demonstrated strong performance in solar-driven water evaporation, achieving an evaporation rate of 3.57 ± 0.04 kg m −2 h −1 under simulated sunlight conditions, with an evaporation efficiency of 93.8 ± 1.5 % and a notable ability to resist salt. This research provides a practical solution for sustainable desalination and holds great potential for the future development of desalination evaporators.
研究领域:
可再生能源
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材料科学
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环境工程
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海水淡化技术
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危险品化学品经营许可证（带存储）