Frontiers in Pharmacology
·
2024
·
IF 4.4
Shi Yaning,Gao Zhixin,Xu Bing,Mao Junbing,Wang Yue,Liu Zongping,Wang Jicang
Cadmium (Cd) is a highly hazardous toxic substance that can cause serious harm to animals. Previous studies have indicated that cadmium chloride (CdCl2) can damage organs, such as the liver, ovaries, and testicles. Naringenin (Nar) represents a flavonoid with various properties that promote the alleviation of Cd-induced damage. In this experiment, 60 chickens were divided into the control group, 150 mg/kg CdCl2 treatment group, 250 mg/kg Nar treatment group, and 150 mg/kg CdCl2 + 250 mg/kg Nar co-treatment group, which were treated for 8 weeks. Kidney tissues samples were collected to investigate kidney function, including oxidative stress (OS), endoplasmic reticulum (ER) stress, and autophagy activity. Experimental results showed the decreased weight of chickens and increased relative weight of their kidneys after CdCl2 treatment. The increase in NAG, BUN, Cr, and UA activities, as well as the increase in MDA and GSH contents, and the decrease activities of T-AOC, SOD, and CAT in the kidney, manifested renal injury by OS in the chickens. TUNEL staining revealed that CdCl2 induced apoptosis in renal cells. CdCl2 upregulates the mRNA and protein expression levels of GRP78, PERK, eIF2α, ATF4, ATF6, CHOP, and LC3, and inhibited the mRNA and protein expression levels of P62 proteins, which leads to ER stress and autophagy. The CdCl2 + Nar co-treatment group exhibited alleviated CdCl2-induced kidney injury, OS, ER stress, and autophagy. Research has demonstrated that Nar reduces CdCl2-induced kidney injury through alleviation of OS, ER stress, and autophagy.
研究领域:
兽医学
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药理学
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毒理学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
JOURNAL OF COORDINATION CHEMISTRY
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2014
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IF 2.212
Yu Jin,Chun-Hua Yu,Wen Zhang
Protonated benzylamine and its N-methylated derivatives, [C6H5CH2NH3−n(CH3)n]+ (n = 0−3), have been adopted as cations in chlorocadmate(II) and chlorocuprate(II) complexes, showing inorganic–organic hybrid architectures. For the Cd(II) compounds, the anionic structures vary from perovskite-type layers (n = 0) to chains (n = 1–3). For Cu(II) compounds, the anionic structures range from perovskite-type layers (n = 0), chains (n = 1) to mononuclear species (n = 2–3). Coordination geometries of the metal ions and intermolecular interactions have been analyzed. Their dielectric properties have been measured.
研究领域:
无机化学
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材料科学
✓ 已验证
DOI
高影响因子
ASIAN JOURNAL OF ANDROLOGY
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2016
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IF 2.644
Xiao-Ran Liu,Yue-Ying Wang,Hai-Rui Fan,Can-Jie Wu,Ashok Kumar,Li-Guo Yang
β-cryptoxanthin (CRY), a major carotenoid of potential interest for health, is obtained naturally from orange vegetables and fruits. A few research studies have reported that CRY could decrease oxidative stress and germ cell apoptosis. The purpose of this study was to examine the effects of CRY on acute cadmium chloride (CdCl 2 )-induced oxidative damage in rat testes. For this study, 24 rats were divided into four groups, one of which serves as a control group that received intraperitoneal (i.p.) injections of corn oil and physiological saline. The other rats were i.p. injected with CRY (10 μg kg −1 ) every 8 h, beginning 8 h before CdCl 2 (2.0 mg kg −1 ) treatment. The pathological and TUNEL findings revealed that CRY ameliorated the Cd-induced testicular histological changes and germ cell apoptosis in the rats. Furthermore, the Cd-induced decrease in the testicular testosterone (T) level was attenuated after CRY administration ( P < 0.05). The administration of CRY significantly reversed the Cd-induced increases in the lipid peroxide (LPO) and malondialdehyde (MDA) levels ( P < 0.01). The testicular antioxidants superoxide dismutase (SOD), catalase (CAT) and glutathione (GSH) were decreased by treatment with Cd alone but were restored by CRY co-treatment. These results demonstrated that the application of CRY can enhance the tolerance of rats to Cd-induced oxidative damage and suggest that it has promised as a pharmacological agent to protect against Cd-induced testicular toxicity.
研究领域:
毒理学
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生殖生物学
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药理学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
CELL AND TISSUE RESEARCH
·
2022
·Vol. 390
·期 2
·293-313
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IF 4.051
Li Zhen-Fang,Hao Shuang-Li,Wang Lan-Min,Qi Hong-Yu,Wang Jia-Ming,Tan Fu-Qing,Yang Wan-Xi
Spermatogenesis is a finely regulated process of germ cell proliferation and differentiation that leads to the production of sperm in seminiferous tubules. Although the mammalian target of rapamycin (mTOR) signaling pathway is crucial for spermatogenesis in mammals, its functions and molecular mechanisms in spermatogenesis remain largely unknown in nonmammalian species, particularly in Crustacea. In this study, we first identified es-Raptor (the core component of mTOR complex 1) and es-Rictor (the core component of mTOR complex 2) from the testis of Eriocheir sinensis . Dynamic localization of es-Raptor and es-Rictor implied that these proteins were indispensable for the spermatogenesis of E. sinensis. Furthermore, es-Raptor and es-Rictor knockdown results showed that the mature sperm failed to be released, causing almost empty lumens in the testis. We investigated the reasons for these effects and found that the actin-based cytoskeleton was disrupted in the knockdown groups. In addition, the integrity of the testis barrier (similar to the blood-testis barrier in mammals) was impaired and affected the expression of cell junction proteins. Further study revealed that es-Raptor and es-Rictor may regulate spermatogenesis via both mTORC1- and mTORC2-dependent mechanisms that involve es-rpS6 and es-Akt/es-PKC, respectively. Moreover, to explore the testis barrier in E. sinensis , we established a cadmium chloride (CdCl 2 )–induced testis barrier damage model as a positive control. Morphological and immunofluorescence results were similar to those of the es-Raptor and es-Rictor knockdown groups. Altogether, es-Raptor and es-Rictor were important for spermatogenesis through maintenance of the actin filament network and cell junctions in E. sinensis.
研究领域:
分子生物学
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生殖生物学
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甲壳动物学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
ENERGY & FUELS
·
2024
·
IF 5.2
Haixuan Gao,Chuanhe Ma,Jinhui Zhang,Jinchun Jiang,Ye Chen,Lin Sun,Hailong Wang
In the prior art of CZTSSe solar cells, the traditional cadmium salt (Cd-salt) CdSO4 is widely considered as a common raw material for preparing CdS buffer layers. However, in this study, we systematically demonstrated the phase structure and transmission spectra improvement effect of the other three types of Cd-salts, Cd(NO3)2, CdCl2, and CdAc2, on the CZTSSe/CdS heterojunction (HJT) compared to CdSO4. CZTSSe/CdS HJT prepared by Cd(NO3)2 showed the strongest CdS phonon characteristic peaks at 295.9 and 597.6 cm–1, indicating a pure crystal phase. The transmittance of CdS films prepared by Cd(NO3)2 is 20–35% higher than the other three Cd-salts in the light range of 350–1000 nm, which effectively improved the band gap of the films (2.41 eV) and depressed the photon absorption and scattering. Accordingly, CZTSSe solar cells based on the aforementioned Cd-salts showed that Cd(NO3)2 possessed the best ability to improve the photovoltaic conversion efficiency (PCE), about 5.7% more than the traditional CdSO4 salt. After Sn2+ replaced by Sn4+ in the precursor solution, the PCE of CZTSSe solar cells using Cd(NO3)2 exceeded 10% (Total area = 0.21 cm2, PCE = 10.23%, VOC = 0.485 V, JSC = 31.4 mA/cm2, FF = 67.1%, without MgF2 antireflective layer).
研究领域:
材料科学
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光伏技术
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可再生能源
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半导体物理
✓ 已验证
产品关联
DOI
高影响因子
SCIENCE OF THE TOTAL ENVIRONMENT
·
2022
·
IF 10.753
Yingxia Hu,Haijie Wu,Chenying Lu,Hanqing Xu,Boyang Li,Wanchun Guan,Mingjiang Wu,Yitian Gao,Haibin Tong
Cadmium (Cd) is a widely distributed toxic heavy metal that enters the environment via anthropogenic mobilization and accumulates in plants and animals, causing metabolic abnormalities even mortality. Although the toxic effects and stress damage of cadmium have been investigated extensively over the past few decades, research on its ability to trigger ferroptosis, growth retardation, and behavioral abnormalities is insufficient. As a result, the effects of CdCl 2 exposure on growth and development, activity and sleep, and ferroptosis in this study were examined in fruit fly ( Drosophila melanogaster ). When exposed to 0.5 mM CdCl 2 , the entire growth period from larvae to adults was prolonged, and the rates of pupation and eclosion were decreased. Additionally, CdCl 2 exposure resulted in a decrease in body weight and individual size of fruit fly and high lethality rate. Moreover, CdCl 2 exposure altered fruit fly behavior, including decreased activity and increased sleep duration, particularly in females. Ferrostatin-1 (Fer-1) is a potent selective ferroptosis inhibitor that effectively slows lipid hydroperoxide accumulation to rescue body size reduction and restore activity and sleep in CdCl 2 -exposed female flies. CdCl 2 exposure could induce ferroptosis in fruit fly mechanistically, as evidenced by inhibition of Nrf2 signaling pathway, accumulation of lipid peroxidation, impairment of GPX4 antioxidant system, and upregulation of iron metabolism. Our findings suggest that Cd exposure triggers ferroptosis, which leads to growth retardation and behavioral disorders in fruit fly.
研究领域:
毒理学
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发育生物学
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神经科学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Journal of the American Chemical Society
·
2020
·
IF 14.612
Zhong-Xia Wang,Hua Zhang,Fang Wang,Hao Cheng,Wen-Hui He,Yu-Hua Liu,Xue-Qin Huang,Peng-Fei Li
Piezoelectric materials with inherent mechanical–electric coupling effect are a crucial family of functional materials in high-end information technology. For practical applications, the transverse piezoelectric performance (d31 or d32) is mainly considered, because this parameter is a vitally important index to characterize the performance of piezoelectric thin films. However, the transverse piezoelectricity of the thin films as a key figure of merit is seldom mentioned in molecular ferroelectrics. Herein, we report that a new 1D halide perovskite ferroelectric N,N-dimethylallylammoniumCdCl3 (DMAACdCl3) exhibits an above room-temperature ferroelectric phase transition with a saturated polarization of 1.9 μC cm–2 and a coercive field of 5.0 kV cm–1. The thin film of DMAACdCl3 is successfully fabricated using an easy processing spinning method and maintains well ferroelectric properties verified by piezoresponse force microscopy (PFM). More significantly, the ferroelectric thin film offers superior transverse piezoelectricity with an in-plane piezoelectric response of about 41 pC N–1, which is about twice that of well-known piezoelectric polymer PVDF (21 pC N–1). Transverse piezoelectricity has been scarcely studied in molecular ferroelectrics, and its exploitation would play an important role in the design of next-generation smart piezoelectric devices.
研究领域:
材料科学
·
凝聚态物理
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应用物理
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纳米技术
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铁电学
·
薄膜技术
✓ 已验证
DOI
高影响因子
危险品化学品经营许可证（带存储）