PHYTOCHEMISTRY
·
2023
·
IF 3.8
Song Ang,Chun Liu,Peng Hong,Lei Yang,Gui'e Hu,Xi Zheng,Jingwei Jin,Rihui Wu,Wing-Leung Wong,Kun Zhang,Lishe Gan,Dongli Li
Four previously undescribed hirsutinolide-type sesquiterpenoids , cyanolides A-D ( 1 – 4 ), along with twelve known analogues ( 5 – 16 ), were isolated from the aerial parts of Cyanthillium cinereum . Their structures were determined by comprehensive analysis of NMR, HRESIMS, and ECD spectra. Compound 1 is a rarely occurring hirsutinolide-type sesquiterpenoid with 1,4-ether ring ruptured and containing a chlorine atom , and compounds 13 – 16 were reported from this plant for the first time. All compounds were tested for their inhibiting effects on prostate cancer cells. As a result, compounds 1 , 3 , and 8 – 14 exhibited significant anti-prostate cancer activity against PC-3 and LNCaP cells with IC 50 values ranging from 2.2 ± 0.4 to 8.5 ± 0.7 μM and 3.0 ± 0.7 to 10.5 ± 1.1 μM, respectively. The preliminary structure-activity relationship was discussed. Further investigation showed that compound 1 induced apoptosis in PC-3 cells.
研究领域:
植物化学
·
肿瘤学
·
药理学
✓ 已验证
DOI
PubMed
高影响因子
JOURNAL OF HAZARDOUS MATERIALS
·
2024
·
IF 12.2
Han Zhang,Yinyin Zhang,Luxiang Zhu,Yanan Liu
The frequent detection of 6:2 chlorinated polyfluorinated ether sulfonate (F-53B) in various environments has raised concerns owing to its comparable or even higher environmental persistence and toxicity than perfluorooctane sulfonate (PFOS). This study investigated the plasma degradation of F-53B for the first time using a water film plasma discharge system. The results revealed that F-53B demonstrated a higher rate constant but similar defluorination compared to PFOS, which could be ascribed to the introduction of the chlorine atom . Successful elimination (94.8–100 %) was attained at F-53B initial concentrations between 0.5 and 10 mg/L, with energy yields varying from 15.1 to 84.5 mg/kWh. The mechanistic exploration suggested that the decomposition of F-53B mainly occurred at the gas-liquid interface, where it directly reacted with reactive species generated by gas discharge . F-53B degradation pathways involving dechlorination , desulfonation , carboxylation , C-O bond cleavage , and stepwise CF 2 elimination were proposed based on the identified byproducts and theoretical calculations. Furthermore, the demonstrated effectiveness in removing F-53B in various coexisting ions and water matrices highlighted the robust anti-interference ability of the treatment process. These findings provide mechanistic insights into the plasma degradation of F-53B, showcasing the potential of plasma processes for eliminating PFAS alternatives in water.
研究领域:
环境科学
·
化学工程
✓ 已验证
产品关联
DOI
PubMed
高影响因子
ACS Earth and Space Chemistry
·
2024
·
IF 2.9
Cici Fan,Weigang Wang,Bo Shi,Zheng Sun,Maofa Ge
The relative rate method was used to determine the rate constant of Cl atoms and 3-buten-1-ol at ambient temperature and pressure. The main products of the reaction were identified as HCOOH with a yield of (50.07 ± 2.65)%, HCHO with a yield of (18.24 ± 0.65)%, HOCH2CHO with a yield of (18.69 ± 0.68)%, ClCH2CHO with a yield of (7.64 ± 0.25)%, respectively. The rate constant was (3.04 ± 0.36) × 10–10 cm3 molecules–1 s–1. The calculated theoretical rate constant was 2.91 × 10–10 cm3 molecules–1 s–1, which was in agreement with the experimental results. Moreover, the theoretical calculation showed that the two Cl-addition pathways were the main reaction pathway, but the proportion of H-abstraction pathways reached 29%, and its importance cannot be ignored. Based on this, the possible reaction mechanisms were deduced. The atmospheric implications of the obtained title reaction were briefly discussed.
研究领域:
大气化学
·
物理化学
✓ 已验证
产品关联
DOI
高影响因子
MICROPOROUS AND MESOPOROUS MATERIALS
·
2025
·
IF 4.7
Jilong Peng,Xunqian Zhang,Rongqing Qin,Fang Lai,Na Shi,Qinggang Ren,Kungang Chai
In the petrochemical industry, efficiently achieving one-step purification of ethylene (C 2 H 4 ) from propylene (C 3 H 6 ) or ethane (C 2 H 6 ) is a highly sought-after yet challenging task. Herein, we present a chlorine-rich Zn-based metal-organic framework (DMOF-1-Cl 2 ) that retains the essential topology of the parent DMOF-1 through the incorporation of 2,5-dichloroterephthalate linkers. The chlorine atoms within the square pores of DMOF-1-Cl 2 , due to their high electronegativity, serve as potential adsorption sites. Gas adsorptive experiments revealed its preferential adsorption of C 3 H 6 and C 2 H 6 over C 2 H 4 at different temperatures. Ideal adsorption solution theory calculation revealed that the selectivity of DMOF-1-Cl 2 for C 3 H 6 /C 2 H 4 and C 2 H 6 /C 2 H 4 reaches 20.8 and 2.2 at 313 K, respectively, outperforming its counterpart (DMOF-1-Br 2 ) and most previously reported adsorbents. Theoretical calculations indicated that the gas molecules are primarily distributed around the chlorine atoms with multiple interactions. Furthermore, dynamic breakthrough experiments fully demonstrated the actual potential for achieving one-step purification of polymer-grade C 2 H 4 , in which DMOF-1-Cl 2 displayed high productivity of 206.1 and 31.6 L kg −1 from C 3 H 6 /C 2 H 4 (2/5, v/v) and C 2 H 6 /C 2 H 4 (1/9, v/v), respectively. Despite the fact that the yield of C 2 H 4 separation from C 2 H 6 /C 2 H 4 mixtures is not extremely high, it still remains at a satisfactory level, demonstrating the practical value and potential of DMOF-1-Cl 2 for industrial applications.
研究领域:
材料科学
·
化学工程
✓ 已验证
产品关联
DOI
高影响因子
POLYMER DEGRADATION AND STABILITY
·
2014
·
IF 2.633
Si Chen,Xiaopeng Xu,Jiahuan Zhang,Wei Tang,Yingjun Qu,Xu Wang
A series of novel ureido organic stabilizers for poly(vinyl chloride) (PVC) with different length of alkyl chains, including N,N' -bis(phenylcarbamoyl)ethylenediamine (NA2), N,N' -bis(phenylcarbamoyl)butylenediamine (NA4) and N,N' -bis(phenylcar- bamoyl)hexamethylenediamine (NA6) were designed and synthesized, which have greater stabilizing efficiency compared with Ca/Zn stabilizers and phenylurea at the same concentration in PVC mixtures. The results of Congo red test, discoloration test, thermogravimetric analysis (TGA) and Fourier transform infrared (FTIR) spectra showed that the ureido moieties of NAn ( n = 2, 4, 6) have stronger ability to replace the labile chlorine atoms in PVC chains, but weaker ability to absorb hydrogen chloride (HCl) than those in phenylurea . On the other hand, longer alkyl chains in the synthesized organic stabilizers had positive effect in stabilizing efficiency for PVC, which was proved by the results that NA6 was the most efficient stabilizer among the present study, followed by NA4 and NA2. Furthermore, mixing the model compound NA6 with zinc stearate in different mass ratios led to a true synergistic effect, the “zinc burning” of PVC products was remarkably postponed.
研究领域:
高分子科学
·
材料化学
✓ 已验证
产品关联
DOI
高影响因子
危险品化学品经营许可证（带存储）