JOURNAL OF CHEMICAL RESEARCH
·
2018
·
IF 0.668
Can Jin,Feng Wang,Bin Sun,Xiaohui Zhuang
A novel method for the preparation of N-chloroaldimines from commonly available aromatic aldehydes has been developed. The reaction proceeded effectively by two steps: aldehydes were initially transformed into imines and then chloro-substitution with NaClO2 gave the N-chloroaldimines. This simple protocol allows for the preparation of a variety of aromatic N-chloroaldimines in moderate to excellent yields without the isolation of the imine intermediate. We also found that 3-nitrobenzaldehyde and 4-cyanobenzaldehyde were converted into the related benzonitrile directly under the standard conditions.
研究领域:
有机化学
·
合成化学
✓ 已验证
产品关联
DOI
高影响因子
JOURNAL OF COORDINATION CHEMISTRY
·
2016
·
IF 1.756
Xiuling Xu,Saisai Yan,Fan Hu,Wei Zhao,Qi Shuai
Three calcium coordination compounds, [Ca(CPA)(H2O)4]·(CPA), 1, [Ca(MCPA)2(H2O)2]·H2O, 2, and [Ca(TCPA)2(H2O)3]·2H2O, 3 [HCPA = 3-chlorophenoxyacetic acid, HMCPA = 2-methyl-4-chlorophenoxyacetic acid, and HTCPA = 2,4,6-trichlorophenoxyacetic acid], have been synthesized by the microwave method with advantages that include shorter reaction times, lower energy consumption, and higher product yield. The structures have been characterized by IR, elemental analysis, and single-crystal X-ray diffraction. Influences on the crystal structures by changing the number and position of chlorine substituent group in phenoxyacetic acid are discussed. Steric hindrance effects involving the Cl and an ability to form the O–H⋯Cl hydrogen bonds enrich the structure diversity. TG analysis reveals that the thermostability for the three compounds is 3 > 1 > 2, which could be influenced by the existence of hydrogen bonds (O–H⋯Cl and O–H⋯O).
研究领域:
无机化学
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材料科学
✓ 已验证
产品关联
DOI
高影响因子
CHEMICAL ENGINEERING JOURNAL
·
2023
·
IF 15.1
Yunning Chen,Zhengkai Wu,Renquan Guan,Xueying Cheng,Qingkun Shang,Yingnan Sun
Improving the efficiency of photogenerated charge separation and transport is the primary goal of designing and constructing efficient composite photocatalysts. The matching of energy bands and the formation of chemical bond between the two components are very conducive to the separation and transmission of photogenerated charges. Herein, three perylene diimide derivatives (PDIs) are synthesized by introducing sulfonic acid group (PDI-SA) and benzenesulfonic acid (PDI-BSA) respectively into the amide bond and further chlorine bay-substituting (Cl-PDI-BSA). The good water solubility of Cl-PDI-BSA ensures its forms a stable chemical bond with TiO 2 through the sulfonic acid group in the single molecular state, coupled with the matching of energy band structure, TiO 2 @Cl-PDI-BSA exhibited excellent performance upon visible light photocatalytic degradation to phenol and trenbolone acetate (TBA). It can remove 100% of phenol in 15 min and 100% trenbolone acetate (TBA) in 30 min, which is 14.3 times that of TiO 2 . Combining to DFT calculation, Kelvin probe force microscope and EPR analysis prove that bay chlorine substitution has a greater impact on the energy band structure and electron cloud distribution of PDIs than N-sulfonation, thereby seriously affecting the transport of photogenerated carriers with TiO 2 .
研究领域:
材料科学
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环境科学
·
化学
✓ 已验证
产品关联
DOI
高影响因子
ACS Applied Materials & Interfaces
·
2023
·
IF 9.5
Weijian Tang,Guojun Zhou,Chengzhi Hu,Afei Li,Zhangxian Chen,Zeheng Yang,Jianhui Su,Weixin Zhang
Owing to the capacity boost from anion redox activities, cation-disordered rock-salt oxides are considered as potential candidates for the next-generation of high energy density Li-ion cathode materials. Unfortunately, the anion redox process that affords ultra-high specific capacity often triggers irreversible O2 release, which brings about structural degradation and rapid capacity decay. In this study, we present a partial chlorine (Cl) substitution strategy to synthesize a new cation-disordered rock-salt compound of Li1.225Ti0.45Mn0.325O1.9Cl0.1 and investigate the impact of Cl substitution on the oxygen redox process and the structural stability of cation-disordered rock-salt cathodes. We find that partial replacement of O2– by Cl– expands the cell volume and promotes anion redox reaction reversibility, thus increasing the Li+ ion diffusion rate and suppressing irreversible lattice oxygen loss. As a result, the Li1.225Ti0.45Mn0.325O1.9Cl0.1 cathode exhibits significantly improved cycling durability at high current densities, compared with the pristine Li1.225Ti0.45Mn0.325O2 cathode. This work demonstrates the promising feasibility of the Cl substitution process for advanced cation-disordered rock-salt cathode materials.
研究领域:
材料科学
·
电化学
✓ 已验证
DOI
高影响因子
MOLECULES
·
2025
·Vol. 30
·期 11
·2333
·
IF 4.6
Shuxin Tang,Yating Zhang,Jun Xia,Jing Qi,Fan Tang,Fei Zhai,Liqi Dong
The development of photoactive molecules for photothermal energy storage is a focus of research in solar energy utilization technology. Azobenzene photoswitch has emerged as a promising candidate for solar energy conversion and storage due to its unique photoisomerization characteristics. Nonetheless, a majority of azobenzene-based molecular photothermal systems have a significant drawback: they depend on ultraviolet light forE-to-Zisomerization to store photon energy rather than visible light, which seriously hinders the development of azobenzene photoswitch in practical solar energy utilization applications. In this study, an azobenzene photothermal molecule that can effectively store visible-light photon energy was design and synthesized, which includes atetra-ortho-chlorinated azo structure as the “head” part and an alkyl chain atpara-position as the “tail” part. The ultraviolet–visible and1H NMR spectrum indicated that the obtainedtetra-ortho-chlorinated azobenzene photothermal molecule could effectively absorb and store photon energy under 550 nm irradiation and release the stored energy upon 430 nm light irradiation. The storage energy density of the charged azobenzene photothermal molecule was determined to be 13.50 kJ/mol through differential scanning calorimetry and 28.21 kJ/mol via density functional theory theoretical calculations. This discrepancy was ascribed to the 64% Z-isomer yield harvesting during the charging process. Furthermore, the obtainedtetra-ortho-chlorinated azobenzene exhibited long-term energy storage (approximately 11 days of half-life) and cyclic stability (100 cycles). Notably, theE-isomer oftetra-ortho-chlorinated azobenzene exhibited a high degree of supercooling, which may be advantageous for use in extremely low-temperature environments.
研究领域:
太阳能材料
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光化学
·
储能技术
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有机合成
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热能转换
✓ 已验证
产品关联
DOI
PubMed
高影响因子
DRUG DEVELOPMENT RESEARCH
·
2018
·Vol. 79
·期 6
·307-312
·
IF 2.646
Zi-Li Ren,Hao Liu,Di Jiao,Hao-Tian Hu,Wei Wang,Jie-Xiu Gong,Ai-Li Wang,Hai-Qun Cao,Xian-Hai Lv
Hit, Lead & Candidate Discovery To discover succinate dehydrogenase inhibitors with a novel structure, we introduced cinnamic acid structure to optimize the lead structure 1 and synthesized four series of cinnamon–pyrazole carboxamide derivatives. The bioassay data showed that compounds (E)-N-(1-[4-chlorophenyl]-4-cyano-1H-pyrazol-5-yl)-3-(2-fluorophenyl) acrylamide ( 5III-d) and (E)-3-(2-chlorophenyl)-N-(1-[4-chlorophenyl]-4-cyano-1H-pyrazol-5-yl) acrylamide ( 5III-f) showed the significant antifungal activity against three fungi. In addition, 5III-d and 5III-f exhibited the excellent inhibitory effect against succinate dehydrogenase (SDH) enzymes with IC 50 values ranging from 19.4 to 28.7 μM. The study demonstrates that the chlorine substituent group is present on both the phenyl and pyrazole rings that have a very good effect on the antifungal effect, and the compounds 5III-d and 5III-f can act as potential SDH inhibitors (SDHI) and throw a sprat for a new generation of SDHI.
研究领域:
药物化学
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微生物学
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植物保护学
✓ 已验证
DOI
PubMed
高影响因子
Advanced Energy Materials
·
2025
·
IF 26
Wenjing Wang,Hao Liang,Ye Ding,Haobo Wu,Wei Zhou,Xin Wen,Mingyu Ma,Wenzhuo Li,Gaoqi Liu,Siyu Ye,Weixuan Liu,Zhiyi Yao,Haitao Lang,Yunlong Liu,Ruiqi Xu,Wenjia Zhou,Xunzhong Wang,Zhijun Ning
Self-assembled monolayers (SAMs) have emerged as highly promising hole transport layers for inverted perovskite solar cells, owing to their low parasitic absorption and effective charge extraction. However, their inherent strong hydrophobicity often inhibits the quality and uniformity of perovskite films and induces defects at the buried interface. In this study, a chlorine-substituted all-hydrophilic molecule is introduced to modify the buried interface. Such decoration transforms the hydrophobic SAM into a super-hydrophilic surface, significantly enhancing the quality and uniformity of perovskite films. This chlorine-substituted molecule exhibits a strong coordination with lead ions and effectively passivates defects at the buried interface of perovskite films. As a result, the single-junction wide-bandgap (1.67 eV) perovskite solar cell achieves a power conversion efficiency of 23.97%, the highest value achieved for MeO-2PACz-based devices. Furthermore, the perovskite-silicon tandem solar cell reaches an efficiency of 31.12%. Additionally, the applicability of chlorine-functionalized all-hydrophilic molecule at the buried interface modification is demonstrated to various SAMs (4PADCB, 2PACz and Me-4PACz) and narrower- or wider-bandgap (1.61, 1.68, and 1.72 eV) perovskite solar cells. This work presents a promising strategy to overcome the challenges associated with SAM-based perovskite solar cells, paving the way for further performance advancement.
研究领域:
材料科学
·
光伏技术
·
表面化学
·
纳米材料
·
能源材料
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半导体器件
·
界面工程
✓ 已验证
DOI
高影响因子
CHEMICAL ENGINEERING JOURNAL
·
2023
·
IF 15.1
Xiaoying Feng,Yixin Kuang,Suxin Zhou,Juan Zheng,Gangfeng Ouyang
The substitution position of functional group is potential to affect the microstructure and adsorption performance of functionalized polystyrene (PS) nanospheres, yet to be explored. In this study, a series of hyper-crosslinked PS nanospheres with isomeric chlorine substitution have been prepared by emulsion polymerization and Friedel-Crafts reaction. The detailed characterizations indicated that the substitution position of chlorine greatly influenced the pore volume and specific surface area of constructed PS nanospheres, and the hyper-crosslinked ortho -Cl-functionalized nanospheres ( o - x ClFNs) possessed the highest specific surface area and largest pore volume, followed by para - and meta -Cl-functionalized nanospheres ( p - x ClFNs and m - x ClFNs). Besides, these PS nanospheres were fabricated as even solid phase microextraction (SPME) coatings to study their extraction performance for substituted benzenes, chlorobenzenes, polychlorinated biphenyls (PCBs) and polybrominated biphenyls (PBBs). The experimental results showed that the p - x ClFNs possessed the most outstanding extraction efficiencies for halogenated organic pollutants, and it was combined with gas chromatography-mass spectrometry (GC–MS) to develop a highly sensitive method, realizing the precise quantifications of trace PCBs and PBBs in environmental water. Our work provided invaluable insights on the choice of functional monomer to construct high-performance adsorbent, also demonstrated the important function of PS on the enrichments of organic pollutants.
研究领域:
材料科学
·
环境科学
·
分析化学
✓ 已验证
产品关联
DOI
高影响因子
MEDICINAL CHEMISTRY RESEARCH
·
2025
·
IF 3.1
Wu Xinhua,Wu Lifang,Li Zhaoquan,Tian Wei,Li Tao
Three series of (dimethyl-, dibutyl-, and diphenyl-) new organotin(IV) complexes based on chlorine substituted aryl ligands were synthesized and characterized by UV, 1 H NMR, 13 C NMR, 119 Sn NMR, HRMS, and X-ray crystallography analysis. MTT results showed that chlorine substitution at different positions on the aryl group exhibited different anticancer activities. Among them, 5-chloro substituents > 3,5-dichloro substituents > 3-chloro substituents on the aryl ring of salicylaldehyde on Schiff base ligand. In addition, different substituents on the tin atom also demonstrated extreme differences in anticancer activities, where dibutyltin > diphenyltin > dimethyltin. Interestingly, the complex LTDB2 exhibited excellent anti-proliferative activity against breast cancer MDA-MB-231 cells (superior to cisplatin) and lower toxicity against human embryonic kidney HEK-293 cells in vitro. Flow cytometry showed that LTDB2 not only induced apoptosis, but also induced cell cycle arrest in G2 phase. These findings provide new insights for further research and development of novel organotin(IV) complexes as anticancer drugs. Complex LTDB2 exhibited excellent anti-proliferative activity against breast cancer MDA-MB-231 cells in vitro and was superior to cisplatin. Flow cytometry showed that LTDB2 not only induced apoptosis, but also induced cell cycle arrest in G2 phase.
研究领域:
化学
·
药理学
·
肿瘤学
·
材料科学
✓ 已验证
DOI
高影响因子
危险品化学品经营许可证（带存储）