ANALYTICAL AND BIOANALYTICAL CHEMISTRY
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2020
·Vol. 412
·期 13
·3063-3071
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IF 3.637
Li Hongmei,Yue Xiaxia,Gao Ningning,Tang Jun,Lv Xiaoyi,Hou Junwei
Clopidol is one of the most widely used anti-coccidiosis drugs. Its residues in poultry products and the environment pose a serious threat to human health. In this work, microwave-assisted synthesis of magnetic ionic liquid/gold nanoparticles (MIL-Au NPs) as the SERS substrates were first designed for sensitive and reliable determination of clopidol residue in egg samples. The experiment shows that MIL(1-methyl-3-hexyl imidazole ferric tetrachloride ([C 6 mim]FeCl 4 )) and microwave play a key role in the dispersion and morphology of Au NPs. Under the optimal conditions, the as-prepared MIL-Au NPs were applied to the SERS detection of clopidol in methanol and egg solution and its detection limits can be as low as to 0.5 μg/kg (equal to 0.5 ppb) in both solutions. The standard curves with regression coefficients of 0.9298 and 0.93496 were constructed in the linear range of 100–1000 ppb and 0.5–50 ppb for clopidol in egg solutions. Moreover, satisfactory recoveries (97.5–103.2%) were obtained for egg samples. The developed SERS method provides a way for quantitation of clopidol and can be applied for the convenient, reliable, and highly sensitive detection of antibiotic residues in food and environment, which has great potential in food safety and biological monitoring.
Graphical abstract
研究领域:
分析化学
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食品安全
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环境科学
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DOI
PubMed
高影响因子
JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS
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2022
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IF 5.235
Xu Li,Rui Zhao,Di Shao,Yue Yuan,Shuyun Bi
The interaction properties of monensin/clopidol with bovine/human serum albumin (BSA/HSA) were determined via multispectral together with molecular modeling techniques in the report. Fluorescence quenching spectra at different temperatures and fluorescence lifetime determination demonstrated that the fluorescence quenching belonged to a static quenching type. In the case of monensin-BSA, clopidol-BSA, monensin-HSA and clopidol-HSA, the binding constants Ka (291 K) were 5.42 × 104, 4.96 × 104, 3.22 × 104 and 2.99 × 104 M−1, respectively; the binding distances r0 were 1.88, 2.53, 2.19 and 2.02 nm, respectively. Monensin and clopidol bound strongly with BSA/HSA with binding free energies equal to −26.37/−25.11 and −26.11/−24.93 kJ mol−1, respectively. The spontaneous binding process was dominated by hydrogen bonds and van der Waals forces as reflected in thermodynamic parameters analyses. Synchronous, CD, FTIR and UV-vis spectra assays confirmed that serum albumins conformations were altered. Using competitive experiment, monensin/clopidol was observed to bind at site I of serum albumins, which were reconfirmed by the results of molecular modeling.Communicated by Ramaswamy H. Sarma
研究领域:
生物化学
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药物化学
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分子生物学
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PubMed
高影响因子
JOURNAL OF CHEMICAL THERMODYNAMICS
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2023
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IF 2.6
Fanfan Li,Yulu Chen,Yanxun Li,Yameng Wan,Xiaoqiang Gao,Jian Xiao,Shuxiu Ma,Yi Yu
The solid–liquid equilibrium data of 2,3-dichloropyridine(23DCP) in 14 pure solvents were measured making use of the laser dynamic monitoring at 278.15/283.15/288.15 K − 313.15 K with 0.1 MPa. The findings of this study showed that the solubility increase of 23DCP in 14 pure solvents had a positive relation with temperature, and the solubility order was 1,4-dioxane > dichloromethane > n-butyl acetate > ethyl acetate > methyl acetate > acetonitrile > n-butanol > isobutyl alcohol > n-propanol > isopropanol > ethanol > cyclohexane > methanol > n-hexane. The solubility data of 23DCP was operated by seven models (Van't Hoff, modified Apelblat, λh, Yaws, NRTL, NRTL-SAC, Wilson) to correlate. And the average ARD values were 1.684 %,1.058 %, 1.031 %, 0.905 %, 0.937 %, 1.012 %, 2.062 % and the average 10 3 RMSD values were 1.978, 1.396, 1.542, 1.221, 1.758, 1.658 and 1.883, respectively. In addition, Hansen solubility parameters were well evaluated to appraise the miscibility of 23DCP in 14 pure solvents. And the interactions between molecules were studied by means of molecular electrostatic potential surface, Hirshfeld surface analysis and density functional theory calculation. Finally, according to Van't Hoff equation, Δ sol G °, Δ sol H ° and Δ sol S ° of 23DCP in 14 pure solvents were got. Δ sol H ° and Δ sol S ° were bigger than zero, representing that this was a dissolution process of endothermic and entropy increase.
研究领域:
化学工程
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物理化学
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DOI
高影响因子
RSC Advances
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2017
·Vol. 7
·期 14
·8264-8271
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IF 3.108
Zhan Jiang,Kaihua Huang,Dian Yang,Shuai Wang,Hong Zhong,Chongwen Jiang
Mn3O4 hollow microspheres have been facilely prepared via a green synthesis of 2,3,5,6-tetrachloropyridine reduced from pentachloropyridine by manganese. The specific hollow microspheres were made by a H2 gas bubble-templating method presenting a high specific surface area (87.1 m2 g−1) and a big total pore volume (0.2030 cm3 g−1). The Mn3O4 hollow microspheres as an anode material demonstrate a good electrochemical performance, with a high reversible capacity of 646.9 mA h g−1 after 240 cycles at a current density of 200 mA g−1. The good cycling performance is attributed to numerous mesopores, high specific surface area and big total pore volume, which can offer good electrical contact and conductivity as well as accommodate the mechanism strains. In addition, the yield and selectivity of 2,3,5,6-tetrachloropyridine achieved up to 99.2% and 99.5%, respectively.
研究领域:
材料科学
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能源科学
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DOI
高影响因子
CHEMICAL RESEARCH IN CHINESE UNIVERSITIES
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2021
·Vol. 37
·期 3
·668-673
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IF 1.307
Feng Fan,Li Jing,Zhang Zhihui,Fu Jiaxu,Zhang Yumin,Gu Qiang
A n ultrasonic-assisted synthesis of bis-isoxazole derivatives was developed. Eight 3-(6-chloropyridin-3-yl)-5-{[(3-arylisoxazol-5-yl)methoxy]methyl}isoxazoles were synthesized by 1,3-dipolar cycloaddition reaction between substituted isoxazolyl alkyne compounds and 6-chloro- N -hydroxynicotinimidoyl chloride. The structures of the synthesized compounds were confirmed by HRMS, FTIR, 1 H and 13 C NMR spectroscopy. Wherein, the antifungal and antibacterial activities of target compounds were tested. The synthesized compounds 6 a and 6 h exhibited better antifungal activity in comparison with the standard drug itraconazole. The minimum inhibitory concentrations(MICs) of both compound 6 a and compound 6 h were both 4 µg/mL against Candida albicans ATCC 10231.
研究领域:
有机化学
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药物化学
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微生物学
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高影响因子
ENVIRONMENTAL SCIENCE & TECHNOLOGY
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2024
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IF 10.8
Ying Chen,Lei Tian,Wen Liu,Yi Mei,Qiu-Ju Xing,Yi Mu,Ling-Ling Zheng,Qian Fu,Jian-Ping Zou,Daishe Wu
Dechlorination of chloropyridines can eliminate their detrimental environmental effects. However, traditional dechlorination technology cannot efficiently break the C–Cl bond of chloropyridines, which is restricted by the uncontrollable nonselective species. Hence, we propose the carbonate species-activated hydrogen peroxide (carbonate species/H2O2) process wherein the selective oxidant (peroxymonocarbonate ion, HCO4–) and selective reductant (hydroperoxide anion, HO2–) controllably coexist by manipulation of reaction pH. Taking 2-chloropyridine (Cl–Py) as an example, HCO4– first induces Cl–Py into pyridine N-oxidation intermediates, which then suffer from the nucleophilic dechlorination by HO2–. The obtained dechlorination efficiencies in the carbonate species/H2O2 process (32.5–84.5%) based on the cooperation of HCO4– and HO2– are significantly higher than those in the HO2–-mediated sodium hydroxide/hydrogen peroxide process (0–43.8%). Theoretical calculations confirm that pyridine N-oxidation of Cl–Py can effectively lower the energy barrier of the dechlorination process. Moreover, the carbonate species/H2O2 process exhibits superior anti-interference performance and low electric energy consumption. Furthermore, Cl–Py is completely detoxified via the carbonate species/H2O2 process. More importantly, the carbonate species/H2O2 process is applicable for efficient dehalogenation of halogenated pyridines and pyrazines. This work offers a simple and useful strategy to enhance the dehalogenation efficiency of halogenated organics and sheds new insights into the application of the carbonate species/H2O2 process in practical environmental remediation.
研究领域:
环境科学
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化学工程
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PubMed
高影响因子
ELECTROCHIMICA ACTA
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2018
·
IF 5.116
Zhiqiao He,Yiwen Tong,Sulin Ni,Xincheng Ye,Chengetai Portia Makwarimba,Xinwen Huang,Shihan Zhang,Shuang Song
Pd was electro-deposited on Ni foam using nitrogen-doped carbon as an inter-layer (EDPd/CNx/Ni). The as-prepared material was employed as the cathode for the electrochemical dechlorination of 3,6-dichloropicolinic acid (3,6-D) in an aqueous solution. When compared to the electrodes that direct the electrodeposition or chemical deposition of Pd on Ni foam, EDPd/CNx/Ni exhibited higher activity and selectivity during the electrocatalytic hydrogenation of 3,6-D to form the intermediates 3-chloropicolinic acid and 6-chloropicolinic acid, as well as the final product, 2-picolinic acid. Furthermore, the modified electrode maintained its high dechlorinating activity after continuous operation for three batches. On the basis of physical-chemical characterization and electrochemical measurements, it is proposed that the superior performance of the EDPd/CNx/Ni electrode benefits sufficiently from the accelerated generation of adsorbed hydrogen ([H] ads ). The electrodeposition method facilitates the generation of Pd with a higher percentage of exposed {111} facets. The CNx functions as an efficient support for the enlargement of the electrochemically active surface area, the reduction of Pd particle size, and improvement of the Pd dispersion. Moreover, CNx may also act as an electrocatalyst for the water-splitting reaction and favors the stabilization of chemisorbed active hydrogen.
研究领域:
环境科学
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电化学工程
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DOI
高影响因子
危险品化学品经营许可证（带存储）