Materials Science & Engineering C-Materials for Biological Applications
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2018
·
IF 5.08
Xiuyan Wang,Yanyan Cao,Husheng Yan
Chlorambucil, a chemotherapeutic agent, is usually administered orally to treat chronic lymphocytic leukemia and some other types of cancers in regimens of conventional and metronomic chemotherapies. However, the hydrolytic instability of chlorambucil is a major limitation in achieving the optimum therapeutic performance. In this work, mesoporous polymeric microspheres were prepared by free radical suspension copolymerization of methyl acrylate and divinylbenzene in the presence of porogen. Chlorambucil was loaded into the mesoporous polymeric microspheres through adsorption of the drug in aqueous media with high loading capacity up to more than 350 mg/g. Chlorambucil-loaded mesoporous polymeric microspheres showed sustained release property in media simulating gastrointestinal fluids, with nearly zero order release kinetics. Furthermore, the mesoporous polymeric microspheres as carriers greatly stabilized chlorambucil against its hydrolysis. The hydrolyzation percentage of chlorambucil that was adsorbed on the microspheres after incubation for 36 h in media simulating gastrointestinal fluids was less than 10%, while more than 90% of free chlorambucil hydrolyzed after incubation in the same media for 4 h. The chlorambucil-loaded mesoporous polymeric microspheres may be used as oral sustained release formulations, especially as oral formulations for the application in metronomic chemotherapy.
研究领域:
药剂学
·
肿瘤学
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PubMed
高影响因子
JOURNAL OF CHROMATOGRAPHY A
·
2024
·
IF 3.8
Rui Shi,Yipeng Huang,Guihua Ruan,Zhengyi Chen,Yanqun Yang,Zhuqiang Wu
The distinctive morphology of dendritic mesoporous silica nanoparticles (DMSN) has recently attracted considerable attention in scientific community. However, synthesis of DMSN with well-defined structure and uniform size for ultrafast extraction of trace herbicide residues from environmental and food samples remains to be a compelling challenge. In this study, sulfhydryl functionalized dendritic mesoporous silica (SH-DMSN) was synthesized and the SH-DMSN showcases monodisperse microspheres with flower shape and precisely tailored and controllable pore sizes. This distinctive structural configuration accelerates mass transfer within the silica layer, resulting in heightened adsorption efficiencies. Furthermore, the particle sizes (455, 765, and 808) of the adsorbent can be meticulously fine-tuned by introducing distinct templates. Specifically, when the particle size is 765 nm, the optimized SH-DMSN exhibits a substantial specific surface area (691.32 m²/g), outstanding adsorption efficiencies (>90 %), remarkably swift adsorption and desorption kinetics (2 min and 3 min, respectively), and exceptional stability. The superior adsorption capabilities of this novel adsorbent, ranging from 481.65 to 1021.7 µg/g for organochlorine herbicides containing amide groups, can be attributed to the interplay of S-π interactions, halogen bonding, and electrostatic attraction interaction. These interactions involve the lone pair electrons of sulfhydryl and silanol groups with the π-electrons, halogen atoms and amide groups in herbicide molecules. This study not only offers a new perspective on advancing the practical utilization of dendritic mesoporous silica but also provides a pragmatic strategy for the separation and analysis of herbicides in diverse sample matrices.
研究领域:
材料科学
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环境科学
·
分析化学
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DOI
PubMed
高影响因子
Surfaces and Interfaces
·
2024
·
IF 5.7
Ziteng Huang,Yaru Li,Jun Mei,Yi Ding,Xianbiao Wang
To efficiently remove atrazine, it is crucial to facilitate synergistic adsorption effect between aromatic structure and hydrophilic adsorption sites through tuning surface hydrophilicity. Herein, we reported a polymer adsorbent which was synthesized by copolymerizing divinylbenzene (DVB) and methyl acrylate (MA) with different monomer ratio, and subsequently hydrolyzing the copolymer to obtain carboxyl group on its surface. The surface hydrophilicity could be easily adjusted by changing the ratio of monomer and the optimal feeding ratio was 4:1 (V DVB :V MA ) in terms of porosity (specific surface area 712.92 m 2 /g) and hydrophilicity regarding atrazine adsorption. The adsorption process followed the Langmuir isotherm with a maximum adsorption capacity of 75.75 mg/g. The mixed surface reaction and film diffusion model revealed that the adsorption procedure is dramatically controlled by film diffusion. Atrazine molecules diffusive and bound with porous adsorbent via strong hydrogen bonding between N (triazine and amine) and carboxyl groups introduced by copolymerization. Furthermore, high porosity caused by aromatic crosslinked network provided sufficient adsorption sites through π-stacking interaction. This work not only supplies a highly efficient adsorbent for atrazine removal but also enables a platform for preparation of polymers with tunable porosity and surface hydrophilicity.
研究领域:
环境科学
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材料科学
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DOI
高影响因子
MICROCHEMICAL JOURNAL
·
2024
·
IF 4.9
Guangping Xia,Yipeng Huang,Shi Yu,Bingmei Lai,Zhenyu Li,Guihua Ruan
The escalating use of herbicides containing chlorophenyl and acylamino (HCAs) in agriculture has intensified concerns regarding their environmental impact, underscoring the need for efficient and eco-friendly methods for their extraction and detection. This study introduces the synthesis of a novel N/S rich covalent organic framework (COF), DFT-TPB-COF, using 2,5-diformylthiophene and 1,3,5-tri(4-aminophenyl) benzene as building blocks. The as-synthesized COF is uniform, spherical and monodisperse, making it an ideal candidate as packed materials in solid-phase extraction column for HCAs extraction from complex environmental samples. The DFT-TPB-COFs show adsorption capabilities ranging from 2.52 to 30.34 mg g −1 for six HCAs, facilitated by π-π interactions, p-π interactions, hydrogen bonding, electrostatic interactions, and hydrophobic interactions. The adsorption–desorption process is rapid (10 min). Additionally, the presence of other types of herbicides showed little interference in the adsorption efficiency of DFT-TPB-COF for HCAs. A sensitive and reliable method combining the DFT-TPB-COFs-filled SPE column with HPLC-UV was developed for detection of six HCAs in various environmental water and soil samples. The method exhibited excellent linearity (1–200.0 ng mL −1 ) and low limits of detection (0.3–0.9 ng mL −1 ) for HCAs. This study not only demonstrates the potential of DFT-TPB-COFs as a suitable packed material in solid-phase extraction column, but also opens avenues for the practical application of COFs in the adsorption of organic pollutants.
研究领域:
环境科学
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材料科学
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DOI
高影响因子
LANGMUIR
·
2026
·
IF 3.9
Xiaowen Huang,Zhuqiang Wu,Yipeng Huang,Guihua Ruan,Ningli Tang
Flower-shaped covalent organic frameworks (COFs) with hierarchically porous structures are highly desirable for rapid and high-efficiency adsorption applications, yet precisely controlling the morphology of COFs to uniform and monodisperse flower shapes under mild conditions remains a significant challenge. Herein, tetrafluoro-p-benzoaldehyde and 4,4′,4″-(1,3,5-triazine-2,4,6-triyl)triphenylamine were used as building blocks for the controllable synthesis of hydrangea-shaped COFs at room temperature by solvent regulation. The use of aprotic solvents facilitated the formation of spherical COFs; however, the addition of a suitable fraction of nonpolar mesitylene in dioxane led to the formation of hydrangea-shaped COFs. The as-synthesized COFs were demonstrated to be good adsorbents for triazine and amide herbicides, benefiting from the hydrangea-shaped structure and rich triazine, imine, and tetrafluorobenzene groups for hydrogen bonding and reinforced π–π interactions. Coupling hydrangea-shaped COFs-based solid-phase extraction with high-performance liquid chromatography, analyses of five herbicides were realized in a wide linear range (1–100 μg/L) and low limits of detection (0.50–0.70 μg/kg). In addition, the relative recoveries of the analytes from spiked soil samples ranged from 85.48% to 103.64% with relative standard deviations less than 3.16%. This study elucidates the effects of solvent properties on the morphologies of COFs and provides inspiration for rational design and controllable synthesis of COFs with well-defined structures and functional groups by facile solvent regulation at room temperature to realize high sorption performances.
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高影响因子
JOURNAL OF SEPARATION SCIENCE
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2022
·Vol. 45
·期 14
·2687-2698
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IF 3.614
Hong Pan,Zushan Gan,Haoyun Hu,Cheng Liu,Yipeng Huang,Guihua Ruan
In this study, monodisperse magnetic carbon microspheres were successfully synthesized through the carbonization of phenolic resin encapsulated Fe 3 O 4 core-shell structures. The magnetic carbon microspheres showed high performance in ultrafast extraction and separation of trace triazine herbicides from environmental water samples. Under optimized conditions, both the adsorption and desorption processes could be achieved in 2 min, and the maximum adsorption capacity for simazine and prometryn were 387.6 and 448.5 μg/g. Coupled with high-performance liquid chromatography-ultraviolet detection technology, the detection limit of triazine herbicides was in the range of 0.30–0.41 ng/mL. The mean recoveries ranged from 81.44 to 91.03% with relative standard deviations lower than 7.47%. The excellent magnetic solid-phase extraction performance indicates that magnetic carbon microspheres are promising candidate adsorbents for the fast analysis of environmental contaminants.
研究领域:
分析化学
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环境科学
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PubMed
高影响因子
JOURNAL OF CHROMATOGRAPHY A
·
2023
·
IF 4.1
Haoyun Hu,Wenjuan Feng,Rui Shi,Hong Pan,Cheng Liu,Guihua Ruan,Yipeng Huang
Here, imine-linked covalent organic frameworks coated Fe 3 O 4 microspheres were fabricated and employed as the self-template to prepare magnetic porous carbon material. The magnetic solid phase extraction (MSPE) performance of such magnetic covalent organic frameworks derived porous carbons (CMCOFs) were studied for the first time, and the improved MSPE performance was verified. The variations of chemical and material properties in the carbonization processes were studied, and it was found that the CMCOFs carbonated at 400°C exhibited highest adsorption efficiencies for chlorine-containing herbicides due to the formation of nitrile components at this stage. The CMCOFs retained high adsorption efficiencies (above 90 %) to chlorine-containing herbicides at wide pH range (3–12) and high salt concentration. The CMCOFs-based MSPE coupled with HPLC technique was in good potential for analysis of trace chlorine-containing herbicides in soil samples. Under the optimized conditions, this approach displayed short extraction and elution time (5 and 8 min) and low limits of detection (0.35–5.5 ng/mL) for chlorine-containing herbicides. The recoveries of spiked analytes and the relative standard deviations in real soil samples were 81.86 %–110.9 % and less than 5.92 %, respectively. This study provides an efficient method for the analysis of trace chlorine-containing herbicides in complex samples, as well as give some inspiration on material modulation by controlled carbonization to achieve improved sorption performances.
研究领域:
环境科学
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材料科学
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DOI
PubMed
高影响因子
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