JOURNAL OF MATERIALS SCIENCE-MATERIALS IN ELECTRONICS
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2022
·Vol. 33
·期 9
·6456-6468
·
IF 2.779
Ni Yafei,Li Haoyue,Li Haimin,Zhuang Jia,Liu Xingchong,Zheng Ronghong,Zhao Shuangshuang,Zhang Hua,Wang Hanyu
It is crucial to promote crystallinity of active layer to improve stability and restrain non-radiative carrier recombination for high-quality perovskite solar cells (PSCs). Here, Chlorpheniramine Maleate (CM) interface layer is introduced between SnO 2 electron transport layer (ETL) and perovskite (PVK) film. The esterification between carboxyl group in CM and hydroxyl group on the surface of SnO 2 greatly enhances the surface evenness of SnO 2 , leading to enhanced smoothness of ETL; thus, the crystallinity of perovskite (PVK) film is validly improved. Meanwhile, the lone pair electrons of nitrogen element in pyridine group in CM coordinate with vacant orbit of Pb 2+ in perovskite that validly decreases the defects of active layer. Thus, the CM interface results into strong connection between PVK and ETL, which greatly enhances the performance and stability of PSCs. After CM modification, the PCE of the PSCs is increased from 19.29 to 21.12%. In addition, unencapsulated CM-modified devices demonstrate much better humidity stability than unmodified one due to high quality of the perovskite film. After 100 h under RH = 70 ± 5% in air condition, the SnO 2 -CM based device still remains 60% of its initial PCE, while the PCE of unmodified device totally breaks down after 72 h.
研究领域:
材料科学
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能源科学
·
化学工程
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DOI
高影响因子
SEPARATION AND PURIFICATION TECHNOLOGY
·
2024
·
IF 8.1
Junjing Li,Wanxin Dang,Yaqian Liu,Liang Wang
The efficiency of an electrocatalytic system with filtered Pd-loaded membrane electrodes was investigated to improve the mass transfer process of the electrocatalytic system. A Pd/CGC/Al 2 O 3 membrane electrode (5 mg·cm −2 graphite + 10 wt% graphene + 5 wt% carbon black) was prepared on the tubular Al 2 O 3 membrane substrate. The results showed that the membrane electrode could realize the complete removal of chlorpheniramine maleate (CPM) 120 min. Furthermore, the Pd/CGC/Al 2 O 3 membrane electrode exhibited good tolerance to sulfites, and the electrocatalytic activity was almost unaffected in the presence of NO 3 – , Cl − , CO 3 2– , and HCO 3 – in the wastewater. The Pd/CGC/Al 2 O 3 membrane electrode surface was interconnected to form a three-dimensional porous membrane structure through the introduction of carbon materials. The membrane electrode had a larger specific surface area and the metal Pd nanoparticles were uniformly loaded on the surface of CGC/Al 2 O 3 tubular electrode. Combined with the analysis of quenching experimental data, the removal mechanism of CPM on Pd/CGC/Al 2 O 3 membrane electrode was proposed. The Pd/CGC/Al 2 O 3 membrane electrode had good stability over 7 cycles and could be adapted to the electrocatalytic hydrodechlorination of chlorinated PPCPs in different environments, which is promising for certain applications.
研究领域:
环境科学
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电化学
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材料科学
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产品关联
DOI
高影响因子
LWT-FOOD SCIENCE AND TECHNOLOGY
·
2020
·
IF 4.006
Nuo Duan,Shuo Qi,Yucong Guo,Wei Xu,Shijia Wu,Zhouping Wang
Clenbuterol hydrochloride (CLB), a kind of β-agonist, has been illegally used as a feed additive for growth promotion in the food industry in many countries. Herein, surface-enhanced Raman scattering (SERS) combined with aptamer recognition was used for the ultrasensitive and quantitative detection of CLB. Fe 3 O 4 @ [email protected] nanoparticles displaying strong SERS enhancement were synthesized and used as the active substrate. Aptamer against CLB was immobilized on the surface of the substrate to form the capture probe. The complementary DNA (cDNA) was linked to gold nanoparticles (AuNPs) carrying the Raman reporter 4-mercaptobenzoic acid (4-MBA) to form the signal probe. The detection of CLB was carried out by competitive binding between free CLB and cDNA linked on the signal probe with the aptamer immobilized on the capture probe. The SERS intensity was significantly improved by the coupling effect between the Fe 3 O 4 @ [email protected] and AuNPs, resulting in high sensitivity for the quantification assays with a limit of detection of 0.003 ng mL −1 . The recoveries of the CLB from spiked pork samples were 90.7–108.0% and the coefficients of variation (CV%) were 2.2–3.1%, demonstrating the high precision and accuracy of the assay.
研究领域:
分析化学
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食品安全
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纳米技术
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产品关联
DOI
高影响因子
CHEMICAL ENGINEERING JOURNAL
·
2015
·
IF 4.321
Lin Wang,Juan Yang,Yongmei Li,Juan Lv,Jinte Zou
Removal of chlorpheniramine in a nanoscale zero-valent iron (nZVI) induced heterogeneous Fenton system was investigated. The removal efficiency of chlorpheniramine depended on its initial concentration, initial pH, H 2 O 2 concentration and nZVI dose. Chlorpheniramine (⩽15 mg/L) was completely removed after 60 min oxidation under the following optimal conditions: initial pH = 3.0, H 2 O 2 concentration = 0.1 mM and nZVI dose = 22.4 mg/L. The degradation of chlorpheniramine fitted well with the pseudo first-order kinetics model, and the rate constants ( k obs ) were obtained ( R 2 > 0.9). Several degradation intermediates of chlorpheniramine were detected and confirmed, including 4-hydroxy-4-methyl-2-pentanone, 2-methylaminopyridine, 4-chlorophenol, 2-propionylpyridine, 2-acetylpyridine, 4-chlorophenyl-2-pyridyl ketone, dimethylamine (DMA) and N-nitrosodimethylamine (NDMA). Based on the identified intermediates, a tentative degradation pathway of chlorpheniramine in the nZVI/H 2 O 2 system was proposed. After nZVI/H 2 O 2 reaction, 52.2% of NDMA formation potential (FP) from chlorpheniramine was reduced. Therefore, nZVI as the catalyst used in the heterogeneous Fenton system is not only an alternative to remove chlorpheniramine, but also effective in reducing NDMA FP.
研究领域:
环境科学
·
化学工程
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DOI
高影响因子
JOURNAL OF CHROMATOGRAPHIC SCIENCE
·
2021
·Vol. 59
·期 4
·388-395
·
IF 1.618
Ma Xiaofei,Li Jingtang,Li Xiaoqi,Feng Zijie,Yang Xuan,Liu Jie,Du Yingxiang
Nowadays, ionic liquids (ILs) functionalized cyclodextrins (CDs) have drawn increasing attention in chiral separation. Herein, a novel β-CD derivative functionalized by L-histidinium IL, mono-6-deoxy-6-L-histidinium-β-cyclodextrin chloride (L-HMCDCl), was synthesized for the first time and utilized for enantioseparation of nefopam and chlorphenamine in capillary electrophoresis. The L-HMCDCl exhibited superior enantioselectivity compared with native β-CD. The effect of some key parameters such as chiral selector concentration, buffer pH and applied voltage on the enantioseparation was investigated in detail. In the interest of the chiral discrimination mechanism and the enhanced enantioselectivity of L-HMCDCl, molecular modeling with AutoDock was employed to study the interaction, which was in good agreement with experimental results.
研究领域:
分析化学
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药物化学
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手性科学
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产品关联
DOI
PubMed
高影响因子
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
·
2022
·
IF 3.571
Chengchen Zhang,Xiaofei Ma
This work presents a synergistic system for enantioseparation in capillary electrophoresis (CE) with a chiral ionic liquid (CIL) based on D-10-camphorsulfonic acid as additive and carboxymethyl-β-cyclodextrin (CM-β-CD) as the chiral selector. The proposed method showed excellent enantioseparation performance towards sixteen chiral drugs. In contrast to the single CM-β-CD system, the notably improved resolution (Rs) and selectivity factor (α) of model drugs were observed in synergistic system. Several key parameters such as CIL concentration, CM-β-CD concentration, buffer pH and separation voltage were investigated, after which Statistical Product and Service Solutions (SPSS) was used to prove the potential synergistic effect. The nuclear magnetic resonance (NMR) results further demonstrated the function of the CIL and the superiority of synergistic system. Finally, chiral impurity determination of chlorpheniramine maleate sample was successfully carried out using the established method.
研究领域:
分析化学
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药学
·
色谱学
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产品关联
DOI
PubMed
高影响因子
JOURNAL OF CHROMATOGRAPHIC SCIENCE
·
2022
·
IF 1.555
Zhao Shiyuan,Miao Panden,Zhang Jian,Gan Jie,Du Yingxiang,Chen Cheng,Sun Xiaodong,Feng Zijie,Ma Xiaofei,Ma Mingxuan,Xi Ying,Ding Wen
How to improve the enantiomer separation efficiency of drugs is a hot topic. In this paper, polydopamine (PDA) coating doped with graphene oxide (GO) by physical adsorption was used to modify the capillary column to enhance the enantioseparation efficiency of the drugs. In the capillary electrochromatography (CEC) system, the novel capillary column with carboxymethyl-β-cyclodextrin (CM-β-CD) as a chiral selector has completed the enantioseparation of four basic drugs (propranolol, metoprolol, amlodipine and chlorpheniramine). The optimum separation conditions were obtained by optimizing the pH of the buffer, the concentration of organic modifier, the concentration of the chiral selector and the voltage, and the resolution and peak shape were significantly improved compared with uncoated bare-fused column. The stability and reproducibility of the new capillary column were satisfactory and the relative standard deviation of intra-day and inter-day was <3.2%, and of column-to-column was <4.8%. The rich functional groups of GO are key factors to improve the enantioseparation efficiency, which also indicates that nanomaterials with easy modification of functional groups and large specific surface area are excellent resources for capillary modification applications.
研究领域:
分析化学
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纳米技术
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药学
·
色谱学
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产品关联
DOI
PubMed
高影响因子
JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES
·
2025
·
IF 2.8
Jing Lin,Dan Li,Peiyuan Luo,Laisheng Li
A bis (3,5-dichlorophenylureido)-β-cyclodextrin stationary phase (CUCDP) was prepared and characterized. It had strong chiral separation abilities for antihistamines ( R s = 1.61–2.58) in isocratic elution, including chlorpheniramine maleate, bromopheniramine maleate, promethazine hydrochloride and trimeprazine tartrate. Based on CUCDP, a new HPLC method for simultaneous separation and determination of the above eight antihistamine enantiomers ( R s = 1.58–1.92) in human plasma by gradient elution was established. The optimized conditions were as follows: a simple sample pretreatment with acetonitrile (ACN) to precipitate protein, a gradient elution of 0.5 % triethylammonium acetate (TEAA, pH = 4.0)-ACN as the mobile phase at a flow rate of 0.5 mL/min, column temperature at 20 °C, a photo-diode array detector (PDA) at 260 nm, and the sampling volume of 10 μL. The good linear relationships for all enantiomers were observed in the concetration range of 0.25–10.0 μg/mL ( R 2 = 0.9986–0.9993). The average recoveries were 84.80 %–103.30 % with the RSDs of 1.24 %–2.26 % ( n = 5). The limits of detection (LODs) and limits of quantification (LOQs) were 0.015–0.05 μg/mL and 0.05–0.15 μg/mL, respectively. At present, the reported cyclodextrin-based CSPs had not such separation ability for antihistamines by HPLC. However, the new CUCDP exhibited high chiral selectivity for antihistamines, which was mainly related to the introduction of bis phenylureido group into the rim of cyclodextrin, and the strengthening of hydrogen bonding, π–π stacking and inclusion between CUCDP and analytes. This method could save analysis time, reduce solvent consumption, and improve efficiency at low cost.
研究领域:
分析化学
·
药物分析
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色谱学
·
手性分离
·
药理学
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产品关联
DOI
PubMed
高影响因子
CHIRALITY
·
2022
·Vol. 35
·期 1
·58-66
·
IF 2.183
Haibo You,Ben Chen,Liqun Fang,Tingting Lin,Ping Xu,Chu Chu,Shengqiang Tong
Carboxymethyl-β-cyclodextrins (CM-β-CDs) with five kinds of degrees of substitution were synthesized and characterized. Analytical enantioseparation of six basic drugs containing N-alkyl groups, including pheniramine, chlorpheniramine, labetalol, propranolol, venlafaxine, and trans-paroxol, was achieved by reversed-phase high-performance liquid chromatography (RP-HPLC) using the synthesized CM-β-CD as chiral mobile phase additives. Key influence factors were optimized, including organic modifier, pH value, CM-β-CD with different degrees of substitution, and concentration of CM-β-CD. The mobile phase was composed of methanol and 10 mmol L −1 of phosphate buffer pH 4.0 containing 10 mmol L −1 of CM-β-CD. Peak resolution for six racemic drugs was gradually increased with an increasing degree of substitution of the synthesized CM-β-CD. The stoichiometric ratio and binding constants for the inclusion complex formed by CM-β-CD and enantiomer were determined, which showed that the stoichiometric ratio for each inclusion complex was 1:1.
研究领域:
分析化学
·
药学
·
色谱学
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产品关联
DOI
PubMed
高影响因子
MICROCHIMICA ACTA
·
2020
·Vol. 187
·期 3
·1-12
·
IF 6.232
Ma Mingxuan,Du Yingxiang,Yang Jiangxia,Feng Zijie,Ding Wen,Chen Cheng
Poly(glycidyl methacrylate)-co-(ethylene dimethacrylate) [poly(GMA-co-EDMA)] monoliths were prepared, and used as a support to attach gold nanoparticles (AuNP) via Au-S bond. Pepsin, acting as a chiral selector, was linked to the surface of the carboxyl-modified AuNP through a hydrochloride/N-hydroxysuccinimide coupling reaction. The material was characterized by scanning electron microscopy, energy dispersive X-ray spectrometry, transmission electron microscopy, thermogravimetric analysis, Fourier transform infrared spectroscopy and N 2 adsorption-desorption isotherm. The pepsin@AuNP@poly(GMA-co-EDMA) monolith showed preferable enantioselectivity for hydroxychloroquine (HCQ), chloroquine (CHQ), hydroxyzine (HXY), labetalol (LAB), nefopam (NEF), clenbuterol (CLE), amlodipine (AML) and chlorpheniramine (CHL) in capillary electrochromatography (CEC). These racemic drugs were monitored at the maximum absorption wavelength (220 nm for HXQ, CHQ, HXY, LAB, NEF; 240 nm for AML; 215 nm for CLE, CHL). In comparison with the pepsin@poly(GMA-co-EDMA) monolith loaded with 5 nm AuNP, the pepsin@poly(GMA-co-EDMA) monolith loaded with 13 nm AuNP shows significantly enhanced enantiomeric resolution (HCQ: 0.62 → 3.45; CHQ: 0.60 → 2.11; HXY: 0.49 → 2.30; LAB: 1.03 → 2.45, 1.45 → 3.46, 0 → 0.67; NEF: 0.53 → 1.29; CLE: 0.42 → 0.56; AML: 0 → 0.83; CHL: 0.24 → 0.55). Pepsin concentration, buffer pH value, buffer concentration and applied voltage were investigated in detail with (±) HCQ and (±) HXY as model analytes. The reproducibility of intra-day, inter-day and column-to-column were explored, and found to be satisfactory.
Schematic presentation of the preparation of gold nanoparticles (AuNP) modified.
研究领域:
分析化学
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纳米技术
·
药学
·
分离科学
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产品关联
DOI
PubMed
高影响因子
JOURNAL OF APPLIED TOXICOLOGY
·
2023
·
IF 3.3
Chijing Zuo,Yan Liu,Jie Wang,Weidong Yu,Yujie Liu,Yanyan Zhang,Jingjing Xu,Daiyin Peng,Can Peng
Compound diclofenac sodium chlorphenamine maleate tablets (CDCT) are widely used for the cold in Asia. However, CDCT can cause hematuria symptoms in clinical, and the underlying mechanism is unknown. This study aims to investigate the CDCT-induced changes of morphology in kidney and metabolites and further explore the possible mechanisms of CDCT-induced nephrotoxicity. Sprague–Dawley rats were exposed to the CDCT at a clinical equivalent dose for 6 days. CDCT exposure can induce kidney injury and death. Pathological changes, including creatinine, urea nitrogen, and histopathology, were observed in rats. Furthermore, metabolomic-driven energy and glycerophospholipid metabolism pathway disorders, accompanied by remarkably changed key metabolites, such as succinate, leukotriene B 4 (LTB 4 ), and cardiolipin (CL), are observed in the CDCT-induced nephrotoxicity. Functionally, succinate accumulation leads to mitochondrial damage, as evidence by the imbalance of complex I and complex II and an increase in mitochondrial reactive oxygen species (mito SOX). Meanwhile, LTB 4 activated the NF-κB signaling, as shown by increased protein of p65, phosphor-p65, and decreased protein of IκBα and phosphor-IκBα. Eventually, the apoptosis pathway was triggered in response to reduced CL, inflammation, and mito SOX, as demonstrated by the expression of cyt c, Bax, Bcl-2, caspase-3, and caspase-9. This study indicated that CDCT-induced metabolic disorders triggered nephrotoxicity and provided a comprehensive information to elucidate the mechanism of CDCT induced nephrotoxicity.
研究领域:
药理学
·
毒理学
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代谢组学
·
病理学
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产品关联
DOI
PubMed
高影响因子
危险品化学品经营许可证（带存储）