Coatings
·
2021
·Vol. 11
·期 11
·1396
·
IF 2.881
Min Zhang,Dong Peng,Feifei Peng,Anwei Huang,Kaiqiang Song,Qingbing He,Changqing Yin,Jinsong Rao,Yuxin Zhang,Haitao Chen,Dalong Cong,Zhongsheng Li
The Al coatings were electrodeposited on the Cu substrate from AlCl3-EMIC ionic liquid (AlCl3:EMIC = 2:1 molar ratio) containing three cyanopyridine additives with different positions of the substituent group on the pyridine ring, which were 2-cyanopyridine, 3-cyanopyridine, and 4-cyanopyridine. The effects of cyanopyridine additives on the deposition potential, morphology, brightness, and corrosion properties of Al coatings were investigated. It was considered that the deposition potential of Al shifted to more negative overpotentials, the quality of Al coatings was promoted, and the corrosion property was improved by the cyanopyridine additives to a varying degree. Especially in the presence of 4-cyanopyridine, the flattest mirror bright Al coating was obtained, which had the smallest homogeneous nanocrystal grain size and strongest Al (200) crystallographic orientation. The average roughness Ra value was as low as 31 nm compared to that in the absence of cyanopyridine additives, which was 417 nm. Furthermore, the corrosion current density of the bright Al coating was three orders of magnitude lower than the rough Al coating, which resulted from the dense nanocrystal structure.Keywords:bright Al;electrodeposition;ionic liquids;cyanopyridine;additives
研究领域:
材料科学
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电化学
·
表面工程
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DOI
高影响因子
MOLECULES
·
2023
·Vol. 28
·期 10
·4164
·
IF 4.6
Jassim Mohamed Hamed Al-Kurdhani,Huajun Wang
A series of supported CuO-based nanoparticle catalysts were prepared by the impregnation method and used for the synthesis of glycerol carbonate from glycerol and CO2in the presence of 2-cyanopyridine as a dehydrant and DMF as a solvent. The effects of supports (activated alumina, silicon dioxide, graphene oxide, graphene, and activated carbon), CuO loading amount, calcination temperature, and reaction parameters on the catalytic activity of the catalyst were investigated in detail. XRD, FTIR, SEM, BET, and CO2-TPD were used for the characterization of the prepared catalysts. It is found that CuO/Al2O3shows a higher catalytic activity, which depends on the CuO loading amount and calcination temperature. The surface area and number of basic sites of the catalyst exhibit a crucial effect on the catalytic activity of CuO/Al2O3. Furthermore, there is a synergistic effect between the catalyst and 2-cyanopyridine where the former has a higher activation ability for glycerol and the latter acts not only as a dehydrant, but also as a promoter for CO2activation. Recycling experiments reveal that this catalyst can be reused for at least five cycles without any inactivation. Based on the experiment results and FTIR characterization, a possible reaction mechanism for the carbonylation of glycerol and CO2is proposed.Keywords:glycerol;glycerol carbonate;carbon dioxide;2-cyanopyridine;CuO/Al2O3
研究领域:
催化化学
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材料科学
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环境化学
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DOI
PubMed
高影响因子
ACS Applied Materials & Interfaces
·
2015
·
IF 6.723
Guojian Chen,Xiaochen Wang,Jing Li,Wei Hou,Yu Zhou,Jun Wang
A family of nitrogen-enriched ultramicroporous carbon materials was prepared by direct carbonization of task-specifically designed molecular carbon precursors of cyanopyridinium-based crystalline dicationic salts (CISs). Varying the molecular structure of CISs, large surface area (918 m2 g–1), high N content (20.10 wt %), and narrow distributed ultramicropores (0.59 nm) can be simultaneously achieved on the sample PCN-14 derived from methyl-linked 4-cyanopyridinium D[4-CNPyMe]Tf2N. It therefore exhibited exceptional performance in greenhouse gas CO2 capture, i.e., simultaneously possessing (1) high CO2 adsorption uptakes: 5.33 mmol g–1 at 273 K, and 3.68 mmol g–1 at 298 K (both at 1.0 bar); (2) unprecedented selectivity of CO2 versus N2: 156; and (3) a high adsorption ratio of CO2 to N2: 148 (at 1.0 bar). This is the first time such a high selectivity and adsorption ratio over carbon materials has been achieved, which is among the highest values over solid adsorbents.
研究领域:
材料科学
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环境科学
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DOI
PubMed
高影响因子
CANADIAN JOURNAL OF CHEMICAL ENGINEERING
·
2017
·Vol. 96
·期 3
·679-687
·
IF 1.356
Zhongrui Liang,Lichao He,Wenchao Wang,Zhiyong Zhou,Zhongqi Ren
Tuberculosis is a serious bacterial infection in developing countries, especially in areas with drug resistance. The development of the anti-tuberculosis drug ethionamide (ETA) is therefore particularly important. We have designed a new route for ETA synthesis and considered the drug's amenability to large-scale manufacture. We evaluated different routes for the synthesis of ETA and selected the most suitable process for the industrial production of this material, which involved the Minisci reaction of 4-cyanopyridine with propionic acid using a AgNO 3 /(NH 4 ) 2 S 2 O 8 catalyst system under acidic conditions. The effects of different parameters on the reaction were studied, and the production of the intermediate of 2-ethyl-4-cyanopyridine was twice recrystallized from methanol to obtain pure ETA. In the Minisci reaction, the system was stirred for an additional 20 min at 80 °C after the addition of ammonium persulphate solution. The subsequent formation of thioamide was conducted at 40 °C to 60 °C for 1.5 h with a 1:5:2 molar ratio of 4-cyanopyridine, propionic acid, and ammonium sulphide. The purity of the crude ETA reached 98.77 % after two recrystallization steps. This process could be scaled up on a much larger scale (1 kg), leading to the yield of alkylation reaction and overall yield of the production process as 44.06 % and 31.26 %, respectively.
研究领域:
药物化学
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有机合成
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结核病研究
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DOI
高影响因子
JOURNAL OF HAZARDOUS MATERIALS
·
2024
·
IF 12.2
Shangcong Gu,Yan Huang,Xinxin Li,Haotian Xin,Haoran Mu,Yan Zhang,Keyi Li,Guiyi Yang,Songfang Zhao,Duxia Cao
SO 2 derivatives, sulfite/bisulfite, are widely employed in both the food processing and drug synthesis industries. Despite their widespread application, excessive levels of sulfite/bisulfite can negatively impact human health. Most probes for detecting sulfite/bisulfite are restricted by their fluorescence within the visible spectrum range and poor solubility in aqueous solution, which limit their use in food testing and biological imaging. Herein, a near-infrared probe comprising of the cyanopyridine cyanine skeleton, 4-(( Z )−2-(( E )−2-chloro-3-(2-cyano-2-(1-methylpyridine-4(1 H )-ylidene)ethylidene)cyclohex-1-en-1-yl)−1-cyanovinyl)−1-methylpyridin-1-ium (abbreviated as CCP ), was developed. This probe enables precise quantification of bisulfite (HSO 3 - ) in almost pure buffered solutions, showing a near-infrared fluorescence emission at 784 nm with an impressively low detection limit of 0.32 μM. The probe stands out for its exceptional selectivity, minimal susceptibility to interference, and strong adaptability. The probe CCP utilizes the C C bond to trigger a near-infrared fluorescence quenching reaction with HSO 3 - via nucleophilic addition, which effectively disrupts the large delocalization within the molecule for accurate HSO 3 - identification. Moreover, the probe has been successfully applied in detecting HSO 3 - in various food products and living cells, simplifying the measurement of HSO 3 - content in water samples. This advancement not only enhances the analytical capabilities but also contributes to ensuring food safety and environmental protection. Environmental Implication SO 2 derivatives including sulfite/bisulfite, serving dual roles as preservatives and antioxidants, have widespread application across various sectors including food preservation, water sanitation, and the pharmaceutical industry. Despite their widespread application, excessive levels of sulfite/bisulfite can affect human health. Developing methods for precisely and sensitively detecting sulfite/bisulfite in food products and biological samples is important for ensuring food safety and environmental protection. Here, a sensitive near-infrared and multifunctional fluorescent probe in a 99.9 % buffered solution, along with water gel encapsulation, has been successfully applied for the detection of bisulfite in food, authentic water samples, and biological cells.
研究领域:
分析化学
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生物医学
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环境科学
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DOI
PubMed
高影响因子
PROCESS BIOCHEMISTRY
·
2013
·
IF 2.414
Xiaolin Pei,Hongyu Zhang,Lijun Meng,Gang Xu,Lirong Yang,Jianping Wu
A nitrile hydratase (NHase) gene from Aurantimonas manganoxydans was cloned and expressed in Escherichia coli BL21 (DE3). A downstream gene adjacent to the β-subunit was necessary for the functional expression of the recombinant NHase. The structural gene order of the Co-type NHase was α-subunit beyond β-subunit, different from the order typically reported for Co-type NHase genes. The NHase exhibited adequate thermal stability, with a half-life of 1.5 h at 50 °C. The NHase efficiently hydrated 3-cyanopyridine to produce nicotinamide. In a 1-L reaction mixture, 3.6 mol of 3-cyanopyridine was completely converted to nicotinamide in four feedings, exhibiting a productivity of 187 g nicotinamide/g dry cell weight/h. An industrial auto-induction medium was applied to produce the recombinant NHase in 10-L fermenter. A glycerol-limited feeding method was performed, and a final activity of 2170 U/mL culture was achieved. These results suggested that the recombinant NHase was efficiently cloned and produced in E. coli .
研究领域:
生物技术
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酶学
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微生物学
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工业化学
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DOI
高影响因子
STAR Protocols
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2022
·
IF 0
Cong Niu,Jianjing Yang,Kelu Yan,Jiafang Xie,Wei Jiang,Bingwen Li,Jiangwei Wen
Here, we present a protocol to decyanopyridate inert N-heterocycles access to N-fused heterocycles via the mechanism of dual proton-coupled electron transfer (PCET). We describe a detailed guide to performing an electrochemical gram-scale protocol for decyanopyridation of inert N-heterocycles. The desired pyridylated quinolone is synthesized in a 5.0 mmol scale with a yield of 76%. The protocol is limited to cyanopyridines. For complete details on the use and execution of this protocol, please refer to Niu et al. (2022) .
研究领域:
有机化学
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电化学
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合成化学
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DOI
PubMed
WORLD JOURNAL OF MICROBIOLOGY & BIOTECHNOLOGY
·
2013
·Vol. 30
·期 1
·245-252
·
IF 1.262
Wang Hualei,Li Guinan,Li Mingyang,Wei Dongzhi,Wang Xuedong
In this study, a novel nitrilase gene from Rhodobacter sphaeroides was cloned and overexpressed in Escherichia coli . The open reading frame of the nitrilase gene includes 969 base pairs, which encodes a putative polypeptide of 322 amino acid residues. The molecular weight of the purified native nitrilase was about 560 kDa determined by size exclusion chromatography. This nitrilase showed one single band on SDS-PAGE with a molecular weight of 40 kDa. This suggested that the native nitrilase consisted of 14 subunits with identical size. The optimal pH and temperature of the purified enzyme were 7.0 and 40 °C, respectively. The kinetic parameters V
max and K
m toward 3-cyanopyridine were 77.5 μmol min −1 mg −1 and 73.1 mmol/l, respectively. The enzyme can easily convert aliphatic nitrile and aromatic nitriles to their corresponding acids. Furthermore, this enzyme demonstrated regioselectivity in hydrolysis of aliphatic dinitriles. This specific characteristic makes this nitrilase have a great potential for commercial production of various cyanocarboxylic acids by hydrolyzing readily available dinitriles.
研究领域:
微生物学
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生物化学
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酶学
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生物技术
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DOI
PubMed
高影响因子
MICROCHIMICA ACTA
·
2024
·Vol. 191
·期 6
·1-10
·
IF 5.3
Qu Xiangwen,Zhou Pengwei,Shi Boya,Zheng Yekai,Kan Lian,Jiang Li
A multifunctional surface-enhanced Raman scattering (SERS) platform integrating sensitive detection and drug resistance analysis was developed for Gram-positive bacteria. The substrate was based on self-assembled Ti 3 C 2 T x @Au NPs films and capture molecule phytic acid (IP6) to achieve specific capture of Gram-positive bacteria and different bacteria were analyzed by fingerprint signal. It had advantages of good stability and homogeneity (RSD = 8.88%). The detection limit (LOD) was 10 2 CFU/mL for Staphylococcus aureus and 10 3 CFU/mL for MRSA, respectively. A sandwich structure was formed on the capture substrate by signal labels prepared by antibiotics (penicillin G and vancomycin) and non-interference SERS probe molecules (4-mercaptobenzonitrile (2223 cm −1 ) and 2-amino-4-cyanopyridine (2240 cm −1 )) to improve sensitivity. The LOD of Au NPs@4-MBN@PG to S. aureus and Au NPs@AMCP@Van to MRSA and S. aureus were all improved to 10 CFU/mL, with a wide dynamic linear range from 10 8 to 10 CFU/mL ( R 2 ≥ 0.992). The SERS platform can analyze the drug resistance of drug-resistant bacteria. Au NPs@4-MBN@PG was added to the substrate and captured MRSA to compare the SERS spectra of 4-MBN. The intensity inhomogeneity of 4-MBN at the same concentrations of MRSA and the nonlinearity at the different concentrations of MRSA revealed that MRSA was resistant to PG. Finally, the SERS platform achieved the determination of MRSA in blood. Therefore, this SERS platform has great significance for the determination and analysis of Gram-positive bacteria. Graphical Abstract
研究领域:
分析化学
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生物传感器
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微生物学
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纳米技术
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药物分析
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DOI
PubMed
高影响因子
危险品化学品经营许可证（带存储）