JOURNAL OF MOLECULAR STRUCTURE
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2022
·
IF 3.841
Jing Su,Liuyang Wang,Qixin Lu,Min Li,Yu Guan,Chunxia Wang,Shaohai Fu
Dyes containing cyano group have the advantages of bright colours and high molar absorption. However, most cyano-containing disperse dyes are not used for alkaline dyeing as they are easily hydrolysed under alkali conditions. Herein, cyano-containing disperse dyes for alkaline dyeing were designed by introducing non-hydrolysable phenylethyl and potentially alkali-hydrolysable ethyl benzoate in adjacent positions to the cyano group, and the effect of the adjacent groups on the alkali resistance of cyano-containing dyes was investigated. Polyester fabric (PET) was dyed under different acidic or alkali conditions by the disperse dyes, then the hydrolysis energy barrier of cyano on the dye and the binding energy of dye-dye and dye-PET under the dyeing conditions were calculated via Density Functional Theory (DFT). The results showed that the cyano-containing disperse dyes with an adjacent benzene ring structure had good alkali resistance in a 5 g/L NaOH dye bath. DFT simulations confirmed that the adjacent phenylethyl did not have a significant effect on the hydrolytic energy barrier of the cyano group, while the adjacent ethyl benzoate reduced the hydrolytic energy barrier of the cyano group. The introduction of an adjacent benzene ring reduced the dye-dye binding energy, contributing to the increasement of dyeing rate at the beginning of the dyeing process. The designed cyano-containing dyes with adjacent benzene rings achieved a colour fastness level of 4–5 or above in various acid and alkali conditions.
研究领域:
化学
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材料科学
✓ 已验证
产品关联
DOI
高影响因子
ACS Applied Bio Materials
·
2021
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IF 0
Fei Huang,Yuhao Li,Jinliang Liu,Jing Zhang,Xiang Wang,Bing Li,Haizhou Chang,Yuqing Miao,Yun Sun
Fluorescent surgical navigation can effectively aid tumor resection. As one of the most popular near-infrared (NIR) fluorophores, cyanine dye has the outstanding optical ability and the potential to act as a fluorescence probe for tumors. Herein, we report a polyethylene glycol-modified amphiphilic cyanine dye (Cy7-NPC) with an NIR luminescence performance, which can self-assemble to form uniform nanomicelles (Cy7-NPC-S) and which can be applied for the optical imaging of abdominal tumors and for fluorescence imaging-guided precision tumor resection. When applied to biological imaging, Cy7-NPC-S showed high biological safety, strong tissue penetration depth for optical imaging, and high optical imaging resolution. Intraperitoneal administration of Cy7-NPC-S produced remarkable imaging efficacy in abdominal tumors. Compared with intravenous injection, abdominal tumors took up intraperitoneal Cy7-NPC-S faster and in greater quantities, thus enabling Cy7-NPC-S to facilitate accurate recognition and extirpation of abdominal tumors in fluorescence-guided surgery. We believe that metabolizable Cy7-NPC-S with NIR luminescence has promising applications and value in the fields of in vivo imaging and fluorescent surgical navigation.
研究领域:
生物医学工程
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肿瘤学
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分子影像学
✓ 已验证
DOI
JOURNAL OF PHYSICAL CHEMISTRY B
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2017
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IF 3.177
Jing Zhang,Qing Tang,Zhong-Zheng Gao,Ying Huang,Xin Xiao,Zhu Tao
Two supramolecular assemblies between twisted cucurbit[14]uril and hemicyanine dyes have been successfully constructed on the basis of host–guest recognition. These supramolecular assemblies could be reversibly switched under acidic and neutral conditions. Furthermore, they responded to selected chemical stimuli such as methyl violet, thereby exhibiting potential analysis application.
研究领域:
化学
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材料科学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
ANALYST
·
2022
·Vol. 147
·期 12
·2793-2801
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IF 5.227
Yunchun Liu,Wanru Zhu,Xinru Wei,Lun Wang,Hongqi Chen
In this work, a single particle imaging method based on the total internal reflection (TIR) imaging platform for the sensing and cell imaging of nitrite (NO2−) in the near-infrared region using cyanine dye-assembled composite upconversion nanoparticles (UCNPs) was developed. The NaYF4:Yb,Tm@NaGdF4 UCNPs were synthesized as energy donors, and the cyanine dye IR-798 was prepared as an energy acceptor. Since the absorption spectrum of the cyanine dye IR-798 and the luminescence spectrum of upconversion nanoparticles overlapped effectively, IR-798 quenched the luminescence of the UCNPs. When NO2− was added to the cyanine dye-assembled composite upconversion nanoparticle system, NO2− destroyed the conjugate structure of IR-798, so that the luminous intensity of UCNPs could be restored. Based on the mechanism, a quantitative image analysis with high sensitivity, low sample usage, and fast response time using the TIR single particle imaging platform was developed to determine the content of nitrite in human serum samples. In addition, the UCNPs-IR-798 probe was applied to image the exogenous NO2− content in HeLa living cells based on the single particle imaging platform.
研究领域:
生物医学工程
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分析化学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
DYES AND PIGMENTS
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2021
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IF 4.889
Hao Liu,Juanjuan Yin,Enyun Xing,Yingying Du,Yu Su,Yaqing Feng,Shuxian Meng
Cyanine dyes are widely used in the field of tumor phototherapy due to their excellent photophysical properties. To explore the heavy atoms effects on the photothermal and photodynamic performance of phototherapeutic agents, chlorine, bromine, and iodine were introduced to synthesize a series of cyanine dyes (IR6, IR7, and IR8). We have found that all halogenated cyanine dyes exhibited high excitation wavelength (around 800 nm) and low dark toxicity. Among them, IR8 behaved the best singlet oxygen production ability in the three dyes. For photothermal performance, IR8 exhibited the best photothermal conversion rate (46.6%), photothermal stability, and excellent therapy efficiency (half-maximal inhibitory concentration, IC 50 = 16.2 μg/mL). IR7 behaved a greater enhancement of the photothermal conversion rate (43.4%) than IR6 (42.3%). In conclusion, the heavy atoms effects on the photothermal and photodynamic properties of cyanine dyes are positively correlated with the increase of the atomic number of the halogen atom, and the iodine atom may be the most worthy of consideration in the all halogen atoms.
研究领域:
肿瘤学
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生物医学工程
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药理学
✓ 已验证
产品关联
DOI
高影响因子
JOURNAL OF PHYSICAL CHEMISTRY B
·
2024
·
IF 2.8
Xiufeng Zhang,Xiaoying Ma,Buyue Zhang,Dawei Yang,Ruiyang Bai,Yuexing Gao,Hongxia Sun,Yalin Tang,Lei Shi
Viscosity, at the subcellular level, plays a crucial role as a physicochemical factor affecting microenvironment homeostasis. Abnormal changes in mitochondrial viscosity often lead to various diseases in the organism. Based on the twisted intramolecular charge transfer mechanism, four hemicyanine dye fluorescent probes (HT-SA, HT-SA-S, HT-Bzh, and HT-NA) were designed and synthesized for viscosity response. The single bond between the nitrogen-containing heterocycle and the carbon–carbon double in the structure of the probe bond served as the viscosity response site. Finally, the probe HT-Bzh was screened as the optimal mitochondrial viscosity probe according to its responsiveness, targeting, and interference resistance. The fluorescence intensity of the probe HT-Bzh increased 22-fold when the viscosity was increased from 13.75 to 811.2 cP. In summary, all four viscosity probes we have developed can be used in different applications depending on the external environment, providing a valuable reference for the design of potential tools to address viscosity monitoring in biological systems.
研究领域:
化学
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生物学
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材料科学
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生物医学工程
✓ 已验证
产品关联
DOI
PubMed
高影响因子
COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
·
2025
·
IF 5.4
Peng-Wei Chen,Lin-Song Li,Yu-Meng Zhang,Bang-Bang Liu,Xianjiao Tang,Liping Chen,Xiaojing Yang,Mei-Xia Zhao
In recent years, most photosensitizers suffer from poor photothermal conversion efficiency (PCE), vulnerability to aggregated-caused quenching under physiological conditions, and are highly dependent on oxygen, which seriously limit their application in cancer therapy. In this study, DTIR780 was an aggregation induced emission (AIE) photosensitizer, which was synthesized through the originality of molecular engineering. Because DTIR780 had a special organelle targeting lysosomes and mitochondria, it had excellent PCE (PCE = 28.9 %), and could simultaneously generate Type I reactive oxygen species (ROS): O 2 ·- and ·OH and Type II ROS: 1 O 2 , showing significantly enhanced tumor phototoxicity in both normoxia and hypoxic tumor microenvironments. In vivo testing demonstrated that DTIR780 NPs was efficiently accumulated at the tumor site while significantly inhibiting tumor growth in a subcutaneous H22 tumor mouse model. In summary, this lysosome and mitochondria targeted DTIR780 NPs has great potential in clinically image-guided type I photodynamic therapy (PDT) and photothermal therapy (PTT), offering a novel avenue for developing high-performance type I PDT/PTT photosensitizers for the efficient treatment of hypoxia tumors.
研究领域:
肿瘤学
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光医学
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纳米医学
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分子影像
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转化医学
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药物递送
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生物材料
✓ 已验证
产品关联
DOI
高影响因子
危险品化学品经营许可证（带存储）