JOURNAL OF APPLIED POLYMER SCIENCE
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2014
·Vol. 131
·期 19
·
IF 1.64
Jiangdong Dai,Zhiping Zhou,Yongli Zou,Xiao Wei,Xiaohui Dai,Chunxiang Li,Yongsheng Yan
A surface imprinted core-shell nanorod with water-compatible property was first prepared, using a two-step “living” polymerization technique, with magnetic attapulgite (MATP) as core, and it was applicable in the enhanced selective removal of sulfamethazine residue from pure water environments. MATP was synthesized by an impregnation and pyrolysis method, and polymerable group was subsequently attached onto the surface. The imprinted polymer nanoshell (13 nm) with the “living” fragments was formed via a reverse atom transfer radical precipitation polymerization, avoiding the tedious graft of initiator and providing the easy-accessible imprinted sites. Ultrathin hydrophilic polymer brushes (2.0 nm) were surface-grafted to improve their water-compatibility. The nanoadsorbent exhibited good thermal stability, magnetism, and hydrophilicity through characterization. The nanoadsorbent showed large adsorption capacity toward sulfamethazine from water, which increased with the increase of contact temperature. Langmuir isotherm fitted the equilibrium data better, and the kinetic data (within 45 min) were well-analyzed by the pseudo-second-order kinetic model. Also, the specific adsorption property of the nanoadsorbent was greatly improved through the surface-grafting, which exhibited excellent selectivity to sulfamethazine compared with other reference antibiotics. Efficient magnetic separation and good reuse of the nanoadsorbent provided the potential possibility for selective recognition and fast removal of antibiotic pollutions from water environments. © 2014 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2014 , 131 , 40854.
研究领域:
材料科学
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环境科学
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分子生物学
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DOI
高影响因子
JOURNAL OF SURFACTANTS AND DETERGENTS
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2019
·Vol. 23
·期 1
·109-118
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IF 1.672
Dan Fei,Guang-Wei Zhou,Zhou-Qiang Yu,Hong-Ze Gang,Jin-Feng Liu,Shi-Zhong Yang,Ru-Qiang Ye,Bo-Zhong Mu
Developing eco-friendly, nonirritant, low-toxic, and high-efficient surface active ingredients for detergents is an ongoing challenge in the detergent field. Surfactin is one of the representative lipopeptides produced by microorganisms. In this article, we report the surfactin isolated from cell-free broth of Bacillus subtilis HSO121 and purified by reversed-phase high-performance liquid chromatography for detergent formulations. The biodegradability, acute dermal irritation, acute oral toxicity (LD 50 and LC 50 ), surface activity, washing efficiency, and compatibility with hard water of the purified biosurfactant surfactin have been studied to explore the feasibility for applications of the surfactin in detergents. Acute oral toxicity tests (LD 50 > 5000 mg kg −1 , LC 50 > 1000 mg kg −1 ) and skin irritation tests (PII = 0) indicate that the surfactin is a low-toxic and nonirritant ingredient for detergent formulation. Moreover, the surfactin shows excellent surface and interfacial properties of emulsification and wettability, high compatibility, and stability in a wide range of temperatures, pH, and hard water and acceptable properties in biodegradability and foaming ability, which suggests that the biosurfactant surfactin is a promising ingredient for detergent formations in our daily life and for industrial applications.
研究领域:
微生物学
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环境科学
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化学工程
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产品关联
DOI
高影响因子
JOURNAL OF CHROMATOGRAPHY A
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2019
·
IF 3.858
Xue Yu,Hainan Zeng,Junfen Wan,Xuejun Cao
The main problem of poor water compatibility of molecularly imprinted polymers (MIPs) has been addressed in this study. A new facile and highly efficient approach was developed to obtain well-defined hydrophilic molecularly imprinted polymer microsphere with excellent specific recognition ability toward Chenodeoxycholic acid (CDCA) in crude bile. Particularly, it involved computational modeling to obtain a polymer network with high affinity for CDCA and addition of a hydrophilic crosslinker (polyethylene glycol (PEG) diacrylate∼200) to increase the hydrophilicity of the polymer surface. To our knowledge, this study first report splitting method in molecular imprinting technology. By using the splitting method, simulation time can be saved under the premise of ensuring accuracy. The adsorption experiments revealed that an optimized CDCA-MIP exhibited better selectivity toward CDCA with inhibition of the nonspecific adsorption. The CDCA-MIP possessed adsorption capacity of 49.86 mg g −1 for CDCA and the imprinting factor was 2.72. Solid-phase extraction (SPE) using the prepared CDCA-MIP as adsorbent was optimized regarding loading and elution conditions, and it was used to extract CDCA from crude bile, resulting in recoveries in the range 94.2–96.1%.
研究领域:
分析化学
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生物化学
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药物化学
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产品关联
DOI
PubMed
高影响因子
POLYMER
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2022
·
IF 4.432
Xue Yu,Jinmin Liao,Hainan Zeng,Junfen Wan,Xuejun Cao
Molecularly imprinted polymers (MIPs), as selective adsorbents, have shown great potential in the selective separation and enrichment of trace targets from complex components. However, the preparation of MIPs with specific recognition in aqueous solution is facing great challenges, thus largely limiting their application scope in selective separation and analysis of water samples. Aiming at the challenges and problems in the above-mentioned molecularly imprinting technology, a new rational method of water-compatible noncovalent imprinted microspheres was proposed. In the method, functional monomers were screened based on molecular dynamics (MD) and then water-compatible spherical MIPs were prepared with a modified suspension polymerization method. To verify this method, a basic molecule (spiramycin) and an acidic molecule (chenodeoxycholic acid) were selected as templates . After the characterization of the synthesized polymers, the adsorption capacities of SPM-MIP and CDCA-MIP were tested in an aqueous environment. In adsorption experiments, CDCA-MIP and SPM-MIP showed higher adsorption capacities and the imprinting factors of CDCA-MIP and SPM-MIP reached 3.96 and 2.51, respectively. Due to the imprinting effect, the prepared SPM-MIP and CDCA-MIP had selectivity . Moreover, SPM-MIP and CDCA-MIP showed the strong protein adsorption resistance in an aqueous medium. These results confirmed that the reasonable design was feasible and significant in designing water-compatible non-covalent imprinted polymers. In addition, the screening strategy of imprinting systems proposed in this study has certain universality and can be widely used to screen various imprinting systems.
研究领域:
分析化学
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材料科学
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生物化学
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DOI
高影响因子
JOURNAL OF CHROMATOGRAPHY A
·
2024
·
IF 3.8
Dandan Han,Shenghui Wang,Niao Zhao,Yahan Cui,Hongyuan Yan
Molecularly imprinted polymer with water-compatibility for effective separation and enrichment of targeted trace pollutants from complicated matrix has captured extensive attention in terms of their high selectivity and matrix compatibility. This study focuses on modified β-cyclodextrin is used as a hydrophilic functional monomer to develop magnetic molecularly imprinted polymers (MMIPs). MMIPs were prepared using Fe 3 O 4 nanoparticles as carriers and bisphenol A (BPA) as templates using a two-step fixation strategy and surface imprinting technology. The structural characteristic and binding properties of the prepared MMIPs were thoroughly studied. The MMIPs exhibited high crystallinity, high adsorption capacity, fast rebinding rate, remarkable selectivity and distinguish reusability. In addition, through magnetic solid-phase extraction separation technology and high-performance liquid chromatography ultraviolet quantitative detection technology, MMIPs are used for selective enrichment and detection of BPA in complex media such as environmental water and milk. This work provides a new route to construct the hydrophilic molecularly imprinted materials and a new sight on developing more effective sample pretreatment strategies for monitoring targeted pollution in complicated aqueous media.
研究领域:
环境科学
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分析化学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
JOURNAL OF CHROMATOGRAPHY A
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2016
·
IF 3.926
Mingyu Wang,Xiaochen Chang,Xingyu Wu,Hongyuan Yan,Fengxia Qiao
A water-compatible dummy molecularly imprinted resin (MIR) was synthesized in water using melamine, urea, and formaldehyde as hydrophilic monomers of co-polycondensation. A triblock copolymer (PEO-PPO-PEO, P123) was used as porogen to dredge the network structure of MIR, and N -(1-naphthyl) ethylenediamine dihydrochloride, which has similar shape and size to the target analytes, was the dummy template of molecular imprinting. The obtained MIR was used as the adsorbent in a green miniaturized solid-phase extraction (MIR⬜mini-SPE) of plant growth regulators, and there was no organic solvent used in the entire MIR⬜mini-SPE procedure. The calibration linearity of MIR⬜mini-SPE⬜HPLC method was obtained in a range 5⬜250 ng mL ↙1 for IAA, IPA, IBA, and NAA with correlation coefficient (r) Ⱕ0.9998. Recoveries at three spike levels are in the range of 87.6⬜100.0% for coconut juice with relative standard deviations Ⱔ8.1%. The MIR⬜mini-SPE method possesses the advantages of environmental friendliness, simple operation, and high efficiency, so it is potential to apply the green pretreatment strategy to extraction of trace analytes in aqueous samples.
研究领域:
分析化学
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环境科学
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产品关联
DOI
PubMed
高影响因子
JOURNAL OF CHROMATOGRAPHY A
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2016
·
IF 3.926
Xiaqing Wu,Xiaoyan Wang,Wenhui Lu,Xinran Wang,Jinhua Li,Huiyan You,Hua Xiong,Lingxin Chen
Versatile molecularly imprinted polymers (MIPs) have been widely applied to various sample matrices, however, molecular recognition in aqueous media is still difficult. Stimuli-responsive MIPs have received increasing attentions due to their unique feature that the molecular recognition is regulated by specific external stimuli. Herein, water-compatible temperature and magnetic dual-responsive MIPs (WC-TMMIPs) with hydrophilic brushes were prepared via reversible addition-fragmentation chain transfer precipitation polymerization for reversible and selective recognition and extraction of bisphenol A (BPA). Transmission electron microscopy (TEM), Fourier transform infrared spectrometer (FT-IR) and vibrating sample magnetometry (VSM) as characterization methods were used to examine the successful synthesis of polymers, and the resultant WC-TMMIPs showed excellent thermosensitivity and simple rapid magnetic separation. Controlled adsorption and release of BPA by temperature regulation were investigated systematically, and the maximum adsorption and removal efficiency toward BPA in aqueous solutions were attained at 35 °C and 45 °C, respectively, as well as a good recoverability was exhibited with the precision less than 5% through five adsorption–desorption cycles. Phenolic structural analogs were tested and good recognition specificity for BPA was displayed. Accordingly, the WC-TMMIPs were employed as adsorbents for magnetic solid-phase extraction (MSPE) and packed SPE of BPA from seawater samples. Using the two modes followed by HPLC-UV determination, excellent linearity was attained in the range of 0.1–14.5 μM and 1.3–125 nM, with low detection limits of 0.02 μM and 0.18 nM, respectively. Satisfactory recoveries for spiked seawater samples were achieved ranging from 86.3–103.5% and 96.2–104.3% with RSD within 2.12–4.33%. The intelligent WC-TMMIPs combining water-compatibility, molecular recognition, magnetic separation, and temperature regulation proved potentially applicable for selective identification, controlled adsorption/release and high-efficiency enrichment/removal of trace targets in complicated aqueous media.
研究领域:
分析化学
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材料科学
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环境科学
✓ 已验证
DOI
高影响因子
ANALYTICAL BIOCHEMISTRY
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2014
·
IF 2.305
Qingwen Zhang,Lijing Jing,Jinling Zhang,Yamin Ren,Yang Wang,Yi Wang,Tianxin Wei,Bo Liedberg
A novel water-compatible macroporous molecularly imprinted film (MIF) has been developed for rapid, sensitive, and label-free detection of small molecule testosterone in urine. The MIF was synthesized by photo copolymerization of monomers (methacrylic acid [MAA] and 2-hydroxyethyl methacrylate [HEMA]), cross-linker (ethylene glycol dimethacrylate, EGDMA), and polystyrene nanoparticles (PS NPs) in combination with template testosterone molecules. The PS NPs and template molecules were subsequently removed to form an MIF with macroporous structures and the specific recognition sites of testosterone. Incubation of artificial urine and human urine on the MIF and the non-imprinted film (NIF), respectively, indicated undetectable nonspecific adsorption. Accordingly, the MIF was applied on a surface plasmon resonance (SPR) sensor for the detection of testosterone in phosphate-buffered saline (PBS) and artificial urine with a limit of detection (LOD) down to 10 −15 g/ml. To the best of our knowledge, the LOD is considered as one of the lowest among the SPR sensors for the detection of small molecules. The control experiments performed with analogue molecules such as progesterone and estradiol demonstrated the good selectivity of this MIF for sensing testosterone. Furthermore, this MIF-based SPR sensor shows high stability and reproducibility over 8 months of storage at room temperature , which is more robust than protein-based biosensors.
研究领域:
分析化学
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生物医学工程
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传感技术
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产品关联
DOI
PubMed
高影响因子
JOURNAL OF CHROMATOGRAPHY A
·
2024
·
IF 3.8
Xue Yu,Yawen Hu,Zanxia Cao,Mengxia Yan,Jianhui Xin,Shuyun Zheng,Junfen Wan,Xuejun Cao
Herein, 2,4-dichlorophenoxyacetic acid (2,4-D) was used as a model template in a rational design strategy to produce water-compatible noncovalent imprinted microspheres. The proposed approach involved computational modelling for screening functional monomers and a simple method for preparing monodisperse and highly cross-linked microspheres. The fabricated non-imprinted polymer (NIP) and 2,4- d -imprinted polymer (2,4- d -MIP) were characterised, and their adsorption capabilities in an aqueous environment were evaluated. Results reveal that the pseudo-second-order kinetics model was appropriate for representing the adsorption of 2,4-D on NIP and 2,4- d -MIP, with R 2 values of 0.97 and 0.99, respectively. The amount of 2,4-D adsorbed on 2,4- d -MIP (97.75 mg g −1 ) was considerably higher than those of phenoxyacetic acid (35.77 mg g −1 ), chlorogenic acid (9.72 mg g −1 ), spiramycin (1.56 mg g −1 ) and tylosin (1.67 mg g −1 ). Furthermore, it exhibited strong resistance to protein adsorption in an aqueous medium. These findings confirmed the feasibility of the proposed approach, providing a reference for the development of water-compatible noncovalent imprinted polymers.
研究领域:
材料科学
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环境科学
·
计算化学
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产品关联
DOI
PubMed
高影响因子
CHEMOSPHERE
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2022
·
IF 8.943
Weiyingxue Yang,Chuixiu Huang,Xiantao Shen
Pharmaceuticals in hospital effluents, often discharged into the public sewage network without sufficient treatment, have shown negative impacts to the human health and aquatic environment. However, the conventional adsorbents used to remove these micropollutants had several deficiencies, including slow uptake kinetics and poor selectivity . To overcome these challenges, water-compatible Janus MIP particles (J-MIPs) with mouth-like openings were synthesized using seeded interfacial polymerization in this work. Among the series of J-MIPs, the selected J-MIP 3 showed fast binding kinetics (∼40 s) towards the target pollutant. The theoretical and instrumental analysis suggested that the electrostatic interaction, hydrogen bond and hydrophobic reaction constituted the dominant mechanism for J-MIP 3 's recognition of target pharmaceutical. Selectivity and robustness tests indicated that the synthetic method was promising in practical application. Finally, the feasibility of the J-MIP 3 fixed-bed column in the rapid removal of propranolol (PRO) from hospital effluents was successfully demonstrated. Compared to the activated carbon fixed-bed column, the J-MIP 3 fixed-bed column showed at least 7-fold enhancement in its treatment efficiency. To the best of our knowledge, this is the first time that the accelerated mass transfer and fast removal of the pharmaceutical from wastewater have been achieved by the synthetic receptor with asymmetric structure. We believe the present study will open new avenues for the development of multi-functional molecularly imprinted polymers as well as Janus materials in environmental science.
研究领域:
环境科学
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材料科学
·
生物医药工程
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产品关联
DOI
PubMed
高影响因子
JOURNAL OF CHROMATOGRAPHY A
·
2017
·
IF 3.981
Wenhua Ji,Tao Wang,Wei Liu,Feng Liu,Lanping Guo,Yanling Geng,Xiao Wang
An efficient, accurate and sensitive method for the determination of five iridoid glycosides (IGs) in Cornus officinalis fructus using molecularly imprinted solid phase extraction (MISPE) coupled with high performance liquid chromatography (HPLC) has been developed. Water-compatible molecularly imprinted beads (MIBs) were synthesized by precipitation polymerization, using alkenyl glycosides glucose as the hydrophilic functional monomer. Scanning electron microscopy showed that the MIBs had a narrow particle size distribution, with diameters in the range 7.5–9.3 μm. The special molecular recognition by the MIBs of IGs in aqueous media was verified by static adsorption, kinetic adsorption, and selectivity experiments. The newly prepared MIBs were used as sorbents in solid phase extraction (SPE) for the selective recognition of five IGs (loganin, morroniside, loganic acid, 7- O -ethyl-morroniside and 7- O -methyl morroniside) in Cornus officinalis fructus. When optimized, the MISPE-HPLC method had good linearity (0.02–100 mg g −1 ), with correlation coefficient ( R ) ≥ 0.994. Recoveries at three spiked levels were in the range 80.0%–94.0%. Because of its excellent specificity and hydrophilicity, SPE based on monodisperse MIBs provides a promising pretreatment strategy for the analysis of active components in natural products, especially for the quality control of traditional Chinese medicines.
研究领域:
分析化学
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药学
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中药学
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产品关联
DOI
PubMed
高影响因子
TALANTA
·
2018
·
IF 4.244
Wen-Hua Ji,Yu-Shuang Guo,Xiao Wang,D.-S. Guo
An accurate, rapid, and sensitive method for the determination of risperidone and 9-hydroxyrisperidone in urine samples was developed by combining water-compatible magnetic molecularly imprinted solid-phase extraction with high performance liquid chromatography. Several variables relating to the efficiency of magnetic solid phase extraction were optimized, including the amount of adsorbent, adsorption time, type of elution solvent, and desorption time. The analytical performance of this method was validated under the optimized conditions. The linearity for risperidone and 9-hydroxyrisperidone was obtained in the range 1–2000 ng mL −1 with correlation coefficient ≥ 0.991. Limits of detection of risperidone and 9-hydroxyrisperidone are 0.21 ng mL −1 and 0.24 ng mL −1 , respectively. Recoveries at three spike levels (10, 100, and 1000 ng mL −1 ) ranged from 94.6% to 102.4% with relative standard deviations (%) ≤ 5.3. These results confirmed that this method can be successfully and facilely used to analyze the multi-residues of risperidone and 9-hydroxyrisperidone in urine samples with high efficiency and good sensitivity.
研究领域:
分析化学
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药物分析
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环境科学
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产品关联
DOI
PubMed
高影响因子
危险品化学品经营许可证（带存储）