Soft Matter
·
2018
·Vol. 14
·期 28
·5888-5897
·
IF 3.709
Si Yu Zheng,Ye Tian,Xin Ning Zhang,Miao Du,Yihu Song,Zi Liang Wu,Qiang Zheng
Hydrogel films have promising applications in medical dressings, flexible electronics, etc. However, it is challenging to fabricate ultrathin hydrogel films with high toughness and controllable thickness. Here, we report a facile approach to prepare tough physical hydrogel films by spin-coating of a poly(acrylic acid-co-acrylamide) (P(AAc-co-AAm)) solution and subsequent gelation in FeCl3 solution to form carboxyl–Fe3+ coordination complexes. The thickness of the obtained gel films, ranging from several to hundreds of micrometers, was easily tunable by adjusting the spin conditions and polymer concentration. The thus obtained hydrogel films showed excellent mechanical properties, with tensile breaking strengths of 0.6–14.5 MPa, breaking strains of 140–840%, Young's moduli of 0.1–61.7 MPa, and tearing fracture energies of 300–1300 J m−2. Based on this approach, responsive tough hydrogel films can also be prepared by spin-coating of a poly(acrylic acid-co-N-isopropylacrylamide) (P(AAc-co-NIPAm)) solution. The obtained gel films showed a fast response (<60 s) and a large output force (∼0.2 MPa) triggered by a concentrated saline solution, making them an ideal material in the design of chemomechanical devices. Furthermore, a bilayer hydrogel film was fabricated by two-step spin-coating of P(AAc-co-NIPAm) and P(AAc-co-AAm) solutions, which showed reversible bending deformation under external stimuli. This simple yet effective approach should be applicable to other systems to prepare versatile hydrogel films with tunable thickness and promising applications in diverse areas.
研究领域:
材料科学
·
生物医学工程
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产品关联
DOI
PubMed
高影响因子
BIOSENSORS & BIOELECTRONICS
·
2022
·
IF 12.545
Chang Liu,Siyu Gou,Yanhui Bi,Qi Gao,Juanjuan Sun,Shanjin Hu,Weiwei Guo
A portable, cost-effective and storable DNA-gold nanoparticle (AuNP) hybrid hydrogel film based biosensing system was developed, with AuNPs serving as both the crosslinking units of the film and the signaling units. Using a layer-by-layer assembly method, hydrogel film composed of three-dimensional hydrophilic network of densely packed AuNPs interconnected by responsive DNA structures was constructed onto a glass slide. By programming the sequence of DNA structures, target-responsive hybrid films were constructed. As a proof of concept , the sequence of a substrate DNA which can be identified and cleaved by Pb 2+ -dependent DNAzyme was encoded to construct Pb 2+ -responsive DNA-AuNP hybrid hydrogel film. The high-density packing of AuNPs as signal substances significantly improved the sensitivity of the ultrathin film biosensing system while reduced the cost of expensive DNA materials. A hydrogel film composed of 10 layers of assembled DNA-AuNP structures generated sufficient visual colorimetric signals for Pb 2+ detection, with a detection limit of 2.6 nM. By introducing UO 2 2+ -dependent DNAzyme, the system could be further applied in the sensitive and selective detection of UO 2 2+ , with a detection limit of 10.3 nM. Compared with bulk-sized DNA hydrogel biosensing systems, the DNA-AuNP hydrogel film biosensing system exhibited faster response thanks to the sub-micrometer ultrathin film structures. Moreover, the protection of fragile non-covalently crosslinked DNA films with solid slides also facilitated the portable application and long-term storage of the resulting biosensing system, with 95% of the response signal retained after three months of storage. The DNA-AuNPs hydrogel film biosensing system is highly promising for future rapid on-site detection applications.
研究领域:
生物化学
·
纳米生物学
·
环境科学
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DOI
高影响因子
ADVANCED FUNCTIONAL MATERIALS
·
2025
·
IF 19
Haimen Lin,Yiheng Li,Rubin He,Wenzhen Zheng,Yipeng Lai,Yiting Xu,Birong Zeng,Conghui Yuan,Lizong Dai
Thin hydrogel films (THFs) with submillimeter thicknesses are promising for on-skin electronics due to their exceptional shape adaptability and interfacial adhesion. However, it remains challenging for THFs simultaneously achieving high transparency, conductivity, and mechanical robustness. Moreover, the fabrication of THFs is limited by the rapid dehydration and uncontrollable swelling of hydrogels. Herein, through the design of a crosslinker 3-cinnamamylphenylboric acid (RBA), a triple-crosslinking strategy is developed to fabricate large-area THFs. Anchoring RBA onto polyvinyl alcohol (PVA) chains followed by UV-crosslinking affords hydrogels (denoted as RBVA) comprising three crosslinks including dynamic boronate ester groups, [2 + 2] photocycloaddition of cinnamamide groups, and hydrophobic aggregation. RBVA THFs with thicknesses tunable from ≈ 50 to 200 µm exhibit light transmittance ≥90% at a wavelength of range 400–800 nm, toughness of 7.2–48.0 MJ m −3 , and conductivity up to 3.63 mS cm −1 . RBVA THFs maintain constant swelling ratios and mechanical properties during long time underwater soaking or cyclic drying-swelling treatment. These thin, transparent, conductive, strong, and underwater stable RBVA THFs can be processed into invisible electronic skin with highly stable underwater sensing performances. The crosslinking strategy may inspire the design of durable and underwater stable THFs, advancing their potential in flexible electronics and biomimetic materials.
研究领域:
材料科学
·
生物医学工程
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产品关联
DOI
高影响因子
Journal of Nanomaterials
·
2019
·
IF 2.233
Xiaojuan Zhang,Wenbin Cai,Lingyun Hao,Wei Zhang
This study synthesized poly(vinyl alcohol)/carboxymethyl chitosan/cyanidin (PVA/CMCS/CY) hydrogel films. First, PVA and CMCS were used to synthesize hydrogel films by ultraviolet irradiation. Meanwhile, CY was in situ combined into the hydrogel films through the electrostatic attraction between CMCS and CY. Next, the products were analyzed using Fourier-transform infrared spectroscopy, scanning electron microscopy, contact angle test, swelling analysis, and mechanical property test. The results revealed that compared with PVA/CMCS hydrogel films, the PVA/CMCS/CY hydrogel films had an interporous structure and good swelling and mechanical properties. Moreover, the drug release experiments demonstrated that the PVA/CMCS/CY hydrogel films had a CY encapsulation efficiency of 33.5% with a sustained CY release of up to 60 h. Furthermore, the examined antibacterial activities against Staphylococcus aureus and Escherichia coli showed that the porous PVA/CMCS/CY hydrogel films exhibited a certain inhibition. Cell viability experiments demonstrated that the PVA/CMCS/CY films displayed no obvious cytotoxicity to human umbilical vein endothelial cells.
研究领域:
材料科学
·
生物学
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产品关联
DOI
高影响因子
Analytical Methods
·
2024
·Vol. 16
·期 11
·1686-1696
·
IF 2.7
Xinyue Zhang,Si Wu,Tao Feng,Yuanhao Yan,Shijing Wu,Yinyu Chen,Yu Wang,Qingmiao Wang,Ning Hu,Li Wang
Based on the versatile properties of bio-derived materials, non-enzymatic assays in combination with electronic devices have attracted increasing interest. Here, we report a novel enzyme-free visualization approach for the detection of erythritol, which is a zero-calorie natural sweetener and serves as an ideal sucrose substitute for diabetics or overweight people who need sugar control. The recognition element of the electrochemical biosensor was constructed by catechol modification on a chitosan-based hydrogel film. The signal transduction was achieved by the competitive binding assay of sweeteners. The results show that 2-fluorophenylboronic acid (FPBA) can form a cyclic boronate ester with the ortho-hydroxyls of both reduced catechol and oxidized quinone, impeding the electron transfer and leading to redox signal attenuation. The addition of sweeteners caused a competitive reaction resulting in bonding between the 1,2-diols and FPBA moieties, and in the recovery of the redox signals. Importantly, the pattern of redox signal changes of catechol can be detected optically, as the oxidized quinone state is darker in color than the reduced catechol state. Using a simple cell phone imaging application, we demonstrate that erythritol can be distinguished from other sweeteners in real samples using the oxidized catechol-Chit0/agarose hydrogel film. Thus, we envision that this method could allow diabetics and people who need to control their sugar intake to detect whether the product contains only erythritol in the field or at home. In addition, this work further illustrates the potential of bio-derived materials for performing redox-based functions and enzyme-free visualization assays.
研究领域:
生物化学
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分析化学
·
材料科学
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产品关联
DOI
PubMed
高影响因子
Food Packaging and Shelf Life
·
2025
·
IF 10.6
Chao Yin,Jun Zheng,Yufan Yang,Xianwen Song,Miao Cui,Rujuan Shen,Yi Zhang
Plant polyphenols represent valuable additives for food packaging; however, their poor hydrophilicity necessitates complex pre-treatments. In this study, we propose a simple and eco-friendly strategy for the direct incorporation of hydrophobic polyphenols into packaging films. Using carboxymethyl chitosan and oxidized carrageenan as substrates, we successfully introduced hydrophobic polyphenols into multifunctional hydrogel films through borate ester bonds. The mechanical strength of these films was further enhanced by schiff base bonds. The prepared hydrogel films exhibited antibacterial rates exceeding 98 % against Escherichia coli and Staphylococcus aureus , and demonstrated excellent antioxidant and UV shielding properties. As the oxidation degree of carrageenan increased, the water vapor permeability rate of the hydrogel films decreased from 1.34 × 10⁻¹ ⁰ g·m⁻¹ ·s⁻¹ ·Pa⁻¹ to 3.13 × 10⁻¹ ¹ g·m⁻¹ ·s⁻¹ ·Pa⁻¹ , while the oxygen permeability rate decreased from 40.61 meq/kg to 20.04 meq/kg. This design effectively mitigates the deterioration of fruits and vegetables caused by dehydration and oxidation. Furthermore, the hydrogel films containing carrageenan with a medium oxidation degree exhibited superior mechanical properties, with tensile strength increasing by 4.8-fold and the ability to bear a load of 200 g. The banana preservation experiments demonstrated that hydrogel films can effectively delay the deterioration of bananas. Notably, the film exhibited excellent biodegradability, degrading by 90 % in soil within 60 days, underscoring its significant potential for developing functional and environmentally friendly food packaging systems.
研究领域:
食品科学
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材料科学
·
环境科学
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产品关联
DOI
高影响因子
COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
·
2022
·
IF 5.518
Guannan Zhang,Anping Zhu,Shihong Wang,Qianshan Chen,Bing Liu,Jun Zhou,Zhaoyang Wu
Liquid crystal droplets have shown unique response performance due to their exclusive optical properties and dispersion. However, the stability of LC droplets during storage and application needs to be improved. Here, we report a novel LC droplet sensing platform to improve the stability of LC droplets significantly. By embedding LC droplets into polyacrylamide hydrogel films, the LC droplets can be preserved for four months without noticeable volume loss and any aggregation even in the absence of surfactant . Interestingly, LC droplets exhibit remarkable stability even in ethanol and N,N-Dimethylformamide aqueous solution. Besides, the mechanical properties of hydrogel film do not reduce after embedding LC droplets. Specifically, the introduction of LC droplets improves the elasticity of the hydrogel film. As a sensing platform, the response performance of the LC droplet-embedded hydrogel film is investigated. After being exposed to ATP solution as low as 1 ng/mL, LC droplets can generate optical signal changes which can be observed by the naked eye. The strategy presented here provides a new sight for the design of LC droplet sensors and contributes to the practical application of LC droplet sensors.
研究领域:
材料科学
·
生物传感
·
化学
✓ 已验证
产品关联
DOI
高影响因子
Frontiers in Bioengineering and Biotechnology
·
2025
·
IF 4.8
Jinxi Wen,Jian Wang,Siqi Wang,Xingping Zhou,You Fu
A one-step hydrothermal method was applied to prepare carbon dots (CDs) with superior fluorescence properties using chitosan as a carbon source. The as-prepared carbon dots were then grafted onto a sodium alginate-gelatin hydrogel film to form a fluorescent hydrogel film (FHGF), emitting at 450 nm under excitation of 350 nm light. In comparison to the CDs, the fluorescence intensity of this film was maintained over 90.0% and the luminescence position remained basically unchanged, caused by the unchanged surface light-emitting structure of the CDs, due to the existence of electrostatic repulsion between the CDs and the hydrogel. Moreover, the tensile-stress of the fluorescent film with 1.0 wt.% of the CDs was increased by 200% to 10.3 Mpa, and the strain was increased from 117% to 153%. The above experimental results are attributed to the hydrogen bonding between the CDs and the sodium alginate-gelatin hydrogel from analyses of the FT-IR spectra. Interestingly, Fe3+ exerted a great quenching effect on this fluorescent film in the concentration range of 0–1.8 μM. The film can be basically used recyclically to detect Fe3+ in solution with a detection limit as low as 0.043 μM. In a word, this work demonstrated an enormous potential of carbon dots in fabricating mechanical and fluorescent properties of the hydrogel and proposed a new detection platform for Fe3+. In view of the promising Fe3+ detection capacity, this hydrogel film can also be applied in oral bacteria surveillance and semi-quantification of ferroptosis in oral cancer.
研究领域:
材料科学
·
生物医学
·
化学
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产品关联
DOI
PubMed
高影响因子
RSC Advances
·
2021
·Vol. 11
·期 37
·22993-23001
·
IF 3.361
Weizhen Wu,Xiaoyi Wu,Miao He,Xiaolin Yuan,Jiaping Lai,Hui Sun
A carbon dot/polyacrylamide (CDs/PAM) composite hydrogel film with stable fluorescence performance was fabricated by merging a hydrogel film and carbon dots (CDs) with blue fluorescence, which were prepared by hydrothermal synthesis using anhydrous citric acid and acrylamide as carbon sources. The obtained CDs/PAM composite hydrogel film exhibited a good fluorescence quenching effect on ornidazole (ONZ), and can be used for the quantitative detection of ONZ. In the ONZ concentration range of 5–60 μM, a good linear relationship between the fluorescence quenching efficiency of the CDs/PAM composite hydrogel film and the concentration of ONZ solution was obtained with a low detection limit of 2.35 μM. In addition, the detection system has good selectivity and strong anti-interference capacity, and can be used in repeated cycles for detection.
研究领域:
材料科学
·
分析化学
·
药物检测
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产品关联
DOI
PubMed
高影响因子
MACROMOLECULAR BIOSCIENCE
·
2016
·Vol. 17
·期 2
·1600281
·
IF 3.68
Min He,Xiaofei Cui,Huiyi Jiang,Xuelian Huang,Weifeng Zhao,Changsheng Zhao
In this study, heparin-mimicking hydrogel thin films are covalently attached onto poly(ether sulfone) membrane surfaces to improve anticoagulant property. The hydrogel films display honeycomb-like porous structure with well controlled thickness and show long-term stability. After immobilizing the hydrogel films, the membranes show excellent anticoagulant property confirmed by the activated partial thromboplastin time values exceeding 600 s. Meanwhile, the thrombin time values increase from 20 to 61 s as the sodium allysulfonate proportions increase from 0 to 80 mol%. In vitro investigations of protein adsorption and blood-related complement activation also confirm that the membranes exhibit super-anticoagulant property. Furthermore, gentamycin sulfate is loaded into the hydrogel films, and the released drug shows significant inhibition toward E. coli bacteria. It is believed that the surface attached heparin-mimicking hydrogel thin films may show high potential for the applications in various biological fields, such as blood contacting materials and drug loading materials.
研究领域:
生物材料学
·
血液相容性研究
✓ 已验证
DOI
PubMed
高影响因子
ADVANCED ENGINEERING MATERIALS
·
2020
·Vol. 22
·期 5
·1901198
·
IF 3.217
Xiaoting Ren,Mingshuai Guo,Lili Xue,Qingyang Zeng,Xianze Gao,Yonglei Xin,Likun Xu,Li Li
The flexible mucus film and hydrophilic hierarchical micro-/nanoprotuberance structure on the skin surfaces of marine organisms contribute to an excellent intrinsic antifouling performance. Inspired by this fact, a self-cleaning mucus-like and hierarchical ciliary bionic antifouling surface (SMCAS) is designed for marine antifouling based on the electrostatic flocking technology. The results of scanning electron microscopy (SEM) show that the bioinspired SMCAS has a hierarchical micro-/nanociliary structure and the micrometer array of polyamide (PA) microfibers is covered with the nanometer carbon nanotube/polyvinyl alcohol (CNT/PVA) hydrogel particles. The biomasses of the two marine microoganisms, Nitzschia closterium f. minutissima and Marinobacter lipolyticus SM19 (T), attached on the SMCAS are investigated using a UV–visible spectrophotometer (UV–vis) and SEM. The results reveal that the microoganisms attached on the SMCAS are significantly lower number in comparison with the organic silicon coating. In addition, the SMCAS has a greater ability of stain removal in the dyed petroleum ether washing test. Therefore, the SMCAS demonstrates an extraordinary antifouling performance due to the synergetic effect of the mucus-like hydrogel film and the hierarchical micro-/nanostructured micropillars.
研究领域:
材料科学
·
生物医学工程
✓ 已验证
DOI
高影响因子
iScience
·
2022
·
IF 6.107
Xiaoxiang Wen,Xuegang Lu,Jianing Li,Chaoping Wei,Hongji Qin,Yuting Liu,Sen Yang
In nature, many organisms (e.g., chameleons) protect themselves by changing their colors in response to environmental changes. Inspired by these organisms, we present a multi-responsive, flexible, and structurally colored hydrogel film with a one-dimensional (1D) ordered periodic groove structure. The groove structure endows the film with bright, highly angle-dependent structural colors, which can be reversibly tuned by stretching and releasing. In addition, because of the thermosensitive properties of the hydrogel, the film can be switched between colored state and opaque white state with temperature. In addition, the optical state of the film is sensitive to solvent and can be reversibly changed between colored state and transparent state with soaking and evaporation of the solvent. This reversible, multi-responsive, flexible, and structurally colored hydrogel film has great potential to be used in the fields of color display, sensors, anti-counterfeiting, and so on because of its flexible and diverse tuning methods, excellent optical performance, and convenient preparation process.
研究领域:
材料科学
·
生物学
✓ 已验证
DOI
高影响因子
危险品化学品经营许可证（带存储）