ACS Applied Materials & Interfaces
·
2020
·
IF 8.758
Xin Su,Dezhao Hao,Xiuqi Xu,Xinglin Guo,Zhengning Li,Lei Jiang
Hydrogels, as a representative of soft and biocompatible materials, have been widely used in biosensors, biomedical devices, soft robotics, and the marine industry. However, the ir-recoverability of hydrogels after dehydration, which causes the loss of original mechanical, optical, and wetting properties, has severely restricted their practical applications. At present, this critical challenge of maintaining hydrogels’ accurate character has attracted less attention. To address this, here we report a hydrogel based on synergistic effects to achieve both well-regulated rehydration and deswelling properties. The hydrogel after dehydration can quickly restore its original state both on the macro- and microscale. In addition, the hydrogel has excellent mechanical stability after several dehydration–rehydration cycles. All of these properties offer a possibility of water condition endurance and increase the service life. The robust property is attributed to the hydrophilic–hydrophobic and ionic interactions induced by the synergy of hydrophilic/oleophilic heteronetworks. Moreover, zwitterionic segments as hydrophilic network play a vital role in fabricating anti-biofouling hydrogels. The durable and reusable hydrogel may have promising applications for biomedical materials, flexible devices, and the marine industry.
研究领域:
材料科学
·
生物医学工程
·
海洋科学
✓ 已验证
DOI
高影响因子
ACS Applied Materials & Interfaces
·
2017
·
IF 7.504
Dishi Wang,Yanxia Zhou,Xinru Li,Xiaoyou Qu,Yunqiang Deng,Ziqi Wang,Chuyu He,Yang Zou,Yiguang Jin,Yan Liu
pH-responsive polymeric micelles have shown promise for the targeted and intracellular delivery of antitumor agents. The present study aimed to elucidate the possible mechanisms of pH-sensitivity and cellular internalization of PEOz-b-PLA micelles in detail, further unravel the effect of hydrophilic/hydrophobic ratio of the micelles on their cellular internalization, and examine the intracellular trafficking routes and fate of PEOz-b-PLA after internalization of the micelles. The results of variations in the size and Zeta potential of PEOz-b-PLA micelles and cross-sectional area of PEOz-b-PLA molecules with pH values suggested that electrostatic repulsion between PEOz chains resulting from ionization of the tertiary amide groups along PEOz chain at pH lower than its pKa was responsible for pH-sensitivity of PEOz-b-PLA micelles. Furthermore, the studies on internalization of PEOz-b-PLA micelles by MCF-7 cells revealed that the uptake of PEOz-b-PLA micelles was strongly influenced by their structural features, and showed that PEOz-b-PLA micelles with hydrophilic/hydrophobic ratio of 1.7–2.0 exhibited optimal cellular uptake. No evident alteration in cellular uptake of PEOz-b-PLA micelles was detected by flow cytometry upon the existence of EIPA and chlorpromazine. However, the intracellular uptake of the micelles in the presence of MβCD and genistein was effectively inhibited. Hence, the internalization of such micelles by MCF-7 cells appeared to proceed mainly through caveolae/lipid raft-mediated endocytosis without being influenced by their hydrophilic/hydrophobic ratio. Confocal micrographs revealed that late endosomes, mitochondria and endoplasmic reticulum were all involved in the intracellular trafficking of PEOz-b-PLA copolymers following their internalization via endocytosis, and then part of them was excreted from tumor cells to extracellular medium. These findings provided valuable information for developing desired PEOz-b-PLA micelles to improve their therapeutic efficacy and reducing the potential safety risks associated with their intracellular accumulation.
研究领域:
药剂学
·
分子生物学
·
肿瘤学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
JOURNAL OF POLYMER RESEARCH
·
2024
·Vol. 31
·期 2
·1-12
·
IF 2.6
Lei Jinxuan,Meng Lingxin,Zhao Pengyun,Wang Jiayin,Lan Tian,Xu Jingmei
A series of poly(aryl ether ketone sulfone) polymers (C-PAEKS-DBS) were synthesized from 4-carboxyphenyl hydroquinone, allyl bisphenol S, and 4,4-difluorobenzophenone by nucleophilic polycondensation. And further a series of side chain sulfonated poly(aryl ether ketone sulfone) proton exchange membranes (CPDA-x) were prepared by simply introducing hydrophilic long alkyl side chains (AMPS) into the polymers by means of double bond cross-linking. The structure of the prepared CPDA-x were characterized by FT-IR, 1 H NMR and SEM. This series of composite membranes showed excellent dimensional stability which including moderate water absorption (ranging from 27.91% to 33.33% at 80 °C) and low swelling ratio (ranging from 10.26% to 16.67% at 80 °C). In addition, the prepared films also exhibited high oxidative stability and mechanical property. This simple strategy for the producing of proton exchange membranes (PEMs) has certain potential and may be applied to the producing of fuel cell membranes with hydrophilic and hydrophobic phase separation structures.
研究领域:
材料科学
·
能源科学
✓ 已验证
DOI
高影响因子
Nature Communications
·
2022
·Vol. 13
·期 1
·1-14
·
IF 17.694
He Huaying,Zhou Weikang,Gao Jing,Wang Fan,Wang Shaobing,Fang Yan,Gao Yang,Chen Wei,Zhang Wen,Weng Yunxiang,Wang Zhengchao,Liu Haiqing
Cotton gauze is a widely used topical hemostatic material for bleeding control, but its high blood absorption capacity tends to cause extra blood loss. Therefore, development of rapid hemostatic cotton gauze with less blood loss is of great significance. Here, we develop an efficient hemostatic cotton gauze whose surface is slightly modified with a catechol compound which features a flexible long hydrophobic alkyl chain terminated with a catechol group. Its hemostatic performance in animal injuries is superior to standard cotton gauze and Combat Gauze TM . Its biosafety is similar to cotton gauze and rebleeding hardly occurs when the gauze is removed. Here, we show its hemostatic capability is attributable to the rapid formation of big and thick primary erythrocyte clots, due to its effective controlling of blood movement through blocking effect from tissue adhesion by catechol, blood wicking in cotton, and the hydrophobic effect from long alkyl chains.
研究领域:
生物医学工程
·
材料科学
·
血液学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
CHEMICAL ENGINEERING SCIENCE
·
2023
·
IF 4.7
Qinghai Long,Shuo Wang,Shufeng Shen
Maintaining water balance in water-lean solvents is drawing special attention as it may affect the capture performance and process stability. In this study, novel water-lean solvents containing ethylene glycol monohexyl ether (EGHE) and secondary alkanolamines was proposed for energy-saving postcombustion CO 2 capture. Excess water from wet flue gas can be discharged from the desorber overhead condensate which can produce a spontaneous phase-separation feature. Less than 0.8 mass% EGHE was observed in the water-rich phase of the biphasic condensate. Effect of water content in these absorbents on CO 2 capture performance was discussed. Most notably, regeneration energy consumption increased significantly as increasing water content in the absorbent. The proposed water-lean absorbents with 10 % H 2 O can reduce the regeneration heat duty by about 40% in comparison with aqueous MEA, indicating that the novel water balance design can make it competitive in a practical sense.
研究领域:
化学工程
·
环境科学
✓ 已验证
产品关联
DOI
高影响因子
TALANTA
·
2019
·
IF 4.916
Wenjie Zhao,Huiying Zuo,Yun Guo,Kejian Liu,Sheng Wang,Lijun He,Xiuming Jiang,Guoqiang Xiang,Shusheng Zhang
A novel hydrophilic–lipophilic balanced (HLB) solid phase extraction sorbent , microporous covalent triazine-terphenyl polymer (CTP CC-TP ) was successfully synthesized and applied for the cleanup and extraction of tetracycline drugs in animal derived food samples. The specific ratio of two monomers , hydrophilic triazine and lipophilic aromatic rings , endowed the new material with hydrophilic–lipophilic balanced character, which made it capable of extracting both polar and nonpolar analytes. Prior to solid-phase extraction, food samples were extracted by McIlvaine buffer and passed through the CTP CC-TP cartridge. The experimental parameters affecting extraction efficiency, including loading, washing and elution were investigated and optimized. With the use of high-performance liquid chromatography-UV detection, a method detection limit in the range of 8.0–16.8 μg kg −1 and good linearity (22.6–1500 μg kg −1 ) for the determination of the tetracyclines in animal derived food samples can be achieved. The relative standard deviations (RSDs) for five replicate extractions of the tetracyclines ranged from 4.8 to 8.2%. The method recoveries for spiked tetracyclines (100 and 1000 μg kg −1 ) in bovine milk, egg, chicken liver samples were in the range of 81.3–98.7% with RSDs ranging from 3.9 to 7.7%, respectively, depending on both the analytes and samples. The method was suitable for the determination of tetracyclines in animal derived food samples.
研究领域:
食品安全
·
分析化学
✓ 已验证
DOI
高影响因子
EUROPEAN POLYMER JOURNAL
·
2023
·
IF 6
Jun Li,Peng Huang,Xiangbin Sun,Xue Bai,Yufeng He,Rongmin Wang
Conventional N-halamine precursor polymers with excess hydrophilic/hydrophobic and rigid/flexible groups have failed to achieve a co-balanced effect of amphiphilicity and rigidity-flexibility. To overcome this problem, hydantoin terpolymer nanohemispheres (P(AMH-St-BA)NHs) were synthesized by regulating both hydrophilic/hydrophobic and rigid/flexible group ratios to 1:1 using emulsion polymerization. Thereafter, a novel N-halamine terpolymer nanohemisphere (P(ClA-St-BA)NHs) with antibacterial activity was fabricated through chlorination treatment. Interestingly, chlorinated nanohemispheres were more dispersed and regularly shaped. Moreover, the effective chlorine content (Cl + ) of P(ClA-St-BA)NHs was detected to be 1.1 % by iodometric/thiosulfate titration, and the existence of N-Cl bonds was supported from the color change of titration. In vitro cytotoxicity suggested that P(AMH-St-BA)NHs possessed superior biocompatibility and safety. Additionally, the antimicrobial performance of samples with three various morphologies was investigated, discovering that the antibacterial rates of P(ClA-St-BA)NHs up to 89.5 % and 93.5 % against E. coli and S. aureus , respectively, exhibited a stronger antimicrobial capability than membranous and porous N-halamine copolymers, which reveals that their special shape elevates the property. In parallel, the antibacterial mechanism of nanohemispheres was also explored, and it was recognized that indirectly released Cl + synergizes with direct contact of N-Cl bonds for antibacterial purposes. By designing nanohemispheres, this method helps to provide new thoughts for realizing the co-balancing effects of hydrophilicity/hydrophobicity and rigidity/flexibility.
研究领域:
材料科学
·
生物学
·
医学
✓ 已验证
产品关联
DOI
高影响因子
INTERNATIONAL JOURNAL OF PHARMACEUTICS
·
2022
·
IF 6.51
Hua Nie,Xiao-Min Liu,Qi-Xuan Yang,Xiao-Dong Luo,Ying Zhao,Sheng-Yuan Zhang
In this study, we explored the effect of the hydrophile–lipophile balance (HLB) in the linker unit of Galactose (Gal)/N-acetylgalactosamine (GalNAc) ligands on their affinity toward asialoglycoprotein receptors (ASGPRs). Two Gal/GalNAc ligands with lipophilic linkers—{(5-cholesten-3b-ol)[(2-acetamido-2-deoxy-d-galactopyranose-6-o)sebacate]} (CHS-6-GalNAc) and {(5-cholesten-3b-ol)[(d-galactopyranose-6-o)sebacate]} (CHS-6-Gal)—and two with hydrophilic linkers—{(5-cholesten-yl)[(4-O-b-D-galactopyranosyl)-D-glucitol-6-yl]sebacate} (CHS-1-Gal) and {(5-cholesten-3a-ol)[(2-acetamido-2-deoxy-d-galactopyranose-6-o)3,6-dioxa-octanedioate]} (CHS-PEG 2 -6-GalNAc)—were synthesized by enzymatic catalysis. Compared with unmodified liposomes, all Gal/GalNAc ligand–modified liposomes showed higher efficiency toward the hepatocyte target as evaluated by weighted-average overall drug-targeting efficiency ( Te* ) in vivo and HepG2 cell uptake efficiency in vitro . The ligands containing linkers with high HLB values ( i.e. , CHS-PEG 2 -6-GalNAc and CHS-1-Gal) exhibited higher ASGPR affinity than those containing linkers with low HLB values ( i.e. , CHS-6-GalNAc and CHS-6-Gal). We used molecular-dynamics (MD) simulations to investigate the structure–activity relationship between the HLB value of the linker in a ligand and ASGPR affinity. MD simulation results indicated that a Gal/GalNAc ligand with a more hydrophilic linker ( i.e. , higher HLB value) unit tended to have a higher solvent-accessible surface area (SASA), leading to lower steric hindrance for effective ASGPR recognition. The results of this study will provide an improved design for Gal/GalNAc ligand–based surface-modified liposomes with high ASGPR affinity.
研究领域:
药剂学
·
生物化学
·
分子生物学
✓ 已验证
DOI
高影响因子
ELECTROPHORESIS
·
2022
·
IF 3.595
Ya-Ling Yu,Min-Zhen Shi,Si-Chen Zhu,Jun Cao
A novel technology by two-phase amphiphilic preconcentration based on surfactants was established for enriching phenolic compounds by micellar electrokinetic chromatography (MEKC). The cationic surfactant cetyltrimethylammonium chloride (CTAC) was combined with the anionic analytes that existed in the sample solution before injection. The boundary was formed between CTAC and sodium dodecyl sulfate (SDS) in the background solution when the sample solution was injected into the capillary, where the analytes bound inside micelles were released due to the stronger electrostatic force between SDS and CTAC. This procedure accelerated the separation of analytes from CTAC and greatly improved the enrichment efficiency. The optimal conditions were obtained after a series of optimizations, and the sensitivity enrichment factors of the four analytes were in the range of 39–93 compared to typical injections in capillary zone electrophoresis. Good linearity for matrix-matched calibrations was established for all analytes with R 2 values of 0.9993–0.9997. The limits of detection (S/N = 3) for kaempferol, quercetin, salvianolic acid C, and salvianolic acid B were 0.0166, 0.0292, 0.0215, and 0.0195 µg/ml, respectively. The intracapillary RSDs of the analytes ranged from 0.8% to 1.3% for migration time and from 0.4% to 1.8% for peak areas. The developed method was successfully applied to the determination of phenolic compounds, the main compounds of Salvia miltiorrhiza Bge., and had been validated for the determination of spiked recoveries in rat urine.
研究领域:
分析化学
·
药理学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
MOLECULAR PHARMACEUTICS
·
2013
·
IF 4.57
Wenjing Li,Xinru Li,Yajie Gao,Yanxia Zhou,Shujin Ma,Yong Zhao,Jinwen Li,Yan Liu,Xinglin Wang,Dongdong Yin
The present study aimed to investigate the effect of monomethoxy poly(ethylene glycol)-block-poly(d,l-lactic acid) (mPEG-PLA) on the activity of P-glycoprotein (P-gp) in Caco-2 cells and further unravel the relationship between PLA chain length in mPEG-PLA and influence on P-gp efflux and the action mechanism. The transport results of rhodamine 123 (R123) across Caco-2 cell monolayers suggested that mPEG-PLA unimers were responsible for its P-gp inhibitory effect. Furthermore, transport studies of R123 revealed that the inhibitory potential of P-gp efflux by mPEG-PLA analogues was strongly correlated with their structural features and showed that the hydrophilic mPEG-PLA copolymers with an intermediate PLA chain length and 10.20 of hydrophilic–lipophilic balance were more effective at inhibiting P-gp efflux in Caco-2 cells. The fluorescence polarization measurement results ruled out the plasma membrane fluidization as a contributor for inhibition of P-gp by mPEG-PLA. Concurrently, mPEG-PLA inhibited neither basal P-gp ATPase (ATP is adenosine triphosphate) activity nor substrate stimulated P-gp ATPase activity, suggesting that mPEG-PLA seemed not to be a substrate of P-gp and a competitive inhibitor. No evident alteration in P-gp surface level was detected by flow cytometry upon exposure of the cells to mPEG-PLA. The depletion of intracellular ATP, which was likely to be a result of partial inhibition of cellular metabolism, was directly correlated with inhibitory potential for P-gp mediated efflux by mPEG-PLA analogues. Hence, intracellular ATP-depletion appeared to be possible explanation to the inhibition mechanism of P-gp by mPEG-PLA. Taken together, the establishment of a relationship between PLA chain length and impact on P-gp efflux activity and interpretation of action mechanism of mPEG-PLA on P-gp are of fundamental importance and will facilitate future development of mPEG-PLA in the drug delivery area.
研究领域:
药学
·
药理学
·
药物递送系统
✓ 已验证
产品关联
DOI
PubMed
高影响因子
JOURNAL OF PETROLEUM SCIENCE AND ENGINEERING
·
2022
·
IF 5.168
Erdong Yao,Yuechun Wang,Hao Bai,Lianqi Sheng,Jianhua Guo,Junjian Li,Kun Zhang,Guolin Yu,Fujian Zhou
With the development of nanotechnology, nanomaterials have shown good potential for enhanced oil recovery , which is of great significance for oil and gas production. Compared with nanoparticles and nanoemulsions , nanosheets have higher interfacial activity due to their two-dimensional structure, which can form a climbing film on the interface of oil-water and efficiently improve oil recovery. However, the influencing factors of the film-climbing effect and the relationship between the film-climbing effect and enhanced oil recovery are still not clear. In this paper, small-sized water-soluble nanosheets which were molybdenum disulfide (MoS 2 ) nanosheets (30–50 nm) were synthesized using a one-step hydrothermal method , which have strong stability during the flooding test. And then, modifiers with different carbon chain lengths were used to modify the hydrophile-lipophile balance (HLB) of nanosheets. Next, the influencing factors of nanosheets' climbing film were discussed, and the two-phase height index was innovatively used to characterize the strength of the nanosheets climbing film in the oil-water system. The results show that the longer the carbon chain length of the modifier, the closer the nanosheets are to neutral wet with stronger interfacial activity. In addition, molybdenum disulfide nanosheets can produce a climbing film at the oil-water interface, which is related to salinity , concentration, and diameter of test jar. In a word, the oil displacement efficiency can be characterized by the two-phase height index, and the higher the index, the higher the oil displacement efficiency. This makes us fully realize the importance of climbing film in tertiary oil recovery, and provides a new method for the effective development of oil and gas resources.
研究领域:
纳米技术
·
石油工程
·
材料科学
✓ 已验证
产品关联
DOI
高影响因子
Polymer Chemistry
·
2023
·Vol. 15
·期 3
·193-201
·
IF 4.6
Yanqiu Du,Haidong Li,Yang Jiang,Yunchao Xiao,Jipeng Guan,Xuejie Liu,Nan Yan
Nanocrystal (NC) superlattices assembled from functional inorganic nanoparticles have received extensive attention due to their intriguing integrated properties and various potential applications arising from strong plasmon coupling interactions. However, the controllable assembly of colloidal NCs in an aqueous solution, especially for dynamical sequential growth, still remains an enormous challenge. Herein, we develop a robust strategy to realize the precisely controllable self-assembly and sequential oriented growth of gold nanoparticles (AuNPs) tethered to poly(ethylene glycol) (PEG) polymeric ligands in a salt solution through the dehydration degree of PEG ligands induced by the Hofmeister effect, thus yielding two-dimensional (2D) monolayer hexagonally-packed superlattices, three-dimensional (3D) single crystals with face-centered cubic (FCC) lattices and adjustable layer numbers, and multiply twinned superlattices depending on the initial salt concentrations. This finding will offer an efficient and robust approach for preparing functional superlattice materials with predictable internal packing symmetry and adjustable dimensions.
研究领域:
纳米生物学
·
胶体化学
·
生物材料学
·
自组装技术
·
纳米医学
·
高分子物理
·
界面科学
✓ 已验证
DOI
高影响因子
危险品化学品经营许可证（带存储）