CELL BIOLOGY INTERNATIONAL
·
2026
·Vol. 50
·期 8
·e70195
·
IF 3.5
Cheng Zhang,Fei Lu,Ting Ye,Yueping Jin,Yunpeng Qin,Kairui Wu,Kai Liu,Xuncui Wang,Hang Song,Xuejun Li
Chronic atrophic gastritis (CAG) with intestinal metaplasia (IM) is a key precancerous lesion that may progress to intestinal‐type gastric adenocarcinoma. Piwei Peiyuan Pill (PPP) has shown significant clinical efficacy in ameliorating CAG with IM, but its active components and underlying mechanisms remain unclear. High‐performance liquid chromatography (HPLC) and ultra‐high performance liquid chromatography coupled with high‐resolution mass spectrometry (UHPLC‐HRMS) were used to identify the components of PPP and the active ingredients in PPP‐containing serum. The therapeutic efficacy and potential mechanisms of PPP were further investigated via transcriptomic sequencing and experimental validation. UHPLC‐HRMS analysis of PPP‐containing serum identified several bioactive components, including esculin, lithospermic acid, and atractylenolide III. In CAG rats, PPP significantly ameliorated gastric mucosal damage and reduced serum IL‐6 and TNF‐α levels. Transcriptomic results showed that IRAK1 was highly expressed in CAG patients with IM and associated with activation of the NF‐κB pathway. PPP intervention dose‐dependently suppressed hyperactivation of the Pellino1/IRAK1/NF‐κB axis and decreased the expression of intestinal metaplasia markers CDX1 and MUC2. Additionally, PPP improved immune function by increasing the proportion of CD4 + T cells and decreasing the proportion of CD8 + T cells in CAG model rats. Taken together, these findings suggest that PPP mitigates CAG and attenuates IM at least in part by suppressing the Pellino1/IRAK1/NF‐κB signaling pathway, indicating that it may serve as a promising therapeutic strategy for reducing inflammation‐associated gastric carcinogenesis.
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Journal of Cleaner Production
·
2026
·
IF 10
Bao Yu,Yuan Cheng,Tongbin Chen,Junxing Yang,Guodi Zheng
The pigsty is a major source of odor emissions, and effective on-site odor control is essential for improving the growth environment of pigs and reducing the burden on downstream deodorization systems. In this study, a simulated pigsty environment was used to systematically evaluate the deodorization efficacy of five organic acid salt solutions applied via surface spraying on pig manure. The objectives were to clarify their physicochemical solubilization effects, underlying microbial mechanisms and key functional taxa. Results showed that sodium lactate significantly outperformed the other organic acid salts, achieving an average reduction of 34.4 % ± 19.4 % in total odor activity over a 48-h cleaning period. This superior performance was primarily due to the effective inhibition of the key odorant p -cresol, with an average removal rate of 42.5 % ± 23.6 % and a peak removal rate of 76.8 % ± 1.2 % at 48 h. Analyses of the critical micelle concentration and Henry's law constant ruled out solubilization as the primary mechanism of p -cresol removal. Furthermore, changes in microbial biomass did not support the hypothesis that lactate deodorizes mainly via broad-spectrum bacterial inhibition. Instead, the primary mechanism involves enhanced microbial degradation of p-cresol. Notably, the biomass of the key bacterial genus Lentilactobacillus increased by 8.1–217.9-fold, promoting a microbial community that includes Faecalibaculum , Bifidobacterium , and Lachnospiraceae NK4A136_group . This community disrupts the stability of the odor-producing microbial symbiotic network through negative interactions. This study provides a new solution for controlling odor emissions from pig manure by identifying key microbial symbiotic mechanisms involved in odor production and inhibition.
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ACS Nano
·
2026
·
IF 16
Huifang Guo,Xueli Sun,Xiaojiao Yang,Dongjie Zuo,Jing Sun,Zi-Ang Nan,Xuekun Gong,Simin Li,Jianyu Wei,Nanfeng Zheng,Hui Shen
A growing body of research has demonstrated that ligand-passivated metal nanoclusters, particularly those stabilized by alkynyl ligands, exhibit catalytic activity without the need for ligand removal. The fundamental origin of catalytic activity in these seemingly inert yet highly active metal nanoclusters has remained unclear. In this study, we investigate an alkynyl-passivated [Ag18Cu12H2(3-MeC6H4C≡C)22(dppe)4](SbF6)4 nanocluster (where dppe represents 1,2-bis(diphenylphosphino)ethane), which demonstrates high performance in the electrocatalytic nitrogen reduction reaction (NRR). Through comprehensive experimental and theoretical investigations, we reveal that the Lewis acid (LA) sites on the cluster surface are responsible for the observed high catalytic activity. Our mechanistic studies elucidate the role of these LA sites in nitrogen molecule activation. This work not only presents a model alkynyl-passivated metal nanocluster for understanding catalytic mechanisms in chemical transformations but also establishes Lewis acidity as an experimentally suitable descriptor for explaining the catalytic behavior of metal nanoclusters passivated by ligands beyond alkynyl.
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FUEL
·
2023
·
IF 7.4
Mingwei Gao,Mingshan Zhang,Peng Liu,Caili Dai,Qing You,Qiang Xue,Mingwei Zhao,Zhehui Jin
CO 2 enhanced oil recovery (CO 2 -EOR) is one of the CO 2 utilization methods which can also geo-sequestrate greenhouse gases. Due to the weak adsorption on rock surface and excellent viscoelasticity performance, CO 2 -responsive zwitterionic wormlike micelles (WLMs) has been recognized as a promising method to control CO 2 channeling. A novel CO 2 responsive zwitterionic WLMs was developed by blending N -octadecyl- N , N -dimethyl-3-ammonio-2-hydroxy-1-propane-sulfonate (OHSB), N , N , 2 , 2 -tetramethyl-1,3-propanediamine (TADPA) and sodium salicylate (NaSal). The responsive behaviors induced by varying agents (CO 2 and HCl) are systematically studied by rheology tests and cryo-TEM measurements. The molecular structures of products are confirmed by 1 H and 13 C NMR. Moreover, the responsive mechanism is discussed in detail. The OHSB/NaSal/TADPA system shows morphological transformations between spherical micelles (a good flowing capacity) and WLMs (conducive to plugging) before and after purging CO 2 . The viscoelasticity and molecular structure of the system with CO 2 bubbling is different from that with HCl titration, because TADPA molecules can react with CO 2 to form a novel zwitterionic product: NH + (CH 3 ) 2 -CH 2 -C(CH 3 ) 2 -CH 2 -NHCO 2 − (TAH + DPACO 2 − , 78.95 %–83.52 %). This work provides a new strategy for the design of CO 2 -responsive zwitterionic WLMs and their applications in CO 2 utilization schemes, including clean fracturing, mobility control, and CO 2 foam flooding, etc.
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JOURNAL OF ETHNOPHARMACOLOGY
·
2023
·
IF 5.4
Liping Han,Ting Li,Yingying Wang,Weizi Lai,Hengpu Zhou,Zhuangwei Niu,Jie Su,Guiyuan Lv,Guangji Zhang,Jianli Gao,Jianbo Huang,Zhaohuan Lou
Ethnopharmacological relevance Weierning tablet (WEN) is a traditional Chinese patent medicine widely used in clinical for chronic atrophic gastritis (CAG) therapy for years. However, the underlying mechanisms of WEN on anti-CAG are still unveiled. Aim of the study The present study aimed to elucidate the characteristic function of WEN on anti-CAG and to illuminate its potential mechanism. Methods The CAG model was established by gavage rats with a modeling solution (consisting of 2% sodium salicylate and 30% alcohol) with irregular diets and free access to 0.1% ammonia solution for two months on end. An enzyme-linked immunosorbent assay was used to measure the serum levels of gastrin , pepsinogen , and inflammatory cytokines. qRT-PCR was applied to measure mRNA expressions of IL-6 , IL-18, IL-10, TNF-α, and γ-IFN in gastric tissue. Pathological changes and the ultrastructure of gastric mucosa were examined by hematoxylin and eosin staining and transmission electron microscopy , respectively. AB-PAS staining was applied to observe the intestinal metaplasia of gastric mucosa. Immunohistochemistry and Western blot were used to measure the expression levels of mitochondria apoptosis-related proteins and Hedgehog pathway-related proteins in gastric tissues. Expressions of Cdx2 and Muc2 protein were determined by immunofluorescent staining. Results WEN could dose-dependently lower the serum level of IL-1β and the mRNA expressions of IL-6, IL-8, IL-10, TNF-α, and γ-IFN in gastric tissue. Also, WEN significantly alleviated the collagen deposition in gastric submucosa, regulated the expressions of Bax, Cleaved-caspase9, Bcl2 , and Cytochrome c to reduce the apoptosis of gastric mucosa epithelial cells, and maintained the integrity of the gastric mucosal barrier. Moreover, WEN could reduce protein expressions of Cdx2, Muc2, Shh, Gli1, and Smo, and reverse intestinal metaplasia of gastric mucosa to block the progress of CAG. Conclusion This study demonstrated a positive effect of WEN on improving CAG and reverse intestinal metaplasia. These functions were related to the suppression of gastric mucosal cells' apoptosis and the inhibition of Hedgehog pathways’ activation.
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Nano Research
·
2023
·Vol. 16
·期 5
·6632-6641
·
IF 9.9
Zhang Zunjie,Liu Yang,Su Xiaozhi,Zhao Ziwei,Mo Zhenkun,Wang Chenyi,Zhao Yaling,Chen Ye,Gao Shuyan
Electrochemical nitrate reduction reaction (NO 3 RR) has great potential for ammonia (NH 3 ) synthesis benefiting from its environmental friendliness and sustainability. Cu-based alloys with elemental diversity and adsorption tunability are widely used as electrocatalyst to lower the reaction overpotential for NO 3 RR catalysis. However, phase separation commonly found in alloys leads to uneven distribution of elements, which limits the possibility of further optimizing the catalytic activity. Herein, an electro-triggered Joule heating method, possessing unique superiority of flash heating and cooling that lead to well-dispersed nanoparticles and uniform mixing of various elements, was adopted to synthesize a single-phase CuNi nano-alloy catalyst evenly dispersed on carbon fiber paper, CFP-Cu 1 Ni 1 , which exhibited a more positive NO 3 RR initial potential of 0.1 V versus reversible hydrogen electrode (vs. RHE) than that of pure copper nanoparticles at 10 mA·cm −2 in 0.5 mol·L −1 Na 2 SO 4 + 0.1 mol·L −1 KNO 3 solution. Importantly, CFP-Cu 1 Ni 1 presented high electrocatalytic activity with a Faradaic efficiency of 95.7% and NH 3 yield rate of 180.58 µmol·h −1 ·cm −2 (2550 µmol·h −1 ·mg
−1 cat
) at −0.22 V vs. RHE. Theoretical calculations showed that alloying Cu with Ni into single-phase caused an upshift of its d-band center, which promoted the adsorption of NO
− 3
and weakened the adsorption of NH 3 . Moreover, the competitive adsorption of hydrogen ions was restrained until −0.24 V. This work offers a rational design concept with clear guidance for rapid synthesis of uniformly dispersed single-phase nano-alloy catalyst for efficient electrochemical NO 3 RR toward ammonia.
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APPLIED SURFACE SCIENCE
·
2023
·
IF 6.7
Haiying Wei,Tingwei Zhang,licheng Li,Farzad Seidi,Huining Xiao
Platinum-loaded dendritic mesoporous silica catalysts (Pt/DMS) with the size controlled by changing the molar ratio of NaSal/CTAB (φ) were successfully prepared using an incipient impregnating method. The resulting catalysts with high specific surface areas and distinctive central-radial pore channels exhibited excellent ethylene catalytic oxidation at low temperatures, enabling the complete ethylene conversion at 25 °C for 60 h and even at 0 °C for 200 min. The φ value plays an important role in controlling the DMS support structure and Pt activity. The high efficiency of low-temperature ethylene oxidation and long-term stability for Pt/DMS are attributed to high Pt dispersion, small Pt size, high Pt 0 content and the rapid CO oxidation process. As an ethylene scavenger, Pt/DMS delayed the postharvest decay, deterioration, and storage quality loss of bananas and avocados, demonstrating the significant potential of as-prepared catalysts in the applications associated with fruit and vegetable (F&V) preservation.
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Reaction Chemistry & Engineering
·
2023
·Vol. 8
·期 8
·2011-2021
·
IF 3.9
Wang Yingshu,Wang Hong,Tang Yixin,Shu Yu,Zhao Suying,Hong Lu,Xu Zhenqi
Electrochemical ammonia synthesis has advantages over the conventional Haber–Bosch process in terms of environment friendliness, sustainability, and cleanliness. However, this process is facing challenges such as low ammonia yield and low Faraday efficiency due to the low solubility and the difficulty in activation of nitrogen in aqueous solutions. To overcome these limitations, finding a catalyst of high efficiency, stability, and selectivity is crucial. Inspired by the concept of noble metal doping and two-dimensional layered catalysts, we have designed a novel catalyst for nitrogen reduction by incorporating ruthenium into lanthanum sulfide. In this context, the inclusion of ruthenium serves to optimize the electron transfer interface, enhance the low conductivity of lanthanum sulfide, and increase the number of active sites. Furthermore, the synergistic effect between the ruthenium and lanthanum ions significantly improves the activity of the catalyst. As a catalyst for the N2 reduction reaction (NRR), Ru/La2S3 demonstrates a superior NH3 formation rate of 19.40 μg h−1 mgcat−1 and a faradaic efficiency of 7.77% at −0.5 V versus the reversible hydrogen electrode (RHE). These values are significantly higher compared to those of La2O3 (1.4%; 12.5 μg h−1 mgcat−1) and La2S3 (2.3%; 10.7 μg h−1 mgcat−1), and most reported values in this field.
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JOURNAL OF CHROMATOGRAPHY A
·
2022
·
IF 4.601
Huazi Wang,Tiantian Wang,MingXiu Hong,Ziyang Wang,Xiaoyan Jin,Hai Wu
This study describes the development of a fully manual method for on-site dispersive liquid-liquid microextraction based on the direct solidification of switchable-hydrophilicity salicylic acid (on-site DLLME-DSSA) coupled with high-performance liquid chromatography with an ultraviolet detector (HPLC-UVD) and its utilization for the detection of benzoylurea insecticides (BUs) in water and honey samples. Salicylic acid (SA), a switchable hydrophilic aromatic acid, was used as an extraction solvent. It can be converted into the hydrophobic/hydrophilic forms in pH-changeable solutions, facilitating facile and effective dispersion and phase separation. Moreover, the melting point of SA (significantly higher than room temperature) enables its direct solidification without an ice-water bath, facilitating its collection by filtration. The dispersion, separation, and collection of the extraction solvent were carried out entirely in a plastic syringe without requiring special apparatus or additional energy. Univariate and response surface analyses were used to optimize various parameters of the on-site DLLME-DSSA method. Under optimal conditions, the limits of determination (LODs) were 1.50 µg L −1 and 0.03–0.09 mg kg −1 in water and honey, respectively. The relative standard deviations (RSDs) for inter-day ( n = 5) and intra-day ( n = 5) precision were ≤8.4%, whereas the extraction recoveries and enrichment factors for the BUs ranged from 67.0 to 97.1% and 29 to 34, respectively. Furthermore, the proposed method was used for the on-site extraction and laboratory detection of BUs from real water and honey samples. Theoretical analyses indicated non-covalent interactions (such as hydrogen bonds, electrostatic interactions, van der Waals forces, and π-π interactions) to be the main driving force for extraction. This study introduces a switchable hydrophilic aromatic acid capable of direct solidification into on-site DLLME for the first time, opening new frontiers in the development of on-site sample pretreatment methods.
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Journal of Environmental Chemical Engineering
·
2022
·
IF 7.968
Weixiang Tao,Peifang Wang,Bin Hu,Xun Wang,Gang Zhou
The electrocatalytic nitrate reduction reaction (NITRR) plays a critical role in maintaining global nitrogen balance, which is strongly depended on the reactive activity of catalysts. Herein, we develop a simple hydrothermal technology to replace the O ions in NiCo 2 O 4 (NCO) by S ions to form NiCo 2 S 4 (NCS), in which the bonding interactions among Ni-O or Co-O bonds are stronger than Ni-S and Co-S bonds. Therefore, more 3d electrons can be localized at Ni or Co sites that can donate more charges to the intermediates. As a result, the ammonia yield can be enhanced to 642 μg h −1 cm −2 and the selectivity can reach 92.42%, which is obviously excellent than NCO. This work provides a new insight into accelerating the electrocatalytic activity by regulating the orbital interaction between anions and cations.
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Nano Life
·
2022
·
IF 0
Shanshan Niu,Lei-Lei Qian,Pan Du,Nan Si,Dawei Jiang,Yan Feng,Bin Huang,Xiaomin Gu,Qiang Zhao,Jiao Ji,Hua Zhu
Graphene coupling molybdenum-based nanocomposite structures were synthesized by changing the pyrolytic temperature to implement the molybdenum-based optimized microstructure. The structural and surface properties tests showed that the presence of the most variable species and a high proportion of divalent molybdenum on the surface of the material could effectively expose catalytic sites to improve reduction ability of N 2 and inhibited hydrogen evolution reaction. Electrochemical investigations indicated that the Mo-700/rGO nanocomposite exhibited a significantly enhanced electrochemical ammonia synthesis performance. In 0.05 M H 2 SO 4 , the Mo-700/rGO electrode achieved a Faradic efficiency of 12.7% at − 0.15 V versus reversible hydrogen electrode (RHE), and an ammonia yield of 3.93 μ g h − 1 cm − 2 at − 0.2 V versus RHE.
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PHYSICAL CHEMISTRY CHEMICAL PHYSICS
·
2022
·Vol. 24
·期 46
·28530-28539
·
IF 3.945
Yong-Hui Zhang,Ying-Ying Li,Xuan-Yu Yang,Fei-Long Gong,Jun-Li Chen,Ke-Feng Xie,Hao-Li Zhang,Shao-Ming Fang
Metal oxide sensors face the challenge of high response and fast recovery at low operating temperatures for the detection of toxic and flammable hydrogen sulfide (H2S) gases. Herein, novel In-doped ZnO with a sunflower-like structure and tunable surface properties was rationally synthesized. The substitutional In atom in the ZnO crystal can dramatically enhance the concentration of oxygen vacancies (Ov), the In–ZnO sites are responsible for fast recovery, and the formation of sub-stable sulfide intermediates gives rise to the high response towards H2S. As a result, the response of the optimized 4In–ZnO sensor is 3538.36 to 50 ppm H2S at a low operating temperature of 110 °C, which is 106 times higher than that of pristine ZnO. Moreover, the response time and recovery time to 50 ppm H2S are 100 s and 27 s, respectively, with high selectivity and stability. First-principles calculations revealed that 4In–ZnO with rich Ov exhibited higher adsorption energy for the H2S molecule than pristine ZnO, resulting in effortless H2S detection. Our work lays the foundation for the rational design of highly sensitive gas sensors through precise doping of atoms in oxygen-rich vacancies in semiconductor materials.
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