Nature Communications
·
2025
·Vol. 16
·期 1
·1-13
·
IF 15.7
Luo Nan,Lu Bing-Qiang,Deng Yu-Wei,Zeng Hua,Zhang Yu,Zhan Jing-Yu,Xu Xiao-Chen,Cao Gui-Zhi,Wen Jin,Zhang Zhiyuan,Feng Xi-Ping,Jiang Xinquan,Chen Feng,Chen Xi
Remineralization is a common strategy for the repair of early demineralized tooth enamels, but the harsh dynamic oral environment often hampers its efficacy. Rapid remineralization is expected to address this challenge, however, the stabilizers of remineralization materials often resist their transformation required for repair. Here, by dissolving the ions of calcium and phosphate in glycerol-dominant solvents, we obtain the calcium phosphate clusters (1–2 nm), which are stabilized by glycerol (with high viscosity and affinity to clusters), but can perform a fast enamel repair via the water-triggered transformation in both static and dynamic environments. Upon the in vitro and in vivo (female Sprague-Dawley rats) studies, the clusters swiftly enter the nano-/micro-sized enamel defect sites, then form a compact hydroxyapatite repair layer within a short time (30 min, much faster than the conventional materials), and significantly recovers mechanical properties. This material is promising for large-scale preparation and applications in dental remineralization.
研究领域:
牙医学
·
材料科学
·
生物医学工程
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产品关联
DOI
PubMed
高影响因子
ADVANCED MATERIALS
·
2023
·Vol. 35
·期 16
·2210753
·
IF 29.4
Yong Qi,Liujun Song,Changtong Zhou,Shufen Zhang
Shape-memory photonic crystals (SMPCs) transform the nanoscale deformation of copolymers into structural color through an undifferentiated response to stimuli; however, activatable selective responses are extremely rare. Herein, activatable dual confined shape-memory effects (CSMEs) derived from the remodeling of the interchain hydrogen bonds (H-bonds) in cold-programmable SMPCs are revealed. The first level is the water-triggered reconstruction of interchain H-bonds, which can activate/lock the collapsed skeleton, showing shape recovery/retention in response to ethanol vapor. The second level is the pressure-induced reorganization of interchain H-bonds that results in the recovered skeleton being locked even when exposed to ethanol vapor or water, while the background porous structure can switch between collapse and recovery. Dual CSMEs result from the Laplace pressure difference and the binding effect of interchain H-bonds in the skeleton according to insights of swelling, in situ deformation tracking, multidimensional infrared spectra, and water wetting/evaporation simulations. The signal interference, source code extraction, and color enhancement of structurally colored patterns can be implemented using CSMEs. This work opens up a new method for fabricating activatable responsive structural color and contributes to the expansion of nanophotonic technology in water printing, erasable watermarks, signal amplifiers, and information coding.
研究领域:
材料科学
·
纳米光学
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产品关联
DOI
PubMed
高影响因子
ADVANCED FUNCTIONAL MATERIALS
·
2024
·Vol. 34
·期 37
·2401999
·
IF 18.5
Yifeng Sheng,Xiaoqing Ming,Chengjiang Lin,Chang Yang,Xiwei Guo,Xiaozheng Duan,He Zhu,Qi Zhang
Stiffness-variable polymers have found their enormous potential in practical applications that require automatic adaptation and modulation. However, prevailing materials are often constrained by specific operational triggers, limited mechanical responsiveness, and inadequate universality. In this study, drawing inspiration from the mechanism of non-solvent induced phase separation (NIPS), a novel series of polymers exhibiting reversible water-triggered stiffening is designed and synthesized by covalently incorporating poly(ethylene glycol) (PEG) as a non-solvent mediator onto the hydrophobic poly(meth)acrylates backbones. Owing to the hydrophilicity difference between PEG sidechains and backbones, these polymers display swift and substantial alterations in stiffness, with large-scale and regulable changes (from several-fold to exceeding 200-fold) upon water penetration, resulting from water-induced microphase separation. Meanwhile, the polymers also possess intrinsic dual-responsive shape-memory properties. Due to the excellent commercial availability, versatility, and designability of these polymers, the work provides novel perspectives for the advancement of water-triggered stiffening materials and opens avenues for their prospective applications in various domains.
研究领域:
材料科学
·
高分子化学
·
生物材料
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DOI
高影响因子
ACS Nano
·
2024
·
IF 15.8
Xiaotong Fu,Zirong Liu,Chenlu Jiao,Pan Chen,Zhu Long,Dongdong Ye
Healthy, convenient, and aesthetic hair dyeing and styling are essential to fashion trends and personal–social interactions. Herein, we fabricate green, scalable, and aesthetic regenerated cellulose filaments (ACFs) with customizable iridescent colors, outstanding mechanical properties, and water-triggered moldability for convenient and fashionable artificial hairdressing. The fabrication of ACFs involves cellulose dissolution, cross-linking, wet-spinning, and nanostructured orientation. Notably, the cross-linking strategy endows the ACFs with significantly weakened internal stress, confirmed by monitoring the offset of the C–O–C group in the cellulose molecular chain with Raman imaging, which ensures a tailorable orientation of the nanostructure during wet stretching and tunable iridescent polarization colors. Interestingly, ACFs can be tailored for three-dimensional shaping through a facile water-triggered adjustable internal stress: temporary shaping with low-level internal stress in the wet state and permanent shaping with high-level internal stress in the dry state. The health, convenience, and green aesthetic filaments show great potential in personal wearables.
研究领域:
材料科学
·
生物工程
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产品关联
DOI
PubMed
高影响因子
Materials Today Bio
·
2024
·
IF 8.7
Xinran Yang,Xiudan Wang,Lizong Tang,Zhiguang Sun,Xing Gao,Yanmei Zhao,Shike Hou,Jie Shi,Qi Lv
Massive blood loss is the main cause of prehospital trauma-related death, the development of rapid and effective hemostatic materials is imminent. Injectable hydrogels have the advantages of covering irregular bleeding sites and quickly closing the wound. However, its inherent viscosity can easily precipitate tissue adhesion in vivo and other complications. Based on the anti-protein properties of zwitterion and our previous work about in situ hemostatic/anti-adhesion hydrogel material, we have synthesized a series of injectable hydrogel composed of sulfobetaine-modified polylactic acid (PLA) and gelatin (Gel). These hydrogels could form a smooth film structure by simple water triggering, thereby conferring anti-adhesive properties. We visualized the changes in surface hydrophobicity using fluorescent probes and demonstrated tissue adhesion, rapid hydrophobic interface response, as well as rapid hemostasis for incompressible wounds through in vivo and in vitro experiments. Additionally, we explored the application of hydrogel materials in the scenario of postoperative bleeding, which can effectively prevent unnecessary adhesion through rapid film formation and the anti-protein property of sulfobetaine. We believe that this multifunctional hemostatic hydrogel has the potential to serve as a prehospital emergency treatment of incompressible bleeding and benefit to the postoperative recovery of patients.
研究领域:
生物材料
·
创伤医学
·
组织工程
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产品关联
DOI
PubMed
高影响因子
ADVANCED MATERIALS
·
2023
·Vol. 35
·期 41
·2304725
·
IF 29.4
Xiaoyun Xu,Zhuang Wang,Min Li,Yupei Su,Qi Zhang,Shuai Zhang,Jinlian Hu
Biocompatible and biodegradable shape-memory polymers have gained popularity as smart materials, offering a wide range of applications and environmental benefits. Herein, the possibility of fabricating regenerated water-triggered shape-memory keratin fibers from wool and cellulose in a more effective and environmentally friendly manner is investigated. The regenerated keratin fibers exhibit comparable shape-memory performance to other hydration-responsive materials, with a shape-fixity ratio of 94.8 ± 2.15% and a shape-recovery rate of 81.4 ± 3.84%. Owing to their well-preserved secondary structure and cross-linking network, keratin fibers exhibit outstanding water-stability and wet stretchability, with a maximum tensile strain of 362 ± 15.9%. In this system, the reconfiguration of the protein secondary structure between α-helix and β-sheet is investigated as the fundamental actuation mechanism in response to hydration. This responsiveness is studied under force loading and unloading along the fiber axis. Hydrogen bonds act as the “switches” clicked by water molecules to trigger the shape-memory effect, while disulfide bonds and cellulose nanocrystals play the role of “net-points” to maintain the permanent shape of the material. Water-triggered shape-memory keratin fibers are manipulable and exhibit potential in the fabrication of textile actuators, which may be applied in smart apparel and programmable biomedical devices.
研究领域:
材料科学
·
生物医学工程
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产品关联
DOI
PubMed
高影响因子
Applied Materials Today
·
2025
·
IF 6.9
Xiaohan Guo,Huan Liu,Aminov Nail,Decheng Meng,Cong Li,Xiaoqing Ye,Huanjun Li
Eutectogels, as emerging soft materials, have garnered significant attention; but integrating multiple functionalities into a single system remains a challenge for practical applications. This work presents a supramolecular eutectogel synthesized via a facile one - step photo - initiated polymerization strategy, employing a synergistic network of hydrogen bonding and electrostatic interactions. The resulting eutectogel exhibits exceptional optical transparency and mechanical performance, achieving a tensile strength of 7.15 MPa, an elongation at break over 700 %, and a toughness of 36.27 MJ·m -3 at ambient conditions. Notably, the supramolecular design enables strong adhesion to various substrates, delivering average bonding strengths of 7.08 MPa (stainless steel) and 5.57 MPa (wood), with stable adhesion retention after 12 - day ambient storage. A unique water - triggered debonding mechanism allows for non - destructive detachment, coupled with full material recyclability through water - based reconfiguration (retaining 85 % strength after five cycles). The eutectogel further demonstrates high - precision 3D printability and antibacterial inhibition zones against Escherichia coli /S. aureus via zwitterionic SBMA hydration layers. This study offers a promising strategy for creating functionally integrated smart soft materials with environmental adaptability.
研究领域:
高分子科学
·
生物材料
·
软物质物理
·
功能材料
·
再生医学
·
抗菌材料
·
增材制造
✓ 已验证
产品关联
DOI
高影响因子
Journal of Materials Chemistry B
·
2021
·Vol. 9
·期 6
·1568-1582
·
IF 6.331
Xiao Yang,Miao Chen,PengPeng Li,Zhixiao Ji,Mingshan Wang,Yakai Feng,Changcan Shi
It is challenging for traditional hemostatic sponges to control massive and noncompressible hemorrhages in the military field and accidental trauma. In this work, a series of highly fluid-absorbent composite sponges with rapid expansion ability based on norbornene anhydride-modified poly(vinyl alcohol) and gelatin (PVA@Gel-Sps) were developed by a foaming technique, chemical and physical crosslinking reactions and lyophilization. The prepared PVA@Gel-Sp2 exhibited a 3500% maximum water absorption ratio with a fast water absorption speed, which was suitable for blood component concentration. Owing to its interconnected macroporous structure, robust mechanical strength and high resilience, the compressed sponge could rapidly re-expand to more than 10 times its volume in response to water and blood. Moreover, due to the synergistic effect of the PVA-based sponge and gelatin, PVA@Gel-Sp2 could obviously shorten the hemostasis time and reduce blood loss in SD rat liver defect noncompressible hemorrhage models, and exhibited better wound healing effects in a full-thickness skin defect model than commercial sponges. These results suggest that PVA@Gel-Sp2 is a potential candidate for controlling noncompressible hemorrhage and promoting wound healing.
研究领域:
材料科学
·
生物医学工程
·
止血
·
伤口愈合
✓ 已验证
DOI
PubMed
高影响因子
JOURNAL OF INDUSTRIAL AND ENGINEERING CHEMISTRY
·
2025
·
IF 6
Junsik Choi,Jinho Hyun
Complex 3D devices require a printing technique for curved geometries under mild conditions. Here, effective 3D transfer printing is achieved by simple water-assisted adhesion switching using a cellulose nanofiber (CNF) film. Patterns printed on the CNF film are transferred to target surfaces by simple hydration of the CNF film. As the CNF film gradually hydrates, the hydrogen bonding between the printed patterns and the film surface weakens. This reduction in adhesion allows the easy delamination of patterns from the CNF film and the spontaneous transfer to target surfaces such as polymers, ceramics, and metals, which have stronger adhesion than the hydrated CNF surface. This hydration-triggered process enables both high-fidelity printing on curved surfaces and functional integrity and easy repair of electrical devices, paving the way for advanced fabrication of flexible electronic circuits.
研究领域:
材料科学
·
纳米技术
·
电子工程
✓ 已验证
产品关联
DOI
高影响因子
BIOSENSORS & BIOELECTRONICS
·
2025
·
IF 10.5
Jian Luo,Yuli Wang,Junhong Yi,Zonglei Wang,Wenqing Yan,Jiawei Yang,Leqi Li,Xinyuan Ye,Mingzhe Wang,Pengcheng Zhou,Qingyuan Sun,Yi Liu,Zichong Ji,Zongman Zhang,Zhihui Pan,Yan Wang
Robust, long-term electrophysiological monitoring demands epidermal electrodes that breathe like skin, adhere to demand, and survive the repetitive strains of daily life. Here, we present a 2.4 μm-thick, transparent, and gas-permeable epidermal electrode that adheres to human skin upon brief wetting with saline solution. The electrode is fabricated through a simple, scalable method using a gelatin matrix composed of gelatin, glycerol, citric acid, and water, reinforced by an electrospun polyurethane nanomesh. This construction yields an interfacial adhesion energy of 1.7 mJ cm −2 and excellent breathability with a water vapor transmission rate of 1339.3 g m −2 day −1 . The film withstands more than 1500 cycles of 60 % uniaxial strain and still exhibits an adhesion energy of 0.8 mJ cm −2 after 48 h of skin attachment. The skin-electrode interface maintains a low contact impedance of 36.7 kΩ at 100 Hz even after 48 h of continuous wear. These properties enable stable and high-fidelity recording of electroencephalogram, electromyogram, and continuous electrocardiogram signals for over 36 h under daily activities, including lab work, commute, meal, nap/sleep, and desk work. The electrode performance remains consistent even after 30 days of ambient storage. We further demonstrate wireless electroencephalogram and electrocardiogram signals acquisition during one full night of sleep, enabling accurate and automatic sleep stage classification based on electroencephalogram spectral features and heart rate dynamics. Together, these results establish the ultrathin gelatin film as a practical platform for real-world, long-term electrophysiological monitoring and point toward its broader use in personalized healthcare wearables.
研究领域:
生物医学工程
·
柔性电子
·
可穿戴设备
·
生理信号监测
·
睡眠医学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
ADVANCED FUNCTIONAL MATERIALS
·
2024
·
IF 18.5
Guoqing Wang,Jianfei Wang,Xinping Wang,Yuanyuan Meng,Xiangzhen Feng,Gaoli Liu,Dong-An Wang,Changjiang Fan
Uncontrolled traumatic hemorrhage is a leading cause of preventable death. As two main forms of hemostatic materials, however, both sponges and hydrogel adhesives usually fail to control massive hemorrhage due to their respective shortcomings. Hemostatic sponge shows weak tissue adhesion, while the gelation process of hydrogel makes it difficult to seal high-pressure bleeding wounds. There is an urgent need to develop next-generation hemostats combining the advantages of sponges and hydrogel adhesives. Herein, a general methodology to prepare novel Fe 3+ -laden porous material (Fe 3+ @GCS) for rapid hemostasis of the high-pressure and severe hemorrhages is proposed, which is fabricated by loading ferric chloride with ethanol into the catechol-modified carboxylated gelatin sponge (GCS). Notably, porous Fe 3+ @GCS can undergo water-triggered rapid transformation to robust-adhesive hydrogels. The sealing strength of Fe 3+ @GCS on wet tissues reaches an astonishing ≈600 mm Hg. Rapid water uptake of Fe 3+ @GCS around wound not only concentrates blood components but also excludes interfacial water, facilitating blood clotting and wound sealing with the in situ formed sticky hydrogel. Fe 3+ @GCS can efficiently stop the high-pressure hemorrhaging from traumatic injuries of arteries and hearts in rats and pigs, respectively, via a simple and short-time pressing. Furthermore, the wound sealing by Fe 3+ @GCS promotes wound repair and healing.
研究领域:
生物材料
·
止血
·
组织工程
·
生物医学工程
✓ 已验证
产品关联
DOI
高影响因子
Advanced Science
·
2024
·
IF 14.3
Yijun Zhao,Xingru Yang,Lun Yang,Fangjian Xing,Cihui Liu,Yunsong Di,Guiyuan Cao,Shibiao Wei,Xifeng Yang,Xiaowei Zhang,Yushen Liu,Zhixing Gan
The smart materials with multi-color and stimuli-responsive luminescence are very promising for next generation of optical information encryption and anti-counterfeiting, but these materials are still scarce. Herein, a multi-level information encryption strategy is developed based on the polychromatic emission of Sb-doped double perovskite powders (SDPPs). Cs 2 NaInCl 6 :Sb, Cs 2 KInCl 6 :Sb, and Cs 2 AgInCl 6 :Sb synthesized through coprecipitation methods exhibit broadband emissions with bright blue, cyan, and orange colors, respectively. The information transmitted by specific SDPP is encrypted when different SDPPs are mixed. The confidential information can be decrypted by selecting the corresponding narrowband filter. Then, an encrypted quick response (QR) code with improved security is demonstrated based on this multi-channel selection strategy. Moreover, the three types of SDPPs exhibit three different water-triggered luminescence switching behaviors. The confidential information represented by Cs 2 NaInCl 6 :Sb can be erased/recovered through a simple water spray/drying. Whereas, the information collected from the green channel is permanently erased by moisture, which fundamentally avoids information leakage. Therefore, different encryption schemes can be designed to meet a variety of encryption requirements. The multicolor and stimuli-responsive luminescence greatly enrich the flexibility of optical information encryption, which leaps the level of security and confidentiality.
研究领域:
材料科学
·
光学
·
密码学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
危险品化学品经营许可证（带存储）