ADVANCED MATERIALS
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2024
·Vol. 37
·期 5
·2412322
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IF 27.4
Jingjing Guo,Jialin Tuo,Jiangtao Sun,Zhuozhou Li,Xiaoyan Guo,Yanyan Chen,Rong Cai,Jing Zhong,Lijun Xu
Stretchable sensors that can conformally interface with the skins for wearable and real-time monitoring of skin deformations, temperature, and sweat biomarkers offer critical insights for early disease prediction and diagnosis. Integration of multiple modalities in a single stretchable sensor to simultaneously detect these stimuli would provide a more comprehensive understanding of human physiology, which, however, has yet to be achieved. Here, this work reports, for the first time, a stretchable multimodal photonic sensor capable of simultaneously detecting and discriminating strain deformations, temperature, and sweat pH. The multimodal sensing abilities are enabled by realization of multiple sensing mechanisms in a hydrogel-coated polydimethylsiloxane (PDMS) optical fiber (HPOF), featured with high flexibility, stretchability, and biocompatibility. The integrated mechanisms are designed to operate at distinct wavelengths to facilitate stimuli decoupling and employ a ratiometric detection strategy for improved robustness and accuracy. To simplify sensor interrogation, spectrally-resolved multiband emissions are generated upon the excitation of a single-wavelength laser, utilizing upconversion luminescence (UCL) and radiative energy transfer (RET) processes. As proof of concept, this work demonstrates the feasibility of simultaneous monitoring of the heartbeat, respiration, body temperature, and sweat pH of a person in real-time, with only a single sensor.
研究领域:
生物医学工程
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材料科学
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健康监测
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DOI
高影响因子
BIOSENSORS & BIOELECTRONICS
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2024
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IF 10.7
Qiulin Chen,Sheng Li,Xiaoyan Tu,Xinfeng Zhang
The pH of human sweat is highly related with a variety of diseases, whereas the monitoring of sweat pH still remains challenging for ordinary families. In this study, we developed a novel dual-emission Tb-MOF using DPA as the ligand and further designed and constructed a skin-attachable Tb-MOF ratio fluorescent sensor for real-time detection of human sweat pH. With the increased concentration of H + , the interaction of H + with carbonyl organic ligand leads to the collapse of the Tb-MOF crystal structure, resulting in the interruption of antenna effect, and correspondingly increasing the emission of the ligand at 380 nm and decreasing the emission of the central ion Tb 3+ at 544 nm. This Tb-MOF nanoprobe has a good linear response in the pH range of 4.12–7.05 (R 2 = 0.9914) with excellent anti-interference ability. Based on the merits of fast pH response and high sensitivity, the nanoprobe was further used to prepare flexible wearable sensor. The wearable sensor can detect pH in the linear range of 3.50–6.70, which covers the pH range of normal human sweat (4.50–6.50). Subsequently, the storage stability and detection accuracy of the sensors were evaluated. Finally, the sensor has been successfully applied for the detection of pH in actual sweat samples from 21 volunteer and the real-time monitoring of pH variation during movement processing. This skin-attachable Tb-MOF sensor, with the advantages of low cost, visible color change and long shelf-life, is appealing for sweat pH monitoring especially for ordinary families.
研究领域:
生物医学工程
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材料科学
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分析化学
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产品关联
DOI
PubMed
高影响因子
Nature Communications
·
2025
·Vol. 16
·期 1
·1-12
·
IF 15.7
Chen Yonghuan,Li Xiuying,Yue Xinru,Yu Weihua,Shi Yuesen,He Zilong,Wang Yuanfeng,Huang Yu,Xia Fan,Li Fengyu
Synthetic drugs fundamentally reshape the illicit drug market due to their low cost, ease of production, and rapid manufacturing processes. However, current drug detection methods, which rely on complex instruments, have limited applicability and often neglect the influence of pH fluctuations, leading to potential bias and unreliable results. Herein, we propose co-calibration DNA probes on a nanoconfined biosensor (N C B S ), covering the range of sweat pH 3–8 to achieve significantly enhanced target signal recognition. The N C B S exhibits a linear response range of 10 3 -10 8 fM with a low limit of detection (LOD) of 3.58 fM in artificial sweat. Compared to the single-aptamer N C B S , the dual-aptamer N C B S offers a broader linear response range, primarily due to the synergistic effects of changes in surface wettability and the capture of hydrion, which together reduce signal interference in proton transport. The linear response range doubles, and its detection sensitivity improves by 4–5 orders of magnitude compared to existing drug detection methods. This sensing strategy expands the application scope of aptamer-based composite probes, offering an approach for ultra-sensitive drug detection and demonstrating significant potential in sweat sensing and drug monitoring fields.
研究领域:
生物传感
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分析化学
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药物检测
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DOI
PubMed
高影响因子
COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
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2024
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IF 4.9
Haichen Yao,Hongkun Liu,Yihang Hou,Shuang Gao,Jiazi Hou
Perspiration conduction is essential for regulating the body's water and temperature balance. Significant advancements have been achieved in the field of textiles engineered for guiding water movement, thanks to their outstanding and practical control of uneven wetting properties. This progress carries important implications for preserving energy, promoting human well-being, and enhancing comfort. Nonetheless, current textile materials intended for sweat conduction are primarily focus on unidirectional transport of water, neglecting the air permeability during water transportation results in dampness and stickiness especially during heavy perspiration. In this study, a fabric with a tailored antisymmetrical wettability establishing an array of gas transport windows was fabricated via electro-blown spinning, endowing the fabric with long-term air permeability. It demonstrated an air permeability rate (APR) of up to 307.49 mm s −1 , a water vapor transmission (WVT) rate of 3133.76 g m −2 day −1 , and a water absorption rate (WAR) capacity of 2039.01 %. Especially, during the process of sweat wicking, the water infiltration restricted air permeability, however, the designed breathable window still maintained a high gas permeation rate of up to 214.61 mm s −1 , which was much higher than non-soaked commercial jeans and lab coat. Additionally, blueberry anthocyanins was incorporated into fabrics, acting as a portable sweat pH sensor based on colorimetric analysis, which was capable of monitoring the pH levels of sweat. When sweat shifted from acidic to alkaline, the anthocyanins underwent a structural transformation from flavylium cations to quinoid alkali. During the process, the fabric underwent a transition in color, changing from red to blue, which contributed to real-time monitoring of human body health performance in a non-invasive manner. This study presented a dependable method for creating intelligent textiles with patterned antisymmetric wettability, demonstrating significant promise for use in functional fabrics designed for individual moisture control.
研究领域:
纺织工程
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生物医学工程
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材料科学
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产品关联
DOI
高影响因子
Advanced Materials Interfaces
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2025
·
IF 4.4
Hui Yang,Na Kong,Mia Angela Judicpa,Ken Aldren S. Usman,Jinlong Tao,Joselito M. Razal,Jizhen Zhang,Yanqiu Shao
Real-time tracking of metabolites, ions, and biomarkers in sweat using wearable sensors is crucial for advancing point-of-care testing, where improving the stability of these technologies is a major focus. In this research, a compact, highly sensitive, and stable real-time electrochemical sweat sensor capable of monitoring changes in hydrogen ion concentration is developed. By surface functionalizing Ti 3 CNT x and combining it with a polyaniline film, a small, flexible pH sensor is fabricated to track biochemical reactions by examining sweat pH during exercise and wound healing. The fluorinated alkyl silane-modified surface significantly increases the contact angle, enhancing the sensor's performance. The assembled pH sensor demonstrates pH-sensitivity of −42.91 (pH 11–1) and −40.15 mV pH−¹ (pH 1–11), comparable to transition metal oxide-based sensors. Additionally, it shows good selectivity through continuous addition and separated solution methods. The modified Ti 3 CNT x exhibited excellent durability in different ionic solutions for over 30 days. The flexible, precise sensor, developed via scalable screen-printing, can be applied in water quality monitoring, food preservation, product processing, biomarker monitoring, and human health.
研究领域:
材料科学
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生物医学工程
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传感技术
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产品关联
DOI
高影响因子
ACS Sensors
·
2024
·
IF 8.2
Zhihui Zhang,Kerui Li,Yaogang Li,Qinghong Zhang,Hongzhi Wang,Chengyi Hou
In recent years, wearable devices have been widely used for human health monitoring. Such monitoring predominantly relies on the principles of optics and electronics. However, electronic detection is susceptible to electromagnetic interference, and traditional optical fiber detection is limited in functionality and unable to simultaneously detect both physical and chemical signals. Hence, a wearable, embedded asymmetric color-blocked optical fiber sensor based on a hydrogel has been developed. Its sensing principle is grounded in the total internal reflection within the optical fiber. The method for posture sensing involves changes in the light path due to fiber bending with color blocks providing wavelength-selective modulation by absorption changes. Sweat pH sensing is facilitated by variations in fluorescence intensity triggered by sweat-induced conformational changes in Rhodamine B. With just one fiber, it achieves both physical and chemical signal detection. Fabricated using a molding technique, this fiber boasts excellent biocompatibility and can accurately discern single and multiple bending points, with a recognition range of 0–90° for a single segment, a detection limit of 0.02 mm–1 and a sweat pH sensing linear regression R2 of 0.993, alongside great light propagation properties (−0.6 dB·cm–1). With its extensive capabilities, it holds promise for applications in medical monitoring.
研究领域:
生物医学工程
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光学传感
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材料科学
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DOI
PubMed
高影响因子
CHINESE JOURNAL OF CHEMISTRY
·
2023
·Vol. 42
·期 5
·491-498
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IF 5.4
Xiangnan Wang,Hongli Zhang,Jiahe Li,Gang Zou
Comprehensive Summary Monitoring of sweat pH plays important roles in physiological health, nutritional balance, psychological stress, and sports performance. However, the combination of functional MOFs with phosphorescent material to acquire the real-time physiological information, as well as the application of dual mode anti-counterfeiting, has seldom been reported. Herein, we developed multifunctional gel films based on MOFs and phosphorescent dyes which responded to H + ions and the related mechanism was studied in detail. Upon exposure to H + , the composite gel film exhibited decreased fluorescent signal but enhanced room temperature phosphorescence (RTP), which could be utilized for sweat pH sensing through a dual-mode. Moreover, multifunctional gel films exhibited a potential application in information encryption and anti-counterfeiting by designing of stimulus responsive multiple patterns. This research provided a new avenue for portable and non-invasive sweat pH monitoring methods while also offering insights into stimulus-responsive multifunctional materials.
研究领域:
生物医学工程
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材料科学
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产品关联
DOI
高影响因子
BIOSENSORS & BIOELECTRONICS
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2024
·
IF 10.7
Zhongzeng Zhou,Xuecheng He,Jingyu Xiao,Jiuxiang Pan,Mengmeng Li,Tailin Xu,Xueji Zhang
The constrained resources on wearable devices pose a challenge in meeting the demands for comprehensive sensing information, and current wearable non-enzymatic sensors face difficulties in achieving specific detection in biofluids. To address this issue, we have developed a highly selective non-enzymatic sweat sensor that seamlessly integrates with machine learning, ensuring reliable sensing and physiological monitoring of sweat biomarkers during exercise. The sensor consists of two electrodes supported by a microsystem that incorporates signal processing and wireless communication. The device generates four explainable features that can be used to accurately predict tyrosine and tryptophan concentrations, as well as sweat pH. The reliability of this device has been validated through rigorous statistical analysis, and its performance has been tested in subjects with and without supplemental amino acid intake during cycling trials. Notably, a robust linear relationship has been identified between tryptophan and tyrosine concentrations in the collected samples, irrespective of the pH dimension. This innovative sensing platform is highly portable and has significant potential to advance the biomedical applications of non-enzymatic sensors. It can markedly improve accuracy while decreasing costs.
研究领域:
生物医学工程
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传感器
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机器学习
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可穿戴技术
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生理监测
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产品关联
DOI
PubMed
高影响因子
ANALYTICAL CHEMISTRY
·
2022
·
IF 8.008
Lijuan Chen,Fan Chen,Gang Liu,Haoliang Lin,Yu Bao,Dongxue Han,Wei Wang,Yingming Ma,Baohua Zhang,Li Niu
Sweat pH is a critical indicator for evaluating human health. With the extensive attention on the wearable and flexible biosensing devices, the technology for the monitoring of human sweat can be realized. In this study, a sensitive, miniaturized, and flexible electrochemical sweat pH sensor was developed for the continuous and real-time monitoring of the hydrogen-ion concentration in human sweat. A flexible electrode was fabricated on the poly(ethylene terephthalate) (PET) substrate by a simple and low-cost screen-printing technology, which was based on the integration of fluoroalkyl silane-functionalized Ti3C2Tx (F–Ti3C2Tx) and the polyaniline (PANI) membrane technology instead of the traditional ion-sensitive membrane. The surface functionalization strategy for Ti3C2Tx with perfluorodecyltrichlorosilane can provide environmental stability. Functionalized Ti3C2Tx (F–Ti3C2Tx) was doped with PANI to obtain improved responsiveness, sensitivity, and reversibility. The constructed microsize, portable, and wearable F–Ti3C2Tx/PANI pH sensor aimed to real-time monitor the pH value of human sweat during exercise. On-body sweat pH monitoring for females and males, respectively, exhibited high accuracy and continuous stability compared with ex situ analyses. This study thus offers a facile and practical solution for developing a highly reliable MXene-based mini-type pH sensor to realize the online monitoring of human sweat pH.
研究领域:
材料科学
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可穿戴技术
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生物医学工程
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电化学
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传感器
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产品关联
DOI
PubMed
高影响因子
危险品化学品经营许可证（带存储）