JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS
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2026
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IF 4.3
Haiqi Li,Ruohui Huang,Jinhong Zhang,Dongli Jiang,Jie Jian
Epigallocatechin gallate (EGCG) exerts cardioprotective effects on acute myocardial infarction (AMI) through multiple pathways. However, the clinical application of EGCG is limited because of its instability under physiological conditions and low bioavailability. In this study, poly (lactic-co-glycolic acid) (PLGA) was used as a drug carrier to prepare EGCG nanoparticles, then EGCG targeting drug delivery system was designed modifying by cardiac homing peptide (CHP).We constructed a preparation route combining double-emulsion solvent evaporation method and carbodiimide method. By optimizing the preparation process, the particle size of EGCG nanoparticle was reduced and the dispersibility was improved. In addition, the established preparation procedure uses safe and low-toxicity reagents, requires no strict temperature control or specialized instrumentation, and therefore significantly reduces the technical difficulty of large-scale industrial production. EGCG-PLGA-CHP had myocardial targeting and good safety in the MTT cytotoxicity test, as well as alleviated AMI by regulating apoptosis-related protein expression in a dose-dependent manner. Compared with EGCG monomer, EGCG-PLGA-CHP achieved a better therapeutic effect. This study provides a new strategy for promoting the application of EGCG in the clinical treatment of AMI.
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EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS
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2026
·
IF 5
Jianmin Chen,Wanhui Wu,Baozhu Feng,Meilian Ning,Ziyan Cai,Qiulong Zhang,Liyang Du,Yunhua Gao
SPFX-SLNs were systematically optimized using BBD-RSM for infected wounds. • Optimized SLNs showed uniform spherical morphology with a size of ∼87 nm. • SPFX-SLNs exhibited 2-fold higher antibacterial potency than the free drug. • MNs enabled efficient skin penetration for targeted SLNs delivery. • Optimized MNs achieved a 98.61% wound closure rate by Day 14. The efficient management of infected skin wounds is severely limited by the thick bacterial biofilm within the lesion, the intractable stratum corneum barrier of the perilesional skin, and the high toxicities of potent antibiotics. Sparfloxacin (SPFX) was withdrawn from the market due to its severe systemic side effects and UV-induced phototoxicity, while its severe hydrophobicity causes localized crystalline cytotoxicity upon topical application. To safely rejuvenate this potent drug, an integrated transdermal system combining photoshielding, SPFX-loaded solid lipid nanoparticles (SPFX-SLNs) with dissolving microneedles (MNs) was developed. This study primarily focuses on the systematic screening, formulation development, and optimization of SPFX-SLNs via Box-Behnken Design-Response Surface Methodology (BBD-RSM). The optimized nanocarriers exhibited a uniform size (86.85 ± 1.89 nm) and a two-fold higher antibacterial potency against Escherichia coli ( E. coli ) than free SPFX. Mechanistically, the solid lipid core locked SPFX in a safe amorphous state to preclude crystal-induced irritation, while functioning as a physical photoshield against UV activation. By depositing the nanomedicine exclusively into infected dermis, the MN platform minimized systemic drug exposure. In a rat model of E. coli -infected biofilm wounds, the formulated SPFX-SLNs MNs achieved over 50% (58.44%) wound closure within 3 days and near-complete re-epithelialization by day 11, and a 98.61% final closure rate by day 14. Ultimately, this work establishes a comprehensive formulation development strategy for a safety-enhanced, biofilm-penetrable nanomedicine-MN hybrid that successfully repurposes a clinically restricted antibiotic for advanced wound regeneration. Download: Download high-res image (242KB) Download: Download full-size image
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SEPARATION AND PURIFICATION TECHNOLOGY
·
2026
·
IF 9.1
Jingyu Zhang,Yicheng Jiang,Yafei Xu,Qingfeng Zhai,Chenyang Luo,Qiang Zhang
The efficient removal of organic pollutants from wastewater with diverse compositions remains a significant challenge due to the inherent limitations of traditional advanced oxidation processes (AOPs). Radical-dominated pathways are often inhibited by water matrix components, whereas nonradical pathways, although more selective and tolerant, exhibit slower reaction rates. Herein, we developed a photo-responsive Fe–B@C catalyst that enables dynamic regulation of reactive oxygen species (ROS) pathways through light irradiation, effectively acting as a switch between nonradical and radical-nonradical synergistic mechanisms. Under dark conditions, the system predominantly generates singlet oxygen ( 1 O 2 ), maintaining high stability against inorganic salts, humic acids, and broad pH variations. Upon illumination, the catalyst switches to a synergistic pathway involving 1 O 2 , hydroxyl radicals (•OH), and sulfate radicals (SO 4 − •), achieving near-complete tetracycline removal and enhanced mineralization. Mechanistic studies reveal that boron facilitates the Fe 3+ /Fe 2+ redox cycle and promotes ROS generation, while light precisely controls the activation mode. This work demonstrates a smart catalyst design strategy, allowing AOPs to adapt to varying wastewater compositions, offering a promising solution for tailored and high-efficiency water treatment.
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CHEMICAL ENGINEERING JOURNAL
·
2026
·
IF 12.5
Yu Tian,Huina Liu,Jianan Li,Yuanyuan Ding,Manman Zhu,Chenguang Liu
A multiscale engineering strategy integrates THEDES with thermosensitive hydrogels. • THEDES enhances 5-ASA solubility, permeability, and anti-inflammatory efficacy. • THEDES-Gel enables prolonged colonic retention and controlled release. • THEDES-Gel provides a versatile platform for insoluble drugs for UC treatment. Overcoming the low aqueous solubility, poor mucosal permeability, and imprecise delivery of drugs remains a critical challenge in pharmaceutical engineering. Herein, we designed a novel therapeutic deep eutectic solvent (THEDES) using 5-aminosalicylic acid (5-ASA) and L-arginine (Arg) at a molar ratio of 1: 1.4, which functioned as both a solubilizer and osmotic enhancer of 5-ASA. THEDES showed satisfactory viscosity (61.7 ± 1.3 Pa·s), pH (8.9), zeta potential (−12.0 ± 1.4 mV), and anti-inflammatory activity when using in colonic microenvironment. To address the subsequent challenges of rapid clearance and leakage of THEDES at the colon lesion site, THEDES was loaded into a poloxamer 407 hydrogel with methylcellulose as the adhesive to construct an in-situ gelling enema system (THEDES-Gel). Notably, the engineered THEDES-Gel significantly prolonged colonic retention compared to THEDES alone, while achieving a high cumulative release rate of 5-ASA (97.0 ± 0.8% at 6 h) under the effect of “Push-Pull-Permeate”. Furthermore, THEDES-Gel was demonstrated to have a significant alleviating effect during the treatment of UC in mice by reducing inflammation and maintaining the normal structure of colonic tissue. THEDES-Gel demonstrates a rational materials design strategy that couples molecular-scale solvent engineering of drugs with macroscopic drug delivery system fabrication for the efficient utilization of insoluble drugs.
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JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
·
2026
·
IF 5.2
Xiaoxi Gao,Dehai Hou,Tianyu Ma,Sizhuo Liu,Ruiping Wang,Yang Ping,Jin Su
A synergistic nano-strategy co-delivering sorafenib and berberine to overcome resistance and reduce toxicity. • Optimized nanostructured lipid carriers with high drug loading, sustained release, and good stability were successfully prepared. • Pharmacokinetics showed significantly enhanced oral bioavailability (4.59-fold and 2.28-fold for SORB and BBR). • Superior antitumor efficacy and biosafety were systematically verified both in vitro and in vivo. Sorafenib (SORB) is a first-line drug for advanced hepatocellular carcinoma, but its clinical use is limited by poor water solubility, low oral bioavailability, and drug resistance. Berberine (BBR) has been shown to reverse multidrug resistance and enhance drug sensitivity. Here, we designed a nanostructured lipid carrier co-loaded with SORB and BBR (SBER NLC). The optimized formulation had a particle size of 123.17 ± 3.28 nm, PDI of 0.211 ± 0.012, and zeta potential of −18.30 ± 0.95 mV. Encapsulation efficiencies were 78.77 ± 0.93% (SORB) and 79.58 ± 1.04% (BBR), with drug loadings of 1.75 ± 0.06% and 1.28 ± 0.13%, respectively. SBER NLC showed stable storage properties and sustained release in simulated gastrointestinal fluids. Pharmacokinetic studies demonstrated significantly enhanced oral bioavailability of both drugs compared with free drug suspension. In vitro, SBER NLC exhibited stronger cytotoxicity and migration inhibition against HepG2 cells, while the blank carrier was nontoxic. In a HepG2 xenograft mouse model, SBER NLC achieved the strongest tumor suppression without causing body weight loss or major organ damage, and induced extensive nuclear pyknosis and necrosis in tumor tissue. This study provides an efficient nano-delivery strategy for combined SORB and BBR in hepatocellular carcinoma treatment. Download: Download high-res image (226KB) Download: Download full-size image
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JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
·
2026
·
IF 5.2
Jianwei Liu,Pu Zheng,Jialong Wang,Jianhong Zhang,Liu Yang,Ghazal Rouhi,Lian Liu,Xiumei Ke,Xiufeng Yu,Qianqian Zhao
Formulation composition dictates hygroscopicity in multicomponent SDs. • Hydrophilic components promote water uptake and H-bond network formation. • Hygroscopicity-driven drug mobility accelerates aggregation and recrystallization. • MD simulations reveal water-distribution-controlled SD stability. • Hygroscopicity governs the solubility–stability balance in SD design. Multicomponent solid dispersions (SDs) show substantial potential for improving the solubility of poorly water-soluble drugs, yet the molecular-level factors influencing their long-term physical stability remain insufficiently understood. In this study, piroxicam binary (PRX-BSD), ternary (PRX-TSD), and quaternary (PRX-QSD) solid dispersions were systematically investigated by combining experimental characterization with molecular dynamics (MD) simulations. PRX-BSD and PRX-TSD established hydrophilic microenvironments and increased PRX solubility from 28.719 μg/mL to approximately 150 μg/mL, whereas PRX-QSD generated an alkaline microenvironment that further increased solubility to 2010.77 μg/mL. During storage, PRX-BSD and PRX-TSD exhibited limited hygroscopicity, gradual crystallinity evolution and well-preserved dissolution performance. In contrast, Na 2 CO 3 -containing PRX-QSD displayed pronounced hygroscopicity and accelerated amorphous recrystallization, leading to a marked reduction in solubility to 92.14 μg/mL. MD simulations provided molecular-level insights into the formulation-dependent hydration behavior and molecular mobility of PRX-SDs. In PRX-BSD and PRX-TSD, water molecules were preferentially localized around PVP VA64 and Tween 80, forming relatively sparse water-mediated hydrogen-bonding networks. In contrast, Na 2 CO 3 in PRX-QSD acted as a strong water-anchoring component, promoting localized water accumulation and denser hydrogen-bonding interactions, which were associated with increased PRX mobility and PRX-PRX interaction tendency. These molecular-level observations provided a further explanation for the experimentally observed recrystallization and solubility loss during storage. Overall, this study highlights the important role of formulation-dependent hygroscopicity in the balancing solubility enhancement and long-term physical stability, providing molecular insights for the rational design of multicomponent SDs. Download: Download high-res image (528KB) Download: Download full-size image
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Gels
·
2026
·Vol. 12
·期 7
·652
·
IF 6.4
Guixi Wang,Sihang Shen,Yichen Tian,Chao Li,Junnan He,Yuzhu Song
Inflammation and oxidative stress induced by high glucose levels constitute essential factors impeding wound healing in diabetes, posing a significant threat to public health. Despite its notable anti-inflammatory and antioxidant potential, the clinical applicability of quercetin is hampered by its hydrophobicity and limited oral bioavailability. To address these issues, the thin-film hydration method was used to encapsulate quercetin into FQ micelles. Subsequently, 3-aminophenylboronic acid-modified oxidized alginate was crosslinked with polyvinyl alcohol, and simultaneously loaded with glucose oxidase (GOX) and FQ micelles, to construct a glucose-activated cascade acidification-triggered controlled-release hydrogel (OSSP@FQ&GOX). The phenylboronic ester bonds in the hydrogel are responsive to glucose and undergo cleavage. GOX-mediated oxidation of glucose produces gluconic acid, resulting in a lower local pH and subsequently triggering FQ micelle release. The released FQ micelles alleviate oxidative stress and exert immunomodulatory effects, while the hydrogel also provides self-healing, and biocompatible properties that facilitate cutaneous regeneration in diabetic mice. Thus, this study highlights the potential of combining GOX with natural products and multi-stimuli-responsive hydrogels for the treatment of chronic diabetic wounds, while also opening new avenues for the development of multifunctional wound dressings.
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Research
·
2026
·
IF 12.9
Jian-Xuan Sun,Ye An,Si-Han Zhang,Jin-Zhou Xu,Abudureyimu Maimaiti,Jing-Yu Xu,Yi-Fan Huang,Yu-Xuan yang,Mei-Cheng Liu,Shao-Gang wang,Qi-Dong Xia
Precision theranostics for castration-resistant prostate cancer remain a major challenge because of tumor heterogeneity, drug toxicity, and resistance to conventional therapies. Here, we report a multifunctional theranostic nanoplatform that integrates multimodal imaging guidance, dual-targeted delivery, photothermal therapy, and immune activation for the precision treatment of prostate cancer. By encapsulating aggregation-induced emission luminogens and magnetic nanoparticles, this system achieves superior second near-infrared fluorescence and magnetic resonance imaging fusion for deep-tissue visualization. The dual-targeting strategy, which integrates magnetic navigation with simultaneous engagement of six-transmembrane epithelial antigen of the prostate 1 and prostate specific membrane antigen (PSMA), effectively addresses tumor heterogeneity by enabling externally guided and biologically specific delivery to both PSMA+ and PSMA− prostate cancer cells. Upon targeted delivery, the synergistic combination of photothermal therapy and chemotherapy achieves potent tumor growth inhibition, activates CD8+ T cells and macrophages to promote robust antitumor immune responses, and elicits durable immunological memory to prevent tumor recurrence. In vitro and in vivo studies demonstrate superior tumor targeting specificity, enhanced imaging contrast, and minimal off-target toxicity. This study provides novel insights into the construction of a multifunctional theranostic nanoplatform in precision oncology, with promising translational potential for clinical management of castration-resistant prostate cancer.
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COMPOSITES COMMUNICATIONS
·
2026
·
IF 8.6
Yuqian Guo,Langqian Chen,Zhixin Jia,Guihua Xiao,Jinghuan Chen,Yun Cheng,Linghua Chen,Leilei Hou,Haiping Wang,Hongjie Zhang
Cellulose elastomer integrates thermochromic, mechanochromic, hydrochromic, and water-deformation. • Rapid thermochromic response within 5 s at 35 °C, near body temperature. • Mechanochromic color change from red to white with 1800% elongation. • Water deformation enables controllable bending and gripping functions. • Multifunctional elastomer shows great promise for robotic electronic skin. Cellulose-based smart materials hold great promise for applications in the field of flexible electronics. Simultaneously realizing multiple stimulus-responsive functionalities while preserving the outstanding mechanical properties of cellulose-based smart materials remains a considerable challenge. High-performance cellulose-based elastomers integrating thermochromic, mechanochromic, hydrochromic, and water deformation capabilities were successfully fabricated through a simple synthetic strategy. Thermochromic response is remarkably rapid, occurring within 5 s at a transition temperature of 35 °C. The response temperature is close to human physiological temperature, and demonstrated excellent reversibility and repeatability. Mechanochromic behavior exhibited a visual color change from red to white upon stretching. Meanwhile, during the mechanochromic process, cellulose-based elastomer achieved an outstanding elongation at break of up to 1800%. Furthermore, water deformation allowed for controllable bending and gripping functions. Given these multifunctional properties, cellulose-based elastomer shows great potential in the field of smart bionic prosthetics, as it could simultaneously perform complex functions such as temperature sensing, joint deformation monitoring, and underwater grasping, thereby providing new design insights for the development of next-generation intelligent biomimetic materials. Download: Download high-res image (453KB) Download: Download full-size image
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JOURNAL OF MATERIALS ENGINEERING AND PERFORMANCE
·
2026
·
IF 2.6
Zheng Weiping,Xia Wenjun,Li Kangyuan,Wang Jingting,Hao Lifeng
A dual-interface engineering strategy is proposed to exploit the anticorrosion potential of cerium oxide fillers by combining an oxygen-vacancy-rich porous core with a fluorinated superhydrophobic shell. Porous CeO 2 (P-CeO 2 ) is synthesized via a P123-templated hydrothermal process and then functionalized with perfluoroalkyl silane to form fluorinated porous CeO 2 (F-CeO 2 ). Conventional CeO 2 , P-CeO 2 , and F-CeO 2 are dispersed into a fluorocarbon resin to prepare composite coatings at different filler loadings. Characterization confirms that fluorination preserves the mesoporous fluorite framework while converting the surface from hydrophilic to superhydrophobic (water contact angle 164°) and promoting an oxygen‑vacancy-enriched surface character. The fluorinated porous particles also show improved colloidal stability in xylene, enabling homogeneous dispersion in the coating matrix. Electrochemical tests in 3.5 wt.% NaCl identify 1.0 wt.% F-CeO 2 as the optimal formulation: The corrosion current density decreases from 5.226 μA·cm −2 for the neat resin to 0.00353 μA·cm −2 , corresponding to 99.93% inhibition efficiency and exceeding coatings with conventional CeO 2 (91.50%) or P-CeO 2 (94.03%). Electrochemical impedance spectroscopy shows that this coating maintains near-ideal capacitive behavior over 21 days of immersion, with coating and double-layer constant-phase exponents remaining ~ 0.92-1.00; a diffusion-controlled Warburg element emerges only after prolonged exposure, indicating delayed electrolyte access to the metal/coating interface. AFM and XRD support a synergistic mechanism in which the fluorinated shell suppresses wetting and ion ingress, while the oxygen-vacancy-rich porous core promotes active passivation. Here, the “dual-functional” design refers to the integration of a superhydrophobic physical barrier provided by the fluorinated shell and a chemical passivation effect induced by oxygen vacancies in the CeO 2 core, which operate synergistically to enhance corrosion resistance. This dual-interface design makes F-CeO 2 an efficient bifunctional filler for durable anticorrosion fluorocarbon coatings. Overall, the approach improves barrier integrity, durability under chloride attack.
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COLLOIDS AND SURFACES B-BIOINTERFACES
·
2026
·
IF 5.9
Fa-you Zhou,Jun Wang,Rui Xu,Li-wei Yang,Wei Xu
NIR triggered PCM gatekeeper enables on demand release of erdafitinib and baicalein from MPDA nanoplatform • MPDA mediates photothermal ablation while erdafitinib provides chemotherapy for synergistic anti-tumor effect • Baicalein endows PMP@ED/Ba with potent non‑enzymatic antioxidant activity to alleviate oxidative stress • PMP@ED/Ba shows excellent biocompatibility and significantly suppresses tumor growth in vivo without major organ toxicity Urothelial carcinoma is a common urinary malignancy with high recurrence, easy progression to muscle-invasive disease, and resistance to conventional therapies. To address the clinical challenges of poor drug retention, low bioavailability, severe toxicity, and the inability of monotherapy to inhibit tumor recurrence and metastasis, a smart responsive nanoplatform (PMP@ED/Ba) based on mesoporous polydopamine (MPDA) was designed and constructed. This platform uses a thermosensitive phase-change material as a gatekeeper to co-load erdafitinib (FGFR inhibitor) and baicalein (antioxidant). Systematic characterizations confirmed the successful fabrication of the nanocomposite with uniform spherical morphology. Under 808 nm NIR irradiation, PMP@ED/Ba exhibited good concentration- and power-dependent heating and photothermal stability, with a photothermal conversion efficiency of 26.3%. The PCM gatekeeper enabled NIR triggered on-demand drug release, preventing premature leakage. DPPH/ABTS assays demonstrated potent non-enzymatic antioxidant activity, efficiently depleting ROS. Hemocompatibility and cytotoxicity tests confirmed good biocompatibility. In vitro and in vivo studies showed that PMP@ED/Ba plus NIR irradiation significantly suppressed T24 tumor growth through synergistic photothermal-chemotherapy, inducing extensive apoptosis and necrosis without major organ toxicity. This smart platform provides an efficient, low-toxicity strategy for locoregional treatment of urothelial carcinoma.
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ACS Nano
·
2026
·
IF 17.3
Song Sizhe,Xu Dongyu,Zhang Hui,Wang Huan,Sun Yuyu,Li Jilai,Chai Renjie
Nerve
guidance conduits play a critical role in bridging nerve
gaps and facilitating neural repair. Recent advances highlight that
structural optimization and functional enhancement can further enhance
the regenerative outcomes. Herein, inspired by the structural features
of celery stalks and native nerves, we propose a biomimetic multichannel
three-dimensional (3D) MXene nanofiber sponge scaffold for reconstructing
large-gap peripheral nerve defects. The scaffold integrates MXene-loaded
sacrificial alginate microfibers, a gas-foamed 3D porous nanofiber
sponge, and a gelatin methacryloyl hydrogel encapsulating neurotrophic
and angiogenic factors. The biomimetic multichannel structure was
obtained by sacrificing the alginate microfibers, during which MXene
nanosheets were released and deposited onto the channels. Benefiting
from the conductive microchannels, the 3D sponge network, and the
bioactive hydrogel, the scaffold potently induced the differentiation
of rat pheochromocytoma cells and supported endothelial tube formation.
Moreover, the scaffold significantly enhanced nerve regeneration and
functional motor recovery in rat long-gap nerve defect models. These
findings demonstrate a potential strategy for the regeneration of
peripheral nerve defects.
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