Materials Science & Engineering C-Materials for Biological Applications
·
2017
·
IF 4.164
Yahui Song,Jianping Gao,Xiaoyang Xu,Huilin Zhao,Ruinan Xue,Jingkuo Zhou,Wei Hong,Haixia Qiu
Thermal sensitive supramolecular hybrid gels for injectable drug release were prepared by adding different amounts of agar into folic acid (FA) gelator. The gelation temperature was modulated in order to form injectable gel with body temperature (37 °C). Such kind of folic acid-agar (FAG) hybrid gel makes it possible to use supramolecular gel as injectable drug loaded gels for drug release. FT-IR and UV–vis spectra indicate that agar macromolecules involve in the self-assembly process through intermolecular H-bonding and π-π stacking interactions with FA molecules. The SEM and TEM images demonstrate that the fiber diameter of FAG hybrid gel is about 20 nm, much smaller than that of FA gel (40 nm). However, FAG hybrid has a denser nano-fibrous network structure than FA gels. Moreover, FAG hybrid gel is endowed with a more ordered network structure and a little better crystallization capability by adding agar. FAG hybrid gel also shows a shear-thinning behavior but the shear viscosity is about 2 times higher than that of FA gel. Compared with FA gel, the storage (G′) and loss (G″) moduli of the FAG gel are higher, which implies an enhanced gel strength. At the same time, both FA and FAG gels are facilely affected by some external factors such as acid, base and salts. In acidic or basic conditions, the strength became weak and the gelation temperature (Tg) decreased. While, within certain concentrations, the salt (NaCl) increased the gel strength and Tg. FAG gel suffered lower mass loss and owned better stability in different pH solutions compared with pure FA gel. The release behavior of the FA and injectable FAG gels was investigated by using Rhodamine B as a mimic model drug. FAG hybrid gel shows a long release profile and the release time is 3 times longer than that of FA gel, up to 30 h, and the accumulative release amount reaches about 86%. So it is a potential injectable gel for sustained release drug delivery system.
研究领域:
材料科学
·
药学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
·
2020
·
IF 3.99
Yonggan Yan,Shulei Xu,Huanxi Liu,Xin Cui,Jinlong Shao,Peng Yao,Jun Huang,Xiaoyong Qiu,Chuanzhen Huang
Designing and fabricating self-healing hydrogel adhesive is essential in many physical and biological applications such as wound closure and cartilage repair. In this work, a new type of hydrogel adhesive has been developed through ultraviolet (UV) curing acrylamide (AM) monomer and hyper-branched polyethylenimine (PEI) polymer. The synthesized PAM-PEI hydrogel (weight ratio for PEI: PAM = 1: 9) shows high stretchability (1D extension ratio > 5500 %) and good plasticity (it can be extended into 2D hydrogel film), quick self-healing property (within 30 s) at ambient enviornment and good adhesiveness to both inorganic (23 kPa ∼ 90 kPa for metal and glass) and organic substrates (∼ 8 kPa for polytetrafluoroethylene , 1 ∼ 7 kPa for skin and liver). More importantly, the adhesion-strip-cycle test suggested that the adhesion measured was reversible and did not attenuate for at least 5 cycles on various surfaces. Rheology tests have demonstrated the repeatability of self-healing behavior of the hydrogel between small (1%) and large (1000 %) strain. In addition, the self-healed hydrogel fragments show good injectability, which can be potentially used for 3D-printing. This work provides a facile way of preparing multifunctional hydrogel adhesive with potential engineering applications.
研究领域:
生物材料学
·
组织工程
·
再生医学
✓ 已验证
产品关联
DOI
高影响因子
CHINESE JOURNAL OF CHEMICAL ENGINEERING
·
2022
·
IF 3.898
Zhongxin Lin,Renliang Huang,Jiangjiexing Wu,Anastasia Penkova,Wei Qi,Zhimin He,Rongxin Su
With excellent biocompatibility and unique physiochemical properties, nanocelluloses including cellulose nanocrystals (CNCs) and cellulose nanofibrils (CNFs) are promising candidates for preparing biomedical hydrogels. CNCs and CNFs are different in morphology and surface charges. Herein, CNCs and two CNFs (CNFs-C, Carboxylated CNFs; CNFs-P, Phosphorylated CNFs) were synthesized and applied to fabricate hydrogels through metal crosslinking. Aluminum crosslinking was found to be the best choice for enhancing the strength. This study systematically compared the morphologies, storage modulus, loss factor, continuous shear ramp, self-healing, swelling, in vitro degradation and injectable properties of the fabricated hydrogels. Further, a radar chart is summarized as guidelines to direct the rational selection to meet the specific requirements of further biomedical applications. At the same nanocellulose concentration and after Al 3+ crosslinking, CNCs hydrogels had strong water holding capacity twice as much as that of CNFs hydrogels. While CNFs hydrogels showed higher hardness and stronger resistance to degradation than that of CNCs. These results provide detailed insights into nanocellulose hydrogels, making it possible to use these guidelines to select hydrogels for desired performance.
研究领域:
生物材料学
·
医学工程
·
高分子科学
✓ 已验证
DOI
高影响因子
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
·
2024
·
IF 7.7
Yun Liu,Haibo Zhao,Yishan Fang,Zhengzong Wu,Bin Yu,Bo Cui
Invasive surgical methods are the current standard for hemostasis and wound closure. In recent years, injectable hydrogels prepared from natural biomacromolecules have shown promise as tissue adhesives to overcome their shortcomings due to their high hydrophilicity and biocompatibility, but the inherent properties of unmodified biomolecules remain a major challenge in their application. In this paper, a hydrogel (DS/Gel-CDH) with self-healing, injectable and adhesive functions was constructed by Schiff base crosslinking between carbonyl hydrazide modified gelatin (Gel-CDH) and dialdehyde starch (DS). The adhesion strength of the hydrogel (34.92 kPa) is much better than that of commercially available protein adhesives (17.44 kPa). In addition, Cytotoxicity and hemolysis tests showed that the hydrogel was non-cytotoxic (cell survival rate was 96.9 %) and could be used as biomaterial in contact with blood. The rats skin incision wound model further confirmed that this hydrogel can adhere to the wound and promote healing. H&E and MT staining showed no signs of toxicity in the tissue around the wound, and IL-6 and IL-1β staining showed no inflammatory reaction. It is proved that the hydrogel has good biocompatibility and degradability in vivo. The results indicate that the multifunctional the DS/Gel-CDH hydrogels are a promising and effective tissue adhesive material.
研究领域:
生物材料学
·
医学工程
·
再生医学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
MACROMOLECULAR CHEMISTRY AND PHYSICS
·
2018
·Vol. 220
·期 3
·1800484
·
IF 2.492
Xiaoya Ding,Gao Li,Chunsheng Xiao,Xuesi Chen
Schiff base bonds formed by primary amines and aldehydes are attractive for the construction of self-healing and injectable hydrogels. However, biomedical applications of the Schiff base–based (SB) hydrogels are usually limited by their inherent low stability due to the rapid exchange dynamic of the Schiff base bond under physiological condition. Herein, a general method to improve the stability of SB hydrogels by simply doubling the Schiff base linkages at the cross-linking points is proposed. The hydrogels formed by single Schiff base linkage ( hydrogel I ) disorganize into nano-aggregates due to the rapid exchange dynamic of Schiff base bond, while the hydrogels formed by double Schiff base linkage ( hydrogel II ) maintain the gel network for longer times due to the improved stability of the double Schiff base linkage at cross-linking points. Moreover, the hydrogel II displays excellent self-healing and injectable properties due to the rapid dynamic nature of Schiff base bonds.
研究领域:
生物材料学
·
医学工程
·
高分子化学
✓ 已验证
产品关联
DOI
高影响因子
Carbohydrate Polymer Technologies and Applications
·
2021
·
IF 0
Ruquan Zhang,Qianru Xu,Yongzhen Tao,Xinyu Wang
Hydrogels with thixotropic and pH-sensitive properties exhibit injectablity and response to external stimulation. Thixotropic and pH-responsive hydrogels were fabricated from xanthan gum (XG) and a hyperbranched β -D-glucan (TM3a) crosslinked with sodium trimetaphosphate (STMP) for injectable and release-controlled application. Thixotropy and creep-recovery tests were carried out to determine injectable and viscoelastic properties of the XG-TM3a-STMP hydrogels. Introduction of TM3a and formation of chemically crosslinking structures resulted in higher yield stress (43.6–168.9 Pa) and elastic modulus (146.9–1245.7 Pa), lower retardation time (32.6–44.4 s), and higher recovery percentage (49.5–66.7%) for XG-TM3a-STMP compared to XG-STMP and XG-TM3a-water. FTIR spectra and SEM observation demonstrated that TM3a disassembled XG aggregates by partially breaking hydrogen bonds, resulting in a relatively thin wall of the grids for XG-TM3a-STMP. The XG-TM3a-STMP hydrogels exhibited pH dependant swelling property and controlled release behavior. The hybrid hydrogels have potential applications in 3D printing or injectable tissue engineering and drug release fields.
研究领域:
生物材料学
·
药物递送系统
·
组织工程
✓ 已验证
产品关联
DOI
MACROMOLECULAR RAPID COMMUNICATIONS
·
2018
·Vol. 39
·期 18
·1800272
·
IF 4.441
Yilong Cheng,Chaoliang He,Kaixuan Ren,Yan Rong,Chunsheng Xiao,Jianxun Ding,Xiuli Zhuang,Xuesi Chen
An advanced hydrogel that features facile formation and injectability as well as light-controlled degradation profile is reported here. By modifying 4-arm poly(ethylene glycol) (4-arm PEG) with 2-nitrobenzyl (NB) and phenol, the 4-arm PEG precursor solutions could form enzymatically cross-linked hydrogels in the presence of horseradish peroxidase (HRP) and hydrogen peroxide (H 2 O 2 ). The gelation time, mechanical strength, and porous structure could be simply tuned by the concentration of HRP and H 2 O 2 . Moreover, the hydrogels underwent controlled degradation under UV light irradiation via photo-cleavage reaction of the NB ester bond. The hydrogels exhibited negligible cytotoxicity toward mouse fibroblast L929 cells in vitro and can be manipulated through injection in vivo.
研究领域:
生物材料学
·
组织工程学
✓ 已验证
DOI
高影响因子
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
·
2024
·
IF 7.7
Penghui Fan,Shangzhi Li,Junfeng Yang,Kaidan Yang,Ping Wu,Qi Dong,Yingshan Zhou
The cystic cavity that develops following spinal cord injury is a major obstacle for repairing spinal cord injury (SCI). The injectable self-healing biomaterials treatment is a promising strategy to enhance tissue repair after traumatic spinal cord injury. Herein, a natural extracellular matrix (ECM) biopolymer hyaluronic acid-based hydrogel was developed based on multiple dynamic covalent bonds. The hydrogels exhibited excellent injectable and self-healing properties, could be effectively injected into the injury site, and filled the lesion cavity to accelerate the tissue repair of traumatic SCI. Moreover, the hydrogels were compatible with cells and various tissues and possessed proper stiffness matched with nervous tissue. Additionally, when implanted into the injured spinal cord site, the hyaluronic acid-based hydrogel promoted axonal regeneration and functional recovery by accelerating remyelination, axon regeneration, and angiogenesis. Overall, the injectable self-healing hyaluronic acid-based hydrogels are ideal biomaterials for treating traumatic SCI.
研究领域:
生物材料学
·
神经科学
·
组织工程学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
MACROMOLECULAR BIOSCIENCE
·
2023
·
IF 4.6
Hanwen Jiang,Yan Xiao,Huanxuan Huang,Wang Yin,Meidong Lang
Antibacterial hydrogel has emerged as an excellent candidate for wound dressing with the ability to eliminate infection and promote wound healing. Herein, a dynamic hydrogel is developed by Schiff base reaction of mixed charged polypeptides and oxidized dextran (ODex). Specifically, biodegradable polypeptides of 1-(propylthio)acetic acid-3-butylimidazole-modified poly(L-lysine) (PLL-PBIM) and adipate dihydrazide-modified poly(L-glutamic acid) (PLG-ADH) are achieved with tunable substitution and charge. By mixing with ODex, charged polypeptides of PLL-PBIM and PLG-ADH led to an injectable and self-healing hydrogel in seconds. The injectable and self-healing performances of the hydrogels are ascribed to the reversible imine and hydrazone bonds formed between polypeptides and ODex. The positively charged hydrogels exhibited over 95% antibacterial activity against E. coli and S. aureus . An optimized balancing of PLG-ADH and PLL-PBIM significantly reduced the hemolysis rate and cytotoxicity of hydrogels. Therefore, the dynamic hydrogel with excellent biocompatibility and inherently antibacterial ability can have potential application for wound dressing.
研究领域:
生物材料学
·
医学工程
·
组织工程
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Journal of Materials Chemistry C
·
2018
·Vol. 6
·期 7
·1746-1752
·
IF 5.976
Qiang Zhang,Libin Liu,Chenguang Pan,Dong Li,Guangjie Gai
Self-healable conductivity is an important feature of electronic skin, which is highly desirable for next-generation wearable devices. However, the preparation of conductors with good mechanical properties combining thermal sensitivity, adhesion, and injectability as well as self-healing capability remains a great challenge. Herein, a series of self-healing conductors were fabricated through random copolymerization of butyl methacrylate (BMA), lauryl methacrylate (LMA) and undecylenyl alcohol modified multi-walled carbon nanotubes (mMWCNTs). The covalent binding between mMWCNTs and polymers avoids the aggregation and uneven dispersion of MWCNTs in the polymer matrix. The resulting conductors possess electrical conductivity (about 11 S m−1) and high mechanical performance (Young's modulus: ∼10 MPa and tensile strength: ∼0.89 MPa) as well as high mechanical and electrical self-healing efficiency (>94% of mechanical strength and >98% of conductivity). More importantly, the composites also exhibit other unique features, including adhesive, injectable, and sensing capability. This work provides new routes to design and fabricate self-healing conductive materials for applications in next-generation wearable devices.
研究领域:
材料科学
·
电子皮肤
·
高分子化学
✓ 已验证
产品关联
DOI
高影响因子
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
·
2019
·
IF 4.784
Ruquan Zhang,Yongzhen Tao,Qianru Xu,Nian Liu,Pu Chen,Yingshan Zhou,Zikui Bai
The hydrogels with injectable and self-healing properties were prepared from xanthan gum (XG) and silk fibroin (SF) by using sodium trimetaphosphate (STMP) as crosslinker. A three-stage model of oscillation-shear-oscillation experiment was designed to mimic injection process and to observe destruction and regeneration of the hydrogels after shear. The XG3-SF-STMP hydrogels immediately recovered to original storage modulus of 80.6%–93.8% on removing shear. The hydrogels were 3D printed into the self-supporting constructions of hydrogel fibers with connected porous structures, and the XG3-SF-STMP hydrogel fibers exhibited smaller width than XG3-STMP. Oscillation rheological behavior indicated that XG3-SF-STMP hydrogels formed rapidly and exhibited more solid-like gel behavior than XG3-STMP. The hydrogel structures were destroyed under a strain (100%) larger than critical strain, but were rebuilt under a small strain (1%) with recovery ratio of 91.36–93.96% within 120 s, suggesting a self-healing property. Introduction of SF particles into XG3-STMP crosslinked networks improved stiffness and retained recoverability. Carboxyl and phosphate groups in the hydrogel networks are beneficial for XG3-SF-STMP hydrogels to absorb enough liquid electrolytes, leading to effective ionic conductivity . The ion-conductive hydrogel with injectable, self-healing, controlled release and non-cytotoxic properties possesses a promising prospect for tissue engineering and drug release application.
研究领域:
材料科学
·
生物医学工程
·
组织工程
✓ 已验证
产品关联
DOI
PubMed
高影响因子
MACROMOLECULAR CHEMISTRY AND PHYSICS
·
2017
·Vol. 218
·期 11
·1700002
·
IF 2.5
Yongqi Yang,Guanghui Gao
A great extent of past work has focused on the development of stimuli-responsive hydrogels that can primarily achieve a two-state transition, such as sol-gel translation. In the current work, a reversible hydrogel with three-state transition is designed. The three transformations between original, oxidized, and reduced states are achieved via controlling the external stimuli conditions. Hydrogels in their original state possess a weak self-healing property and negligible fluidity. The oxidized state hydrogel can keep molding, however, losing the self-healing property. In contrast, the reduced state hydrogels exhibit strong self-healing property. Moreover, the hydrogel becomes injectable subsequent to dithiothreitol addition. Thereafter, under UV-light irradiation or NaClO immersion, the hydrogels can be remolded to any desired shapes. These properties provide novel designing strategies and potential applications for smart and reusable materials.
研究领域:
材料科学
·
生物医学工程
✓ 已验证
DOI
高影响因子
危险品化学品经营许可证（带存储）