CHEMICAL ENGINEERING JOURNAL
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2022
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IF 16.744
Jing Zhao,Zhe Zhang,Fei Xia,Gang Li,Qimanguli Saiding,Lei Xiang,Haipeng Xu,Peijun Yao,Xiaoying Wang,Zhengwei Cai,Wenguo Cui,Xingtao Zhou
Corneal lenticule transplantation can be applied in the correction of refractive errors and various corneal diseases. However, current techniques to preserve cornea are limited due to their short preservation time and the structures and optical retention of cornea tissues. Inspired by the composition of the natural human tear film, a nutrient hydrogel capsule that could maintain the homeostasis of tear film was constructed for preserving human corneal lenticules in this study. The nutritional preservation solution containing sodium alginate was coordinated with calcium ions by rapid diffusion to form a stereoscopic capsule, in which chondroitin sulfate interacted with the corneal lenticule surface electrostatically to form a lubricating layer for three-dimensional preservation and nutritional supply. The light transmittance, cell activity, and collagen fiber density of human corneal lenticules after mid-term preservation in nutrient capsules were higher than those traditional preservation methods. Furthermore, after human allogeneic transplantation, the implanted lenticules remained transparent without displacement or graft rejection, and the corrected distance visual acuity increased by two or more lines in 70% of the patients’ operated eyes after surgery. Nutrient capsules could provide not only a simple, safe, and controlled strategy for three-dimensional preservation, but also new approach for other living tissues preservation.
研究领域:
眼科
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组织工程
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生物材料
✓ 已验证
DOI
高影响因子
DRUG DELIVERY
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2023
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IF 6
Huamei Li,Fuda Dai,Hanyu Liu,Qi Tao,Jie Hu,Yangrong Zhang,Zhenping Xiao,Ilva D. Rupenthal,Huihui Li,Fan Yang,Wei Li,Huaqing Lin,Dongzhi Hou
Recently, various novel drug delivery systems have been developed to overcome ocular barriers in order to improve drug efficacy. We have previously reported that montmorillonite (MT) microspheres (MPs) and solid lipid nanoparticles (SLNs) loaded with the anti-glaucoma drug betaxolol hydrochloride (BHC) exhibited sustained drug release and thus intraocular pressure (IOP) lowering effects. Here, we investigated the effect of physicochemical particle parameters on the micro-interactions with tear film mucins and corneal epithelial cells. Results showed that the MT-BHC SLNs and MT-BHC MPs eye drops significantly prolonged the precorneal retention time due to their higher viscosity and lower surface tension and contact angle compared with the BHC solution, with MT-BHC MPs exhibiting the longest retention due to their stronger hydrophobic surface. The cumulative release of MT-BHC SLNs and MT-BHC MPs was up to 87.78% and 80.43% after 12 h, respectively. Tear elimination pharmacokinetics study further confirmed that the prolonged precorneal retention time of the formulations was due to the micro-interaction between the positively charged formulations and the negatively charged tear film mucins. Moreover, the area under the IOP reduction curve (AUC) of MT-BHC SLNs and MT-BHC MPs was 1.4 and 2.5 times that of the BHC solution. Accordingly, the MT-BHC MPs also exhibit the most consistent and long-lasting IOP-lowering effect. Ocular irritation experiments showed no significant toxicity of either. Taken together, MT MPs may have the potential for more effective glaucoma treatment.
研究领域:
药剂学
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眼科医学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
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2024
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IF 4.5
Lidan Zhang,Chengxin Tian,Chunying Zhao,Guangjie Wang,Miaomiao Pei,Changshan Sun,Tongying Jiang
The purpose of this study was to develop an ophthalmic preparation (LA/Res/HP-β-CD) containing alpha-lipoic acid (LA) and resveratrol (Res)/hydroxypropyl-β-cyclodextrin (HP-β-CD) inclusion complex and to investigate the effect of LA/Res/HP-β-CD on medicating the dry eye disease. The inclusion complex of Res/HP-β-CD was prepared by solvent evaporation method to solve the poor water-solubility of Res, and the optimal proportion of resveratrol and lipoic acid in formulation was screened by hydroxyl radical scavenging test in vitro. Comparing with Res/HP-β-CD, the preparations of LA/Res/HP-β-CD had longer t 1/2 and larger AUC in tears, had more advantages in increasing Res concentration in cornea, conjunctiva and sclera, improving tear secretion and tear film stability, repairing the corneal epithelial and conjunctiva injury, improving mucin and inorganic salt components of tears, reducing pro-inflammatory factor IL-1β in the cornea, enhancing Vitamin D level of eyes. These results showed that LA improved the therapeutic effect of Res, and the combined preparations would exhibit a potential application prospect in treating dry eye disease.
研究领域:
药学
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眼科
✓ 已验证
DOI
高影响因子
PROGRESS IN ORGANIC COATINGS
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2025
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IF 7.3
Haiping Yu,Xiaoyan Li,Mengwei Xu,Hong Zhao,Zaisheng Cai
Hydrophilic anti-fogging coatings face dual challenges of insufficient water resistance and poor weathering durability in practical applications. To address these issues, we propose a natural composite coating system integrating hyaluronic acid (HA), glycerol (Gly), FeCl 3 , and zinc oxide nanoparticles (ZnO-NPs) via a facile mixing strategy. Inspired by the mucin-mediated hydration dynamics of tear films, the HA framework constructs a self-replenishing layer to inhibit fogging while achieving underwater oleophobicity through surface hydration, effectively repelling oily contaminants. Glycerol maintains flexibility and hydration equilibrium through hydrogen-bonded water retention, whereas FeCl 3 crosslinking enhances mechanical strength and water stability via dynamic coordination bonds emulating tear film's ion-modulated self-repair, thereby resisting hydration-induced degradation. ZnO-NPs further endow the coating with photo-induced hydrophilicity. The optimized coating exhibits exceptional water resistance, weathering durability, and mechanical robustness, retaining high transmittance and stable hydrophilicity after 120 h of water immersion, 120 h of xenon lamp irradiation, 40 adhesion cycles, and 300 abrasion tests. Remarkably, the coating demonstrates rapid self-healing within 10 s and superior self-cleaning performance. This study proposes a sustainable strategy to synergistically enhance water resistance and weathering resistance.
研究领域:
材料科学
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高分子科学
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表面工程
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生物材料
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纳米技术
✓ 已验证
产品关联
DOI
高影响因子
危险品化学品经营许可证（带存储）