STEROIDS
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2020
·
IF 1.948
Bairen Du,Jingjing Zhang,Yanjie Dong,Junwei Wang,Longwen Lei,Rengfei Shi
A novel method for determining the testosterone/epitestosterone concentration ratio in human urine was established by capillary electrophoresis with diode-array detector. The urine samples were firstly purified by the solid extraction. The optimal experimental conditions were: running buffer pH = 4.74, 15.0 mmol L −1 HAc-NaAc, separation voltage 25 kV, temperature 25 °C, sample injection pressure 3.43 × 10 3 Pa, and duration 10 s. The testosterone and epitestosterone linear range were determined as 8.0–960.0 ng mL −1 , respectively. The testosterone and epitestosterone detection limits were determined as 4.6 and 4.5 ng mL −1 , respectively. The relative standard deviation was less than 0.36%.
研究领域:
分析化学
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医学检验
·
运动科学
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产品关联
DOI
PubMed
高影响因子
Science of Advanced Materials
·
2018
·Vol. 10
·期 10
·1381-1388
·
IF 1.318
Yao Shujuan,Li Qiancheng,Kong Ningning,Li Chao,Wei Mingming,Song Ruru,Ren Xiaozhen,Pu Xipeng,Li Wenzhi
We presented facile synthesis of Cu3–x
Zn
x
SnS4 composites (CZTSs, 0 ≤ x ≤ 3) with variety morphologies via simple one-pot hydrothermal process without hazardous chemicals, simply by varying initial precursor Cu/(Zn +
Sn) concentration ratio. The influence of initial Cu/(Zn+Sn) concentration ratio on the microstructures and properties of composites was investigated. The morphological, structural, and optical properties of the samples were characterized by field-emission scanning and transmission electron
microscopes, X-ray diffraction, N2 adsorption–desorption, and UV-Vis diffuse reflectance. The photocatalytic activity of the samples was studied using visible light irradiation of rhodamine B. Benefiting from the initial precursor Cu/(Zn+Sn) concentration, the as-prepared
3D hierarchical carnation-flowerlike CZTSs with high initial zinc concentration exhibit superior adsorption capability and much higher photocatalytic activity than that with low initial zinc concentration. The possible degradation mechanism of RhB was proposed.
研究领域:
材料科学
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环境科学
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DOI
高影响因子
Journal of Optics
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2015
·Vol. 17
·期 2
·025901
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IF 2.059
Cheng Liu,Baojun Li
The fabrication and characterization of luminescent solar concentrators (LSCs) that contain multiple dyes are reported. LSCs were fabricated using one, two, or three dyes doped in a poly(methyl methacrylate) (PMMA) waveguide, and their performance was characterized. The three-dye LSC had a power conversion efficiency of 1.40% with an optical concentration ratio of 1.2. This efficiency is 16.7% greater than the maximum value of the single-dye LSCs. The external quantum efficiency of the three-dye LSC was greater than the single-dye LSCs.
研究领域:
材料科学
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可再生能源
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产品关联
DOI
高影响因子
ADVANCED FUNCTIONAL MATERIALS
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2016
·Vol. 26
·期 40
·7224-7233
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IF 11.382
Sheng Cao,Jinju Zheng,Jialong Zhao,Zuobao Yang,Minghui Shang,Chengming Li,Weiyou Yang,Xiaosheng Fang
Dual emission quantum dots (QDs) have attracted considerable interest as a novel phosphor for constructing ratiometric optical thermometry because of its self-referencing capability. In this work, the exploration of codoped Zn–In–S QDs with dual emissions at ≈512 and ≈612 nm from intrinsic Cu and Mn dopants for ratiometric temperature sensing is reported. It is found that the dopant emissions can be tailored by adjusting the Mn-to-Cu concentration ratios, enabling the dual emissions in a tunable manner. The energy difference between the conduction band of the host and Cu dopant states is considered as the key for the occurrence of Mn ion emission. The as-constructed QD ratiometric temperature sensor exhibits a totally robust stability with a fluctuation of ≈ I Cu / I tot versus times lower than 1% and almost no hysteresis in cycles over a broad window of 100–320 K. This discovery represents that the present cadmium-free, intrinsic dual-emitting codoped QDs can open a new door for the synthesis of novel QDs with stable dual emissions, which poise them well for challenging applications in optical nanothermometry.
研究领域:
材料科学
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纳米技术
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光学传感
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半导体量子点
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温度测量
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DOI
高影响因子
BRITISH JOURNAL OF PHARMACOLOGY
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2019
·Vol. 176
·期 17
·3236-3249
·
IF 6.583
Zhiyuan Ma,Shuanghui Lu,Dongli Sun,Mengru Bai,Ting Jiang,Nengming Lin,Hui Zhou,Su Zeng,Huidi Jiang
Background and Purpose Entecavir (ETV), a first-line antiviral drug against hepatitis B virus (HBV), has the possibility to be used to prevent mother-to-child transmission. The aim of present study was to clarify the mechanism of ETV uptake into hepatocytes and evaluate the alteration of ETV's hepatic distribution during pregnancy. Experimental Approach The roles of equilibrative nucleotide transporter (ENT) 1 and organic anion transporter (OAT) 2 in ETV accumulation and anti-HBV efficacy were studied in human ENT1 or OAT2 overexpressed cell models and HepG2.2.15 cells, respectively; meanwhile, the liver-to-plasma ETV concentration ratios in non-pregnant and pregnant mice were measured to evaluate the effect of pregnancy on ETV hepatic distribution. Key Results ETV was shown to be a substrate of ENT1 and OAT2. An ENT1 inhibitor significantly decreased the efficacy of ETV in HepG2.2.15 cells, while overexpression of OAT2 increased susceptibility of HBV to ETV. The liver-to-plasma ETV concentration ratios in pregnant mice were sharply reduced; whereas, the absolute concentration of ETV in the liver did not obviously alter in pregnancy. Although oestradiol and progesterone showed a concentration-dependent inhibition on ETV accumulation both in hepatic cell lines and in primary human hepatocytes, a physiologically relevant concentration of oestradiol and progesterone did not affect antiviral activity of ETV. Conclusions and Implications OAT2 and ENT1 are the main transporters involved in the hepatic uptake and anti-HBV efficacy of ETV. The concentration of ETV in the liver was not obviously altered during pregnancy, which indicates that dosage adjustment in pregnancy is not necessary.
研究领域:
药理学
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肝病学
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病毒学
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分子生物学
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DOI
PubMed
高影响因子
PHYSICS OF FLUIDS
·
2023
·Vol. 35
·期 1
·
IF 4.6
Yuan Shuai,Zhou Mingyong,Liu Xijiang,Li Qiang,Drummer Dietmar,Jiang Bingyan
With the recent great interest in microfluidic devices, a better understanding of preconcentration technology has become increasingly important. Herein, concentration enrichment of charged samples is achieved by using field-amplified sample stacking (FASS) technology in the microchannel. This paper aims to develop a fundamental understanding of FASS and to propose a method to enhance the enrichment quality of FASS. First, numerical investigations are carried out to systematically study the effects of various parameters including the applied voltage, the charged properties of the sample, the buffer concentration ratio, the injection length, and the microchannel width on FASS enrichment performance. The results show that reducing the width of the microchannel is an effective way to improve the enrichment quality. The maximum enrichment ratio can be improved by 67.35% by reducing the width of the microchannel to less than 10 μ m due to the inhibition of background buffer diffusion. Second, to improve traditional FASS performance, a high-conductance gradient boundary is established by photoinitiating fabrication of a porous plug at the enriched interface position. This structure provides a region that reduces the local size of the internal channel to less than 5 μ m and has high flow resistance, but allows the electromigration of the charged analyte. Experimental results show that an electropherogram signal increases by a maximum factor of 329 in electrophoretic enrichment of fluorescein–Na with 5 × 10 −7 M initial concentrations, and the enrichment quality of traditional FASS is greatly improved.
研究领域:
微流控学
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分析化学
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电泳
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产品关联
DOI
高影响因子
SCIENCE OF THE TOTAL ENVIRONMENT
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2022
·
IF 10.753
Chenxing Li,Xiaojiao Zhou,Yangyi Xiao,Tuqiao Zhang,Miaomiao Ye
Recently, solar-driven seawater desalination based on air-water interfacial heating has triggered significant research interest due to its high water evaporation rate, high photothermal conversion efficiency, low energy consumption, simple operation and low cost. However, as the air-water interface temperature reaches as high as 40–70 °C, volatile organic compounds (VOCs) will volatilize into the condensed desalinated water and results in the polluted freshwater. In this work, anionic, cationic, and nonionic surfactants were applied for the first time to inhibit the phenolic compounds such as phenol, p -methylphenol and p -chlorophenol entering into the condensed freshwater. Results showed that the concentration of phenol could be reduced by the addition of cetyl trimethyl ammonium bromide (CTAB). The phenol's distillation concentration ratio (R D ) reduced from 76% to 35% due to the electrostatic interaction and the micellar encapsulation between the CTAB and phenol. Moreover, parameters including CTAB dose, initial phenol concentration, solar intensity, pH, and salinity that affecting the R D were also investigated. Finally, a real seawater solar-driven distillation experiment also revealed that the water quality of freshwater was improved by the addition of CTAB. This work revealed that the surfactants such as CTAB can be potentially used to inhibit VOCs entering into the condensed freshwater during solar-driven seawater distillation.
研究领域:
环境科学
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化学工程
·
水处理
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产品关联
DOI
PubMed
高影响因子
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