Marine Drugs
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2022
·Vol. 20
·期 10
·654
·
IF 6.085
Pathum Chandika,Pipuni Tennakoon,Tae-Hee Kim,Se-Chang Kim,Jae-Young Je,Jae-Il Kim,Bonggi Lee,BoMi Ryu,Hyun Wook Kang,Hyun-Woo Kim,Young-Mog Kim,Chang Su Kim,Il-Whan Choi,Won Sun Park,Myunggi Yi,Won-Kyo Jung
Coagulation is a potential defense mechanism that involves activating a series of zymogens to convert soluble fibrinogen to insoluble fibrin clots to prevent bleeding and hemorrhagic complications. To prevent the extra formation and diffusion of clots, the counterbalance inhibitory mechanism is activated at levels of the coagulation pathway. Contrariwise, this system can evade normal control due to either inherited or acquired defects or aging which leads to unusual clots formation. The abnormal formations and deposition of excess fibrin trigger serious arterial and cardiovascular diseases. Although heparin and heparin-based anticoagulants are a widely prescribed class of anticoagulants, the clinical use of heparin has limitations due to the unpredictable anticoagulation, risk of bleeding, and other complications. Hence, significant interest has been established over the years to investigate alternative therapeutic anticoagulants from natural sources, especially from marine sources with good safety and potency due to their unique chemical structure and biological activity. This review summarizes the coagulation cascade and potential macromolecular anticoagulants derived from marine flora and fauna.Keywords:blood coagulation;anticoagulant;marine sources;marine anticoagulant macromolecules;chemically modified macromolecules
研究领域:
生物学
·
医学
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产品关联
DOI
PubMed
高影响因子
Materials
·
2022
·Vol. 15
·期 23
·8402
·
IF 3.748
Junhao Xie,Shuai Qi,Qianping Ran,Lei Dong
Marine fouling on concrete has become one of the severest problems that damage the surface and even cause internal corrosion of marine concrete. Dissimilarly to the previous abuse of toxic antifoulants, developing hydrophobic waterborne antifouling materials could be regarded as one of the most environment-friendly and potential directions to protect marine concrete. However, the insufficient hydrophobicity, antifouling, and mechanical properties limit their application. Herein, we reported a series of hybrid coatings combining hyperbranched polyglycerol (HPG) decorated waterborne fluoro silicone polyurethane (H) and HPG-grafted graphene oxide (G-HPG) that improve the hydrophobicity, antifouling, and mechanical properties. The hybrid materials were modified by the hyperbranched polyglycerol synthesized based on the anionic-ring-opening reaction between glycerol and ethylene glycol or polyethylene glycol. Remarkably, the hydrophobicity (115.19°) and antifouling properties (BSA absorption of 2.33 μg/cm2andP. tricornutumattachment of 1.289 × 104CFU/cm2) of the materials could be developed by the modification of HPG with higher generation numbers and backbone molecular weights. Moreover, the mechanical properties negligibly decreased (tensile strength decreased from 11.29 MPa to 10.49 MPa, same pencil hardness and adhesion grade as H of 2H and grade 2). The results revealed that the HPG of higher generation numbers and backbone molecular weights could benefit materials with enhanced antifouling properties and hydrophobicity. The method of hyperbranched modification can be regarded as potentially effective in developing the durability and antifouling properties of marine antifouling materials.Keywords:hyperbranched polyglycerol;waterborne fluoro silicone polyurethane;graphene oxide;marine antifouling materials;marine concrete
研究领域:
材料科学
·
海洋生物学
·
环境科学
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DOI
PubMed
高影响因子
Environmental Technology & Innovation
·
2024
·
IF 6.7
Xiao-Huang Chen,Su-Huai Chang,Rui Jiang,Yong-Qiang Tian,Li-Ping Jia,Feng-Jiao Liu,Xu-Guang Huang
Cadmium (Cd), a prevalent pollutant in near-shore seawater ecosystems, poses a significant threat to marine biota. Zinc (Zn) and Cd can have interchangeable physiological effects in marine plankton, and both can influence the synthesis of siliceous walls. Consequently, the concentrations of zinc and silicon may jointly impact the toxicity of Cd. This study endeavors to elucidate the combined effect of silicon (Si) and zinc (Zn) on the growth and physiological responses of the marine diatom species Thalassiosira weissflogii when subjected to Cd-induced stress conditions (190.7 μg L −1 ). Our results reveal statistically improvements ( p <0.05) in biomass production, reductions ( p <0.05) in superoxide dismutase (SOD) activity and extracellular secretion in T. weissflogii when high concentrations of Si (172 µmol L −1 ) and Zn (18.3 nmol L −1 ) were applied simultaneously. Additionally, examination of Cd bioconcentration factors (BCF) derived from Cd uptake kinetics and intracellular Cd content measurements underscores the ability of elevated Si and Zn concentrations to reduce intracellular Cd accumulation ( p <0.05). The ability of Si and Zn to mitigate Cd toxicity was further evidenced by increased cellular biosilica content and maintenance of cell morphology, suggesting a protective role in preserving structural integrity and growth. Our findings underscore the synergistic benefits of Si and Zn in enhancing the resilience of T. weissflogii to Cd stress, providing valuable insights into the potential use of nutrient amendments as a strategy for mitigating heavy metal contamination in marine environments.
研究领域:
海洋生物学
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环境科学
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DOI
高影响因子
Coatings
·
2022
·Vol. 12
·期 6
·855
·
IF 3.236
Yu Yang,Guoqing Wang,Longlin Lei,Yangkai Xiong,Zhiqiang Fang,Lei Huang,Jinbo Liu,Daxiong Hu,Jianhe Liao
The accumulation of marine biological growth has irreversible negative effects on shipping and coastal fisheries. In this paper, a new antibacterial nanofiller—triazole fluoroaromatic hydrocarbon−modified nano−zinc oxide (ZnO−APTES−TRF)—was prepared by a Cu(I)−catalyzed azide–alkyne click chemical reaction. The modification of nano−ZnO with triazole ring fluoroaromatic hydrocarbons were testified by FT−IR, XPS, and EDS. The grafting rate of ZnO−APTES−TRF can reach 32.38%, which was verified by the TGA test. The ZnO−APTES−TRF was mixed with zinc acrylate resin to produce a low surface energy antifouling coating with a surface water contact angle of 106°. The bactericidal rate of ZnO−APTES−TRF againstEscherichia coli,Staphylococcus aureus, andPseudoalteromonassp. can reach more than 98% due to the synergistic effect of triazole and fluorine. The 120−day marine experiment shows that the low surface energy antifouling coating of ZnO−APTES−TRF/ZA is expected to be widely used in the field of marine antifouling.Keywords:antifouling;marine;ZnO;triazole;modification;hydrophobic
研究领域:
材料科学
·
海洋生物学
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DOI
高影响因子
JOURNAL OF INDUSTRIAL AND ENGINEERING CHEMISTRY
·
2025
·
IF 6
Chenglin Zhang,Jiangpeng Li,Su Zhan,Wenjun Jiang,Feng Zhou
The notorious issue of hazardous growth in ballast water and its potential for widespread diffusion pose significant challenges to the sustainable development of maritime transportation economies. Here, a simplified and sustainable method is presented for synthesizing metallic Bi-doped Bi 2 Sn 2 O 7 , assisted by H 2 O 2 to construct a Fenton-like system for the photocatalytic inactivation of marine bacteria. The introduction of metallic Bi is beneficial to the overall sterilization improvement, notably, the 3BBSO (Bi/Bi 2 Sn 2 O 7 ) exhibits optimal selectivity in marine bacteria inactivation, with improved decomposition of H 2 O 2 . The combination of metallic Bi and additional H 2 O 2 contributes to the separation of photo-generated charges and the production of •OH radicals, thereby enhancing sterilization efficiency in natural seawater. Furthermore, characterization results demonstrate that the metallic Bi act as a pivotal active sites for the enrichment of free electrons and adsorption centers for •OH, increasing the light absorption range and promoting photocatalytic bacterial inactivation. DFT simulations suggest that metallic Bi provides an optimal position for H 2 O 2 abundance, utilizing aggregated electrons to generate more •OH radicals. This sustainable framework offers valuable insights into the treatment of ballast water by deactivating the concentration of marine microorganisms.
研究领域:
环境科学
·
微生物学
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产品关联
DOI
高影响因子
Biotechnology for Biofuels
·
2019
·Vol. 12
·期 1
·1-15
·
IF 5.452
Fang Wei,Xue Saisai,Deng Pengjun,Zhang Xuecheng,Wang Xiaotang,Xiao Yazhong,Fang Zemin
Background Starch is an inexpensive and renewable raw material for numerous industrial applications. However, most starch-based products are not cost-efficient due to high-energy input needed in traditional enzymatic starch conversion processes. Therefore, α-amylase with high efficiency to directly hydrolyze high concentration raw starches at a relatively lower temperature will have a profound impact on the efficient application of starch. Results A novel raw starch digesting α-amylase (named AmyZ1) was screened and cloned from a deep-sea bacterium Pontibacillus sp. ZY. Phylogenetic analysis showed that AmyZ1 was a member of subfamily 5 of glycoside hydrolase family 13. When expressed in Escherichia coli , the recombinant AmyZ1 showed high activity at pH 6.0–7.5 and 25–50 °C. Its optimal pH and temperature were 7.0 and 35 °C, respectively. Similar to most α-amylases, AmyZ1 activity was enhanced (2.4-fold) by 1.0 mM Ca 2+ . Its half-life time at 35 °C was also extended from about 10 min to 100 min. In comparison, AmyZ1 showed a broad substrate specificity toward raw starches, including those derived from rice, corn, and wheat. The specific activity of AmyZ1 towards raw rice starch was 12,621 ± 196 U/mg, much higher than other reported raw starch hydrolases. When used in raw starch hydrolyzing process, AmyZ1 hydrolyzed 52%, 47% and 38% of 30% (w/v) rice, corn, and wheat starch after 4 h incubation. It can also hydrolyze marine raw starch derived from Chlorella pyrenoidosa , resulting in 50.9 mg/g DW (dry weight of the biomass) of reducing sugars after 4 h incubation at 35 °C. Furthermore, when hydrolyzing raw corn starch using the combination of AmyZ1 and commercial glucoamylase, the hydrolysis rate reached 75% after 4.5 h reaction, notably higher than that obtained in existing starch-processing industries. Conclusions As a novel raw starch-digesting α-amylase with high specific activity, AmyZ1 efficiently hydrolyzed raw starches derived from both terrestrial and marine environments at near ambient temperature, suggesting its application potential in starch-based industrial processes.
研究领域:
生物化学
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工业微生物学
·
酶工程
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产品关联
DOI
PubMed
高影响因子
FUEL
·
2023
·
IF 7.4
Zhonghua Xue,Yali Feng,Haoran Li,Chenglong Xu,Jinrong Ju,Lianping Dong,Chongyi Yang,Weiren Bao,Jiancheng Wang,Haoyu Wang,Ruiyu Ma
The search for efficient adsorbents to mitigate the impact of antibiotic pollutants on marine ecosystems, food security and human health is a burgeoning field of research. Further, Trimethoprim (TMP) and sulfamethoxazole (SMX) are widely distributed in the marine environment and are difficult to degrade. In this research, we used gravity separation to enrich the residual carbon from the coal gasification coarse slag and used the resulting carbon-high product (GC) as a low-cost and high-efficiency adsorbent. TMP and SMX were investigated for their adsorption behavior in seawater using GC under varied conditions. The findings indicated that the adsorption capacities of TMP and SMX by GC were 5.0017 mg/g and 5.1391 mg/g, respectively. The equilibrium durations of TMP and SMX by GC were 21 min and 40 min, respectively. Various adsorption models were fitted to the adsorption behavior of two pollutants by GC. The results showed that the adsorption processes of the two pollutants were consistent with the Freundlich equation and the quasi-secondary kinetic model, suggesting that both pollutants were adsorbed on GC surface by both physical and chemical processes. GC more effectively adsorbed TMP than SMX under a competitive adsorption procedure. When we introduced molecular dynamics simulation into this research, the microscopic procedures of GC adsorbing two pollutants were investigated. The energy composition and hydrogen bond types in the adsorption process were quantified. Finally, we summarized the adsorption mechanism of GC adsorbing two pollutants. This work will pave the way for developing effective, low-cost and environmentally friendly novel materials for the adsorption and purification of antibiotic pollutants in the marine environment. This research can produce positive economic and environmental effects in the comprehensive utilization of coal gasification slag.
研究领域:
环境科学
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材料科学
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生物学
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产品关联
DOI
高影响因子
LUMINESCENCE
·
2020
·Vol. 35
·期 6
·897-902
·
IF 1.855
Keke Ning,Guoqiang Xiang,Cuicui Wang,Feihong Huang,Jinzhi Liu,Lanlan Zhang,Minmin Yan,Bingqian Hu,Wen Lei
A ‘turn-on’ fluorescence method for detection of hydrogen peroxide (H 2 O 2 ) in marine food samples is presented in this article. Using this method, a carbon dots (CDs)–MnO 2 probe was formed in which fluorescence intensity (FI) of CDs was quenched through fluorescence resonance energy transfer by addition of MnO 2 nanosheets. When H 2 O 2 was added into the CDs–MnO 2 solution, the MnO 2 nanosheets formed Mn 2+ ions due to a redox reaction between H 2 O 2 and MnO 2 nanosheets, and CD FI was recovered. Under optimized conditions, the detection limit for H 2 O 2 was 0.87 μM, and analytical linear range was 4–100 μM. Furthermore, this developed fluorescence sensing system was successfully used with satisfactory results to determine trace H 2 O 2 content in marine food samples.
研究领域:
分析化学
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食品科学
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海洋生物学
✓ 已验证
DOI
高影响因子
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
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2024
·
IF 6.2
Chuanyue Chen,Xueer Wang,Yingrong Jin,Yinchang Yao,Suchang Li,Zhi Liao,Xiaolin Zhang,Xiaojun Yan
The increasing deposition of microplastics (MPs) in aquatic ecosystems is a worldwide concern. MPs can interact with other environmental pollutants, such as heavy metals, and change their toxicity. In this study, we focused on the effects of MPs and lead (Pb), as a toxic heavy metal, on marine mussel Mytilus coruscus under separate and co-exposure situations at environmentally relevant concentrations: MPs (1 mg/L) and Pb (50 μg/L). We found that MPs alone or in combination with Pb significantly decreased the respiration and filtration rates of the mussels ( p < 0.05). Histological observations revealed varying extents of damage to the gill and digestive gland caused by a single exposure to MPs, which was aggravated by co-exposure to Pb. In addition, co-exposure induced a higher level of oxidative stress, which was reflected by an increase in hydrogen peroxide and malondialdehyde content, and a decrease in antioxidant enzyme activity. Meanwhile, co-exposure poses a significant threat to the immune function of the mussels, as evidenced by induction of hemocytes to produce excess reactive oxygen species (ROS), significantly reducing lysosome activity ( p < 0.05), inhibiting the expression of autophagy-related genes, and inducing the expression of apoptosis-related genes, resulting in hemocyte apoptosis. Furthermore, the TLR/MyD88/NFκB signaling pathway is involved in the immune response of mussels to environmental stress. This study provides novel perspectives on the toxicity of MPs combined with Pb in marine animals, as well as the molecular mechanisms underlying their ecotoxicological effects.
研究领域:
环境科学
·
毒理学
·
分子生物学
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DOI
PubMed
高影响因子
Journal of Environmental Chemical Engineering
·
2023
·
IF 7.7
Binyuan Gao,Chongran Sun,Tao Yang,Haina Cheng,Hongbo Zhou,Yuguang Wang,Zhu Chen
Red mud is a highly saline and alkaline solid waste generated in alumina refinery, which entails dealkalization for safe disposal and valorization. Herein, Trichocomaceae sp. K-2, a novel fungus isolated from marine sediment , was used for the simultaneous dealkalization of red mud and recovery of valuable metals. The fungus demonstrated robust growth at high salinity (45 g/L NaCl), good tolerance to high pH (up to 12), and capability of utilizing low-cost substrates derived from lignocellulosic biomass. Both structural and free alkali can be removed by Trichocomaceae sp. K-2 to achieve a significantly lower minimum pH (<4) in a considerably short timeframe (<16 days), and the alkali removal efficiency as high as 94% was attained. Moreover, concomitant leaching of valuable Nd, Sc and Y from red mud during dealkalization was feasible. Physical disintegration and chemical erosion by the secreted organic acids were responsible for the effective dealkalization, as well as leaching of valuable metals. This study sheds lights on how marine microorganisms can be harnessed to the green disposal of red mud, and provokes the exploration of more robust and versatile marine microbes for the sustainable and cost-effective management of other highly saline and alkaline solid waste.
研究领域:
环境科学
·
微生物学
✓ 已验证
DOI
高影响因子
ADVANCED FUNCTIONAL MATERIALS
·
2024
·
IF 18.5
Jiafei Hu,Yan Liu,Chengxiu Yang,Shaowei Wu,Haomiao Wang,Yuhang Qin,Yuchen Yong,Lihui Liu,Xu Li,Shijie Gu,Yueguo Hu,Peisen Li,Jian Huang,Qi Zhang,Mengchun Pan
Long-term access to undersea information is of critical importance for undersea sensing. However, the paramount challenge in marine wearable technology lies in achieving durable and stable adhesion, coupled with biocompatibility, for devices submerged in the saline conditions of the ocean. Here, a self-healing, seawater-resistant hydrogel is reported that exhibits robust adhesion to diverse biotic and abiotic surfaces. Remarkably, the presented hydrogel is augmented with octopus sucker-inspired microstructures, a feature that markedly improves its capability of organism adhesion underwater. The hydrogel exhibits robust mechanical properties in water, with over 20-fold elongation in a fully swollen state, and a mechanical healing efficiency exceeding 90% after healing for 30 min. The hydrogel is applied toward several representative undersea scenes. Specifically, the hydrogels equipped with flexible pressure sensors are reliably affixed to fish and turtles for sensing hydraulic pressure for more than 20 days, while the hydrogels featuring a compact camera are mounted on corals and crabs for constant monitoring of surroundings. Furthermore, the hydrogel is molded into a mesh structure for integrating multiple sensors, functioning as multi-node marine wearable platforms. The underwater hydrogel, with its broad applicability, introduces an approach to real-time undersea monitoring and non-invasive marine life internet construction.
研究领域:
材料科学
·
海洋生物学
·
生物医学工程
✓ 已验证
产品关联
DOI
高影响因子
NEW JOURNAL OF CHEMISTRY
·
2025
·
IF 2.5
Xiaotao Liu,Xueting Hua,Jian Lu,Jun Wu,Yuexia Feng
Information regarding adsorption–desorption of pollutants on degradable microplastics in marine environments is limited. Biodegradable microplastics including polylactic acid (PLA), polyhydroxyalkanoate (PHA), and polybutylene adipate (PBAT) as well as non-biodegradable microplastic controls including polypropylene (PP) and polyethylene (PE), were selected to investigate the adsorption and desorption behaviors of phenanthrene on biodegradable microplastics in seawater. The results showed that PP (5.3%) and PE (5.5%) had relatively high adsorption and desorption capacity for phenanthrene, while PBAT had similar phenanthrene adsorption but lower desorption capacity (desorption rate 3.8%). PLA had the lowest adsorption capacity (118 μg g−1), while PHA had the lowest desorption rate (3.1%) for phenanthrene. Adsorption of phenanthrene by PLA was sensitive to the salinity, while that of PBAT, PP and PE was not affected by the salinity. The high adsorption and weak desorption of phenanthrene on PBAT were mainly affected by π–π interactions and the low crystallinity of PBAT, while those on PLA and PHA were mainly affected by hydrophilicity. The replacement of non-degradable plastics by degradable plastics could modify the adsorption–desorption behaviors of phenanthrene in marine environments. These findings provide new insights into the environmental friendliness of degradable plastics in marine environments.
研究领域:
环境科学
·
海洋学
·
污染生态学
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产品关联
DOI
高影响因子
危险品化学品经营许可证（带存储）