JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A
·
2013
·Vol. 102
·期 7
·2408-2416
·
IF 2.834
Li Chen,Ying Zhang,Shen Li,Xiuli Wang,Na Li,Yu Wang,Xin Guo,Shan Zhao,Weiting Yu,Guangwei Sun,Yang Liu,Xiaojun Ma
Immobilization of hepatocytes in microcapsules has been a potentially alternative methodology for bioartificial livers (BALs). Moreover, the stability and permeability are the key parameters of these microcapsules. However, these alginate-based microcapsules are unstable if the surrounding medium disrupts the ionic interactions between alginate and the polycation. As hundreds of components are included in human plasma, the stability and permeability in plasma of microcapsules need to be sufficiently investigated. In the present study, the stability of three kinds of alginate-based microcapsules was evaluated when they were immersed in plasma. Our results showed that stability of alginate-α-poly ( l -lysine)-alginate (α-APA) microcapsules was well maintained, better than those of alginate-ε-poly ( l -lysine)-alginate (ε-APA) and alginate–chitosan–alginate (ACA) microcapsules. Also, factors affecting the stability of microcapsules in plasma were analyzed and it showed that heparin was the key factor that affected the stability of α-APA microcapsules, whereas heparin and low molecular electrolytes such as HCO 3 − and H 2 PO 4 − /HPO 4 2− were the factors to ε-APA and ACA microcapsules. In addition, the permeability evaluation showed no decrease in permeability of microcapsules after incubation in plasma. Our study might provide a foundation for the selection and modification of materials for microcapsule-based BAL devices. © 2013 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 102A: 2408–2416, 2014.
研究领域:
生物材料
·
组织工程
·
再生医学
·
肝病学
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药物递送系统
✓ 已验证
DOI
高影响因子
COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
·
2018
·
IF 2.829
Rongli Zhang,Jingjing Lv,Cuige Zhang,Renchun Yang,Xingchen Sun,Bo Song,Ching-Ping Wong
A new kind of dopamine modified alginate colloid particles (DA-ALG CPs) was prepared via the direct chemical self-assembly triggered by the amidation reaction between dopamine and alginate in aqueous solution. The structure and morphology of the DA-ALG CPs were characterized by infrared spectroscopy , Zeta PALS and scanning electron microscope . The prepared DA-ALG CPs were then used as particulate emulsifier to prepare Pickering emulsions . The properties of the emulsion were characterized by optical microscope . The results revealed that the prepared DA-ALG CPs exhibited good emulsifying property at a wide pH value range, which will endow the potential application of the Pickering emulsions stabilized by DA-ALG CPs in food and biological medicine fields.
研究领域:
高分子材料学
·
胶体与界面化学
·
食品科学
·
生物医学工程
·
药物递送
·
纳米医学
✓ 已验证
DOI
高影响因子
JOURNAL OF MATERIALS CHEMISTRY
·
2011
·Vol. 21
·期 40
·16028-16034
·
IF 5.101
Jun Shi,Zhengzheng Zhang,Gefei Li,Shaokui Cao
Alginate/CaCO3 hybrid beads with pH- and thermal-responsive drug release properties were prepared under compressed CO2 using aliphatic poly(urethane-amine)s (PU) as the thermal-responsive component. Polyacrylic acid (PAA) was used as a crystal growth additive to control the structure of the hybrid beads. The hybrid beads were characterized by using scanning electron microscopy, X-ray powder diffraction and thermogravimetric analysis. The interaction between PAA and aliphatic PU contributed to the formation of alginate beads with a compact CaCO3 shell. Indomethacin release behaviour was found to be pH- and thermal-responsive. The release profiles were sustained with CaCO3 microparticles, indicating that the compact CaCO3 shell could hinder the permeability of the encapsulated drug and reduce the drug release effectively. The results suggest that the hybrid alginate beads can be used as “smart” polysaccharide materials for sustained dual-responsive drug delivery.
研究领域:
生物材料
·
药物递送系统
·
高分子科学
·
纳米医学
·
药剂学
·
生物化学
·
组织工程
✓ 已验证
DOI
高影响因子
Materials Science & Engineering C-Materials for Biological Applications
·
2016
·
IF 3.42
Haibin Li,Fei Jiang,Song Ye,Yingying Wu,Kaiping Zhu,Deping Wang
The strontium-substituted hydroxyapatite microspheres (SrHA) incorporated alginate composite microspheres (SrHA/Alginate) were prepared via adding SrHA/alginate suspension dropwise into calcium chloride solution, in which the gel beads were formed by means of crosslinking reaction. The structure, morphology and in vitro bioactivity of the composite microspheres were studied by using XRD, SEM and EDS methods. The biological behaviors were characterized and analyzed through inductively coupled plasma optical emission spectroscopy (ICP-OES), CCK-8, confocal laser microscope and ALP activity evaluations. The experimental results indicated that the synthetic SrHA/Alginate showed similar morphology to the well-known alginate microspheres (Alginate) and both of them possessed a great in vitro bioactivity. Compared with the control Alginate, the SrHA/Alginate enhanced MC3T3-E1 cell proliferation and ALP activity by releasing osteoinductive and osteogenic Sr ions. Furthermore, vancomycin was used as a model drug to investigate the drug release behaviors of the SrHA/Alginate, Alginate and SrHA. The results suggested that the SrHA/Alginate had a highest drug-loading efficiency and best controlled drug release properties. Additionally, the SrHA/Alginate was demonstrated to be pH-sensitive as well. The increase of the pH value in phosphate buffer solution (PBS) accelerated the vancomycin release. Accordingly, the multifunctional SrHA/Alginate can be applied in the field of bioactive drug carriers and bone filling materials.
研究领域:
生物材料学
·
骨组织工程
·
药物递送系统
·
生物医学工程
·
再生医学
·
生物无机化学
·
药剂学
✓ 已验证
DOI
高影响因子
危险品化学品经营许可证（带存储）