Acta Biomaterialia
·
2025
·
IF 9.6
Shengming Wu,Chenlong He,Huawei Liu,Han Zhou,Jingwen Qin,Ming Yin,Muqing Yang,Wenjie Tang,Yilong Wang
Tumor catalytic therapy is challenged by uncontrolled reaction sites and limited radical diffusion, leading to both safety concerns and insufficient therapeutic depth. Here, we develop an injectable UCNPs@TiO 2 –nitrate hydrogel system that enables intratumoral, in situ generation of long-lived nitrate radicals (•NO 3 , t 1/2 ≈ 60 μs) with superior diffusion capability under near-infrared (NIR) irradiation. In this system, upconversion nanoparticles convert 980 nm NIR light into ultraviolet (UV) emission, which activates TiO 2 to generate oxidative holes that catalyze NO 3 - into •NO 3 . The hydrogel matrix spatially confines radical generation within the tumor site, achieving controlled and sustained release. Compared to conventional short-lived •OH systems, •NO 3 exhibits enhanced penetration and prolonged reactivity, and its combination with •OH provides synergistic oxidative damage. In vitro and in vivo results demonstrate that the dual-radical system significantly improves tumor suppression while maintaining favorable biocompatibility. This work offers a robust strategy to overcome the diffusion and safety limitations of conventional catalytic therapy by achieving spatiotemporally confined and synergistic radical generation within tumors. Statement of Significance This study introduces a hydrogel platform that converts near-infrared light into UV to activate TiO 2 and generate long-lived nitrate radicals (•NO 3 ) in vivo . These radicals offer extended lifetime and reactivity, allowing deeper tumor penetration compared to traditional short-lived species like •OH. The system achieves spatiotemporally controlled radical release at tumor sites, enhancing catalytic therapy precision. A dual-radical strategy combining •NO 3 and •OH further boosts therapeutic efficacy. Importantly, this approach shows minimal systemic toxicity and strong translational potential. These findings expand the reactive species toolbox and offer a promising direction for radical-based cancer therapy.
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高影响因子
MOLECULAR PHARMACEUTICS
·
2023
·
IF 4.9
Xiaohong Chen,Yubo Liu,Ping Liu
Precisely modulating the synergistic release behavior of multiple bioactive substances has emerged as a formidable challenge in recent years. In this work, we successfully prepared core–sheath nanofibers, where a thin cellulose acetate (CA) coating enrobed the core. Curcumin (Cur) was encapsulated in the core layer as a model drug, while zinc oxide (ZnO) nanoparticles were loaded on the sheath layer. The prepared fiber exhibited a straight cylindrical morphology containing nanoparticles, and the distinct core–sheath nanostructure was demonstrated through transmission electron microscopy (TEM). X-ray diffraction (XRD) and Fourier transform infrared (FTIR) were conducted to study the physical state and compatibility among CA, Cur, and ZnO. Drug release data indicated that core–sheath nanofibers were able to decelerate the rate of drug release, and the thickness of the sheath layer increased in the presence of ZnO particles. Most remarkably, these core–sheath nanofibers exhibited the remarkable ability to sustain the release of drugs and zinc ion (Zn2+), the two-day synergistically release behavior leading to a significant increase in cell proliferation. This material preparation strategy for the synergistic and controlled release of two bioactive substances is instructive for the exploration of innovative and versatile drug delivery systems.
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高影响因子
ACS Applied Nano Materials
·
2023
·
IF 5.9
Yishan Guo,Chuying Huang,Jiahui Zhang,Zhen Wang,Xiaopeng Guo,Yumiao Wei
Myocardial infarction (MI) is the leading cause of death from cardiovascular disease worldwide. In MI, the loss of blood perfusion causes the excessive production of reactive oxygen species (ROS), which lead to persistent damage to myocardial cells, such as inflammation. Recently, some biomaterials that can clear excessive ROS and exert anti-inflammatory effects were reported for the treatment of MI. Based on previous studies, emerging two-dimensional nanomaterials, such as black phosphorus nanosheets (BPNs), have a remarkable ability to scavenge ROS. Interestingly, the biodegradability of BPNs is also excellent. In this study, we loaded polydopamine (PDA)-modified BPNs, which enhance the stability of BPNs to a large extent, into an alginate-hyaluronic acid hydrogel (ALGHA) to construct a conducive and injectable microenvironment control platform after MI. The ALGHA-BP-PDA hydrogel exhibited good biocompatibility, and the loaded BP-PDA displayed the ability to continuously capture ROS, which could well regulate oxidative stress in the progression of MI. The clearance of excessive ROS inhibited the activation of the NF-κB signaling pathway by downregulating the phosphorylation of IκBα in cardiomyocytes, thereby alleviating the inflammatory response. In summary, the BP-PDA functional microenvironment control platform provides an innovative therapeutic idea for MI therapy.
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Materials Science & Engineering C-Materials for Biological Applications
·
2019
·
IF 4.959
Honglin Luo,Deqiang Gan,Miguel Gama,Junpin Tu,Fanglian Yao,Quanchao Zhang,Haiyong Ao,Zhiwei Yang,Junjie Li,Yizao Wan
Developing fibrous scaffolds with hierarchical structures that closely mimic natural extracellular matrix (ECM) is highly desirable. However, fabricating scaffolds with true nanofibers (<100 nm) and submicrofibers (<1 μm) remains a big challenge. In this work, to mimic the fibrillar structure of natural ECM, bacterial cellulose (BC) nanofibers were hybridized with cellulose acetate (CA) submicrofibers for the first time. The interpenetrated nano-submicron fibrous BC/CA scaffold was fabricated using the combined electrospinning and modified in situ biosynthesis method. The BC/CA scaffold has an integrated symmetrical nanostructure in which BC nanofibers (42 nm in diameter) penetrate into the submicrofibrous CA (820 nm in diameter) scaffold. The BC/CA scaffold shows an interconnected porous structure with a high porosity of >90%. Additionally, the combination of CA submicrofibers with BC nanofibers leads to significantly improved mechanical properties over nanofibrous BC and submicrofibrous CA scaffolds and enlarged pores over nanofibrous BC scaffold. In addition, the biological behaviors of prepared BC/CA on MC3T3-E1 cells were investigated. Results suggested that BC/CA scaffold is beneficial for cell migration and proliferation. Moreover, the BC/CA scaffold shows higher alkaline phosphatase (ALP) activity, and calcium depositions. In addition, the hierarchical structures can effectively improve the expression of osteogenic gene (ALP mRNA and Runx2 mRNA) and protein (ALP). We believe that the methodology might provide biomimetic morphological microenvironments for enhanced tissue regeneration.
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高影响因子
POLYMER ENGINEERING AND SCIENCE
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2019
·Vol. 59
·期 9
·1882-1888
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IF 1.92
Chengtao Gao,Jianbing Guo,Haibo Xie
Traditional plasticizers to modify polylactic acid (PLA) usually leads to limited biodegradation, due to its inherent non-biodegradability of additives. In this work, we report a melt blending method to modify PLA using the alginic acid and two different alginates combined with nano CaCO 3 , a fully sustainable and biodegradable component. And, the mechanical, thermal, and rheological properties of the composites are investigated. We demonstrated that the filled samples show a lower tensile strength and higher impact strength which means a toughening effect occurs. Dynamic mechanical analysis experiments showed that the calcium alginate-filled samples show higher performances than other filled samples not only in static mechanical but also dynamic mechanical properties. The fracture morphology of the samples shows that a better interfacial reaction has been constituted for gel calcium alginate between CaCO 3 and PLA. Nevertheless, the thermogravimetric analysis results indicate that a lower thermal stability has been achieved in alginate filled samples. Chemorheological study indicated the alginate-filled samples also show a lower modulus and viscosity than neat PLA. It was found that the complex viscosity decrease with the addition of alginates, in comparison with PLA/CaCO 3 composites, and the samples filled with calcium alginate show a higher viscosity than those of sodium alginate and alginic acid. The alginate derivatives showed interesting potential as new green plastic additives attributed to origin from the biodegradable natural resources with a polymeric matrix. POLYM. ENG. SCI., 59:1882–1888, 2019. © 2019 Society of Plastics Engineers
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Materials Science & Engineering C-Materials for Biological Applications
·
2016
·
IF 3.42
Yu Chen,Yong Zhang,Fengju Wang,Weiwei Meng,Xinlin Yang,Peng Li,Jianxin Jiang,Huimin Tan,Yongfa Zheng
The volume phase transition of a hydrogel initiated by shrinking may result in complex patterns on its surface. Based on this unique property of hydrogel, we have developed a novel solvent precipitation method to prepare a kind of novel superabsorbent polymers with excellent hemostatic properties. A porous carboxymethyl chitosan grafted poly (acrylic acid) (CMCTS-g-PAA) superabsorbent polymer was prepared by precipitating CMCTS-g-PAA hydrogel with ethanol. Its potential application in hemostatic wound dressing was investigated. The results indicate that the modified superabsorbent polymer is non-cytotoxic. It showed a high swelling capacity and better hemostatic performance in the treatments of hemorrhage model of ear artery, arteria cruralis and spleen of the New Zealand white rabbit than the unmodified polymer and other commonly used clinic wound dressings. The hemostatic mechanism of the porous CMCTS-g-PAA polymer was also discussed.
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高影响因子
危险品化学品经营许可证（带存储）