COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
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2018
·
IF 2.829
Tingting Zhou,Jiagen Li,Peng Liu
A facile one-pot approach has been developed to prepare novel pH-responsive ionic nanohydrogels with high drug-loading capacity and desirable size for tumor-specific intracellular triggered release of anticancer drug DOX , in which the ionic crosslinking of alginate (AL) or its derivatives (oxidized alginate (OAL) or PEGylated OAL (mPEG-OAL)) and the DOX-loading ocurred simultaneously. It was found that the modification was benificial to the formation of the DOX-loaded ionic nanohydrogels with smaller diameter and narrower size distribution, even with similar DOX loading capacity. Especially for the mPEG-OAL, the resultant mPEG-OAL/DOX ionic nanohydrogels showed a hydrodynamic diameter of 135 nm with very narrow size distribution. All the three DOX-loaded ionic nanohydrogels (AL/DOX, OAL/DOX, and mPEG-OAL/DOX) showed the pH-responsive characteristic, and the last one exhibited the best capacity for controlled release, in a sustained release mode.
研究领域:
药剂学
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生物材料学
·
肿瘤学
✓ 已验证
产品关联
DOI
高影响因子
BIOMACROMOLECULES
·
2024
·
IF 5.5
Min Cui,Shuwei Liu,Xuelai Xie,Jinhong Yang,Tianyuan Wang,Yuyang Jiao,Min Lin,Kunyan Sui
Material reinforcement commonly exists in a contradiction between strength and toughness enhancement. Herein, a reinforced strategy through self-assembly is proposed for alginate fibers. Sodium alginate (SA) microstructures with regulated secondary structures are assembled in acidic and ethanol as reinforcing units for alginate fibers. Acidity increases the flexibility of the helix and contributes to enhanced extendibility. Ethanol is responsible for formation of a stiff β-sheet, which enhances the modulus and strength. The structurally engineered SA assembly exhibits robust mechanical compatibility, and thus reinforced alginate fibers possess an improved tensile strength of 2.1 times, a prolonged elongation of 1.5 times, and an enhanced toughness of 3.0 times compared with SA fibers without reinforcement. The reinforcement through self-assembly provides an understanding of strengthening and toughening mechanism based on secondary structures. Due to a similar modulus with bones, reinforced alginate fibers exhibit good efficacy in accelerating bone regeneration in vivo.
研究领域:
材料科学
·
生物材料
·
生物医学工程
✓ 已验证
产品关联
DOI
PubMed
高影响因子
CARBOHYDRATE POLYMERS
·
2017
·
IF 4.811
Zhen Sang,Wenqian Zhang,Zhiyuan Zhou,Huakang Fu,Yeqiang Tan,Kunyan Sui,Yanzhi Xia
Alginate is a kind of marine-derived plant polysaccharide with useful properties including inherent flame-retardancy and biocompatibility, yet poor flowability and low processing efficiency induced by high viscosity impede its further industrial applications. In this study, PEG-substituted tertiary amines were adapted to functionalize alginate with different molecular weight via acid-base reaction to improve the flowability. Based on alginate with low molecular weight, alginate fluids exhibited excellent flowability at room temperature in the absence of solvent. For alginate with high molecular weight, gelatinous precipitated phase exhibited significant shear-thinning properties and higher solid content despite lack of solvent-free flowability, which was applied to wet-spinning. The alginate fibers exhibited increased tensile strength by 104% and elongation at break by 132% compared with conventional alginate fibers, and the spinning efficiency was significantly improved. The proposed strategy is expected to extend to highly efficient processing of other polysaccharides to obtain high-performance biomedical materials.
研究领域:
材料科学
·
生物医学工程
✓ 已验证
产品关联
DOI
PubMed
高影响因子
FOOD RESEARCH INTERNATIONAL
·
2025
·
IF 8
Zhanpeng Liu,Hongxin Jiang,Renyong Zhao,Xinwei Wang,Bin Zhang,Qiang Huang,Hao Li,Paul Van der Meeren
In this study, a novel alginate-cyclodextrin hybrid bubble hydrogel was developed for the stable encapsulation of ethylene gas. Ethylene gas was introduced into aqueous bubble systems prepared using sodium alginate (SA), α-cyclodextrin (α-CD), SA + α-CD, β-cyclodextrin (β-CD), or SA + β-CD. Among these, the α-CD bubble system demonstrated the highest ethylene-loading ability (0.88 mL/g carrier ). However, over 50 % of the encapsulated ethylene was released from all bubble systems within 60 h due to cavity disintegration, demonstrating that these bubble systems were unstable for gas storage. Therefore, to enhance gas storage stability, the bubble systems were converted into bubble hydrogels. The gas contents of SA, SA + α-CD, and SA + β-CD bubble hydrogels significantly decreased to 0.31, 0.23 and 0.18 mL/g carrier , respectively. This phenomenon could be attributed to bubble rupture and coalescence induced by mechanical stress during gelation. Regarding storage stability, 70–80 % ethylene was retained in the bubble hydrogel systems at room temperature after 28 days storage, indicating that the hydrogel structure significantly improved gas-storage stability. This can be ascribed to the hydrogel film coating and the water layer around the surface of cavities. Therefore, the bubble hydrogel represents a promising encapsulation matrix for fruit ripening applications.
研究领域:
食品科学
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材料科学
·
高分子科学
·
农业技术
✓ 已验证
产品关联
DOI
PubMed
高影响因子
FOOD CHEMISTRY
·
2025
·
IF 9.8
Kaiwen Xie,Xiang Xu,Chengcheng Gao,Zhenjiong Wang,Linghan Meng,Xiao Feng,Xiaozhi Tang
The regulatory effects of different mannuronate/guluronate ratios in sodium alginate (SA) and calcium ion (Ca 2+ ) concentrations on the structure and properties of starch-SA interpenetrating polymer network (IPN)-enhanced extruded buckwheat noodles were investigated. The thermal stability of buckwheat noodles was improved by increasing the G block proportion, and 1% Ca 2+ concentration led to the highest thermal stability. With increasing G proportion and Ca 2+ concentration, cooking loss and elongation at break of extruded noodles gradually decreased. The cooking time initially decreased and then increased. Noodle hardness, chewiness, and breaking strength significantly increased. In vitro starch digestion showed that when the SA M/G ratio was 1:2 and the Ca 2+ concentration was 1%, the predicted glycemic index of noodles was the lowest and the resistant starch content was the highest. According to curve fitting based on the sensory evaluation results, the overall noodle acceptability was higher when hardness was between 3800 and 5200 g.
研究领域:
食品科学
·
生物化学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Applied Sciences-Basel
·
2018
·Vol. 8
·期 9
·1518
·
IF 1.689
Keteng Li,Genhua Wu,Min Wang,Xiaohong Zhou,Zhuqing Wang
A low-cost alginate-melamine hybrid sorbent (named as Alg-Mel) was designed and synthesized for the removal of Pb2+from water. The as-prepared Alg-Mel sorbent exhibited high affinity and selectivity to Pb2+. The selectivity coefficients of the Alg-Mel for Pb2+/Cd2+, Pb2+/Cu2+, Pb2+/Cr3+and Pb2+/Co2+were all over 7. It is found that the hybrid sorbent could uptake 95.4% of Pb2+from Pb2+-containing solutions (0.48 mM), and the maximum adsorption capacity for Pb2+reaches 1.39 mmol/g (287.7 mg/g), which is much higher than that of most reported lead ion-sorbents. Furthermore, the Alg-Mel can be regenerated by a simple acid-washing process and used repeatedly. The results of adsorption mechanism analysis reveal that the adsorption of Pb2+by Alg-Mel is mainly ascribed to the chemical coordination and ion exchange effects.Keywords:adsorption;alginate;adsorbent;lead ion;wastewater
研究领域:
环境科学
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化学工程
·
材料科学
✓ 已验证
产品关联
DOI
高影响因子
Gels
·
2022
·Vol. 8
·期 6
·343
·
IF 4.432
Tianzhu Shi,Zhengfeng Xie,Xinliang Mo,Yulong Feng,Tao Peng,Dandan Song
In this paper, functionalized sodium alginate hydrogel (FSAH) was prepared to efficiently adsorb heavy metals and dyes. Hydrazide-functionalized sodium alginate (SA) prepared hydrazone groups to selectively capture heavy metals (Pb2+, Cd2+, and Cu2+), and another functional group (dopamine grafting), serves as sites for adsorption methylene blue (MB), malachite green (MG), crystal violet (CV). Thermodynamic parameters of adsorption indicated that the adsorption process is endothermic and spontaneous. The heavy metals adsorption by FSAH was physical adsorption mainly due toΔHθ< 40 kJ/mol, and the adsorption of cationic dyes fitted with the Langmuir models, which indicated that the monolayer adsorption is dominated by hydrogen bonds, electrostatic interactions, and π-π interactions. Moreover, the adsorption efficiency maintained above 70% after five adsorption-desorption cycles. To sum up, FSAH has great application prospect.Keywords:sodium alginate;modification;heavy metals;dye;adsorption
研究领域:
材料科学
·
环境科学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
CARBOHYDRATE POLYMERS
·
2025
·
IF 12.5
Yajun Li,Yueren Wu,Tong Wu,Can Zhang,Jianwu Dai,Jianping Tang,Lin Li,Liyang Shi
Biopolymeric fibers have garnered significant attention in biomedical applications due to their ability to promote tissue regeneration through aligned microstructures. Alginate (Alg) is commonly used to prepare wet-spun fibers through ionic interactions. However, ion-crosslinked Alg fibers present limitations in tissue regeneration due to their rapid degradation under physiological conditions and the absence of binding sites for bioactive molecules. In this study, oxidized methacrylated alginate (OMA) derivatives were synthesized to create Alg fibers crosslinked by both Ca 2+ ions and photo-initiated covalent bonds. Moreover, aldehyde groups introduced on the oxidized chains facilitate covalent conjugation of bioactive molecules via Schiff base reactions. As a model bioactive factor, C domain peptide of insulin-like growth factor-1 (IGF-1C) was conjugated to fibers, and the resulting fibers (OMA-P) were evaluated for their potential in muscle regeneration. Cell experiments showed that OMA-P fibers promoted C2C12 myoblast proliferation and guided their oriented growth. In rat volume muscle loss (VML) models, OMA-P fibers significantly improved muscle regeneration compared to peptide-free OMA fibers and OMA-P sponges without aligned structure, because of the dual effects of axial guidance cue and bioactive peptide conjugation. This study presents a novel method for fabricating bioactive fibers, highlighting their potential as structured scaffolds for regenerative medicine.
研究领域:
生物医学工程
·
组织再生
·
材料科学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
FOOD HYDROCOLLOIDS
·
2025
·
IF 12.4
Yingchun Song,Yuyu Teng,Yudi Chen,Jiahui Nie,Yajie Dong,Qianqian Fan,Junxiang Zhu,Hao Wu,Yongkai Yuan
Biofilm-state probiotics can effectively improve their tolerance in harsh environments. Previous studies have shown that calcium alginate is an effective carrier for promoting biofilm formation, but its mechanism is unclear. Here, we show that tuning alginate molecular weight (Mw) and mannuronic/guluronic (M/G) directs Lactobacillus rhamnosus GG (LGG) biofilm formation and gastrointestinal tolerance. Our key finding is that calcium alginate beads with low Mw and low M/G alginates produce denser biofilms and superior gastrointestinal tolerance. These formulations markedly improved LGG survival in simulated challenges (gastric acid: 0.02–0.28 log CFU/g loss; bile: 1.54–2.31 log CFU/g), outperforming free cells. Mechanistic analysis revealed that low Mw and low M/G alginate matrices, with larger specific surface area, pore size, and volume, enhanced quorum-sensing autoinducer-2 signaling and subsequent protective extracellular substance synthesis, thereby improving the gastrointestinal tolerance of biofilm-state LGG. Overall, the findings emphasized that controlling alginate structure provides a rational, material-based strategy for designing advanced probiotic or bioactive delivery systems.
研究领域:
微生物学
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材料科学
·
食品科学
·
分子生物学
·
药剂学
·
生物材料
✓ 已验证
产品关联
DOI
高影响因子
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
·
2022
·
IF 8.025
Xue Wang,Huan Zhang,Qingdong He,Haifeng Xing,Ke Feng,Fang Guo,Wenbo Wang
A series of sodium alginate (SA) grafted polymer composite beads were synthesized by a solution free-radical graft polymerization reaction performed in a surface crosslinked alginate bead reactor. The outer surface of the precursor droplet containing reactants including SA, acrylamide (AM), N,N′ -methylene- bis -acrylamide (MBA), ammonium persulfate (APS), sepiolite (SP) and gelatin (GE) was instantly crosslinked with Ca 2+ ions to form a capsule-like bead when it was dropped into aqueous solution of calcium chloride , and simultaneously the reactants inside the capsule-like “bead reactor” were polymerized in-situ to form new composite beads with crosslinked network structure, abundant functional groups, excellent single or co-adsorption ability and easily separable advantages. The optimal composite bead shows high adsorption capacities of 390.78, 1425.65 and 533.91 mg/g toward Methylene Blue (MB), Basic Fuchsin (BF) and Pb(II), respectively. After adsorption with the composite bead, 99.71% of MB, 99.99% of BF and 99.97% of Pb(II) were removed from original dye or Pb(II) solutions. Moreover, above 99.22% of BF and 95.33% of Pb(II) was co-removed from their binary mixture (BF concentration, 100 mg/L; Pb(II) concentration, 50 mg/L). This paper provides a simple green way to synthesize efficient and recyclable biopolymer-based adsorbents capable of purifying dyes and heavy metal ions in water.
研究领域:
环境科学
·
材料科学
✓ 已验证
DOI
高影响因子
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
·
2024
·
IF 7.7
Jie Song,Lijun Chen,Yingnan Zhou,Zhiwen Yuan,Yuhua Niu,Zhiqiang Wei
With the rapid development of industrialization, the removal of heavy metal ions and small organic molecules from wastewater has triggered a hot debate. ZIF-8 was grown on a sodium alginate backbone using an in situ growth technique, the core-shell P-SMG@ZIF-8 was synthesized. It was also characterized by FTIR, XRD, SEM, UV–Vis and XPS, and the optimal conditions and mechanism of adsorption were explored. At pH 2.0, a contact time of 200 min, and 298 K, removal of Cu(II) and Ph up to 80.2 %, 65.6 % by P-SMG@ZIF-8, adsorption behavior consistent with Langmuir model for pseudo-secondary rates, the saturated adsorption of Cu(II) and Ph could reach up to 83.5812 mg/g and 78.1779 mg/g, respectively. And the adsorbed P-SMG@ZIF-8 is easy to separate and reusable, which is a cost-effective and efficient natural product-based adsorption material.
研究领域:
环境科学
·
材料科学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
CARBOHYDRATE POLYMERS
·
2019
·
IF 6.044
Yu Bai,Yun Zhao,Yang Li,Jiachao Xu,Xiaoting Fu,Xin Gao,Xiangzhao Mao,Zhaoyong Li
In this study, we fabricated a soft, transparent UV-shielding film (Alg-Fe 3+ -EDTA) by crosslinking sodium alginate with a ferric ion solution containing EDTA. The obtained films were characterized via SEM, ATR-FTIR, XRD, TG and DTG; the results indicated that the synergistic gelation of ferric alginate and alginic acid existed in Alg-Fe 3+ -EDTA film. The Alg-Fe 3+ -EDTA film performance to be optimized under the following conditions: 1.6% Fe 3+ , 0.8% EDTA, and crosslinking duration of 12 min. The Alg-Fe 3+ -EDTA film had high visible light transmittance, the UV-C (200–280 nm) and UV-B (280–315 nm) shielding rates were 100%, and the UV-A (315–400 nm) shielding rate was 98.37%; the UPF reached 50+; additionally, the tensile strength and elongation-at-break were 56.85 MPa and 10.45%, respectively, and still have ultraviolet shielding effect under water environments or after strong light irradiation. This work provides an efficient method to improve the optical and mechanical ability of ferric alginate films.
研究领域:
材料科学
·
生物医学工程
✓ 已验证
产品关联
DOI
PubMed
高影响因子
危险品化学品经营许可证（带存储）