COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
·
2018
·
IF 2.829
Tingting Zhou,Jiagen Li,Peng Liu
A facile one-pot approach has been developed to prepare novel pH-responsive ionic nanohydrogels with high drug-loading capacity and desirable size for tumor-specific intracellular triggered release of anticancer drug DOX , in which the ionic crosslinking of alginate (AL) or its derivatives (oxidized alginate (OAL) or PEGylated OAL (mPEG-OAL)) and the DOX-loading ocurred simultaneously. It was found that the modification was benificial to the formation of the DOX-loaded ionic nanohydrogels with smaller diameter and narrower size distribution, even with similar DOX loading capacity. Especially for the mPEG-OAL, the resultant mPEG-OAL/DOX ionic nanohydrogels showed a hydrodynamic diameter of 135 nm with very narrow size distribution. All the three DOX-loaded ionic nanohydrogels (AL/DOX, OAL/DOX, and mPEG-OAL/DOX) showed the pH-responsive characteristic, and the last one exhibited the best capacity for controlled release, in a sustained release mode.
研究领域:
药剂学
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生物材料学
·
肿瘤学
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产品关联
DOI
高影响因子
Bioresources and Bioprocessing
·
2015
·Vol. 2
·期 1
·1-8
·
IF 0
Yang Xin,Zhu Liying,Jiang Ling,Xu Qing,Xu Xian,Huang He
Background Trehalose has many advantages due to its inertness and the ability to stabilize biomolecules. Trehalose synthase can catalyze intramolecular rearrangement of the inexpensive maltose into trehalose in a single step, which represents a simple, fast, and low-cost method for the future industrial production of trehalose. Results In this work, an intelligent visualization method for producing trehalose via trehalose synthase was for the first time established and optimized by corresponding enzymatic hydrolysis with kudzu root starch as the initial raw material. For the first step, kudzu root starch was liquefied by α-amylase at a certain dextrose equivalent value of 19–21, and β-amylase and pullulanase to saccharify for a certain time, a four-factor nine-level experimental design with nine experiments was performed according to the uniform design table U
* 9
(9 4 ) to optimize the yield of maltose. Then, optimization of trehalose conversion ratio from kudzu root starch hydrolysate was carried out with a four-factor 12-level experimental design to forecast the optimal process conditions. By comparing verification tests and predicted results, the optimized operating conditions were pH 7.1, 22 °C, 32.5 % (14,000 U/ml) loading amounts of TreS enzyme and after 24 h, along with a 70.6 % trehalose conversion rate. Conclusions The intelligent visualization method has succeeded in exploiting the conversion process of trehalose from kudzu root starch hydrolysate, which contributes significant benefits to the further commercial production of trehalose.
研究领域:
生物化学
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食品科学
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工业微生物学
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产品关联
DOI
BIOMACROMOLECULES
·
2024
·
IF 5.5
Min Cui,Shuwei Liu,Xuelai Xie,Jinhong Yang,Tianyuan Wang,Yuyang Jiao,Min Lin,Kunyan Sui
Material reinforcement commonly exists in a contradiction between strength and toughness enhancement. Herein, a reinforced strategy through self-assembly is proposed for alginate fibers. Sodium alginate (SA) microstructures with regulated secondary structures are assembled in acidic and ethanol as reinforcing units for alginate fibers. Acidity increases the flexibility of the helix and contributes to enhanced extendibility. Ethanol is responsible for formation of a stiff β-sheet, which enhances the modulus and strength. The structurally engineered SA assembly exhibits robust mechanical compatibility, and thus reinforced alginate fibers possess an improved tensile strength of 2.1 times, a prolonged elongation of 1.5 times, and an enhanced toughness of 3.0 times compared with SA fibers without reinforcement. The reinforcement through self-assembly provides an understanding of strengthening and toughening mechanism based on secondary structures. Due to a similar modulus with bones, reinforced alginate fibers exhibit good efficacy in accelerating bone regeneration in vivo.
研究领域:
材料科学
·
生物材料
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生物医学工程
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产品关联
DOI
PubMed
高影响因子
WATER AIR AND SOIL POLLUTION
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2020
·Vol. 231
·期 2
·1-12
·
IF 1.9
Zeng Ganning,Hong Chunxian,Zhang Yan,You Hanzhang,Shi Wenyue,Du Mingming,Ai Ning,Chen Bing
A novel polymer/activated carbon composite was prepared in this study by one-step chemical activation of Sargassum horneri , followed by surface modification with chitosan, a widely abundant biopolymer. The prepared composite was used as adsorbent to remove one of the most toxic metal ions, Cr(VI), from aqueous solution. Surface characterization tests revealed the material to be predominantly mesoporous with the specific surface area of 293.4 m 2 ·g −1 and the average pore diameter of 6.27 nm. Enhanced uptake capacity of Cr(VI) by the prepared composite was obtained due to the presence of more metal-binding functional (amino and hydroxyl) groups on its surface. Extremely fast adsorption rate of Cr(VI) was also achieved due to the porous structure of the prepared composite. This study has clearly shown that Sargassum horneri can be a potential alternative precursor for carbon-based adsorbents and the proper designed polymer/AC composites can be tailor-made adsorbents for heavy metal removal.
研究领域:
环境科学
·
材料科学
✓ 已验证
DOI
高影响因子
FOOD RESEARCH INTERNATIONAL
·
2025
·
IF 8
Zhanpeng Liu,Hongxin Jiang,Renyong Zhao,Xinwei Wang,Bin Zhang,Qiang Huang,Hao Li,Paul Van der Meeren
In this study, a novel alginate-cyclodextrin hybrid bubble hydrogel was developed for the stable encapsulation of ethylene gas. Ethylene gas was introduced into aqueous bubble systems prepared using sodium alginate (SA), α-cyclodextrin (α-CD), SA + α-CD, β-cyclodextrin (β-CD), or SA + β-CD. Among these, the α-CD bubble system demonstrated the highest ethylene-loading ability (0.88 mL/g carrier ). However, over 50 % of the encapsulated ethylene was released from all bubble systems within 60 h due to cavity disintegration, demonstrating that these bubble systems were unstable for gas storage. Therefore, to enhance gas storage stability, the bubble systems were converted into bubble hydrogels. The gas contents of SA, SA + α-CD, and SA + β-CD bubble hydrogels significantly decreased to 0.31, 0.23 and 0.18 mL/g carrier , respectively. This phenomenon could be attributed to bubble rupture and coalescence induced by mechanical stress during gelation. Regarding storage stability, 70–80 % ethylene was retained in the bubble hydrogel systems at room temperature after 28 days storage, indicating that the hydrogel structure significantly improved gas-storage stability. This can be ascribed to the hydrogel film coating and the water layer around the surface of cavities. Therefore, the bubble hydrogel represents a promising encapsulation matrix for fruit ripening applications.
研究领域:
食品科学
·
材料科学
·
高分子科学
·
农业技术
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产品关联
DOI
PubMed
高影响因子
Analytical Methods
·
2012
·Vol. 4
·期 10
·3471-3477
·
IF 1.547
Xu Han,Lianghui Cao,Heyong Cheng,Jinhua Liu,Zigang Xu
Ion-pair reversed phase high performance liquid chromatography coupled to inductively coupled plasma mass spectrometry (RP-HPLC-ICP-MS) has been used to determine two inorganic iodine species (I− and IO3−) and two organic iodinated amino acids (MIT and DIT) in seaweed and seawater samples within 5 min. The mobile phase used for a reversed phase C18 column was as follows: 2.0 mM tetraethylammonium hydroxide, 10 mM L-phenylalanine and 1% methanol (pH 8.9). Values of 1.5 mL min−1 for the flow rate of the mobile phase and 25 °C for the column temperature were selected for rapid separation of iodine species. The detection limits for IO3−, I−, MIT and DIT were 0.061, 0.052, 0.079 and 0.24 μg L−1, each, and the repeatabilities of peak height and peak area (20 μg L−1 for iodide and iodate, 40 μg L−1 for MIT, 100 μg L−1 for DIT) were all lower than 4%. Under the optimized conditions, the proposed method was successfully applied for the speciation analysis of iodine in seaweed and seawater samples. Recoveries of IO3−, I−, MIT and DIT in seaweed and seawater samples were between 90 and 110%. All results prove its advantages including high sensitivity, environmentally friendly, low time consumption, which are beneficial for routine analysis of iodine speciation in environmental and food fields.
研究领域:
分析化学
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环境科学
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食品科学
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产品关联
DOI
高影响因子
Applied Sciences-Basel
·
2018
·Vol. 8
·期 9
·1518
·
IF 1.689
Keteng Li,Genhua Wu,Min Wang,Xiaohong Zhou,Zhuqing Wang
A low-cost alginate-melamine hybrid sorbent (named as Alg-Mel) was designed and synthesized for the removal of Pb2+from water. The as-prepared Alg-Mel sorbent exhibited high affinity and selectivity to Pb2+. The selectivity coefficients of the Alg-Mel for Pb2+/Cd2+, Pb2+/Cu2+, Pb2+/Cr3+and Pb2+/Co2+were all over 7. It is found that the hybrid sorbent could uptake 95.4% of Pb2+from Pb2+-containing solutions (0.48 mM), and the maximum adsorption capacity for Pb2+reaches 1.39 mmol/g (287.7 mg/g), which is much higher than that of most reported lead ion-sorbents. Furthermore, the Alg-Mel can be regenerated by a simple acid-washing process and used repeatedly. The results of adsorption mechanism analysis reveal that the adsorption of Pb2+by Alg-Mel is mainly ascribed to the chemical coordination and ion exchange effects.Keywords:adsorption;alginate;adsorbent;lead ion;wastewater
研究领域:
环境科学
·
化学工程
·
材料科学
✓ 已验证
产品关联
DOI
高影响因子
FOOD CHEMISTRY
·
2025
·
IF 9.8
Kaiwen Xie,Xiang Xu,Chengcheng Gao,Zhenjiong Wang,Linghan Meng,Xiao Feng,Xiaozhi Tang
The regulatory effects of different mannuronate/guluronate ratios in sodium alginate (SA) and calcium ion (Ca 2+ ) concentrations on the structure and properties of starch-SA interpenetrating polymer network (IPN)-enhanced extruded buckwheat noodles were investigated. The thermal stability of buckwheat noodles was improved by increasing the G block proportion, and 1% Ca 2+ concentration led to the highest thermal stability. With increasing G proportion and Ca 2+ concentration, cooking loss and elongation at break of extruded noodles gradually decreased. The cooking time initially decreased and then increased. Noodle hardness, chewiness, and breaking strength significantly increased. In vitro starch digestion showed that when the SA M/G ratio was 1:2 and the Ca 2+ concentration was 1%, the predicted glycemic index of noodles was the lowest and the resistant starch content was the highest. According to curve fitting based on the sensory evaluation results, the overall noodle acceptability was higher when hardness was between 3800 and 5200 g.
研究领域:
食品科学
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生物化学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Gels
·
2022
·Vol. 8
·期 6
·343
·
IF 4.432
Tianzhu Shi,Zhengfeng Xie,Xinliang Mo,Yulong Feng,Tao Peng,Dandan Song
In this paper, functionalized sodium alginate hydrogel (FSAH) was prepared to efficiently adsorb heavy metals and dyes. Hydrazide-functionalized sodium alginate (SA) prepared hydrazone groups to selectively capture heavy metals (Pb2+, Cd2+, and Cu2+), and another functional group (dopamine grafting), serves as sites for adsorption methylene blue (MB), malachite green (MG), crystal violet (CV). Thermodynamic parameters of adsorption indicated that the adsorption process is endothermic and spontaneous. The heavy metals adsorption by FSAH was physical adsorption mainly due toΔHθ< 40 kJ/mol, and the adsorption of cationic dyes fitted with the Langmuir models, which indicated that the monolayer adsorption is dominated by hydrogen bonds, electrostatic interactions, and π-π interactions. Moreover, the adsorption efficiency maintained above 70% after five adsorption-desorption cycles. To sum up, FSAH has great application prospect.Keywords:sodium alginate;modification;heavy metals;dye;adsorption
研究领域:
材料科学
·
环境科学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
CARBOHYDRATE POLYMERS
·
2025
·
IF 12.5
Yajun Li,Yueren Wu,Tong Wu,Can Zhang,Jianwu Dai,Jianping Tang,Lin Li,Liyang Shi
Biopolymeric fibers have garnered significant attention in biomedical applications due to their ability to promote tissue regeneration through aligned microstructures. Alginate (Alg) is commonly used to prepare wet-spun fibers through ionic interactions. However, ion-crosslinked Alg fibers present limitations in tissue regeneration due to their rapid degradation under physiological conditions and the absence of binding sites for bioactive molecules. In this study, oxidized methacrylated alginate (OMA) derivatives were synthesized to create Alg fibers crosslinked by both Ca 2+ ions and photo-initiated covalent bonds. Moreover, aldehyde groups introduced on the oxidized chains facilitate covalent conjugation of bioactive molecules via Schiff base reactions. As a model bioactive factor, C domain peptide of insulin-like growth factor-1 (IGF-1C) was conjugated to fibers, and the resulting fibers (OMA-P) were evaluated for their potential in muscle regeneration. Cell experiments showed that OMA-P fibers promoted C2C12 myoblast proliferation and guided their oriented growth. In rat volume muscle loss (VML) models, OMA-P fibers significantly improved muscle regeneration compared to peptide-free OMA fibers and OMA-P sponges without aligned structure, because of the dual effects of axial guidance cue and bioactive peptide conjugation. This study presents a novel method for fabricating bioactive fibers, highlighting their potential as structured scaffolds for regenerative medicine.
研究领域:
生物医学工程
·
组织再生
·
材料科学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
FOOD HYDROCOLLOIDS
·
2025
·
IF 12.4
Yingchun Song,Yuyu Teng,Yudi Chen,Jiahui Nie,Yajie Dong,Qianqian Fan,Junxiang Zhu,Hao Wu,Yongkai Yuan
Biofilm-state probiotics can effectively improve their tolerance in harsh environments. Previous studies have shown that calcium alginate is an effective carrier for promoting biofilm formation, but its mechanism is unclear. Here, we show that tuning alginate molecular weight (Mw) and mannuronic/guluronic (M/G) directs Lactobacillus rhamnosus GG (LGG) biofilm formation and gastrointestinal tolerance. Our key finding is that calcium alginate beads with low Mw and low M/G alginates produce denser biofilms and superior gastrointestinal tolerance. These formulations markedly improved LGG survival in simulated challenges (gastric acid: 0.02–0.28 log CFU/g loss; bile: 1.54–2.31 log CFU/g), outperforming free cells. Mechanistic analysis revealed that low Mw and low M/G alginate matrices, with larger specific surface area, pore size, and volume, enhanced quorum-sensing autoinducer-2 signaling and subsequent protective extracellular substance synthesis, thereby improving the gastrointestinal tolerance of biofilm-state LGG. Overall, the findings emphasized that controlling alginate structure provides a rational, material-based strategy for designing advanced probiotic or bioactive delivery systems.
研究领域:
微生物学
·
材料科学
·
食品科学
·
分子生物学
·
药剂学
·
生物材料
✓ 已验证
产品关联
DOI
高影响因子
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
·
2024
·
IF 7.7
Jie Song,Lijun Chen,Yingnan Zhou,Zhiwen Yuan,Yuhua Niu,Zhiqiang Wei
With the rapid development of industrialization, the removal of heavy metal ions and small organic molecules from wastewater has triggered a hot debate. ZIF-8 was grown on a sodium alginate backbone using an in situ growth technique, the core-shell P-SMG@ZIF-8 was synthesized. It was also characterized by FTIR, XRD, SEM, UV–Vis and XPS, and the optimal conditions and mechanism of adsorption were explored. At pH 2.0, a contact time of 200 min, and 298 K, removal of Cu(II) and Ph up to 80.2 %, 65.6 % by P-SMG@ZIF-8, adsorption behavior consistent with Langmuir model for pseudo-secondary rates, the saturated adsorption of Cu(II) and Ph could reach up to 83.5812 mg/g and 78.1779 mg/g, respectively. And the adsorbed P-SMG@ZIF-8 is easy to separate and reusable, which is a cost-effective and efficient natural product-based adsorption material.
研究领域:
环境科学
·
材料科学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
危险品化学品经营许可证（带存储）