Marine Drugs
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2022
·Vol. 20
·期 5
·284
·
IF 6.085
Yuting Zhu,Shanhao Han,Jianhui Li,Hongwei Gao,Bo Dong
Marine ascidian is becoming one of the main sources of an antitumor drug that has shown high bioactivity and extensive application in cancer treatment.Halocynthia roretzi, an edible marine sea squirt, has been demonstrated to have various kinds of biological activities, such as anti-diabetic, anti-hypertension, and enhancing immunity. In this study, we reported that aqueous extracts from the edible parts ofH. roretzipresented significantly inhibiting the efficiency on HepG-2 cell viability. The separate mixed compound exhibited strong effects of inhibitory proliferation and induced apoptosis via the generation of ROS along with the concurrent loss of mitochondrial membrane potential on tumor cells. Furthermore, we found that there existed a significantly synergistic effect of the ascidian-extracted compound mixture with the anti-cancer drug doxorubicin. In the presence of the extracts fromH. roretzi, the dose of doxorubicin at the cellular level could be reduced by a half dose. The extracts were further divided by semipreparative-HPLC and the active ingredients were identified as a mixture of fatty amide, which was composed of hexadecanamide, stearamide, and erucamide by UHPLC-MS/MS. Our results suggest that the potential toxicity of ascidianH. roretziin tumor cells, and the compounds extracted fromH. roretzicould be potentially utilized on functional nutraceuticals or as an adjunct in combination with chemotherapy.Keywords:ascidian;Halocynthia roretzi;anti-tumor;drug combination;doxorubicin
研究领域:
海洋生物学
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肿瘤学
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药理学
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DOI
PubMed
高影响因子
Polymers
·
2021
·Vol. 13
·期 24
·4322
·
IF 4.329
Xiang He,Ruyue Liu,Huiqing Liu,Ruixiao Wang,Zhenhao Xi,Yixiang Lin,Jie Wang
In order to replace traditional wound treatments such as sutures, tissue adhesives with strong wet tissue adhesion and biocompatibility have attracted more attention to the applications of non-invasive wound closure. Herein, inspired by tunicate adhesive protein, a series of 2,3,4-trihydroxybenzaldehyde (TBA)-modified chitosan hydrogels (CS-TBA-Fe) were prepared by easily mixing the solutions of chitosan-FeCl3and TBA via the Schiff-base reaction and the coordination between Fe3+and pyrogallol groups. The gelation time was greatly shortened to only several seconds after induced even trace Fe3+. The hydrogel (CS-TBA-Fe) exhibited ~12-fold enhanced wet tissue adhesion strength (60.3 kPa) over the commercial fibrin glue. Meanwhile, the hydrogel also showed robust adhesion to various substrates such as wood, PMMA, and aluminum. The swelling ratio and rheological property can be simply controlled by changing the concentrations of chitosan, TBA, and Fe3+. Moreover, the hydrogel displayed a rapid and highly efficient self-healing ability and an excellent antibacterial activity againstE. coli. The overall results show that the CS-TBA-Fe hydrogel with enhanced wet adhesiveness will be a promising tissue adhesive material.Keywords:facile preparation;tunicate-inspired;chitosan;hydrogel;tissue adhesive
研究领域:
生物材料学
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医学工程
·
生物化学
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DOI
PubMed
高影响因子
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
·
2025
·
IF 8.5
Peiyuan Li,Huan Liao,Yingbin Lv,Siyan Liang,Jingwen Zhong,Wei Su
Wound infections are a primary cause of delayed wound healing, and film dressings have garnered significant attention in wound management. However, the development of biologically sourced and green-synthesized film dressings with rapid antimicrobial functionality remains an urgent technological breakthrough. In this study, we successfully developed gelatin sodium alginate/sea sheath molecularly modified berberine hydrochloride film (GS/CB). The incorporation of sea sheath powder significantly enhances the mechanical properties of the gelatin‑sodium alginate film.The calcium ions (Ca 2+ ) provided by the sea sheath create a cross-linking effect within the sodium alginate-gelatin network, resulting in tensile properties of the GS/CB films that are 2.6 times greater than those of the control films. This enhancement allows the films to meet the requirements for wound applications. In in vitro antimicrobial experiments, the films incorporated with sodium oleate-modified berberine hydrochloride showed good antimicrobial effects, with an inhibition rate of 97.79 % against Staphylococcus aureus ( S. aureus ) and 98.57 % against methicillin-resistant Staphylococcus aureus ( MRSA ). In in vivo wound healing experiments, the film effectively eliminated MRSA from the wound, achieving a bacterial clearance rate of 98.5 %. Compared to transparent film dressings, the GS/CB film demonstrated superior wound care efficacy and significantly accelerated wound healing. Furthermore, both in vivo and in vitro tests indicated that the film possesses excellent biocompatibility. Therefore, the GS/CB film holds great potential and application value as a new wound dressing for the treatment of infectious wounds.
研究领域:
生物材料学
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医学
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抗菌材料研究
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DOI
PubMed
高影响因子
Materials Today Bio
·
2024
·
IF 8.7
Cuicui Ding,Kuan Cheng,Yue Wang,Yifan Yi,Xiaohong Chen,Jingyi Li,Kaiwen Liang,Min Zhang
Recently, biomacromolecules have received considerable attention in hemostatic materials. Collagen, an ideal candidate for hemostatic sponges due to its involvement in the clotting process, has been facing challenges in extraction from raw materials, which is time-consuming, expensive, and limited by cultural and religious restrictions associated with traditional livestock and poultry sources. To address these issues, this study explored a new shortcut method that using wild Halocynthia roretzi (HR), a marine fouling organism, as a raw material for developing HR collagen fiber sponge (HRCFs), which employed urea to disrupt hydrogen bonds between collagen fiber aggregates. This method simplifies traditional complex manufacturing processes while utilized marine waste, thus achieving dual green in terms of raw materials and manufacturing processes. FTIR results confirmed that the natural triple-helical structure of collagen was preserved. HRCFs exhibit a blood absorption ratio of 2000–3500 %, attributed to their microporous structure, as demonstrated by kinetic studies following a capillary model. Remarkably, the cytotoxicity and hemolysis ratio of HRCFs are negligible. Furthermore, during in vivo hemostasis tests using rabbit ear and kidney models, HRCFs significantly reduce blood loss and shorten hemostasis time compared to commercial gelatin sponge and gauze, benefiting from the capillary effect and collagen's coagulation activity. This study provides new insights into the design of collagen-based hemostatic biomaterials, especially in terms of both raw material and green manufacturing processes.
研究领域:
生物医学工程
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海洋生物学
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材料科学
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DOI
PubMed
高影响因子
FOOD CHEMISTRY
·
2024
·
IF 8.5
Cuicui Ding,Yifan Yi,Kuan Cheng,Yue Wang,Shaoyun Wang,Min Zhang
The extraction of collagen for packaging films typically requires a time-consuming process and the use of substantial chemicals. Herein, we present a full life cycle green preparation method for rapidly producing collagen-based food packaging films using Halocynthia roretzi (HR), a collagen-rich marine organism, as raw material. We first prepared the micro/nano-sized collagen fibers from HR tissue by utilizing urea and sonication as effective hydrogen-bond breakers. Subsequently, the collagen fiber was rapidly fabricated into a film through vacuum filtration. The resulting collagen fiber film (CFF) exhibited a uniform and dense surface, along with good tensile properties , water resistance, and biodegradability. In addition, the deposition of chitosan (CS) on the surface of CFF resulted in a remarkable preservation effect for both strawberries and pork. This full life cycle preparation method for collagen-based films provides a promising and innovative approach to the sustainable preparation of food packaging films.
研究领域:
生物材料学
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海洋生物学
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食品科学
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产品关联
DOI
PubMed
高影响因子
BIOELECTROCHEMISTRY
·
2025
·
IF 4.5
Jiahao Sun,Shihang Lu,Ming Cheng,Nianting Xue,Shiqiang Chen,Guangzhou Liu,Yuanyuan Gao,Li Lai,Wenwen Dou
Microbiologically influenced corrosion (MIC) affects offshore production activities severely. Although adding biocides is a simple method, it can cause environmental damage over time. Using green biocide enhancers is a viable strategy to reduce the amount of biocides. In this study, four novel peptides, named Peptide T/Tc/Ts/Tcs, were designed by a natural peptide extracted from the Arctic sea squirt to enhance the efficacy of tetrakis hydroxymethyl phosphonium sulfate (THPS) in mitigating the biocorrosion of EH36 steel caused by Desulfovibrio ferrophilus . The combination of 40 ppm THPS and 100 nM Peptide T/Tc/Ts/Tcs reduced the corrosion rates of EH36 steel by 68 %, 71 %, 86 %, and 90 % after the 7-d incubation, respectively. Notably, 40 ppm THPS + 100 nM Peptide Ts/Tcs achieved similar antimicrobial and biocorrosion mitigation effects as 100 ppm THPS. It suggests that optimizing the cationic and hydrophobic properties of peptides could enhance the bactericidal properties of biocides.
研究领域:
材料科学
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微生物学
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环境科学
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DOI
PubMed
高影响因子
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
·
2023
·
IF 8.2
Weijie Lin,Shuai Wu,Shibo Han,Jie Xie,Hongshen He,Qiuxia Zou,Dezhong Xu,Dengwen Ning,Ajoy Kanti Mondal,Fang Huang
The highly conductive and elastic three-dimensional mesh porous material is an ideal platform for the fabrication of high electrical conductivity conductive aerogels. Herein, a multifunctional aerogel that is lightweight, highly conductive and stable sensing properties is reported. Tunicate nanocellulose (TCNCs) with a high aspect ratio, high Young's modulus , high crystallinity, good biocompatibility and biodegradability was used as the basic skeleton to prepare aerogel by freeze-drying technique. Alkali lignin (AL) was used as the raw material, polyethylene glycol diglycidyl ether (PEGDGE) was used as the cross-linking agent, and polyaniline (PANI) was used as the conductive polymer. Preparation of aerogels by freeze-drying technique, in situ synthesis of PANI, and construction of highly conductive aerogel from lignin/TCNCs. The structure, morphology and crystallinity of the aerogel were characterized by FT-IR, SEM, and XRD. The results show that the aerogel has good conductivity (as high as 5.41 S/m) and excellent sensing performance. When the aerogel was assembled as a supercapacitor, the maximum specific capacitance can reach 772 mF/cm 2 at 1 mA/cm 2 current density, and maximum power and energy density can reach 59.4 μWh/cm 2 and 3600 μW/cm 2 , respectively. It is expected the aerogel can be applied in the field of wearable devices and electronic skin.
研究领域:
材料科学
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化学工程
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DOI
PubMed
高影响因子
CELLULOSE
·
2021
·Vol. 28
·期 16
·10415-10424
·
IF 5.044
Huang Da,Li Dong,Mo Kangwei,Xu Rui,Huang Yanan,Cui Yande,Zhang Qunchao,Chang Chunyu
Owing to non-degradable waste plastics causing serious environmental pollution, the development of natural polymeric materials has become an important topic. Herein, multilayer tunicate cellulose films (MTCFs) were fabricated by a top-down approach, where the alkali treated mantles of tunicate were layer-by-layer hot-pressed. Strong hydrogen bonds that formed between tunicate cellulose layers resulted in good interfacial compatibility of multilayer films. The as-prepared MTCFs exhibited improved thermal stabilities, excellent mechanical properties, and good degradability in natural soil. This work provided a top-down approach for the preparation of biodegradable multilayer films as packaging materials.
研究领域:
材料科学
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环境科学
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生物技术
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DOI
高影响因子
CARBOHYDRATE RESEARCH
·
2021
·
IF 2.104
Shuai Wu,Dengwen Ning,Dezhong Xu,Yanan Cheng,Ajoy Kanti Mondal,Qiuxia Zou,Hongyi Zhu,Fang Huang
First time aerogels composite with super hydrophobic properties were developed by using tunicate cellulose nanocrystals (TCNC), which expanded the application scope of animal cellulose resources. In this study, the TCNC was firstly cross-linked with silica and methyltrimethylsilane (MTMS), further coated with fluorodopa to form an aerogel with super hydrophobic properties. The aerogel was characterized by scanning electron microscope (SEM), transmission electron microscopy (TEM), Fourier transform infrared spectra (FT-IR), and X-ray photoelectron spectroscopy (XPS). Results indicated that the contact angle of aerogel was 158.7°, which showed good hydrophobicity . The composite aerogel has superior stability in wide pH range, after 72 h immersion in pH = 0 and 12 solutions, the contact angle was still greater than 150°. The aerogel shows excellent oil-water separation ability and it can be repeatedly used more than 10 times. The separation efficiency can all reach more than 90% for different water-oil mixtures. This synthesized super hydrophobic aerogels derived from tunicate cellulose has greatly extended the application of marine animal celluloses.
研究领域:
材料科学
·
海洋生物学
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产品关联
DOI
PubMed
高影响因子
Nanomaterials
·
2023
·Vol. 13
·期 7
·1221
·
IF 5.3
Chen Jiang,Meiyan Wu,Fang Zhang,Chao Liu,Mingliang Sun,Bin Li
Tunicate nanocellulose with its unique properties, such as excellent mechanical strength, high crystallinity, and good biodegradability, has potential to be used for the preparation of light management film with tunable transmittance and haze. Herein, we prepared a whole tunicate cellulose film with tunable haze levels, by mixing tunicate microfibrillated cellulose (MFC) and tunicate cellulose nanofibrils (CNF). Then, the obtained whole tunicate cellulose film with updated light management was used to modify the organic solar cell (OSC) substrate, aiming to improve the light utilization efficiency of OSC. Results showed that the dosage of MFC based on the weight of CNF was an important factor to adjust the haze and light transmittance of the prepared cellulose film. When the dosage of MFC was 3 wt.%, the haze of the obtained film increased 74.2% compared to the pure CNF film (39.2%). Moreover, the optimized tunicate cellulose film exhibited excellent mechanical properties (e.g., tensile strength of 168 MPa, toughness of 5.7 MJ/m3) and high thermal stability, which will be beneficial to the workability and durability of OSC. More interestingly, we applied the obtained whole tunicate cellulose film with a high haze (68.3%) and high light transmittance (85.0%) as an additional layer to be adhered to the glass substrate of OSC, and a notable improvement (6.5%) of the power conversion efficiency was achieved. With the use of biodegradable tunicate cellulose, this work provides a simple strategy to enhance light management of the transparent substrate of OSC for improving power conversion efficiency.Keywords:cellulose composite films;cellulose nanofibrils;micro-fibrillated cellulose;tunicate;organic solar cells
研究领域:
材料科学
·
可再生能源
·
纳米技术
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产品关联
DOI
PubMed
高影响因子
CHEMICAL ENGINEERING JOURNAL
·
2024
·
IF 13.3
Qin Yang,Mingtao He,Zhongrui Yu,Yijie Liu,Yilan Bai,Tianci Liu,Tingting Wang,Lingtao Meng,Fanjun Meng,Qinglin Ma,Yuju Che
Despite the current progress in multistimuli-responsive ionic conductive hydrogels, it is still a significant challenge to develop superior multistimuli-responsive ionic conductive hydrogels with satisfactory mechanical property, antibacterial and self-healing capability to meet the practical applications. In this study, a novel inherently antibacterial ionic conductive hydrogel (PCNAT-Fe) with excellent flexible, fatigue resistant, self-recovery ability, temperature/pH-responsive ability and tensile strain/temperature/pH-sensitive conductivity was fabricated via one step copolymerization of acrylic acid (AA) and N -isopropylacrylamide (NIPAM) in the presence with carboxymethyl chitosan (CMCS), Tunicate cellulose nanocrystals (TCNCs) and FeCl 3 . Benefiting from the synergy of TCNCs, FeCl 3 and thermos/pH-sensitive materials, the hydrogel is concurrently endowed with excellent stretchability (1237.2 %), high conductivity (6.62S/m), biocompatibility, anti-drying capability, excellent mechanical and conductive repeatability. More importantly, the PCNAT-Fe hydrogel can ingeniously perceive large/subtle deformation (GF: 0.75 in the strain range of 0–50 %, 1.02 in the strain range of 50–150 %, response time 0.96 s and 2.81 in the strain range of 150–350 %, 3.40 in the strain range of 350–700 %), external temperature (TCR: −1.452 %/ o C in 25–37 °C, responsive time 3.3 s and −1.062 %/ o C in 37–75 °C) and pH values via the changes of relative resistance within fast responsive time, which can be applied as human–computer interfaces to interactively monitor human motions, ambient temperature and pH values in real time.
研究领域:
材料科学
·
生物医学工程
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产品关联
DOI
高影响因子
CARBOHYDRATE POLYMERS
·
2025
·
IF 12.5
Yang Yang,Gengyu Zhou,Yang Chen,Ning Lin,Jingzhi Ma
Diabetic periodontitis, characterized by persistent inflammation and impaired periodontal tissue regeneration under hyperglycemic conditions, urgently requires innovative therapeutic strategies. Microneedle (MN) technique has recently emerged as a promising solution for diabetic periodontitis by enabling minimally invasive and localized drug delivery. In this study, we developed poly(lactic acid) (PLA)-based MNs reinforced with PLA-grafted tunicate cellulose nanocrystals (TCNC-g-PLA@PLA-MNs), demonstrating favorable mechanical strength and biocompatibility. After loading with irisin and interleukin-1 (IL-1) receptor antagonist (IL-1ra) via surface polydopamine functionalization, the MNs exhibited anti-inflammatory effects by markedly reducing the expressions of IL-6 by 0.53-fold, IL-8 by 0.23-fold, and MCP-1 by 0.41-fold in human periodontal ligament cells (hPDLCs). Additionally, they significantly promoted osteogenic differentiation, increasing the expressions of ALP by 1.87-fold, OPN by 2.21-fold, OCN by 1.39-fold, and Runx2 by 2.28-fold, which was further supported by enhanced ALP staining. Furthermore, the MNs improved the migration ability of hPDLCs under inflammatory and high-glucose culture conditions. Our findings highlight that the TCNC-g-PLA@PLA-MNs effectively integrate structural reinforcement and therapeutic functionality, providing a novel and potential platform to promote periodontal regeneration in the context of diabetic periodontitis.
研究领域:
生物材料学
·
口腔医学
·
药剂学
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产品关联
DOI
PubMed
高影响因子
危险品化学品经营许可证（带存储）