JOURNAL OF COLLOID AND INTERFACE SCIENCE
·
2019
·
IF 6.361
Xiaoming Luo,Haoran Yin,Jing Ren,Haipeng Yan,Xin Huang,Donghai Yang,Limin He
The mixing of binary droplets is of paramount importance in microfluidic systems. In order to reveal the mixing mechanism of two free droplets suspended in the immiscible phase, we have developed a novel experimental setup to study the internal mixing in coalescing droplets with varying interfacial tension differences and droplet sizes. It is confirmed that the interfacial energy of droplets supports the jet flow and liquid bridge expansion during the coalescence of droplets. The increase of interfacial tension difference can increase the intensity of jet flow accompanied with slower liquid bridge expansion, which enhances the mixing of droplets. The decrease of droplet size can increase the initial velocity of jet flow. However, the intensity of jet flow decreases due to the rapid expansion of the liquid bridge, which results in weaker internal mixing. On this basis, a Reynolds number incorporating the jet velocity and droplet size is proposed to characterize the vortex size, which represents the degree of droplet mixing. This study presents an effective approach for enhancing the mixing of droplets.
研究领域:
微流控技术
·
流体力学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
ULTRASOUND IN MEDICINE AND BIOLOGY
·
2022
·
IF 3.694
Shifang Guo,Zhen Ya,Pengying Wu,Lei Zhang,Mingxi Wan
High-intensity focused ultrasound (HIFU) thrombolysis provides a targeted and non-invasive therapy for thrombosis-related diseases. Rapid thrombolysis and restoration of blood flow are vital to reduce the disability and death rate . The objective of this study was to explore the feasibility of using a high-intensity focused acoustic vortex (HIFAV) to enhance sonothrombolysis. The in vitro clots were treated with HIFU with a peak negative pressure (PNP) of 2.86 MPa (HIFU A) or 3.27 MPa (HIFU B) or HIFAV with a PNP of 2.14 MPa. The results revealed that HIFAV thrombolysis could achieve a significantly higher efficiency than HIFU (HIFAV: 65.4%, HIFU A: 24.1%, HIFU B: 31.6%, p < 0.01), even at a lower intensity. The average size of the debris particles generated in HIFAV thrombolysis was similar to that in HIFU. Additionally, the cavitation activities were found to be more intense in HIFAV thrombolysis. Although the efficiency of HIFAV thrombolysis was higher when the pulse repetition frequency increased from 100 to 500 Hz (41.4% vs. 65.4%, p < 0.05), it decreased when the PRF reached 1000 Hz (29.9%). Lastly, it was found that increasing the duty cycle from 5% to 15% led to a higher efficiency in HIFAV thrombolysis (40.3% vs. 75.2%, p < 0.001). This study illustrated that HIFAV provided enhanced thrombolysis and that its efficiency could be further increased by optimizing the ultrasound parameters.
研究领域:
生物医学工程
·
超声治疗
·
血栓性疾病
✓ 已验证
DOI
高影响因子
INDUSTRIAL & ENGINEERING CHEMISTRY RESEARCH
·
2022
·
IF 4.326
Chenxu Wang,Feng Yu,Ke Lu,Zhimou Wang,Jie Yu,Wentao Bao,Gang Wang,Banghua Peng,Xuhong Guo
The traditional preparation methods for metal–organic framework (MOF) materials include direct mixing, solvothermal, and mechanical methods. These methods are conducted through several days of slow coordination reactions and discontinuities. Presently, pure organic solvents are used to synthesize MOFs, leading to harsh conditions for MOF synthesis. Therefore, this study used the multi-inlet vortex mixer and MeOH, EtOH, H2O, and Baijiu to synthesize the Co-MOF. They can solve the problem of the uneven macromixing and slow penetration of materials into the microchannel compared to the traditional synthetic intermittent method, while providing continuous rapid industrial magnification and other characteristics. MOF materials were synthesized using Baijiu as a solvent for the first time. Baijiu as the solvent reduced the synthetic conditions of MOF materials and allowed for the reuse of industrial ethanol wastewater, making the synthesis of MOF materials convenient. The catalyst, Co@N-C-FNP-Baijiu, prepared by carbonizing ZIF-67-FNP-Baijiu using Baijiu as the solvent has Eonset = 0.93 VRHE and E1/2 = 0.82 VRHE, which is second to the oxygen reduction reaction performance of the catalyst prepared using MeOH as the solvent. The open-circuit voltage, peak power density, and specific capacity of Zn-air batteries assembled with Co@N-C-FNP-Baijiu as cathode catalysts are similar to those of Pt/C batteries.
研究领域:
材料科学
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化学工程
·
能源科学
✓ 已验证
DOI
高影响因子
MOLECULES
·
2019
·Vol. 24
·期 16
·3016
·
IF 3.06
Ying Xue,Lin-Sen Qing,Li Yong,Xian-Shun Xu,Bin Hu,Ming-Qing Tang,Jing Xie
So far, there is no report on the quality evaluation of lemonade available in the market. In this study, a sample preparation method was developed for the determination of flavonoid glycosides by ultra-performance liquid chromatography–mass spectrometry (UPLC-MS) based on vortex-assisted dispersive liquid-liquid microextraction. First, potential flavonoids in lemonade were scanned and identified by ultra-performance liquid chromatography–time of flight mass spectrometry (UPLC-TOF/MS). Five flavonoid glycosides were identified as eriocitrin, narirutin, hesperidin, rutin, and diosmin according to the molecular formula provided by TOF/MS and subsequent confirmation of the authentic standard. Then, an ultra-performance liquid chromatography–triple quadrupole mass spectrometry (UPLC-QqQ/MS) method was developed to determine these five flavonoid glycosides in lemonade. The results showed that the content of rutin in some lemonade was unreasonably high. We suspected that many illegal manufacturers achieved the goal of low-cost counterfeiting lemonade by adding rutin. This suggested that it was necessary for relevant departments of the state to make stricter regulations on the quality standards of lemonade beverages.Keywords:vortex-assisted dispersive liquid-liquid microextraction;flavonoid glycoside;UPLC-MS;counterfeiting lemonade
研究领域:
分析化学
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食品科学
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药物分析
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Advanced Science
·
2021
·Vol. 8
·期 18
·2100950
·
IF 16.806
Xiaoli Liu,Yifan Zhang,Yu Guo,Wangbo Jiao,Xiao Gao,Wee Siang Vincent Lee,Yanyun Wang,Xia Deng,Yuan He,Ju Jiao,Ce Zhang,Guoqing Hu,Xing-Jie Liang,Haiming Fan
Effective delivery of anticancer drugs into the nucleus for pharmacological action is impeded by a series of intratumoral transport barriers. Despite the significant potential of magnetic nanovehicles in electromagnetic field (EF)-activated drug delivery, modularizing a tandem magnetoresponsive activity in a one-nanoparticle system to meet different requirements at both tissue and cellular levels remain highly challenging. Herein, a strategy is described by employing sequential EF frequencies in inducing a succession of magnetoresponses in the magnetic nanovehicles that aims to realize cascaded tissue penetration and nuclear accumulation. This nanovehicle features ferrimagnetic vortex-domain iron oxide nanorings coated with a thermo-responsive polyethylenimine copolymer (PI/FVIOs). It is shown that the programmed cascading of low frequency (L f )-EF-induced magnetophoresis and medium frequency (M f )-EF-stimulated magneto-thermia can steer the Doxorubicin (DOX)-PI/FVIOs to the deep tissue and subsequently trigger intracellular burst release of DOX for successful nuclear entry. By programming the order of different EF frequencies, it is demonstrated that first-stage L f -EF and subsequent M f -EF operation enables DOX-PI/FVIOs to effectively deliver 86.2% drug into the nucleus in vivo . This nanodelivery system empowers potent antitumoral activity in various models of intractable tumors, including DOX-resistant MCF-7 breast cancer cells, triple-negative MDA-MB-231 breast cancer cells, and BxPC-3 pancreatic cancer cells with poor permeability.
研究领域:
纳米技术
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生物医学工程
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癌症研究
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药物递送系统
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材料科学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Advanced Optical Materials
·
2025
·
IF 7.2
Yuanfeng Liu,Le Zhou,Kristiaan Neyts,Jingbo Sun,Ji Zhou
So far, second harmonic generation (SHG) is usually obtained through ferroelectric materials with spontaneous polarization because of the broken spatial inversion symmetry. In recent years, ferroelectric systems with topological defects such as vortex domains have aroused great research interest. The SHG response from such ferroelectric topological structures is intriguing toward SHG applications and topological characterizations. In this work, a spherulite material with a single ferroelectric vortex domain is synthesized and studied on its ferroelectric properties and optical nonlinearity. The spherulite material is in a sphere-cap shape, composed of polar molecules RM734, with both the average molecular orientation and the polarity arranged azimuthally, forming a single vortex domain, which is demonstrated by the ferroelectric hysteresis loop and piezoelectric force microscopy. Such a large single vortex domain can produce second-order nonlinearity with local polarity features, which are, in turn, used to characterize the topological structure of the ferroelectric vortex domain. The topological similarity between such a single vortex domain material and the optical vortex beam may shed light on promising ways of optical vortex generation.
研究领域:
材料科学
·
光学
✓ 已验证
产品关联
DOI
高影响因子
ADVANCED FUNCTIONAL MATERIALS
·
2018
·Vol. 28
·期 36
·1801127
·
IF 13.325
Hanchuan Tang,Zhesi Chen,Ni Tang,Shuaifeng Li,Yaxi Shen,Yugui Peng,Xuefeng Zhu,Jianfeng Zang
Acoustic metasurfaces that can manipulate and control sound waves at 2D subwavelength scales open new avenues to unusual applications, such as asymmetric transmission, super-resolution imaging, and particle manipulation. However, the long-standing goals of pushing frontier metamaterials research into real practice are still severely constrained by cumbersome configuration, large acoustic loss, and rigid structure of the existing metamaterials. An ultrathin metasurface (10–300 µm in thickness, up to ≈λ/650, λ the wavelength) that is capable of imparting sound wave with a nontrivial phase shift with high transmittance (>80%) in the range of 5–30 kHz is fabricated here. The metasurface is comprised of a porous network of soft polymer fiber/rigid beads that are physically equivalent to crosslinked spring-mass resonators. Moreover, the traditional paper-cutting art to carve the ultrathin metasurface into hollow-out patterns is incorporated, resulting in a variety of remarkable functions, including acoustic vortex, focusing, and super-resolution. The hollow-out patterning approach innovates the traditional one-step metadevice fabrication process into two separated steps: 1) fabrication of ultrathin metasurfaces; 2) hollow-out patterning of metasurfaces. The strategy opens an avenue to mass production of acoustic metadevices, shedding light on the applications of the metamaterials in acoustic cloaking, acoustic positioning, and particle manipulation.
研究领域:
材料科学
·
声学工程
·
纳米技术
✓ 已验证
产品关联
DOI
高影响因子
WATER SCIENCE AND TECHNOLOGY
·
2013
·Vol. 69
·期 3
·580-586
·
IF 1.102
Meng Lifen,Cheng Jiaxi,Yang Yaling
A simple and practical extraction method of supramolecular solvents (SUPRAS) was developed for separation and enrichment of trace amounts of palladium (Pd) and silver (Ag) in water samples prior to flame atomic absorption spectrometry (FAAS) analysis. The SUPRAS selected was made up of an aqueous solution containing tetrahydrofuran and nonanoic acid. Pd and Ag reacted with diethyldithiocarbamate to form hydrophobic chelates, which were extracted into the vesicles of SUPRAS. Different parameters such as the concentration of chelating agent, sample pH, supramolecular solvent and the effect of foreign ions were studied. Under the optimal conditions, the linear ranges of Pd and Ag were from 10 to 1,000 μg/L. The relative recoveries of Pd and Ag in tap and river water samples at the spiking level of 10 ug/mL ranged from 90.8 to 116%. The relative standard deviations were 3.6–4.0% ( n = 9), the limits of detection were 2.8 and 1.9 μg/L and the enrichment factors were 36 and 18 for Pd and Ag, respectively. The quantification limits were 3.2 and 2.4 μg/L. The method was successfully applied to the determination of Pd and Ag in water samples.
研究领域:
分析化学
·
环境化学
·
分离科学
·
痕量元素分析
·
样品前处理
✓ 已验证
DOI
高影响因子
MICROCHEMICAL JOURNAL
·
2020
·
IF 3.594
Youyi Wu,Mengxuan Chen,Xuedong Wang,Yunlu Zhou,Mengqi Xu,Zhanen Zhang
Herein, we newly synthesized twenty kinds of hydrophobic deep eutectic solvents (HDESs) using long-chain fatty alcohols, fatty acids, quaternary ammonium salts and menthol as hydrogen bond donors (HBDs) and hydrogen bond acceptors (HBAs). Based on their physicochemical properties, six of HDESs with low density and melting point were selected for further investigation. After screening, one kind of HDES composed of 1-dodecanol (HBD) and octanoic acid (HBA) was chosen as the extraction solvent. Using vortexing instead of traditional dispersive solvent, a newly dispersive liquid-liquid microextraction method based on solidification of floating hydrophobic DES (DLLME-SFHDES) was developed to enrich endocrine disrupting chemicals in sewage and analyzed by HPLC with fluorescence detector. Single-factor optimization was performed, and three key factors were selected with a Plackett-Burman design. The optimal factors were further evaluated and verified by a central composite design. Under the optimal extraction conditions, the proposed method showed a good linear relationship in the ranges of 4.39–5000 ng L −1 ( r 2 > 0.9994) for estradiol, estriol, bisphenol A and bisphenol F. The limits of detection (S/N = 3) and quantification (S/N = 10) were 1.33–2.92 and 4.39–9.64 ng L −1 , respectively. The intra-day and inter-day precision ( n = 6) were less than 6.2%, and the obtained enrichment factors were in the range of 96–111. Four endocrine disrupting chemicals within 59–11,000 ng L −1 were detected in sewage samples from three local wastewater treatment plants with good recoveries (85.3–112%). In general, the vortex assisted DLLME-SFHDES method was proved to be a green alternative for the determination of endocrine disrupting chemicals in environmental waters.
研究领域:
分析化学
·
环境科学
✓ 已验证
产品关联
DOI
高影响因子
BULLETIN OF THE KOREAN CHEMICAL SOCIETY
·
2019
·Vol. 40
·期 10
·943-950
·
IF 0.602
Wenfei Zhao,Xu Jing,Mingchang Chang,Junlong Meng,Cuiping Feng
In this research, a novel method—namely vortex-assisted emulsification microextraction—was introduced for the determination of pyrethroids (flucythrinate, beta-cypermethrin, and fenvalerate) in mushrooms ( Agaricus bisporus , Lentinula edodes , Auricularia auricular , and Flammulina velutiper ). A green solvent 1-dodecanol was used as the extraction solvent. The low freezing point makes 1-dodecanol easy to solidify and separate after retention in an ice bath. To avoid the use of dispersion solvents, vortex agitation was applied instead to increase the contact area between extraction solvent and samples. The type and volume of extraction solvent, time of extraction, and addition of sodium chloride were optimized. Under optimal conditions, linear responses were obtained within 1–100 μg/g ( R 2 ≥ 0.999). The extraction recovery was within 70.2–89.2% with relative standard deviations of less than 8.1%. This method was simple, fast, and environmentally friendly, and was successfully applied to extract and analyze pyrethroids in Agaricus bisporus , Lentinula edodes , Auricularia auricular , and Flammulina velutiper .
研究领域:
分析化学
·
食品安全
✓ 已验证
产品关联
DOI
高影响因子
FOOD CHEMISTRY
·
2024
·
IF 8.5
Baoqing Bai,Siyuan Meng,Yanli Guo,Ziqing Zhang,Rui Chen,Tao Bo,Jinhua Zhang,Sanhong Fan,Yukun Yang
In this study, vortex-assisted liquid-liquid microextraction (VA-LLME) based on hydrophobic deep eutectic solvents (HDES) was used to efficiently and sustainably extract five phenolic acids and tetramethylpyrazine (TMP) from Shanxi aged vinegar (SAV). The VA-LLME technique was employed to investigate the extraction mechanism of HDES with the best extraction performance for the target compounds using a conductor-like screening model for real solvents (COSMO-RS). An artificial neural network combined with a genetic algorithm (ANN-GA) was developed to optimize the extraction conditions based on single-factor and response surface methodology, while also analyzing the interactive effects on the phenolic acids and TMP in the extracted solution during the extraction phase. The optimized conditions were determined, and the greenness of the procedure was evaluated using an analytical greenness metric, indicating that this technique can serve as a green alternative for the determination of phenolic acids and TMP in SAV.
研究领域:
食品科学
·
分析化学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
LAB ON A CHIP
·
2024
·Vol. 24
·期 10
·2802-2810
·
IF 6.1
Huihui Xu,Zhaoxun Wang,Wei Wei,Tiechuan Li,Xuexin Duan
Liposomes have garnered significant attention owing to their favorable characteristics as promising carriers. Microfluidic based hydrodynamic flow focusing, or micro-mixing approaches enable precise control of liposome size during their synthesis due to the comparable size scale. However, current microfluidic approaches still have issues such as high flow rate dependency, complex chip structures, and ease of clogging. Herein, we present a novel microfluidic platform for size-tunable liposome synthesis based on an ultra-high-frequency acoustic resonator. By designing the shape and orientation of the acoustic resonator in the three-phase laminar flow, it combined the features of both hydrodynamic flow focusing and rapid micro-mixing. The distribution of lipid precursor solution in laminar flow and the mixing conditions could be regulated by the confined acoustic streaming vortex. We successfully synthesize liposomes with adjustable sizes and narrow size distributions. Notably, this platform regulates the product size by adjusting only the input power, which is less dependent on the flow rate. Furthermore, the vortex-like fluid flow generated along the device edge effectively prevents precipitation due to excessive lipid concentration or contact with the wall.
研究领域:
生物工程
·
药剂学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
危险品化学品经营许可证（带存储）