Journal of Energy Storage
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2025
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IF 9.8
Liwei Yang,Xinshuai Yan,Jianguo Duan,Xiaoxiao Huang,Qing Ma
As an intermittent energy source, the efficient utilization of solar energy relies on stable and efficient energy conversion and storage technologies. Phase change materials (PCM) have become ideal candidate materials for solar thermal storage due to their high energy storage density and reversible cycling characteristics. However, traditional organic solid-liquid phase transition materials are prone to leakage during the phase transition process and have a relatively low photothermal conversion efficiency, which limits their practical application. To address the above issues, this study designed a novel composite phase change material (CPCM). By collaboratively loading nanomaterials of different dimensions, such as copper nanowires (CuNWs) and MXene, into a graphene porous framework and encapsulating paraffin (PW), the reduced graphene oxide (rGO)/ CuNWs/MXene/PW (rGCuMPW) composite material was successfully constructed. Among them, the high light absorption capacity of MXene, combined with the excellent thermal conductivity of CuNWs, significantly improved the photothermal conversion efficiency (92.11 %) and thermal energy storage density (ΔH = 165.77 J·g −1 ) of the material. In addition, this material still maintains a stable phase transition enthalpy value after 100 cycles, demonstrating excellent cycle stability and reusability. The CuNWs-MXene synergistic modification strategy proposed in this study not only effectively reduces the leakage rate of organic PCM, but also significantly improves the performance of photothermal conversion and thermal energy storage, providing a new type of high-performance CPCM for the efficient utilization of solar energy.
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JOURNAL OF CONTROLLED RELEASE
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2026
·
IF 12.4
Jingxia Chen,Xiuyu Liu,Jiaxin Luo,Yihan Wang,Zhen Ci,Yangfan Pei,Siyu Chen,Sicong Ren,Jingjie Zhai,Huixin Lv,Yanmin Zhou
Critical-sized bone defects pose a significant clinical challenge, with inadequate blood supply being a major factor impairing bone healing. In the initial stage of bone healing, the blood clot acts as a “natural glue,” serving not only as a scaffold for stem cell growth but also providing a reservoir of cytokines and growth factors that regulate and reconstruct the osteogenic microenvironment. In this study, we hierarchically integrated platelet concentrates with distinct functions into an injectable thermosensitive hydrogel, constructing a “biomimetic blood clot” system. First, leukocyte-platelet-rich fibrin (L-PRF) lyophilized powder, which promotes the osteogenic differentiation of periosteum-derived mesenchymal stem cells (PMSCs), was incorporated into methacrylated gelatin hydrogel microspheres (GM) to form GM L-PRF . Subsequently, advanced platelet-rich fibrin (A-PRF) lyophilized powder, which enhances the angiogenic differentiation of lamina propria-derived mesenchymal stem cells (LMSCs), was blended into a hydrogel precursor composed of chitosan (CS), polygalacturonic acid (PgA), β-glycerophosphate (β-GP), and GM L-PRF . This yielded a thermosensitive hydrogel, designated CSPgA A-PRF GM L-PRF (CP A G L ), which exhibits favorable mechanical properties at 37 °C and enables the programmed release of growth factors from both A-PRF and L-PRF. The CP A G L hydrogel could induce the differential differentiation of distinct types of MSCs. It facilitates vascularized bone regeneration by activating the JAK2-STAT3/HIF-1α and the TGF-β/Wnt signaling pathway, thereby effectively initiating the coupled an gio -osteogenic process. In summary, the biomimetic blood clot system CSPgA A-PRF GM L-PRF represents a potential injectable biomaterial strategy for bone defect repair.
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JOURNAL OF PHARMACEUTICAL SCIENCES
·
2026
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IF 3.9
Jian Zhang,Xiaqian Xu,Anqi Zhu,Jie He,Guangrui Liu,Ting Cui,Yanna Lin,Yijing Wang,Guisen Zhang,Chao Hao
A colchicine-loaded nanoemulgel (COL-nEMG) was developed for rapid and potent topical therapy of acute gouty arthritis (AGA). An O/W COL-loaded nanoemulsion (COL-nEMS, 14.20 ± 1.73 nm) was first prepared and optimized step by step, including excipient screening, pseudo-ternary phase diagram, in vitro transdermal delivery and D-optimal design. The optimized COL-nEMS containing 10% isosorbide dimethyl ether (DMI) was then dispersed into a gel matrix to produce the final COL-loaded nanoemulgel (COL-nEMG-DMI10). COL-nEMG-DMI10 exhibited a homogeneous appearance, favorable rheological properties, stable three-dimensional porous structure, and good storage stability with a steady-state transdermal flux of 54.6 ± 3.7 µg/cm²/h and 8 h cumulative permeation amount of 425.6 ± 28.3 µg/cm². In an AGA mouse model, COL-nEMG-DMI10 demonstrated rapid therapeutic effects with joint swelling inhibition rate (JSIR) of 37.0 ± 3.4% and maximum possible effect of 37.5 ± 5.3% at 1 h post-administration. In addition, COL-nEMG-DMI10 significantly suppressed the levels of local inflammatory cytokines, including TNF-α and IL-1β, in the ankle joints of AGA animals. This COL-nEMG-DMI10 topical formulation provides a promising treatment strategy for AGA with rapid and pronounced therapeutic efficacy.
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Small
·
2026
·
IF 11.8
Gaofeng Shu,Kai Li,Shiji Fang,Qianhui He,Jiayi Shi,Peiyao Liu,Fazong Wu,Min Xu,Weiqian Chen,Kai Yan,Jin Su,Jiansong Ji,Minjiang Chen
The therapeutic efficacy of transarterial chemoembolization (TACE) is strongly limited by the hypoxic and immunosuppressive tumor microenvironment (TME). Herein, monodisperse perfluorooctyl bromide (PFOB)-loaded fucoidan/gelatin microspheres (P@FGMS) with excellent oxygen-carrying capability were prepared for enhanced TACE treatment of hepatocellular carcinoma (HCC). It was found that the introduction of fucoidan endowed P@FGMS with excellent electrostatic affinity for positively charged doxorubicin (DOX) and metformin (MET), enabling their efficient co-loading and sustained release. The resulting drug-loaded microspheres (DMP@FGMS) largely enhanced chemotherapy sensitivity through an in-outside hypoxia remodeling strategy: the supplement of exogenous O 2 via PFOB and inhibition of intracellular oxygen consumption by MET. Notably, DMP@FGMS could not only modulate hypoxic TME, but also generate intracellular ROS and disrupt the redox homeostasis, thereby triggering cancer ferroptosis. Moreover, DMP@FGMS effectively remodeled the immunosuppressive TME by alleviating tumor hypoxia and inducing immunogenic cell death (ICD), thereby enhancing CD8 + T cell infiltration while reducing immunosuppressive cell populations. Consequently, DMP@FGMS could effectively suppress tumor growth in an orthotopic HCC rat model, with this effect further potentiated by combination with immune checkpoint blockade therapy. Therefore, this study demonstrates that DMP@FGMS is a potent embolic agent capable of remodeling the hypoxic/immunosuppressive TME, representing a promising strategy for TACE treatment of HCC.
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ACS Sustainable Chemistry & Engineering
·
2026
·Vol. 14
·期 30
·13802-13811
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IF 7.6
Xu Xinyue,Xu Ying,Shi Siwen,Wen Jialong,Yuan Tongqi
The development and functional utilization of light-colored lignin are largely hindered by uncontrolled condensation reactions during extraction, which reduces lignin reactivity and compromises its functional performance. Herein, a formic acid/L-Cysteine (FA/L-Cys) pretreatment system was developed to fractionate functional light-colored lignin from bamboo. Under mild conditions (100 ° C, 1 h), this system achieved 95.3% delignification and 71.3% lignin recovery, affording pale beige lignin with a lightness value of 80.9. 2D-HSQC NMR analysis revealed that L-Cys suppressed lignin condensation by nucleophilically trapping reactive intermediates. When incorporated into a sun protection factor (SPF) 15 sunscreen formulation at 5 wt %, the optimized lignin (L-Cys-0.3) increased the SPF to 71.7. Moreover, L-Cys-0.3-derived lignin nanoparticles efficiently stabilized Pickering emulsions and exhibited a 12-fold enhancement in UV absorption capacity compared with their LNPs aqueous dispersion counterparts. This work highlights condensation-controlled fractionation as an effective strategy for producing light-colored lignin with potential applications in sustainable sunscreens and functional Pickering emulsion systems.
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Advanced Healthcare Materials
·
2026
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IF 11
Yuyao Pan,Ling Huang,Shangwen Sun,Yue Yan,Hai Xu,Jia Yan,Hanbang Chen,Na Li,Shijia Tang,Feimin Zhang
Diabetic patients frequently experience impaired healing of tooth extraction wounds, likely due to excessive reactive oxygen species (ROS) in the diabetic bone microenvironment, which compromises bone marrow mesenchymal stem cells (BMSCs). While Prussian blue nanoparticles (PBNPs) show promise as ROS scavengers, their clinical application remains limited due to the lack of stable, targeted and minimally invasive delivery systems. To address this, we developed an injectable microsphere system encapsulating PBNPs through microfluidic technology (GelMA/PEGDA/PBNPs). These microspheres exhibited excellent mechanical properties, controlled biodegradability, a pro-proliferative microenvironment, and photoacoustic imaging (PAI) tracking capabilities. In vitro, they significantly enhanced stem cell expansion, reversed oxidative stress in BMSCs, and enhanced osteogenesis. In vivo, these microspheres, through surface-loaded stem cell delivery, accelerated regeneration of irregular bone defects in tooth extraction sockets in diabetic rat. Transcriptomic sequencing analysis indicated that the antioxidant effects of the microspheres were closely associated with activation of the PI3K/AKT/mTOR signaling pathway. The optimized system enhanced local retention, achieved sustained and stable release of PBNPs, improved bioavailability of PBNPs, and enabled real-time tracking of the implants. This nano-hybrid microsphere system provides a novel minimally invasive therapeutic strategy for bone tissue defects in diabetic patients, demonstrating significant potential for clinical translation.
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Journal of Environmental Chemical Engineering
·
2026
·Vol. 14
·期 2
·121811
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IF 7.5
Xiuchan Xiao,Jun Wang,Huamei He,Zhicheng Feng,Chaoran Duan,Jungang Yuan,Ya Liu
The high treatment costs and substantial energy consumption associated with high-salinity fracturing flowback fluids remain critical bottlenecks restricting the development of shale gas. This study constructed a functionalized layered oil-water hydrogel solar interfacial evaporator (FG-SWE), aiming to achieve low energy consumption and zero emission treatment of high-salinity fracturing flowback fluids. The evaporator was synthesized via one-pot polymerization and consists of three functional layers (top: MXene, middle: 12-hydroxystearic acid (HSA)-based, bottom: porous), each responsible for light absorption, thermal management, and water transport, respectively. Results showed that under one sun irradiation, FG-SWE demonstrated an evaporation rate of 2.80 kg m −2 h −1 and a photothermal conversion efficiency over 95 % in 10 wt% standard saline waters, with the hydrophobic area ratio of the evaporation interface set at 30 %. Furthermore, the phase-change heat storage layer has a melting enthalpy of 125.8 kJ kg −1 , enabling continuous nighttime evaporation with a daily water production of 17 kg·m −2 . Furthermore, the FG-SWE effectively treated high-salinity flowback fluid, reducing total dissolved solids content (TDS) from 8 × 10 4 mg L −1 to < 125 mg L −1 to meet drinking water standards. The evaporator also demonstrated excellent anti-fouling properties and long-term stability, retaining 90.7 % performance over 30 days of continuous operation. This study provides a promising technology for high-salinity wastewater, thereby supporting the green development of shale gas and enhanced recycling of water resources.
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ACS Applied Materials & Interfaces
·
2026
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IF 7.8
Jianning Yu,Enfeng Yang,Haitao Deng,Guoliang Liu,Wenxuan Zhao,Xiangdong Yang,Xiugong He,Dezhao Hao,Ye Tian,Lei Jiang
The growth in oil demand has driven technological innovation in enhanced oil recovery (EOR). Chemical flooding, widely adopted for its effectiveness in improving oil recovery, enhances the macroscopic sweep efficiency by altering interfacial properties. However, strong oil–solid adhesion leads to residual oil, posing a key technical challenge. Although low-salinity water flooding can disrupt the hydrated ion bridge structure, its efficacy is limited, and it fails to fully resolve residual oil issues. To tackle this residual oil challenge, we developed traditional Chinese medicine (TCM) composite agents based on polyphenol–silicon complexation with dual EOR functions: in situ oil displacement and long-term oil isolation. Under weak alkaline conditions, the TCM composite agent continuously reacts with silicon, overcoming van der Waals forces between crude oil and silicate, thereby effectively displacing oil in micron-scale grooves. The polyphenol–silicon complexes, along with polyphenol, form a hydrophilic coating with micro/nanostructures via π–π interactions, maintaining superoleophobic and nonadhesive properties against crude oil even after 1 week. Additionally, the TCM agents altered the wettability of shale from oil-wet to water-wet and achieved an 88.24% recovery rate in core flooding tests. This breakthrough offers a solution for crude oil recovery, promoting efficient and environmentally sustainable development in the industry.
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ENERGY & FUELS
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2026
·
IF 6
Tianle Li,Liangliang Yan,Jingyi Yu,Yuxiu An
The deployment of amphiphilic nanomaterials in reservoir environments is often hampered by the stability-activity trade-off, where physical desorption leads to structural failure. To overcome this, we developed a covalent core–shell nanohybrid (DNM) by anchoring a sulfonate-rich AM/AMPS copolymer shell onto a rigid KH570-modified silica core via in situ polymerization. This covalent grafting strategy effectively mitigates the shell detachment issues prevalent in physically adsorbed systems. The resulting “rigid-core/flexible-shell” architecture exhibits a salinity-adaptive behavior, achieving optimal dispersion at ∼20,000 mg/L TDS through a balance of electrostatic and Hofmeister effects. While the interfacial tension reduction is moderate (∼0.29 mN/m), the DNM significantly alters rock wettability from oil-wet (119.3°) to water-wet (41.3°) via a structural wedge mechanism. Dynamic core flooding demonstrated a 35% enhancement in oil recovery, driven by the synergistic coupling of the “Log-jamming” effect for mobility control and interfacial stripping for oil mobilization. These findings confirm that covalent hybridization provides a robust molecular solution for mobilizing residual oil in moderate-salinity reservoirs.
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Advanced Science
·
2026
·
IF 14.1
Xiaokai Li,Yonghui Zhang,Yongxin Li,Jiahao Zhang,Yuheng Li,Zhengyu Li,Jianwu Wang,Yaochen Lv,Yanan Wang,Jiyu Liu,Xin Liu,Huanxi Zheng
Underwater smart adhesives with switchable adhesion have attracted significant attention for applications in marine engineering and biomedical fields. However, achieving both robust adhesion and rapid on-demand detachment in aquatic environments remains a critical challenge. Inspired by the diving bell spider, we propose a design strategy based on heterogeneous wettability surfaces to achieve switchable adhesion between two surfaces. The heterogeneous wettability surface design confines the oil phase within air cavities formed in superhydrophobic (lipophilic) regions, thereby creating annular oil rings, which establish stable oil/water interfaces that spatially isolate the internal water bridge from the external aquatic environment. The Laplace pressure difference generated at the oil/water interfaces induces robust adhesion between surfaces. In addition, the adhesion strength can be linearly enhanced by constructing multiple, uniformly arranged oil/water interfaces. Rapid on-demand separation can also be achieved through controlled electrolysis of the internal water bridge by applying voltage between the surfaces. Finally, we demonstrate the practical applicability of this adhesive by integrating it into an unmanned underwater vehicle (UUV) for efficient underwater anchoring and ship-hull hitchhiking, highlighting its broad application potential in underwater engineering scenarios.
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Frontiers in Bioengineering and Biotechnology
·
2026
·
IF 5.8
Jinyu Zhong,Shiliang Zhang,Wei Huang,Jie Cheng,Xiaoning Li,Sen Wang,Tong Zhang,Guodong Sui
Introduction: Invasive aspergillosis (IA) is a life-threatening disease in immunocompromised individuals, creating an urgent need for rapid, sensitive, and user-friendly methods for early detection of Aspergillus spores in clinical and environmental samples. Methods: In this study, we developed a rapid ultrasonication-based beads beating (USBB) method for cell lysis and fungal DNA release, along with an integrated magnetic beads-based direct amplification (MBDA) method utilizing microfluidic chip technology. Our flexible thin-film microfluidic chip was developed to enable immediate contacting with an ultrasonic oscillator for nucleic acid extraction. Results and discussion: The chip achieved a lysis efficiency of 85.5% for Aspergillus at 10 5 spores per sample. Magnetic beads releasing Fe ions at 75-860 ng/mL allowed high-efficiency direct PCR amplification. Complete transfer of the nucleic acid extract into PCR amplification led to a 100-fold improvement in detection sensitivity. The integrated USBB-MBDA system completed the entire workflow from sample-in to result-out within 35 min (5 min fungal DNA release and 30 min TaqMan assay). Using this approach, we achieved simultaneous triplex detection of Aspergillus fumigatus, Aspergillus flavus , and Aspergillus niger , with a sensitivity as low as 10 spores per test. Validation on 37 clinical samples showed complete concordance with MALDI-TOF mass spectrometry (MS). This study establishes an integrated nucleic acid extraction and magnetic bead–enabled direct amplification strategy, providing a versatile approach for the development of automated analytical platforms with broad applicability to in vitro diagnostics.
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JOURNAL OF APPLIED POLYMER SCIENCE
·
2026
·
IF 3.1
Lixian Wang,Zhixin Li,Lizhi Zhao,Baitao Xu,Guangyue Du,Ziteng Han,Ziyi Fan,Huiqin An,Hui Ye,Qingping Xin,Yuzhong Zhang
Membranes with slippery liquid-infused porous surfaces (SLIPS) have emerged as highly promising candidates for oil/water separation owing to high separation efficiency and anti-fouling properties. However, the fabrication of SLIPS is complex and often involves organic solvents, posing environmental and cost concerns. This study developed an oleogel-based slippery membrane via a green solvent-free method. A beeswax/paraffin oil oleogel was hot-pressed onto the surface of polypropylene (PP) membrane. The obtained PP-OleG membrane exhibited self-lubricating property, enabling water droplets to slide on the surface. Further infusion of paraffin oil yielded a PP-OleG-oil membrane with enhanced slippery property and anti-protein adhesion. The oleogel and oil layers on the membrane surface demonstrated good stability. Both PP-OleG and PP-OleG-oil membranes outperformed unmodified PP in water-in-oil emulsion separation. Notably, the PP-OleG-oil membrane protected by oleogel and oil layers prevented direct contact between contaminants and the membrane substrate, resulting in excellent anti-fouling performance. After six cycles of filtration, the flux recovery rate reached 86%, and the separation efficiency remained above 98.5%. This oleogel-based membrane offers a feasible approach to enhancing anti-fouling performance in oil/water separation and also provides insights for wastewater treatment through green strategies.
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