ACS Applied Materials & Interfaces
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2019
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IF 8.456
Bingfang Wang,Yuanyuan Luo,Bo Liu,Guotao Duan
Ni3(HITP)2, a novel and promising two-dimensional metal–organic framework (MOF) material, has been utilized in the areas of catalysis, sensing, and supercapacitors. It is very suitable for preparing field-effect transistor (FET) devices due to its good conductivity, porous structure, as well as easy film formation. Nevertheless, there is a challenge to transfer membrane materials undamaged to the substrates. Here, we reported a simple approach to fabricate the Ni-MOF-based FET with an in situ grown Ni3(HITP)2 membrane as the channel material of the FET. With this method, we obtained a large-area, dense, and uniform film composed of thin sheets, and the thickness and density of the MOF film were tunable through changing the reaction time. The as-prepared Ni-MOF-FET had a good mobility of 45.4 cm2 V–1 s–1 and on/off current ratio of 2.29 × 103. Moreover, this FET served as a liquid-gated device for the first time with bipolar behavior and good response to the gluconic acid at the range from 10–6 to 10–3 g/mL, verifying the potential of the Ni-MOF-FET as biosensors.
研究领域:
材料科学
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生物传感
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电子工程
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DOI
PubMed
高影响因子
Journal of Instrumentation
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2021
·Vol. 16
·期 09
·P09021
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IF 1.415
R. Zhang,Y. Jia
DNA methylation sensor is an emerging demand of modern medical for laboratory, though lots of efforts have been contributed in this discipline, the easy-to-operate and efficient sensing terminal is still in deficiency. In this work, a total solution processable printing technology is proposed to fabricate the DNA methylation sensor, which is based on the liquid gate graphene field effect transistor (Lg-GFET). Meanwhile, the graphene ink (G-ink) was prepared by using the modified liquid-exfoliation method, to facilitate printing production. Then, five kinds of tested single strand DNA (ssDNA) which have 0 to 4 5-methylcytosine (5mC) sites were covalently anchored on the graphene channel. X-ray photoelectron spectroscopy (XPS) was conducted to demonstrate the analyte ssDNA was successfully fixed. Thirdly, the 5mC sites were identified by their antibody of 5mC (5mCab) and transduced as the changed current between the source and drain electrodes (Ids). It is found the proposed sensor has good linear sensitivity (about -1.68% for per 5mC) to the amount of 5mC sites on the tested ssDNAs with Pearson correlation coefficient -0.98 and excellent anti-interference to unmethylated ssDNAs. Besides, the cost is estimated to be about $ 1.5 for each of the proposed DNA methylation sensor. Conclusively, the proposed low-cost component may be an efficient candidate for promoting the instant DNA methylation determination.
研究领域:
生物传感器
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纳米技术
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分子生物学
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医学诊断
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DOI
高影响因子
ADVANCED FUNCTIONAL MATERIALS
·
2025
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IF 19
Yange Luan,Qijie Ma,Yihong Hu,Xinyi Hu,Guanyu Chen,Jiaru Zhang,Zhong Li,Dongdong Xie,Guanghui Ren,Yunyi Yang,Guifu Ding,Kate Fox,Bao Yue Zhang,Jian Zhen Ou
2D nanomaterials have shown significant advances in next-generation biosensor development. However, current 2D-enabled electronic biosensors rarely achieve a detection limit down to pico-gram level, possibly due to their intrinsic low carrier mobilities, biocompatibility or instability. TiO 2 , a biocompatible material, has been widely adopted in bio-applications. Recently, 2D TiO 2 with a unique planar hexagonal phase exhibits a reduced bandgap of 2 eV and high p-type mobility. A small perturbation could stimulate an observable electronic swing, enabling a high-performance biosensor in a label-free manner. Here, 2D h-TiO 2 is fabricated into a liquid-gated field-effect transistor, while a wide spectrum, nonspecific biomarker carcinoembryonic antigen (CEA) is selected as the target molecule. The h-TiO 2 surface is first functionalized with 3-aminopropyltriethoxysilane and subsequently decorated with anti-CEA, creating an affinity probe toward CEA molecules. The real-time response to different concentrations of CEA is tested from 1 pg mL −1 to 10 ng mL −1 under a low working voltage of 0.05 V, and an ultralow detection limit of 0.22 pg mL −1 is achieved. Meanwhile, the selectivity of the devices is demonstrated using cytokeratin-19-fragment and neuron-specific enolase. The results highlight the potential of layered hexagonal metal oxides for high-performance biosensors, enabling future low-power portable devices for disease diagnosis.
研究领域:
纳米材料
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生物传感器
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电子器件
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生物医学诊断
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材料科学
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产品关联
DOI
高影响因子
ACS Sensors
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2021
·
IF 7.711
Rong Zhang,Yunfang Jia
Circadian rhythm of salivary cortisol is of clinical significance, tracking salivary cortisol in domicile is welcomed by both doctor and patient, due to its merits of noninvasion, ease of sampling, and free-of-stress response. Here, we present a portable salivary cortisol test setup based on a liquid gate graphene field effect transistor (Lg-GFET) for the first time. In this work, the Lg-GFET was prepared by the printing technology and exploited as a sensitive material. In the procedures of device preparation, the modified liquid exfoliation method and direct-ink-write technology were utilized for synthesizing the graphene ink and printing Lg-GFETs; then, the as-prepared Lg-GFETs were decorated and functionalized by tetrakis(4-carboxyphenyl) porphyrin and the cortisol aptamer, successively. Their sensitivity, selectivity, and robustness are seriously examined. The test results indicate that the sensors have good linear sensitivities over a seven-log analyte concentration range (0.01 to 104 nM) and the anti-interference ability to distinguish from the substancess with similar chemical structures. Moreover, the conceptual application for tracking circadian rhythm was carried out successfully. Conclusively, the proposed flexible Lg-GFET-based salivary cortisol detection platform can satisfy the requirements of the salivary cortisol’s assay for instant detection. Additionally, it also provides an alternative solution for developing similar household medical appliances.
研究领域:
生物传感器
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即时检测
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石墨烯技术
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医疗器械
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生物医学工程
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产品关联
DOI
PubMed
高影响因子
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