OPTICAL FIBER TECHNOLOGY
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2025
·
IF 2.7
Zhoujie Li,Ting Liu,Xuezhi Huang,Qing Yu,Yin Wang,Fang Cheng,Tegoeh Tjahjowidodo
Optical fiber pressure sensors have become indispensable in various fields due to their unique advantages. Traditional sensors based on fiber Bragg gratings or Fabry-Pérot resonators offer high sensitivity and the ability to perform distributed measurements. However, these sensors often suffer from complex manufacturing processes and high costs. To address these challenges, we propose an innovative approach utilizing a polydimethylsiloxane (PDMS)-based liquid-core optical fiber probe for pressure sensing. The fiber probe is prepared by sealing a fluorescent dye solution within the PDMS-based hollow-core fiber and then inserting the end face of a silica optical fiber into it, which only relies on extremely simple fabrication operations and cost-effective materials. When integrated with an excitation laser and a fiber spectrometer, the sensor enables calibration and quantitative detection of pressure based on the correlation between pressure and the fluorescence intensity. The experimental results show that the sensor exhibits a high sensitivity of 400.508 a.u./N and a high resolution of 0.093 N, along with high detection accuracy, good repeatability and stability, rapid dynamic response, and excellent long-term stability within the 0–30 N load range. Moreover, it is capable of effectively monitoring various human activities, such as finger tapping and palm pressure, which are crucial for applications in medical monitoring, wearable devices, human activity monitoring, and smart products.
研究领域:
光学工程
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生物医学工程
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产品关联
DOI
高影响因子
ACS Sensors
·
2022
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IF 9.618
Ting Liu,He Ding,Jianwei Huang,Chengsen Zhan,Shouyu Wang
This paper first reports a liquid-core hydrogel optical fiber fluorescence probe. It is composed of a liquid core, a high-refractive-index hydrogel fiber core, and a low-refractive-index hydrogel fiber cladding, which is completely different from many existing optical fiber fluorescence probes. The sensing solution with sensitive materials is sealed as a liquid core, and it can sufficiently react with small-molecule targets penetrating through the hydrogel fiber cladding and core, thus inducing variations in the fluorescence signals. These fluorescence signals can be localized and transmitted within the probe and finally collected and quantified for target detection. This proposed probe can be simply and rapidly fabricated and reused, and it was proven to have high sensitivity, accuracy, and selectivity in practical applications. Therefore, this liquid-core hydrogel optical fiber fluorescence probe will enable a novel sensing platform for small-molecule analyte detection that faces on-site detection challenges.
研究领域:
生物医学工程
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光学传感
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分析化学
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产品关联
DOI
PubMed
高影响因子
NANOTECHNOLOGY
·
2020
·Vol. 31
·期 36
·365502
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IF 3.551
Sen Liang,Yuan Wang,Lixuan Mu,Guangwei She,Wensheng Shi
Intracellular thermometry with favorable biocompatibility and precision is essential for insight into temperature-related cellular events. Here, liquid-core nanocapsule ratiometric fluorescent thermometers (LCN-RFTs) were prepared by encapsulating thermosensitive organic fluorophores (N,N'-di(2-ethylhexyl)-3,4,9,10-perylene tetracarboxylic diimide, DEH-PDI) with hydrophobic solvent (2,2,4-trimethylpentane, TMP) into polystyrene/silica hybrid nanoshells. As the fluorescent thermosensitive unit of the LCN-RFT, the TMP solution of DEH-PDI was responsible for the fluorescence response to temperature. Benefitting from the hydrophilic nanoshells, the LCN-RFTs exhibited favorable anti-interference and biocompatibility. Furthermore, the LCN-RFTs showed an excellent precision of 0.02 °C–0.10 °C in a simulated physiological environment from 10.00 °C to 90.00 °C, and were employed to realize intracellular thermometry with an outstanding precision of 0.06 °C–0.14 °C. This work provides a feasible method of using hydrophobic organic fluorophores for intracellular thermometry by encapsulating them into nanocapsules.
研究领域:
生物医学工程
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纳米技术
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细胞生物学
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DOI
高影响因子
TALANTA
·
2018
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IF 4.244
Jiying Xu,Yi Chen
The signal amplification methods of surface plasmon resonance (SPR) are mainly with sample selectivity . Herein proposed is a liquid core coupling SPR sensing method with adjustable sensitivity and universal applicability. A liquid core coupling unit and based on which a wavelength interrogation SPR sensor have been designed and constructed, in which a conventional chip could be used with an ingenious design and the sensitivity can be adjusted by changing the liquid core refractive index . The experimental data revealed that the sensitivity can be enhanced for 7.8 times by decreasing the liquid core refractive index from 1.5174 to 1.4502. The real applicability was validated by determination of carcinoembryonic antigen (CEA) with the signal intensity of the early stage colon cancer patient clearly up-regulated for nearly 18 folds compared with the healthy. It exhibited an adequate sensitivity, and further considering its simplicity avoiding the troublesome analysis process and/or chip preparing procedure, and extendibility to SPR imaging, the proposed method would be promising for medical diagnostics, food safety, environmental monitoring, and so on.
研究领域:
光学
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生物传感
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医学诊断
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环境科学
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产品关联
DOI
PubMed
高影响因子
Regenerative Biomaterials
·
2024
·
IF 5.6
Chen Jianwei,Liu Zeyang,Wang Zixian,Zhang Xiuxiu,Zhang Yi,Zhan Zhen,Gong Xiaohua,Xu Tao
There are many instances of hollow-structure morphogenesis in the development of tissues. Thus, the fabrication of hollow structures in a simple, high-throughput, and homogeneous manner with proper natural biomaterial combination is valuable for developmental studies and tissue engineering, while it is a significant challenge in biofabrication field. We present a novel method for the fabrication of a hollow cell module using a coaxial co-flow capillary microfluidic device. Sacrificial gelatin laden with cells in the inner layer and GelMa in the outer layer are used via a coaxial co-flow capillary microfluidic device to produce homogenous micro-beads. The overall and core sizes of core-shell microbeads were well controlled. When using human vein vascular endothelial cells (HUVECs) to demonstrate how cells line the inner surface of core shell beads, as the core liquifies, a hollow cell ball with asymmetric features is fabricated. After release from the GelMa shell, individual cell balls are obtained and deformed cell balls can self-recover. This platform paves way for complex hollow tissue modelling in vitro, and further modulation of matrix stiffness, curvature, and biochemical composition to mimic in vivo microenvironments.
研究领域:
组织工程
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生物医学工程
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细胞生物学
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微流控技术
✓ 已验证
产品关联
DOI
PubMed
高影响因子
危险品化学品经营许可证（带存储）