ACS Applied Materials & Interfaces
·
2013
·
IF 5.008
Hui Zhang,Ronghua Shi,Anjian Xie,Juchuan Li,Long Chen,Ping Chen,Shikuo Li,Fangzhi Huang,Yuhua Shen
A novel inorganic/organic hybrid hydrogel system containing titanium dioxide (TiO2)/poly(ethylene glycol) double acrylates (PEGDA) was prepared by in situ photopolymerization on tumor cells for photodynamic therapy (PDT). TiO2 nanorods with diameter of ∼5 nm and length of ∼25 nm in this system presented dual functions, as effective photosensitizers for PDT and initiators for causing the in situ formation of hydrogel, under near-infrared (NIR) irradiation. The hybrid hydrogel retained the TiO2 around tumor cell to form a drug-loaded hydrogel shell. This resulted in a high concentration of singlet oxygen (1O2) under NIR irradiation, which induced apoptosis of tumor cell. Also, the hydrogel could reduce the side effects by preventing TiO2 from migrating to normal tissue. Furthermore, the TiO2 nanorods in this hydrogel shell were photochemically recyclable and could be reused in regular treatment. The outcomes of this study provide a new way to exploit multifunction of inorganic semiconductor nanomaterials for a variety of biomedical applications.
研究领域:
生物医学工程
·
纳米医学
·
癌症治疗
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产品关联
DOI
PubMed
高影响因子
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
·
2022
·Vol. 29
·期 28
·43169-43178
·
IF 5.19
Piao Mingyue,Du Hongxue,Sun Yuwei,Teng Honghui
Hybrid hydrogel was synthesized by immobilizing TiO 2 in polyethylene glycol diacrylate (TiO 2 @PEGDA) as an efficient adsorbent with photocatalysis property for bisphenol A (BPA) elimination. TiO 2 @PEGDA exhibited spherical and rough structure with limited crystallinity and abundant functional groups. The contact angle increased to 61.96° (TiO 2 @PEGDA) from 46.73° (pristine PEGDA), indicating that hydrogel hydrophilicity decreased due to the presence of TiO 2 . The swelling capacity of TiO 2 @PEGDA (9.0%) was decreased compared with pristine PEGDA (15.6%). Adsorption results demonstrated that the maximum adsorption capacity of TiO 2 @PEGDA (101.4 mg/g) for BPA was slightly higher than that of pristine PEGDA (97.68 mg/g). The adsorption capacity was independent with pH below 8 and decreased obviously when the value of pH was higher than 8. The adsorption behavior was fitted well with the pseudo-second-order kinetic and the Langmuir isotherm model. Both ΔG 0 and ΔH 0 were negative, indicating that BPA adsorbed on TiO 2 @PEGDA was an exothermic and spontaneous process. Regeneration study was performed by photocatalysis, and the adsorption capacity was 85.6% compared with the initial capacity after four-cycle use, indicating that TiO 2 @PEGDA could be recycled without significant adsorption capacity loss. Consequently, TiO 2 @PEGDA can serve as an eco-friendly and promising material for efficiently adsorbing BPA with self-clean property.
研究领域:
环境科学
·
材料科学
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产品关联
DOI
PubMed
高影响因子
FIRE TECHNOLOGY
·
2022
·Vol. 58
·期 4
·2077-2091
·
IF 3.605
Nabipour Hafezeh,Shi Hu,Wang Xin,Hu Xiangming,Song Lei,Hu Yuan
Wildfires have been recognized as a natural incident in some forests, however, fire season is now more severe and extensive, even in tropical rainforests in which fire could have damaging impacts. A hydrogel is a 3-D polymeric structure encompassing cross-linked and hydrophilic macromolecules. In comparison with water, hydrogels have shown some superiorities in terms of water-binding, cooling, and sealing, which make them be applied in forest fire prevention programs for improving fire-extinguishing performance. In this study, an environmentally friendly phosphorus-modified methylcellulose/silica hybrid hydrogel was prepared based on the modified methylcellulose by 9,10-dihydro-9-oxa-10-phosphaphenanthrene-10-oxide–itaconic acid (DOPO-ITA) and silica nanoparticles. In the fire prevention experiments, the grass treated with the methylcellulose@DOPO-ITA@silica hybrid hydrogel shows self-extinguishing behavior, whereas those treated with ordinary water or methylcellulose hydrogel can be easily ignited after one week. In the firefighting experiments, the methylcellulose@DOPO-ITA@silica hybrid hydrogel displays a much shorter extinguishing time and lower consumption volume than ordinary water and the methylcellulose@DOPO-ITA hydrogel. This work presents an environmentally friendly, non-toxic, and biodegradable cellulose-based hybrid hydrogel for the fire prevention and firefighting of wildfires.
研究领域:
材料科学
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环境科学
✓ 已验证
DOI
高影响因子
CHEMICAL ENGINEERING JOURNAL
·
2018
·
IF 6.735
Shucheng Liu,Xuan Zhang,Yue Ma,Xue Bai,Xueping Chen,Jinxin Liu,Jianming Pan
By immobilization of nano-sized adsorbents into a water-rich matrix to fabricate a hybrid hydrogel has raised considerable attention in aqueous phase molecular recognition, owing to the combination of inherent advantages of easy operation, good mechanical performance and abundant recognizing sites by a light-triggered chemical polymerization strategy. The boronic acid and vinyl-functionalized multi-walled carbon nanotubes (VMWCNTs-COOH-BA) were introduced to hydrogel matrix, and then as-prepared hybrid hydrogels (MBA-H-5.0) were applied for selective adsorption and separation of luteolin (LTL). Surface hydrophilicity, mechanical performance and specific surface area of the hybrid hydrogels were enhanced by the addition of functional VMWCNTs-COOH-BA. In static adsorption, MBA-H-5.0 showed a large LTL loading amount (35.91 mg g −1 at 308 K), fast capture kinetics (3.0 h), remarkable selectivity, and excellent recyclability (8.24% loss in adsorption amount after seven adsorption-desorption cycles). The abundant boron-containing functional groups such as boronic acid played a vital role on adsorption, and the copolymerization of VMWCNTs-COOH-BA and hydrogel matrix prevented from the leakage of nanostructured adsorbents. This study sheds new light on the design of high performance hybrid hydrogel by embedding functional adsorbents for selective separation and enrichment of natural flavonoids.
研究领域:
材料科学
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环境科学
·
化学工程
✓ 已验证
产品关联
DOI
高影响因子
Advanced Healthcare Materials
·
2018
·Vol. 8
·期 2
·1801458
·
IF 5.609
Haishi Qiao,Jing Jia,Wei Chen,Bin Di,Oren A. Scherman,Chi Hu
The fabrication, characterization, and therapy efficiency of a noncovalent-bonded hydrogel network, which is assembled by utilizing cucurbit[7]uril as a supramolecular linker to “stick” superparamagnetic γ-Fe 2 O 3 nanoparticles onto the polymer backbone of catechol-functionalized chitosan are described. The unique barrel-shaped structure of cucurbit[7]uril not only facilitates host–guest recognition with the catechol derivatives, but also forms robust electrostatic interactions between its carbonyl portals and the γ-Fe 2 O 3 nanoparticles in a supramolecular manner, which leaves the physical and chemical properties of the nanoparticles intact. The γ-Fe 2 O 3 nanoparticles display vibrational movement and heat generation under an alternating magnetic field, endowing the formed hybrid supramolecular hydrogel with both thermo- and chemotherapy modalities, which are demonstrated both in vitro and in vivo. Here, a facile strategy is introduced to construct noncovalent interactions between a polymer matrix and the incorporated nanoparticles, which is amendable to a wide range of biomedical and industrial applications.
研究领域:
生物材料
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纳米医学
·
肿瘤治疗
✓ 已验证
DOI
PubMed
高影响因子
BIOSENSORS & BIOELECTRONICS
·
2016
·
IF 7.476
Yueshuang Xu,Xiaoping Zhang,Chengxin Luan,Huan Wang,Baoan Chen,Yuanjin Zhao
Barcodes-based suspension array have for demonstrated values in multiplex assay of tumor markers. Photonic barcodes which are encoded by their characteristic reflection peaks are the important supports for suspension array due to their stable code, low fluorescent background and high surface-volume ratio. Attempts to develop this technology tend to improve the function of the photonic barcodes. Here, we present a new type of hybrid hydrogel photonic barcodes for efficient multiplex assays. This photonic barcodes are hybrid inverse opal hydrogel composed of poly(ethylene glycol) diacrylate (PEG-DA) and agarose . The polymerized PEG-DA hydrogel could guarantee the stabilities of the inverse opal structure and its resultant code, while the agarose could offer active chemical groups for the probe immobilization and homogeneous water surrounding for the bioassay. In addition, the interconnected pores inverse opal structure could provide channels for biomolecules diffusing and reaction into the voids of barcodes. These features imparted the hybrid hydrogel photonic barcodes with limits of detection (LOD) of 0.78 ng/mL for carcinoembryonic antigen (CEA) and 0.21 ng/mL for α-fetoprotein (AFP), respectively. It was also demonstrated that the proposed barcodes showed acceptable accuracy and detection reproducibility, and the results were in acceptable agreement with those from common clinic method for the detections of practical clinical samples. Thus, our technique provides a new platform for simultaneous multiplex immunoassay .
研究领域:
生物医学工程
·
分析化学
·
分子诊断
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产品关联
DOI
PubMed
高影响因子
EUROPEAN POLYMER JOURNAL
·
2018
·
IF 3.741
Jianyu Xu,Xin Liu,Xiuyan Ren,Guanghui Gao
Hybrid crosslinking hydrogels have exhibited excellent mechanical properties, however, the relationship between chemical and physical crosslinking in the various deformation stages is still indistinct. Here, a hybrid hydrogel was explored by inducing low density of chemical crosslinking into latex particle hydrogels (LP-Gel), in which latex particles act as physical crosslinking centers for inducing efficient aggregation of hydrophobic chains. The resulting hybrid hydrogel exhibited extraordinary mechanical performance. It is found that the role of chemical and physical crosslinking was different during different deformation levels. The synergistic effects of chemical and physical crosslinking allow hydrogels to dissipate a large number of energy, significantly enhancing the mechanical strength of hydrogels. Moreover, the hybrid hydrogel exhibited puncture resistant, excellent ductility and rapid recovery.
研究领域:
材料科学
·
生物材料
✓ 已验证
产品关联
DOI
高影响因子
Journal of Materials Chemistry B
·
2013
·Vol. 1
·期 46
·6411-6417
·
IF 0
Yunlong Wang,Bing Han,Ronghua Shi,Le Pan,Hui Zhang,Yuhua Shen,Chuanhao Li,Fangzhi Huang,Anjian Xie
Due to the limits of photodynamic therapy (PDT) in clinical use, the development of a new system for PDT may hold promise to improve the situation. In this article, we report the preparation of a novel hybrid hydrogel (HHG) containing poly (ethylene glycol) double acrylates (PEGDA), polyethylene glycol 400 (PEG400), phthalocyanine zinc (ZnPc) and phosphotungstic acid (PTA) based on in situ photopolymerization. ZnPc is used as both the photoinitiator for initiating the formation of HHG and the photosensitizer for producing singlet oxygen to kill tumor cells. PTA plays a significant co-initiator role in the photopolymerization process and has a positive impact on the acceleration of singlet oxygen generation. The HHG shows good biocompatibility, swelling and drug retention abilities, and especially can be easily and rapidly formed on tumor cells in situ by irradiating the precursor with near-infrared light. The HHG shell not only prevents diffusion of the photosensitizer, but also maintains a high ZnPc concentration in or on tumor cells for more effective PDT. Thus, this novel HHG is an attractive candidate for local PDT and has a huge potential application in the future development of cancer treatment.
研究领域:
生物医学工程
·
肿瘤学
·
材料科学
✓ 已验证
DOI
PubMed
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
·
2020
·
IF 5.162
Jingkun Zhao,Ce Sun,Haiyan Li,Xu Dong,Xiaodong Zhang
A series of agar/κ-carrageenan mixed hydrogels with different mass ratios were prepared, and their physicochemical properties, gelling behavior and drug release performance were determined and analyzed. The results showed that the gel strength, the gelling temperature and the gel melting temperature decreased with the increase of κ-carrageenan, while the apparent viscosities increased. Optical rotation and differential scanning calorimetry (DSC) indicated that there did exist intermolecular interactions between agar and κ-carrageenan, and the detailed gelling mechanism of the mixed hydrogels was proposed, which was different from that of the previous research. Besides, agar/κ-carrageenan mixed hydrogels were used as carriers for the delivery of metformin hydrochloride (MET). The results showed that the drug loading efficiency and the sustained release capacity of agar hydrogels could be enhanced by the addition of κ-carrageenan, and the release profile was mainly dominated by the electrostatic interaction between the MET and the polysaccharides . These results indicated that κ-carrageenan had the potential to improve the physicochemical properties and drug release performance of agar hydrogel.
研究领域:
材料科学
·
药剂学
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产品关联
DOI
PubMed
高影响因子
Journal of Materials Chemistry C
·
2022
·Vol. 10
·期 10
·3959-3970
·
IF 8.067
Guoyi Pan,Jingye Yan,Zilun Tang,Jieheng Zhang,Xiaofeng Lin,Dongpeng Yang,Jianyu Wu,Wenjing Lin,Guobin Yi
The composite materials combining quantum dots (QDs) and photonic crystals (PCs) could produce complex and high-dimensional anti-counterfeiting patterns, which solves the problems of simple coding information and a low anti-counterfeiting level of monochromatic materials. Herein, we reported a novel hybrid hydrogel made up of CdTe QDs and SiO2 PCs for optical anti-counterfeiting and information encryption–decryption. The hybrid hydrogel was prepared by adding CdTe QDs and gelatin-methacryloyl (GelMA) precursor filler into a poly(ethyleneglycol) diacrylate (PEGDA)-based inverse opal hydrogel. Firstly, GelMA-based pregel and CdTe QDs were photo-cured to obtain patterned fluorescent labels, whose fluorescence intensities were greater than those of the single CdTe QD solution. Then, the PEGDA-based inverse opal hydrogel and hybrid hydrogel containing CdTe QDs and SiO2 PCs were prepared, both of which had angular dependence of structural colors and good water wettability. The hybrid hydrogel had a double optical anti-counterfeiting function because it also had fluorescence characteristics under UV light. Moreover, through a simple combination of CdTe QDs and PCs, more complex and higher-dimensional optical composite coding effects were achieved, providing a good single platform for exploring the combination effects. In addition, the preparation process was simple and flexible, which only need to provide visually confused structural and fluorescence color, such as our patterned “100”. Then, the hidden signal could be quickly identified by relevant spectral detection. Therefore, this work offers a simple avenue for encoding complex information from a single hybrid hydrogel platform and provides a method for rapid information decoding.
研究领域:
材料科学
·
光学工程
✓ 已验证
产品关联
DOI
高影响因子
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
·
2024
·
IF 7.7
Reza Hafezi Moghaddam,Shayessteh Dadfarnia,Ali Mohammad Haji Shabani,Seyed Pezhman Shirmardi
A humic acid-gelatin (HA-Gel) hydrogel, a gallic acid-xanthan gum (GA-XG) hydrogel, a HA-Gel/GA-XG hydrogel, and superabsorbent polymer (SAP) of HA-Gel/GA-XG/polyacrylamide (PAM) hydrogel were synthesized using electron beam irradiation method. The capability of synthesized hydrogels in loading and controlled release of fulvic acid (FA) was studied. The chemical and physical structure of sorbents was confirmed by various analyses. The effect of irradiation dose on mechanical properties, gel percentage, swelling, and absorbency under load (AUL) of the sorbents was investigated. By changing the hydrogel structures into the SAP form, its swelling capacity was increased from 37 to 320 g/g. Both hybrid hydrogel and SAP were reusable for up to 7 cycles. The maximum fertilizer loading capacities for SAP and hybrid hydrogel were 402.1 and, 175.5 mg g −1 , respectively. In comparison to hydrogels, the SAP showed a slower FA-release performance. Thus, in soil media, 86 % of FA was released in 15–20 days from the hybrid hydrogel while with the SAP, 81 % of FA was released in 30–35 days. The significant improvement in the growth of fodder corn treated with FA-loaded SAP in the greenhouse media in comparison to the control groups showed the effective performance of the designed SAP, favoring its practical applications.
研究领域:
材料科学
·
农业科学
·
环境科学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
COLLOIDS AND SURFACES B-BIOINTERFACES
·
2018
·
IF 3.997
Renshu Zhang,Lei Lei,Qianqian Song,Xingyi Li
Combining a low-molecular-weight hydrogel (LMWH) with a polymeric hydrogel overcomes the disadvantages of the LMWH ( e.g. , its low mechanical property) and is associated with the enhancement of materials performance, which is useful in a variety of biomedical applications. In the present work, a hybrid hydrogel that combines dexamethasone sodium phosphate (Dexp) and a polysaccharide (alginate) was explored via a calcium ion coordination strategy. With the addition of Ca 2+ to an aqueous solution of Dexp/alginate, the Ca 2+ /Dexp/alginate hybrid hydrogel formed spontaneously. The formed Ca 2+ /Dexp/alginate hybrid hydrogels were thoroughly characterized by scanning electron microscopy (SEM), Fourier transform infrared spectroscopy (FTIR) and powder X-ray diffraction (XRD). An in vitro drug release study indicated that the formed Ca 2+ /Dexp/alginate hybrid hydrogel provided a slower drug release rate than did the Ca 2+ /Dexp hydrogel, and the drug release behaviour could be finely tailored by the change of Ca 2+ concentration. More importantly, the subcutaneous injection of the Ca 2+ /Dexp/alginate hybrid hydrogel significantly extended the in vivo retention of the hydrogel in situ compared to that of the Ca 2+ /Dexp hydrogel. The in vivo pharmacokinetic analysis indicated that the Ca 2+ /Dexp/alginate hybrid hydrogel could greatly extend drug release in vivo and significantly improve drug bioavailability compared to the Ca 2+ /Dexp hydrogel. As such, the formed Ca 2+ /Dexp/alginate hybrid hydrogel combined the greater resilience of an alginate network with the long in vivo duration of a low-molecular-weight hydrogel (Ca 2+ /Dexp hydrogel) and remarkably enhanced drug bioavailability, which might open an avenue for the design of self-assembling steroidal drug-polysaccharide hybrid hydrogels for drug delivery applications.
研究领域:
生物材料学
·
药剂学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
危险品化学品经营许可证（带存储）