INDUSTRIAL CROPS AND PRODUCTS
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2024
·
IF 5.6
Ni Wei,Chundong Yang,Yan Su,Chenhuan Lai,Qiang Yong
To investigate the disparate effects of carbocation scavengers on promoting the enzymatic hydrolysis of softwood and hardwood, five carbocation scavengers were supplemented during acid pretreatment of masson pine and poplar in this study, including 2-naphthol (2 N), 2-naphthol-7-sulfonate (NS), p -hydroxybenzoic acid (PB), vanillic acid (VA) and syringic acid (SA). The results showed that naphthols (2 N and NS) with only one nucleophilic site enhanced delignification and enzymatic hydrolysis more significantly than the monophenols with several reactive sites. Adding 2 N and NS increased the hydrolysis yield of acid-pretreated masson pine (AM) from 14.87% to 20.58% and 35.52%, respectively. Correspondingly, the hydrolysis yield of acid-pretreated poplar (AP) improved from 56.54% to 80.47% and 86.9%, respectively. Moreover, as pretreatment severity increased, the enzymatic digestibility of AM and AP first increased and then decreased. However, the naphthols modification retarded this decline, especially for the enzymatic hydrolysis of pretreated poplar. The structure of carbocation scavengers and the lignin unit composition jointly determined the improvement on enzymatic hydrolysis of woody biomass by carbocation scavengers. Furthermore, the naphthols promoted the enzymatic hydrolysis mainly by alleviating enzyme non-productive binding.
研究领域:
生物化学
·
生物质能
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产品关联
DOI
高影响因子
Journal of Advanced Research
·
2025
·
IF 13
Longfa Kou,Yitianhe Xu,Shize Li,Zhinan He,Di Huang,Zhanzheng Ye,Yixuan Zhu,Yunzhi Wang,Xinyu Di,Yuqi Yan,Yinhao Lin,Wanling Zhu,Xianbao Shi,Hailin Zhang,Ruijie Chen
Introduction Acute lung injury (ALI) is a life-threatening condition characterized by rapidly progressing respiratory distress and hypoxemia. Oxidative stress-induced inflammation in lung tissue plays a crucial role in the progression of ALI. Excessive generation of reactive oxygen species (ROS) in the pulmonary microenvironment activates inflammatory signaling pathways, enhancing the transcription of pro-inflammatory factors and ultimately leading to tissue necrosis. Objectives Bilirubin (BR), an exceptional endogenous antioxidant, possesses the ability to counteract elevated levels of reactive oxygen species (ROS) through direct reactions or by inducing antioxidant systems such as Nrf2/HO-1 signaling. However, its limited solubility poses a hindrance to further applications. Hence, it is imperative to develop a suitable bilirubin-based system for biological utilization. Methods In this study, we developed a bilirubin-based ROS-sensitive adaptive nanoscavenger (GP@BR) by co-assembling bilirubin-conjugated glycol chitosan (GC-BR) and bilirubin-conjugated polyethylene glycol (PEG-BR), aiming to alleviate oxidative stress for ALI treatment. Results The different conjugations endowed the bilirubin derivatives with varying sensitivity towards reacting with ROS, enabling GP@BR to exert antioxidative properties specifically in oxidative environments on demand. Besides its excellent antioxidant properties, GP@BR also demonstrated the ability to absorb excess inflammatory cytokines. Moreover, our optimized nanoscavenger facilitated bilirubin transport across the mucosal layer on pulmonary epithelial cells. In vivo studies confirmed that GP@BR significantly improved ALI symptoms and suppressed pulmonary fibrosis. Conclusion This study highlighted the potential of ROS-sensitive adaptive properties and multiple actions of this nanoscavenger in the treatment of ALI.
研究领域:
医学
·
药学
·
生物材料学
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产品关联
DOI
PubMed
高影响因子
Water
·
2019
·Vol. 11
·期 12
·2532
·
IF 2.524
Md. Nahid Pervez,Felix Y. Telegin,Yingjie Cai,Dongsheng Xia,Tiziano Zarra,Vincenzo Naddeo
In this study, a Fenton-activated persulfate (Fe2+/PS) system was introduced for the efficient degradation of Mordant Blue 9 (MB 9) as a textile dye in an aqueous solution. Results showed that the degradation of MB 9 was markedly influenced by operational parameters, such as initial pH, PS concentration, Fe2+concentration, and initial dye concentration. Optimal reaction conditions were then determined. Inorganic anions, such as Cl−and HCO3−, enhanced the degradation efficiency of MB 9 under optimal conditions. Addition of HCO3−reduced the degradation performance of MB 9, whereas the addition of Cl−increased the degradation percentage of MB 9. In addition, quenching experiments were conducted using methanol and tert-butyl alcohol as scavengers, and methanol was identified as an effective scavenger. Thus, the degradation of MB 9 was attributed to SO4•−and•OH radicals. The degradation and mineralization efficiency of MB 9 was significantly reduced using the conventional Fenton process i.e., Fe2+/ hydrogen peroxide (HP) because of the formation of a Fe complex during degradation. Meanwhile, the Fe2+/persulfate (PS) system improved the degradation and mineralization performance.Keywords:Fenton-activated;Fe-complex;persulfate;mordant dyes;scavengers
研究领域:
环境科学
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化学工程
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DOI
高影响因子
APPLIED OPTICS
·
2024
·Vol. 63
·期 9
·2279-2285
·
IF 1.7
Yuelin Wang,Wenhui Fang,Wenhui Fang,Kai Zhang,Zhiwei Men,Zhiwei Men
The stratum corneum of the outermost skin is an important barrier impeding transdermal
permeation, and permeation enhancers can reduce the barrier resistance
of the stratum corneum and enhance the permeation of drugs in tissues.
The optical imaging depth, signal intensity, and scattering
coefficient variation rules of skin tissues in time dimension are
obtained by using optical coherence tomography (OCT). The effect of
optical clearing agents (OCAs) on OCT imaging is obtained by
quantitatively analyzing the changes in the optical properties of
tissues. D-fructose, one of the monosaccharides, and sucrose, one of
the disaccharides, were selected for the ex vivo
optical clearing experiments on pig skin tissues utilizing the
dimethyl sulfoxide (DMSO) carrier effect. We find that DMSO synergized
with sugars applied to skin tissue has a more significant increase in
the optical imaging depth and signal intensity, and a reduction in the
scattering coefficient with an increasing concentration of DMSO. DMSO
with a high concentration and D-fructose with saturated concentration
(10:1; v/v) effectively reduce light attenuation in OCT imaging and
improve the image quality. This operation will also shorten the
application time to minimize skin damage from hyperosmotic agents.
研究领域:
生物医学工程
·
药学
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DOI
PubMed
高影响因子
JOURNAL OF SEPARATION SCIENCE
·
2012
·Vol. 35
·期 17
·2223-2227
·
IF 2.733
Rui Wang,Jianguang Luo,Lingyi Kong
Scutellaria baicalensis Georgi is a well-known medical plant widely used as a famous traditional Chinese medicine. It has been reported that S. baicalensis can protect against oxidative stress and possess anti-inflammatory effect. In the present paper, an HPLC-diode array-chemiluminescence detection method for on-line detection was successfully developed to screen antioxidants in complex S. baicalensis extracts. Using the proposed approach, eight compounds in the S. baicalensis extracts were found to possess a potential antioxidant activity. Furthermore, the effects of purified compounds on protecting RAW 264.7 cells from hydrogen peroxide injury were also investigated in vitro to confirm the established method, which were consistent with the results of HPLC-diode array-chemiluminescence detection method. These results demonstrated that this method was a useful technique for rapidly screening and identifying bioactive components from complex herbal medicines.
研究领域:
药理学
·
植物化学
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产品关联
DOI
PubMed
高影响因子
Biomaterials Science
·
2025
·
IF 5.7
Yuhang Miao,Kaizhen Wang,Xin Liu,Xin Wang,Yanwei Hu,Zhenwei Yuan,Dawei Deng
Chemotherapy and surgery, though effective in cancer treatment, trigger the release of nucleic acid-containing pro-inflammatory compounds from damaged tumor cells, known as nucleic acid-associated damage-associated molecular patterns (NA-DAMPs). This inflammation promotes tumor metastasis, and currently, no effective treatment exists for this treatment-induced inflammation and subsequent tumor metastasis. To address this challenge, we developed a biomimetic liposome complex (Lipo-Rh2) incorporating a hybrid structure of liposomes and dendritic polymers, mimicking cell membrane morphology. Lipo-Rh2 leverages the multivalent surface properties of dendritic polymers to clear cell-free nucleic acids while serving as both a structural stabilizer and targeting ligand via embedded ginsenoside Rh2. Experimental data show that Lipo-Rh2 effectively reduces free nucleic acids in mouse serum through charge interactions, downregulates Toll-like receptor expression, decreases inflammatory cytokine secretion, and inhibits both primary tumor growth and metastasis. Compared to the current nucleic acid scavenger PAMAM-G3, Lipo-Rh2 demonstrates stronger antitumor effects, lower toxicity, and enhanced targeting capabilities. This biomimetic liposome-based nucleic acid scavenger represents a novel approach to nucleic acid clearance, expanding the framework for designing effective therapeutic agents.
研究领域:
药理学
·
肿瘤学
·
分子生物学
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产品关联
DOI
PubMed
高影响因子
Plasmonics
·
2020
·Vol. 15
·期 6
·1827-1833
·
IF 2.335
Wang Junren,Li Hua,Yu Haili,He Yi
Considerable efforts have been made to develop reactive oxygen species (ROS) scavengers for removing high level of ROS. However, most of the reported ROS scavengers are nondegradable and involve harsh reaction conditions as well as utilize various surface ligands. In order to overcome these drawbacks, in the present work, we develop a facile and mild synthesis avenue for preparation of surface-clean hydrogen-doped molybdenum oxide (H 0.34 MoO 3 ) via simply mixing MoO 3 dispersion with aluminum foil under an acidic environment without any surface capping reagents at room temperature. The resulting H 0.34 MoO 3 can act as a broad-spectrum ROS scavenger, including . OH, H 2 O 2 , O 2 − , and 1 O 2 as well as 2, 2-diphenyl-1-picrylhydrazyl (DPPH). The free radical scavenging activity of H 0.34 MoO 3 achieves as high as 71.6% and 99.1% for . OH and DPPH scavenging, which is comparable and superior to that of ascorbic acid that is a classic free radical scavenger. More significantly, the resulting H 0.34 MoO 3 is degrade, which can be degraded into molybdate ions under a neutral environment (pH 7.4).
研究领域:
材料科学
·
生物医学工程
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DOI
高影响因子
JOURNAL OF CHROMATOGRAPHY A
·
2015
·
IF 4.169
Dapeng Li,Ting Wang,Yujie Guo,Yuanjia Hu,Boyang Yu,Jin Qi
Nitric oxide (NO) is an important cellular signaling molecule with extensive physiological and pathophysiological effects. NO scavengers have the potential to treat inflammation, septic shock and other related diseases, and numerous examples have been chemically synthesized or isolated from natural products . The chemical diversity of natural products, however, means that a huge effort is necessary to efficiently screen and identify bioactive compounds, especially NO scavengers. In this article, we propose an effective analytical method to screen for NO scavengers in three natural products using an online system that couples high performance liquid chromatography with tandem diode array and fluorescence detection (HPLC-DAD-FLD). Eighteen compounds from radix of Scutellaria baicalensis Georgi and green tea displayed significant NO scavenging activity whereas components of Pueraria lobata (Willd.) Ohwi had no discernable activity. The structures of the active compounds were elucidated using Agilent Accurate-Mass Q-TOF LC/MS system. Preliminary analysis of structure–activity relationships indicated that, in flavonoids, a 2,3-double bond and a 3-H atom or a 3-OH group are essential for activity. In tannins, poly-hydroxyl groups are important for NO scavenging activity. Method validation indicated that the newly developed method is both reliable and repeatable. The online method that we present provides a simple, rapid and effective way to identify and characterize NO scavengers present in natural products.
研究领域:
药理学
·
分析化学
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DOI
高影响因子
INTERNATIONAL JOURNAL OF FOOD SCIENCE AND TECHNOLOGY
·
2020
·Vol. 56
·期 6
·2983-2991
·
IF 2.773
Shujie Wang,Guoqin Liu,Weiwei Cheng
Summary This research investigated the effect of carnosic acid (CA), tert-butyl hydroquinone (TBHQ), sesamol (SL) and L-ascorbyl palmitate (AP) on the inhibition of glycidyl esters (GEs) and oxidation parameter changes in rice bran oil (RBO) during heat processing. The electron spin resonance (ESR) analysis showed that the free radical scavenging ability of them was ranked as CA > TBHQ > SL > AP. With the addition of CA, TBHQ, SL and AP (0.6 g kg −1 ), the GEs content was reduced significantly from 987.98 ± 8.45 to 283.87 ± 4.78, 303.21 ± 4.38, 440.52 ± 3.82 and 500.55 ± 2.99 μg kg −1 , respectively. All four free radical scavengers had the highest inhibitory effect on C18:2-GE, followed by C18:1-GE and C16:0-GE. Moreover, the free radical scavengers were also effective to inhibit oil oxidation. Overall, the natural-free radical scavenger may be a promising candidate to mitigate GE formation and oil oxidation due to its effectiveness and safety.
研究领域:
食品科学
·
化学
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产品关联
DOI
高影响因子
ACS Applied Energy Materials
·
2024
·
IF 5.4
Xinhe Zhang,Li Li,Hongsheng Liu,Bin Huang,Yutong Duan,Shufang Lou,Weiguang Yang
To prevent the chemical degradation of proton-exchange membranes (PEMs) caused by free-radical attacks, in this study, magnetron sputtering technology was employed to deposit Ce, Ti, and Mo elements as free-radical scavengers (FRSs) onto the surface of polytetrafluoroethylene to fabricate perfluorosulfonic acid/polytetrafluoroethylene-M (PFSA/PTFE-M; M = metal ion) composite membranes. By controlling the injection dose, a surface layer of a radical-quenching-ion barrier with controlled depth and dosage was successfully fabricated. After 96 h Fenton testing, the residual weight and the fluoride ion release rates of the modified composite membranes were higher and lower than those of the pristine PFSA/PTFE membrane, respectively. Significantly, the PFSA/PTFE-Mo-3 min membrane exhibited the best chemical stability, highest residual weight of 88.75%, and lowest fluoride ion release rate of 0.414 mmol/g. Furthermore, after accelerated aging tests, the proton conductivity of the modified enhanced composite membranes was higher than that of the pristine PFSA/PTFE membrane, which was opposite to the trend observed before the accelerated aging tests. This indicates that introducing metal ions via magnetron sputtering is an effective method to enhance the chemical stability of PEMs.
研究领域:
材料科学
·
电化学
·
表面工程
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DOI
高影响因子
Energy & Environmental Science
·
2024
·Vol. 17
·期 8
·2945-2955
·
IF 32.4
Binyang Tuo,Ziyu Wang,Ziqiu Ren,Hanwen Zhang,Xinqi Lu,Yiqiang Zhang,Shuangquan Zang,Yanlin Song
The stability issues of perovskite solar cells (PSCs), especially illumination stability, have become a bottleneck that limits their further development, which needs urgent attention. Herein, we present a novel strategy for enhancing the illumination stability of PSCs using the radical scavenger of 2,2,6,6-tetramethylpiperidine-1-oxyl (TEMPO) to interrupt photoinduced radical decomposition. It is demonstrated that selectively generated triiodide with the addition of TEMPO can obliterate I-deficient phases during crystallization and passivate defects. More importantly, the photochemical decomposition of targeted perovskite polycrystalline films has been observably inhibited by the free-radical elimination effect of TEMPO. By harnessing TEMPO's defect passivation and radical-scavenging effects, target perovskite devices achieve an outstanding power conversion efficiency of 25.03%, maintaining over 90% of their initial efficiency after continuous maximum power point tracking under ISOS-L-2 conditions at 65 °C for 1000 hours. We demonstrate a novel perspective on the management of photochemical behavior in perovskite devices.
研究领域:
材料科学
·
能源技术
✓ 已验证
产品关联
DOI
高影响因子
SCIENCE OF THE TOTAL ENVIRONMENT
·
2023
·
IF 9.8
Jiafu Li,Jingsi Chen,Zengli Zhang,Xiaojun Liang
To prevent the reactions of disinfection byproducts (DBPs) or natural organic matters with residual chlorine in drinking water in the course of the water store, residual chlorine is quenched by chlorine quenchers, while some chlorine quenchers may result in dechlorination of DBPs. Phenolic compounds are a group of highly toxic DBPs compared to regulated aliphatic DBPs (trihalomethanes (THMs) and haloacetic acids (HAAs)), which might be a great threat to drinking water safety. Nevertheless, impact of popular chlorine quenchers on phenolic DBPs is less understanding. In this study, the influences of ammonium chloride , ascorbic acid , sodium thiosulfate , and sodium sulfite on phenolic DBPs are assessed. Total concentration of 19 phenolic DBPs in drinking water from 7 Chinese cities was 145–1821 ng/L, suggesting a widely occurrence of these pollutants. Four assessed chlorine quenchers have not impacts on mass spectra of studied phenolic DBPs. Additionally, when the storage time ≤24 h, recoveries of 19 phenolic DBPs using four assessed chlorine quenchers are within the accept levels (70–130 %). However, when the storage time increased to 168 h, ascorbic acid and sodium thiosulfate satisfied the recovery requirement of phenolic DBPs during the sample analysis, and ammonium chloride and sodium sulfite showed a unacceptable impact on bromo-chloro-phenols. In general, ascorbic acid and sodium thiosulfate are recommended to be the ideal chlorine quenchers of phenolic DBPs. Mechanism study indicated that sodium sulfite induced the dechlorination of 2-chloro-4-bromophenol via nucleophilic reaction. This study is the first attempt to provide the impact of chlorine quenchers on phenolic DBPs and corresponding reaction mechanism.
研究领域:
环境科学
·
公共卫生
✓ 已验证
产品关联
DOI
PubMed
高影响因子
危险品化学品经营许可证（带存储）